Vincent B Young

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. pmc Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota
    Carole J Kuehl
    Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, 48824, USA
    Infect Immun 73:6952-61. 2005
  2. pmc Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
    Vincent B Young
    Department of Microbiology and Molecular Genetics, Infectious Diseases Unit, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    J Clin Microbiol 42:1203-6. 2004
  3. pmc In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants
    Vincent B Young
    Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 72:2521-7. 2004
  4. doi request reprint Overview of the gastrointestinal microbiota
    Vincent B Young
    Department of Medicine, Division of Infectious Diseases, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Adv Exp Med Biol 635:29-40. 2008
  5. ncbi request reprint Changes in cystic fibrosis airway microbiota at pulmonary exacerbation
    Lisa A Carmody
    Department of Pediatrics and Communicable Disease, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Ann Am Thorac Soc 10:179-87. 2013
  6. ncbi request reprint Detection of mixed populations of Clostridium difficile from symptomatic patients using capillary-based polymerase chain reaction ribotyping
    Adam A Behroozian
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan, USA
    Infect Control Hosp Epidemiol 34:961-6. 2013
  7. pmc Poor functional status as a risk factor for severe Clostridium difficile infection in hospitalized older adults
    Krishna Rao
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan
    J Am Geriatr Soc 61:1738-42. 2013
  8. pmc Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy
    Katie L Mason
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:3371-80. 2012
  9. pmc Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation
    Dionysios A Antonopoulos
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI 48109 5623, USA
    Infect Immun 77:2367-75. 2009
  10. pmc Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus
    Jason S Pratt
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 74:4496-504. 2006

Collaborators

Detail Information

Publications50

  1. pmc Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota
    Carole J Kuehl
    Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, 48824, USA
    Infect Immun 73:6952-61. 2005
    ....
  2. pmc Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
    Vincent B Young
    Department of Microbiology and Molecular Genetics, Infectious Diseases Unit, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    J Clin Microbiol 42:1203-6. 2004
    ....
  3. pmc In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants
    Vincent B Young
    Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 72:2521-7. 2004
    ..However, a CDT-negative H. hepaticus mutant had a significantly diminished capacity to induce lesions in this murine model of inflammatory bowel disease...
  4. doi request reprint Overview of the gastrointestinal microbiota
    Vincent B Young
    Department of Medicine, Division of Infectious Diseases, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Adv Exp Med Biol 635:29-40. 2008
    ..Following this discussion we will introduce methods that have been used to study the structure, function and dynamics of this community...
  5. ncbi request reprint Changes in cystic fibrosis airway microbiota at pulmonary exacerbation
    Lisa A Carmody
    Department of Pediatrics and Communicable Disease, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Ann Am Thorac Soc 10:179-87. 2013
    ..In persons with cystic fibrosis (CF), repeated exacerbations of pulmonary symptoms are associated with a progressive decline in lung function. Changes in the airway microbiota around the time of exacerbations are not well understood...
  6. ncbi request reprint Detection of mixed populations of Clostridium difficile from symptomatic patients using capillary-based polymerase chain reaction ribotyping
    Adam A Behroozian
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan, USA
    Infect Control Hosp Epidemiol 34:961-6. 2013
    ..To investigate the simultaneous occurrence of more than 1 Clostridium difficile ribotype in patients' stool samples at the time of diagnostic testing...
  7. pmc Poor functional status as a risk factor for severe Clostridium difficile infection in hospitalized older adults
    Krishna Rao
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan
    J Am Geriatr Soc 61:1738-42. 2013
    ..To determine the role of impaired functional status as a risk factor for severe Clostridium difficile infection (CDI) in older adults...
  8. pmc Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy
    Katie L Mason
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:3371-80. 2012
    ..Previous studies have focused on the ability of bacteria to alter C. albicans; this study addresses the ability of C. albicans to alter the bacterial microbiota during nonpathogenic colonization...
  9. pmc Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation
    Dionysios A Antonopoulos
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI 48109 5623, USA
    Infect Immun 77:2367-75. 2009
    ....
  10. pmc Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus
    Jason S Pratt
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 74:4496-504. 2006
    ..hepaticus. These results suggest that CDT plays a key immunomodulatory role that allows persistence of H. hepaticus and that in IL-10-/- mice this alteration of the host immune response results in the development of colitis...
