Research Topics
Species | Vincent B YoungSummaryAffiliation: Michigan State University Country: USA Publications
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Publications
Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiotaCarole J Kuehl
Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, 48824, USA
Infect Immun 73:6952-61. 2005....- Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiotaVincent B Young
Department of Microbiology and Molecular Genetics, Infectious Diseases Unit, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
J Clin Microbiol 42:1203-6. 2004.... - In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutantsVincent B Young
Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Infect Immun 72:2521-7. 2004..However, a CDT-negative H. hepaticus mutant had a significantly diminished capacity to induce lesions in this murine model of inflammatory bowel disease... 
Overview of the gastrointestinal microbiotaVincent B Young
Department of Medicine, Division of Infectious Diseases, The University of Michigan, Ann Arbor, Michigan 48109, USA
Adv Exp Med Biol 635:29-40. 2008..Following this discussion we will introduce methods that have been used to study the structure, function and dynamics of this community...- Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapyKatie L Mason
Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Infect Immun 80:3371-80. 2012..Previous studies have focused on the ability of bacteria to alter C. albicans; this study addresses the ability of C. albicans to alter the bacterial microbiota during nonpathogenic colonization... - Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbationDionysios A Antonopoulos
Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI 48109 5623, USA
Infect Immun 77:2367-75. 2009.... - Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticusJason S Pratt
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
Infect Immun 74:4496-504. 2006..hepaticus. These results suggest that CDT plays a key immunomodulatory role that allows persistence of H. hepaticus and that in IL-10-/- mice this alteration of the host immune response results in the development of colitis... - Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strainsCasey M Theriot
Department of Internal Medicine Division of Infectious Diseases, University of Michigan, Ann Arbor, USA
Gut Microbes 2:326-34. 2011..Cefoperazone treated mice represent a useful model of C. difficile infection that will help us better understand the pathogenesis and virulence of this re-emerging pathogen... - Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrheaJu Young Chang
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA
J Infect Dis 197:435-8. 2008..Preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrent CDAD, which is often recalcitrant to existing therapies... - Ecological succession of bacterial communities during conventionalization of germ-free miceMerritt G Gillilland
Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA
Appl Environ Microbiol 78:2359-66. 2012.... - The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile InfectionAngela E Reeves
Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, MI, 48109, USA
Gut Microbes 2:145-58. 2011..We demonstrate that altering the balance of these two opposing processes alters clinical outcome and thus may lead to novel preventative and therapeutic approaches for CDI... - The microbiome of the lungJames M Beck
Pulmonary Section, Medical Service, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI, USA
Transl Res 160:258-66. 2012..As this field advances over the next several years, we anticipate that studies using larger cohorts, multicenter designs, and longitudinal sampling will add to our knowledge and understanding of the lung microbiome... - Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremiaSeth T Walk
The Department of Internal Medicine, University of Michigan Health System, Ann Arbor, 48109, USA
Anaerobe 17:252-6. 2011..In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections... - Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitisNabeetha A Nagalingam
Department of Microbiology and Molecular Genetics, Michigan State University, Ann Arbor, Michigan, USA
Inflamm Bowel Dis 17:917-26. 2011.... - Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colonYunwei Wang
Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Rm 9031, 900 E 57th Street, Chicago, IL 60637, USA
Appl Microbiol Biotechnol 88:1333-42. 2010..In summary, these studies demonstrate the feasibility of the approach to study the structure and metagenomic profiles of human intestinal mucosa-associated microbial communities at small spatial scales... - Lethal toxin is a critical determinant of rapid mortality in rodent models of Clostridium sordellii endometritisYibai Hao
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Anaerobe 16:155-60. 2010..Injections of a monoclonal anti-TcsL IgG protected animals from death during C. sordellii ATCC9714 infection, suggesting that such an approach might improve the treatment of patients with C. sordellii-induced toxic shock syndrome... - Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistanceRobert A Britton
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
Trends Microbiol 20:313-9. 2012..difficile and how antibiotic administration disturbs host-microbiota homeostasis, leading to CDI... - Decade-long bacterial community dynamics in cystic fibrosis airwaysJiangchao Zhao
