Jon Valla

Summary

Affiliation: Midwestern University
Country: USA

Publications

  1. pmc Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Alzheimers Dis 22:307-13. 2010
  2. pmc FDG autoradiography reveals developmental and pathological effects of mutant amyloid in PDAPP transgenic mice
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Int J Dev Neurosci 26:253-8. 2008
  3. pmc Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models
    Rachel M Nicholson
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Brain Res 1347:179-85. 2010
  4. pmc Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention
    Andrew B Wolf
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Alzheimers Dis 32:217-32. 2012
  5. pmc APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease
    Andrew B Wolf
    Department of Biochemistry, Midwestern University, Glendale, AZ, USA
    Neurobiol Aging 34:1007-17. 2013
  6. pmc Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
    Winnie S Liang
    Neurogenomics Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA
    Proc Natl Acad Sci U S A 105:4441-6. 2008
  7. pmc Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease
    Jesse M Hunter
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 27:361-76. 2011
  8. pmc Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Arizona Alzheimer s Disease Consortium, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Mitochondrion 6:323-30. 2006
  9. pmc Age- and transgene-related changes in regional cerebral metabolism in PSAPP mice
    Jon Valla
    Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Brain Res 1116:194-200. 2006
  10. ncbi request reprint Nonprogressive transgene-related callosal and hippocampal changes in PDAPP mice
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Neuroreport 17:829-32. 2006

Collaborators

Detail Information

Publications10

  1. pmc Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Alzheimers Dis 22:307-13. 2010
    ..This functional biomarker may prove useful in early detection and tracking of AD and indicates that mitochondrial mechanisms may contribute to the predisposition to AD before any evidence of amyloid or tau pathology...
  2. pmc FDG autoradiography reveals developmental and pathological effects of mutant amyloid in PDAPP transgenic mice
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Int J Dev Neurosci 26:253-8. 2008
    ..The posterior cingulate is preferentially vulnerable to both effects of transgene in the PDAPP mouse, and both are independent of amyloid deposition...
  3. pmc Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models
    Rachel M Nicholson
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Brain Res 1347:179-85. 2010
    ..These mouse brain regional changes are homologous to alterations seen in PET scans from human AD patients and could thus be useful biomarkers for early testing of novel interventions...
  4. pmc Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention
    Andrew B Wolf
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    J Alzheimers Dis 32:217-32. 2012
    ..Several regions involved have been shown to mediate responses to steroid hormones, indicating a mechanism for sex-based vulnerability. Thus, these findings may have broad implications for the human response to future therapeutics...
  5. pmc APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease
    Andrew B Wolf
    Department of Biochemistry, Midwestern University, Glendale, AZ, USA
    Neurobiol Aging 34:1007-17. 2013
    ..This research might lead to the identification of novel therapeutic targets for the treatment and/or prevention of Alzheimer's disease...
  6. pmc Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
    Winnie S Liang
    Neurogenomics Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA
    Proc Natl Acad Sci U S A 105:4441-6. 2008
    ..Cerebral metabolic rate for glucose abnormalities in FDG PET studies of AD may be associated with reduced neuronal expression of nuclear genes encoding subunits of the mitochondrial electron transport chain...
  7. pmc Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease
    Jesse M Hunter
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 27:361-76. 2011
    ..Understanding the strengths and limitations of Tg mouse AD models through rigorous biochemical, pathological, and functional analyses will facilitate the derivation of models that better approximate human sporadic AD...
  8. pmc Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Arizona Alzheimer s Disease Consortium, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Mitochondrion 6:323-30. 2006
    ..This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease...
  9. pmc Age- and transgene-related changes in regional cerebral metabolism in PSAPP mice
    Jon Valla
    Neurology Research, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Brain Res 1116:194-200. 2006
    ....
  10. ncbi request reprint Nonprogressive transgene-related callosal and hippocampal changes in PDAPP mice
    Jon Valla
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Neuroreport 17:829-32. 2006
    ..These findings and previous work with APP knockouts suggest that PDAPP mice have impaired white matter development due to interference with native murine APP...