  11. pmc Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response
    Amir A Sadighi Akha
    Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5642, USA
    Immunology 140:111-22. 2013
    ..difficile and highlight eIF2α phosphorylation and the interleukin-22-pSTAT3-RegIIIγ axis as two of the pathways that could be used to contain and counteract the damage inflicted on the intestinal epithelium. ..
  12. ncbi request reprint Colitis-induced bone loss is gender dependent and associated with increased inflammation
    Regina Irwin
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Inflamm Bowel Dis 19:1586-97. 2013
    ..Patients with inflammatory bowel disease (IBD) are at increase risk for bone loss and fractures. Therefore, in the present study, we examined the effect of experimental IBD on bone health...
  13. pmc Disruption of the human gut microbiota following Norovirus infection
    Adam M Nelson
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    PLoS ONE 7:e48224. 2012
    ..These results demonstrate that some patients have a disrupted microbiota following Norovirus infection, and therefore may be at elevated risk for long-term health complications...
  14. pmc Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains
    Casey M Theriot
    Department of Internal Medicine Division of Infectious Diseases, University of Michigan, Ann Arbor, USA
    Gut Microbes 2:326-34. 2011
    ..Cefoperazone treated mice represent a useful model of C. difficile infection that will help us better understand the pathogenesis and virulence of this re-emerging pathogen...
  15. pmc A clinical and epidemiological review of non-toxigenic Clostridium difficile
    Mukil Natarajan
    Department of Internal Medicine, University of Michigan Health System, 5510 E MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5680, USA
    Anaerobe 22:1-5. 2013
    ..Evidence for a therapeutic or preventive role for NTCD is limited but clinical prophylaxis studies are ongoing. NTCD potentially represents an exciting new tool in preventing CDI and its recurrences. ..
  16. doi request reprint The systemic inflammatory response to Clostridium difficile infection
    Krishna Rao
    Division of Infectious Diseases, The University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America Department of Internal Medicine, The University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America Division of Infectious Diseases, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America
    PLoS ONE 9:e92578. 2014
    ..The systemic inflammatory response to Clostridium difficile infection (CDI) is incompletely defined, particularly for patients with severe disease...
  17. pmc Clostridium difficile ribotype diversity at six health care institutions in the United States
    Sheila Waslawski
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Hospital and Health Systems, Ann Arbor, Michigan, USA
    J Clin Microbiol 51:1938-41. 2013
    ..Regionally important ribotypes were identified, and institutions in close proximity did not necessarily share more ribotype diversity than institutions that were farther apart...
  18. pmc Suppression of Clostridium difficile in the gastrointestinal tracts of germfree mice inoculated with a murine isolate from the family Lachnospiraceae
    Angela E Reeves
    Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan, USA
    Infect Immun 80:3786-94. 2012
    ..difficile and novel therapeutic approaches for the treatment and prevention of C. difficile infection...
  19. doi request reprint Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea
    Ju Young Chang
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA
    J Infect Dis 197:435-8. 2008
    ..Preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrent CDAD, which is often recalcitrant to existing therapies...
  20. ncbi request reprint Role of the intestinal microbiota in resistance to colonization by Clostridium difficile
    Robert A Britton
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan
    Gastroenterology 146:1547-53. 2014
    ..Increasing our understanding of how the intestinal microbiota manage C difficile could lead to better means of controlling this important nosocomial pathogen...
  21. doi request reprint Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
    Casey M Theriot
    1 Division of Infectious Diseases, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA 2 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Commun 5:3114. 2014
    ..Our results indicate that antibiotic-mediated alteration of the gut microbiome converts the global metabolic profile to one that favours C. difficile germination and growth. ..
  22. pmc Comparison of the respiratory microbiome in healthy nonsmokers and smokers
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:1067-75. 2013
    ..Results from 16S rDNA-encoding gene sequence-based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome...
  23. pmc Ecological succession of bacterial communities during conventionalization of germ-free mice
    Merritt G Gillilland
    Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Appl Environ Microbiol 78:2359-66. 2012
    ....
