Affiliation: Michigan State University
Zhao Y, Tan Y, Strynar M, Perez G, Haslam S, Yang C. Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice. Reprod Toxicol. 2012;33:563-576 pubmed publisher
..These results indicate that PFOA effects on ovaries mediate its inhibition of mammary gland development in Balb/c and C57Bl/6 mice and that PPARα expression is a contributing factor. ..
Humphries B, Wang Z, Oom A, Fisher T, Tan D, Cui Y, et al
. MicroRNA-200b targets protein kinase C? and suppresses triple-negative breast cancer metastasis. Carcinogenesis. 2014;35:2254-63 pubmed publisher
..Our findings suggest that miR-200b and PKC? may serve as promising therapeutic targets for metastatic TNBC. ..
Li Z, Liu X, Wang L, Wang Y, DU C, Xu S, et al
. The role of PGC-1? and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells. Toxicology. 2016;355-356:39-48 pubmed publisher
..Together, the findings from this study suggest that PGC-1? and MRP1 plays important roles in protecting TM4 cells against lead-induced mitochondrial toxicity, providing a better understanding of lead-induced mitochondrial toxicity. ..
Wang Z, Humphries B, Xiao H, Jiang Y, Yang C. MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase C? and Wnt5b-protein kinase C? positive feedback loop and inhibiting Rac1 activation. J Biol Chem. 2014;289:18373-86 pubmed publisher
..Together, these findings indicate that miR-200b suppresses arsenic-transformed cell migration by targeting PKC? and Wnt5b-PKC? positive feedback loop and subsequently inhibiting Rac1 activation. ..
Humphries B, Wang Z, Yang C. The role of microRNAs in metal carcinogen-induced cell malignant transformation and tumorigenesis. Food Chem Toxicol. 2016;98:58-65 pubmed publisher
..This review aims to discuss recent studies showing that miRNAs play important roles in metal carcinogen-induced cell malignant transformation and tumorigenesis. Some thoughts for future further studies in this field are also presented. ..