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 109:5809-14. 2012..These features are the key parameters with which to assess the complex ecology of the CF airway... - Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritisKatie L Mason
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Infect Immun 80:150-8. 2012..albicans. Altogether, these data implicate a dichotomy between C. albicans colonization and gastric disease that is bacterial microbiome dependent... - Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free miceKathryn A Eaton
Unit for Laboratory Animal Medicine, 018 Animal Research Facility, University of Michigan, Ann Arbor, MI 48109 0614, USA
Infect Immun 76:3054-63. 2008..The disease in mice was Stx2 and bacterial strain dependent. This animal model should be a useful tool for studying the pathogenesis of renal disease secondary to EHEC infection... - Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in miceLaura Harris
Department of Physiology, Michigan State University, East Lansing, Michigan, USA
Am J Physiol Gastrointest Liver Physiol 296:G1020-9. 2009..Changes in serum TNF-alpha (increased) and IGF-I (decreased) paralleled changes in bone parameters and returned to normal values with recovery, suggesting a potential role in the skeletal response... - Genetic diversity of Campylobacter sp. isolates from retail chicken products and humans with gastroenteritis in Central MichiganBrooke R Fitch
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
J Clin Microbiol 43:4221-4. 2005..Campylobacter jejuni isolates from clinical sources had a greater diversity of flagellin alleles and a higher rate of quinolone resistance than isolates from retail chicken products... - Stabilization of the murine gut microbiome following weaningPatrick D Schloss
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
Gut Microbes 3:383-93. 2012..These results suggest a high degree of stability in the microbiome once the community reached the second state... - Disruption of the Human Gut Microbiota following Norovirus InfectionAdam M Nelson
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
PLoS ONE 7:e48224. 2012..These results demonstrate that some patients have a disrupted microbiota following Norovirus infection, and therefore may be at elevated risk for long-term health complications... - The intestinal microbiota in health and diseaseVincent B Young
Division of Infectious Diseases, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, USA
Curr Opin Gastroenterol 28:63-9. 2012..This review discusses some of the recent work that reveals how the gut microbiome helps establish and protect intestinal health and how disturbances in this microbial community can lead to disease states... - Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving ForwardVincent B Young
Department of Medicine, University of Michigan Ann Arbor, MI, USA
Front Microbiol 2:144. 2011..It is our sincere hope that this discussion will help advance future efforts in this area by identifying current challenges and limitations and by suggesting strategies to overcome these obstacles... - Evolutionary genetics of a new pathogenic Escherichia species: Escherichia albertii and related Shigella boydii strainsKatie E Hyma
Microbial Evolution Laboratory, 165 Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824, USA
J Bacteriol 187:619-28. 2005..coli-like ancestor approximately 28 million years ago and formed a distinct evolutionary branch of enteric pathogens that has radiated into groups with distinct virulence properties... - Significance of the microbiome in obstructive lung diseaseMeiLan K Han
Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
Thorax 67:456-63. 2012..Whether we can manipulate bacterial communities to improve clinical outcomes remains to be seen... - Streptococcus intermedius causing infective endocarditis and abscesses: a report of three cases and review of the literatureMaryAnn P Tran
Department of Medicine, Infectious Diseases Division, Michigan State University, East Lansing, Michigan, USA
BMC Infect Dis 8:154. 2008..Identification of Streptococcus intermedius is difficult, leading to the development of molecular methods to more accurately identify and characterize this organism... - Spherules, hyphae, and air-crescent signAdriano R Tonelli
Department of Internal Medicine, Michigan State University, East Lansing, Michigan 48824, USA
Am J Med Sci 335:504-6. 2008..Chronic fibrocavitary pneumonia should be especially considered in patients who lived in endemic areas and have risk factors such as diabetes mellitus or pulmonary fibrosis related to smoking... - Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrusSeth T Walk
Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan, USA
Inflamm Bowel Dis 16:1841-9. 2010..One proposed mechanism is that H. polygyrus infection favors the outgrowth or suppression of certain bacteria, which in turn help modulate host immunity... 
Explaining unexplained diarrhea and associating risks and infectionsDonna M Denno
Department of Health Services, University of Washington School of Medicine, Seattle, WA, USA
Anim Health Res Rev 8:69-80. 2007..By filling these gaps in our knowledge it should be possible to formulate rational prevention mechanisms for human gastrointestinal illnesses...