  24. pmc The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection
    Angela E Reeves
    Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, MI, 48109, USA
    Gut Microbes 2:145-58. 2011
    ..We demonstrate that altering the balance of these two opposing processes alters clinical outcome and thus may lead to novel preventative and therapeutic approaches for CDI...
  25. ncbi request reprint Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: current promise and future needs
    Mark J Koenigsknecht
    aDepartment of Internal Medicine, Division of Infectious Diseases bDepartment of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan, USA
    Curr Opin Gastroenterol 29:628-32. 2013
    ..In patients with recurrent CDI, the microbiota remains in a state with decreased diversity, and FMT from a healthy individual restores the gut microbiota and subsequently colonization resistance against the pathogen...
  26. pmc Depression, antidepressant medications, and risk of Clostridium difficile infection
    Mary A M Rogers
    Department of Internal Medicine, University of Michigan, 016 440E NCRC, Ann Arbor, MI 48109 2800, USA
    BMC Med 11:121. 2013
    ..Our objective was to evaluate whether depression or the use of anti-depressants altered the risk of developing CDI, using two distinct datasets and study designs...
  27. pmc Stabilization of the murine gut microbiome following weaning
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
    Gut Microbes 3:383-93. 2012
    ..These results suggest a high degree of stability in the microbiome once the community reached the second state...
  28. pmc Procalcitonin levels associate with severity of Clostridium difficile infection
    Krishna Rao
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e58265. 2013
    ..Procalcitonin (PCT), a serum biomarker with specificity for bacterial infections, has been little studied in CDI. We hypothesized that PCT associated with CDI severity...
  29. pmc The microbiome of the lung
    James M Beck
    Pulmonary Section, Medical Service, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI, USA
    Transl Res 160:258-66. 2012
    ..As this field advances over the next several years, we anticipate that studies using larger cohorts, multicenter designs, and longitudinal sampling will add to our knowledge and understanding of the lung microbiome...
  30. pmc Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia
    Seth T Walk
    The Department of Internal Medicine, University of Michigan Health System, Ann Arbor, 48109, USA
    Anaerobe 17:252-6. 2011
    ..In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections...
  31. pmc Lethal toxin is a critical determinant of rapid mortality in rodent models of Clostridium sordellii endometritis
    Yibai Hao
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    Anaerobe 16:155-60. 2010
    ..Injections of a monoclonal anti-TcsL IgG protected animals from death during C. sordellii ATCC9714 infection, suggesting that such an approach might improve the treatment of patients with C. sordellii-induced toxic shock syndrome...
  32. pmc Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon
    Yunwei Wang
    Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Rm 9031, 900 E 57th Street, Chicago, IL 60637, USA
    Appl Microbiol Biotechnol 88:1333-42. 2010
    ..In summary, these studies demonstrate the feasibility of the approach to study the structure and metagenomic profiles of human intestinal mucosa-associated microbial communities at small spatial scales...
  33. pmc Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitis
    Nabeetha A Nagalingam
    Department of Microbiology and Molecular Genetics, Michigan State University, Ann Arbor, Michigan, USA
    Inflamm Bowel Dis 17:917-26. 2011
    ....
  34. ncbi request reprint The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates
    Paul E Carlson
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Anaerobe 24:109-16. 2013
    ..less severe disease based on an in vitro C. difficile phenotype and suggest that clinical outcome is better predicted by bacterial attributes other than ribotype...
  35. pmc Clostridium difficile ribotype does not predict severe infection
    Seth T Walk
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Clin Infect Dis 55:1661-8. 2012
    ..Studies of Clostridium difficile outbreaks suggested that certain ribotypes (eg, 027 and 078) cause more severe disease than other ribotypes. A growing number of studies challenge the validity of this hypothesis...
  36. pmc Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
    Robert A Britton
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Trends Microbiol 20:313-9. 2012
    ..difficile and how antibiotic administration disturbs host-microbiota homeostasis, leading to CDI...
  37. pmc Decade-long bacterial community dynamics in cystic fibrosis airways
    Jiangchao Zhao
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:5809-14. 2012
    ..These features are the key parameters with which to assess the complex ecology of the CF airway...
  38. pmc Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis
    Katie L Mason
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Infect Immun 80:150-8. 2012
    ..albicans. Altogether, these data implicate a dichotomy between C. albicans colonization and gastric disease that is bacterial microbiome dependent...
