Hugo R Arias

Summary

Affiliation: Midwestern University
Country: USA

Publications

  1. pmc Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors
    H R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ 85308 3550, USA
    Br J Pharmacol 157:320-30. 2009
  2. doi request reprint Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 43:1330-9. 2011
  3. doi request reprint Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave, Glendale, AZ 85308, USA
    Neurochem Int 57:153-61. 2010
  4. doi request reprint Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona 85308, USA
    Biochemistry 49:4169-80. 2010
  5. pmc Interaction of 18-methoxycoronaridine with nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona, USA
    Biochim Biophys Acta 1798:1153-63. 2010
  6. doi request reprint Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 42:1007-18. 2010
  7. doi request reprint Different interaction between tricyclic antidepressants and mecamylamine with the human alpha3beta4 nicotinic acetylcholine receptor ion channel
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ 85308, USA
    Neurochem Int 56:642-9. 2010
  8. doi request reprint Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave Glendale, AZ, USA
    Int J Biochem Cell Biol 42:712-24. 2010
  9. ncbi request reprint Interaction of ibogaine with human alpha3beta4-nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 42:1525-35. 2010
  10. doi request reprint Interaction of selective serotonin reuptake inhibitors with neuronal nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona 85308, USA
    Biochemistry 49:5734-42. 2010

Detail Information

Publications21

  1. pmc Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors
    H R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ 85308 3550, USA
    Br J Pharmacol 157:320-30. 2009
    ..Our study explores several possibilities, including direct interactions of BAs with the nAChR channel...
  2. doi request reprint Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 43:1330-9. 2011
    ..These results indicate that the size of the binding sites for ibogaine analogs, located between the serine and nonpolar rings and shared with TCP, is an important structural feature for binding and for inducing desensitization...
  3. doi request reprint Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave, Glendale, AZ 85308, USA
    Neurochem Int 57:153-61. 2010
    ....
  4. doi request reprint Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona 85308, USA
    Biochemistry 49:4169-80. 2010
    ..The higher receptor specificity for JN403 could be important for the treatment of alpha7-related disorders, including dementias, pain-related ailments, depression, anxiety, and wound healing...
  5. pmc Interaction of 18-methoxycoronaridine with nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona, USA
    Biochim Biophys Acta 1798:1153-63. 2010
    ..Ibogaine analogs inhibit the AChR by interacting with a luminal domain that is shared with PCP, and by inducing desensitization...
  6. doi request reprint Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 42:1007-18. 2010
    ..The high proportion of protonated mecamylamine calculated at physiological pH suggests that this drug can be attracted to the channel mouth before binding deeper within the receptor ion channel finally blocking ion flux...
  7. doi request reprint Different interaction between tricyclic antidepressants and mecamylamine with the human alpha3beta4 nicotinic acetylcholine receptor ion channel
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, AZ 85308, USA
    Neurochem Int 56:642-9. 2010
    ....
  8. doi request reprint Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave Glendale, AZ, USA
    Int J Biochem Cell Biol 42:712-24. 2010
    ....
  9. ncbi request reprint Interaction of ibogaine with human alpha3beta4-nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Ave, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 42:1525-35. 2010
    ....
  10. doi request reprint Interaction of selective serotonin reuptake inhibitors with neuronal nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona 85308, USA
    Biochemistry 49:5734-42. 2010
    ..In conclusion, SSRIs inhibit the most important neuronal AChRs with potencies and affinities that are clinically relevant by binding to a luminal site that is shared with tricyclic antidepressants...
  11. doi request reprint Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions?
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA
    Int J Biochem Cell Biol 41:2098-108. 2009
    ..This new evidence paves the way for further investigations using AChRs as targets for the action of safer antidepressants and novel anti-addictive compounds...
  12. doi request reprint Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308 3550, USA
    Int J Biochem Cell Biol 41:1441-51. 2009
    ..We also explore potential intracellular mechanisms by which alpha7 AChR activation mediates this vital cellular process...
  13. pmc Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona 85308, USA
    Biochemistry 48:4506-18. 2009
    ..Bupropion interacts with a luminal binding domain shared with PCP that is located between the serine and valine rings, and this interaction is mediated mainly by an entropy-driven process...
  14. ncbi request reprint Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766 1854, USA
    Biochemistry 45:2014-26. 2006
    ..Binding of CrV probably increases desensitization of the resting channel and stabilizes the desensitized state...
  15. ncbi request reprint Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766 1854, USA
    Biochemistry 42:7358-70. 2003
    ..A plausible location of neutral and charged adamantane derivatives is shown in a model of the resting ion channel...
  16. ncbi request reprint Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 E Second Street, Pomona, CA 91766 1854, USA
    Int J Biochem Cell Biol 38:1254-76. 2006
    ....
  17. ncbi request reprint Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766 1854, USA
    Curr Protein Pept Sci 6:451-72. 2005
    ....
  18. doi request reprint Positive and negative modulation of nicotinic receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, Midwestern University, Glendale, AZ, USA
    Adv Protein Chem Struct Biol 80:153-203. 2010
    ..More exciting is the potential combination of specific agonists with specific PAMs. However, we are still in the beginning of understanding how these compounds act and how these drugs can be used therapeutically...
  19. ncbi request reprint Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766, USA
    Int Rev Neurobiol 54:1-50. 2003
    ..GAs inhibition channels by at least two mechanisms, an open-channel-blocking and/or an allosteric mechanism. 7. Certain GAs may inhibit AChR function by competing for the agonist binding sites or by augmenting the desensitization rate...
  20. doi request reprint Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Midwestern University, Glendale, Arizona 85308, USA
    Int Rev Neurobiol 88:223-55. 2009
    ..This new evidence opens a window for further investigation using AChRs as targets for the action of safer antidepressants and novel antiaddictive compounds...
  21. doi request reprint Interaction of lipids and ligands with nicotinic acetylcholine receptor vesicles assessed by electron paramagnetic resonance spectroscopy
    Hugo Rubén Arias
    Department of Pharmaceutical Sciences, Midwestern University, Glendale, AZ, USA
    Methods Mol Biol 606:291-318. 2010
    ..This is consistent with the existence of annular and non-annular lipid domains on the AChR...