Stephanie Watts

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. pmc Serotonin and blood pressure regulation
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Pharmacol Rev 64:359-88. 2012
  2. pmc Chemerin connects fat to arterial contraction
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Arterioscler Thromb Vasc Biol 33:1320-8. 2013
  3. pmc 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved
    ROBERT PATRICK DAVIS
    Department of Pharmacology and Toxicology, Michigan State University, East, Lansing, MI 48824 1317, USA
    BMC Pharmacol 12:4. 2012
  4. doi request reprint Smooth muscle pharmacology in the isolated virgin and pregnant rat uterus and cervix
    Emma S Darios
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 341:587-96. 2012
  5. pmc Inability of serotonin to activate the c-Jun N-terminal kinase and p38 kinase pathways in rat aortic vascular smooth muscle cells
    A K Banes
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Ml 48824, USA
    BMC Pharmacol 1:8. 2001
  6. pmc Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertension
    Amy K L Banes
    Department of Pharmacology and Toxicology, Michigan State University, E Lansing, MI 48824, USA
    BMC Pharmacol 3:12. 2003
  7. doi request reprint The love of a lifetime: 5-HT in the cardiovascular system
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824 1317, USA
    Am J Physiol Regul Integr Comp Physiol 296:R252-6. 2009
  8. pmc Serotonylation of vascular proteins important to contraction
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 4:e5682. 2009
  9. pmc Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    Am J Physiol Heart Circ Physiol 301:H1236-47. 2011
  10. pmc Comparison of the function of the serotonin transporter in the vasculature of male and female rats
    Aurea Elizabeth Linder
    Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Clin Exp Pharmacol Physiol 38:314-22. 2011

Research Grants

  1. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2007
  2. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009