  39. ncbi request reprint Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice
    Laura Harris
    Department of Physiology, Michigan State University, East Lansing, Michigan, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1020-9. 2009
    ..Changes in serum TNF-alpha (increased) and IGF-I (decreased) paralleled changes in bone parameters and returned to normal values with recovery, suggesting a potential role in the skeletal response...
  40. pmc Genetic diversity of Campylobacter sp. isolates from retail chicken products and humans with gastroenteritis in Central Michigan
    Brooke R Fitch
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    J Clin Microbiol 43:4221-4. 2005
    ..Campylobacter jejuni isolates from clinical sources had a greater diversity of flagellin alleles and a higher rate of quinolone resistance than isolates from retail chicken products...
  41. pmc Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free mice
    Kathryn A Eaton
    Unit for Laboratory Animal Medicine, 018 Animal Research Facility, University of Michigan, Ann Arbor, MI 48109 0614, USA
    Infect Immun 76:3054-63. 2008
    ..The disease in mice was Stx2 and bacterial strain dependent. This animal model should be a useful tool for studying the pathogenesis of renal disease secondary to EHEC infection...
  42. ncbi request reprint Alteration of the murine gastrointestinal microbiota by tigecycline leads to increased susceptibility to Clostridium difficile infection
    Christine M Bassis
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA
    Antimicrob Agents Chemother 58:2767-74. 2014
    ..These results indicate that microbiotic dynamics are key in the development of CDI, and a better understanding of these dynamics may lead to better strategies to prevent and treat this disease. ..
  43. pmc The intestinal microbiota in health and disease
    Vincent B Young
    Division of Infectious Diseases, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, USA
    Curr Opin Gastroenterol 28:63-9. 2012
    ..This review discusses some of the recent work that reveals how the gut microbiome helps establish and protect intestinal health and how disturbances in this microbial community can lead to disease states...
  44. pmc Evolutionary genetics of a new pathogenic Escherichia species: Escherichia albertii and related Shigella boydii strains
    Katie E Hyma
    Microbial Evolution Laboratory, 165 Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824, USA
    J Bacteriol 187:619-28. 2005
    ..coli-like ancestor approximately 28 million years ago and formed a distinct evolutionary branch of enteric pathogens that has radiated into groups with distinct virulence properties...
  45. pmc Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward
    Vincent B Young
    Department of Medicine, University of Michigan Ann Arbor, MI, USA
    Front Microbiol 2:144. 2011
    ..It is our sincere hope that this discussion will help advance future efforts in this area by identifying current challenges and limitations and by suggesting strategies to overcome these obstacles...
  46. pmc Significance of the microbiome in obstructive lung disease
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:456-63. 2012
    ..Whether we can manipulate bacterial communities to improve clinical outcomes remains to be seen...
  47. pmc Streptococcus intermedius causing infective endocarditis and abscesses: a report of three cases and review of the literature
    MaryAnn P Tran
    Department of Medicine, Infectious Diseases Division, Michigan State University, East Lansing, Michigan, USA
    BMC Infect Dis 8:154. 2008
    ..Identification of Streptococcus intermedius is difficult, leading to the development of molecular methods to more accurately identify and characterize this organism...
  48. ncbi request reprint Spherules, hyphae, and air-crescent sign
    Adriano R Tonelli
    Department of Internal Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Med Sci 335:504-6. 2008
    ..Chronic fibrocavitary pneumonia should be especially considered in patients who lived in endemic areas and have risk factors such as diabetes mellitus or pulmonary fibrosis related to smoking...
  49. pmc Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus
    Seth T Walk
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan, USA
    Inflamm Bowel Dis 16:1841-9. 2010
    ..One proposed mechanism is that H. polygyrus infection favors the outgrowth or suppression of certain bacteria, which in turn help modulate host immunity...
  50. ncbi request reprint Explaining unexplained diarrhea and associating risks and infections
    Donna M Denno
    Department of Health Services, University of Washington School of Medicine, Seattle, WA, USA
    Anim Health Res Rev 8:69-80. 2007
    ..By filling these gaps in our knowledge it should be possible to formulate rational prevention mechanisms for human gastrointestinal illnesses...