Jonathan M Carlson

Summary

Affiliation: Microsoft Research
Country: USA

Publications

  1. ncbi request reprint HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck
    Jonathan M Carlson
    Microsoft Research, Redmond, WA 98052, USA
    Science 345:1254031. 2014
  2. pmc Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
    Jonathan M Carlson
    Microsoft Research, eScience Group, Los Angeles, California, USA
    J Virol 86:5230-43. 2012
  3. pmc Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag
    Jonathan M Carlson
    eScience Group, Microsoft Research, Redmond, Washington, United States of America
    PLoS Comput Biol 4:e1000225. 2008
  4. pmc Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study
    Santiago Avila-Ríos
    Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico
    Retrovirology 6:72. 2009
  5. pmc Increased sequence coverage through combined targeting of variant and conserved epitopes correlates with control of HIV replication
    Justine Sunshine
    Department of Global Health, University of Washington, Seattle, Washington, USA
    J Virol 88:1354-65. 2014
  6. pmc Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1
    Jonathan M Carlson
    Microsoft Research, Los Angeles, California, USA
    J Virol 86:13202-16. 2012
  7. doi request reprint HIV evolution in response to HLA-restricted CTL selection pressures: a population-based perspective
    Jonathan M Carlson
    Microsoft Research, Redmond, WA, USA
    Microbes Infect 10:455-61. 2008
  8. pmc PhyloDet: a scalable visualization tool for mapping multiple traits to large evolutionary trees
    Bongshin Lee
    Microsoft Research, One Microsoft Way, Redmond, WA 98052, USA
    Bioinformatics 25:2611-2. 2009

Collaborators

Detail Information

Publications8

  1. ncbi request reprint HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck
    Jonathan M Carlson
    Microsoft Research, Redmond, WA 98052, USA
    Science 345:1254031. 2014
    ..Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission. ..
  2. pmc Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
    Jonathan M Carlson
    Microsoft Research, eScience Group, Los Angeles, California, USA
    J Virol 86:5230-43. 2012
    ..Given the clinical correlates of immune escape, such heterogeneity suggests that certain epitopes will lead to discordant outcomes if applied universally in a vaccine...
  3. pmc Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag
    Jonathan M Carlson
    eScience Group, Microsoft Research, Redmond, Washington, United States of America
    PLoS Comput Biol 4:e1000225. 2008
    ..Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes...
  4. pmc Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study
    Santiago Avila-Ríos
    Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico
    Retrovirology 6:72. 2009
    ..However, it is not known whether characteristic HLA frequency distributions in different populations have resulted in additional unique footprints...
  5. pmc Increased sequence coverage through combined targeting of variant and conserved epitopes correlates with control of HIV replication
    Justine Sunshine
    Department of Global Health, University of Washington, Seattle, Washington, USA
    J Virol 88:1354-65. 2014
    ..Additionally, sequence coverage serves as a valuable measure by which to evaluate the protective potential of future vaccination strategies. ..
  6. pmc Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1
    Jonathan M Carlson
    Microsoft Research, Los Angeles, California, USA
    J Virol 86:13202-16. 2012
    ..Thus, the factors defining protective cellular immune responses may be more complex than simply targeting conserved viral regions. The results provide new information to guide vaccine design and immunogenicity studies...
  7. doi request reprint HIV evolution in response to HLA-restricted CTL selection pressures: a population-based perspective
    Jonathan M Carlson
    Microsoft Research, Redmond, WA, USA
    Microbes Infect 10:455-61. 2008
    ..Here we summarize recent advances in our understanding of the consequences of CTL escape on HIV evolution at the population level and discuss its implications for HIV vaccine design...
  8. pmc PhyloDet: a scalable visualization tool for mapping multiple traits to large evolutionary trees
    Bongshin Lee
    Microsoft Research, One Microsoft Way, Redmond, WA 98052, USA
    Bioinformatics 25:2611-2. 2009
    ..In this note, we introduce PhyloDet (short for PhyloDetective), an evolutionary tree visualization tool that enables biologists to visualize multiple traits mapped to the tree...