Murphy N, Petersen R, Phillips A, Yordanov B, Dalchau N. Synthesizing and tuning stochastic chemical reaction networks with specified behaviours. J R Soc Interface. 2018;15: pubmed publisher
..In future, synthesis techniques such as these could be used to automate the design of engineered biological circuits and chemical systems. ..
Smith S, Dalchau N. Model reduction enables Turing instability analysis of large reaction-diffusion models. J R Soc Interface. 2018;15: pubmed publisher
..These examples show that our method significantly simplifies the study of pattern formation in large systems where several species can be considered immobile. ..
Eccleston R, Coveney P, Dalchau N. Host genotype and time dependent antigen presentation of viral peptides: predictions from theory. Sci Rep. 2017;7:14367 pubmed publisher
..In conjunction with epitope prediction algorithms, this modelling approach could be used to refine experimental targets for potential T-cell vaccines, both for HIV and other viruses. ..
Dalchau N, Baek S, Briggs H, Robertson F, Dodd A, Gardner M, et al. The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose. Proc Natl Acad Sci U S A. 2011;108:5104-9 pubmed publisher
..We demonstrate that GI acts as part of the sucrose-signaling network and propose this role permits metabolic input into circadian timing in Arabidopsis. ..