Collaborators

Detail Information

Publications73

  1. pmc Serotonin and blood pressure regulation
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Pharmacol Rev 64:359-88. 2012
    ..The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension...
  2. pmc Chemerin connects fat to arterial contraction
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Arterioscler Thromb Vasc Biol 33:1320-8. 2013
    ..We presently tested the hypothesis that chemerin is expressed in perivascular adipose tissue and is vasoactive, supporting the existence of a chemerin axis in the vasculature...
  3. pmc 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved
    ROBERT PATRICK DAVIS
    Department of Pharmacology and Toxicology, Michigan State University, East, Lansing, MI 48824 1317, USA
    BMC Pharmacol 12:4. 2012
    ....
  4. doi request reprint Smooth muscle pharmacology in the isolated virgin and pregnant rat uterus and cervix
    Emma S Darios
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 341:587-96. 2012
    ..This work highlights the unappreciated smooth muscle function of the cervix versus uterus and cervical changes in pharmacology during pregnancy...
  5. pmc Inability of serotonin to activate the c-Jun N-terminal kinase and p38 kinase pathways in rat aortic vascular smooth muscle cells
    A K Banes
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Ml 48824, USA
    BMC Pharmacol 1:8. 2001
    ..Parallel MAPK pathways, the c-Jun N-terminal Kinase (JNK) and p38 pathway, are activated by stimulators of the ERK/MAPK pathway. We hypothesized that 5-HT would activate the JNK and p38 pathways in rat vascular smooth muscle cells...
  6. pmc Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertension
    Amy K L Banes
    Department of Pharmacology and Toxicology, Michigan State University, E Lansing, MI 48824, USA
    BMC Pharmacol 3:12. 2003
    ..We performed DOCA-salt time course (days 1, 3, 5 and 7) studies using treatment groups of: DOCA-high salt, DOCA-low salt, Sham and Sham-high salt rats...
  7. doi request reprint The love of a lifetime: 5-HT in the cardiovascular system
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824 1317, USA
    Am J Physiol Regul Integr Comp Physiol 296:R252-6. 2009
    ..This work underscores that our knowledge of the functions of 5-HT in the cardiovascular system is significantly incomplete. As such, this field is an exciting one in which to be, because there are superb questions to be asked...
  8. pmc Serotonylation of vascular proteins important to contraction
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 4:e5682. 2009
    ..We tested the hypothesis that 5-HT is a substrate for transglutaminase in arterial vascular smooth muscle, with protein serotonylation having physiological function...
  9. pmc Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    Am J Physiol Heart Circ Physiol 301:H1236-47. 2011
    ..We conclude that IDO is an enzyme active primarily in brown fat surrounding the thoracic aorta and depresses aortic contractility...
  10. pmc Comparison of the function of the serotonin transporter in the vasculature of male and female rats
    Aurea Elizabeth Linder
    Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Clin Exp Pharmacol Physiol 38:314-22. 2011
    ..5. Collectively, these data suggest that SERT function, when challenged with 5-HT, is modestly more important in the vasculature of the female compared with male rat...
  11. pmc 5-hydroxtryptamine receptors in systemic hypertension: an arterial focus
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Cardiovasc Ther 29:54-67. 2011
    ..Serotonin (5-hydroxytryptamine [5-HT]) was named for its isolation from blood serum (sero-) and ability to contract smooth muscle (-tonin). Thus, its relationship with the cardiovascular system began with its discovery...
  12. ncbi request reprint Characterization of the contractile 5-hydroxytryptamine receptor in the renal artery of the normotensive rat
    Stephanie W Watts
    Department of Pharmacology and Toxicology, B445 Life Sciences Bldg, Michigan State University, East Lansing, MI 48824 1317
    J Pharmacol Exp Ther 309:165-72. 2004
    ..This unique pharmacology may reflect differences in 5-HT receptor coupling between tissues or heterogeneity in the subtype(s) of 5-HT receptors expressed in the renal artery...
  13. ncbi request reprint Morphological and biochemical characterization of remodeling in aorta and vena cava of DOCA-salt hypertensive rats
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823 1317, USA
    Am J Physiol Heart Circ Physiol 292:H2438-48. 2007
    ..These findings suggest that large veins may not undergo vascular remodeling in DOCA-salt hypertension...
  14. ncbi request reprint Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptors
    S W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    J Cardiovasc Pharmacol 38:539-51. 2001
    ..Thus, while mRNA and possibly protein for multiple 5-HT receptors are present in aortic smooth muscle, only the 5-HT 2A receptor plays a significant role in directly modulating contractility and activating the Erk MAPK pathway...
  15. ncbi request reprint Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertension
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Hypertension 39:825-9. 2002
    ..Although similarities were observed for large and small arteries, differences under the condition of DOCA-salt hypertension exist that may determine serotonergic compounds effective in lowering blood pressure...
  16. pmc Endothelin-1-induced venous contraction is maintained in DOCA-salt hypertension; studies with receptor agonists
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    Br J Pharmacol 137:69-79. 2002
    ..The ET(B) receptor was present in the aorta but, unlike in veins, does not mediate contraction directly. A sustained response to ET-1 in the venous circulation may contribute to the elevated blood pressure in the DOCA-salt model...
  17. pmc Endothelin receptors: what's new and what do we need to know?
    Stephanie W Watts
    Dept of Pharmacology and Toxicology, B445 Life Sciences Bldg, East Lansing, MI 48824 1317, USA
    Am J Physiol Regul Integr Comp Physiol 298:R254-60. 2010
    ..Do these exist for ET receptors and can we take advantage of this possibility in drug design? These and other questions will be posed in this minireview on topics on ET receptors...
  18. pmc Big ET-1 processing into vasoactive peptides in arteries and veins
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Vascul Pharmacol 47:302-12. 2007
    ..These results suggest at least one potential significant difference - the role of chymase - in in vitro enzymatic processing of big ET-1 in arteries and veins...
  19. ncbi request reprint Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility
    Carrie A Northcott
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    Clin Exp Pharmacol Physiol 32:851-8. 2005
    ..4. These data underscore the relevance of an enzyme historically classified as one committed to growth/anti-apoptosis in modifying contractility and supports involvement of PI3K in genetically based hypertension...
  20. doi request reprint Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat
    A Elizabeth Linder
    Dept of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Am J Physiol Heart Circ Physiol 294:H1745-52. 2008
    ....
  21. ncbi request reprint Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats
    Ronald J Johnson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 20:665-76. 2002
    ..To identify the receptors by which endothelin-1 (ET-1) increases venomotor tone in hypertension...
  22. ncbi request reprint NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension
    Lixin Li
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824 1317, USA
    Hypertension 42:316-21. 2003
    ..These results suggest that superoxide contributes to ET-1-induced venoconstriction through an elevated venous NADPH oxidase activity in mineralocorticoid hypertension...
  23. ncbi request reprint Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats
    Carrie A Northcott
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Mich 48824 1317, USA taetscar msu edu
    Circ Res 91:360-9. 2002
    ..These data support an increase in PI3-kinase activity and p110delta density in aorta from L-NNA and DOCA-salt rats. Importantly, this increase contributes to the enhanced contractility observed in two models of hypertension...
  24. ncbi request reprint Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous function
    Keshari M Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Cardiovasc Pharmacol 47:742-50. 2006
    ..These data suggest that while NO deficiency increases oxidative stress and sympathetic activity in both arterial and venous vessels, the impact on veins does not make a major contribution to this form of hypertension...
  25. ncbi request reprint 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat
    Amber Russell
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
    J Pharmacol Exp Ther 303:179-87. 2002
    ..Thus, these data suggest that the up-regulated 5-HT(2B) receptor in the LNNA hypertensive rats is physiologically activated to maintain elevated blood pressure...
  26. ncbi request reprint Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats
    Xiaoling Dai
    Department of Physiology, Michigan State University, East Lansing, MI 48823, USA
    Hypertension 43:1048-54. 2004
    ....
  27. ncbi request reprint Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension
    Erica A Wehrwein
    Department of Pharmacology and Toxicology, B445 Life Science Bldg, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 309:1011-9. 2004
    ..These data reflect spontaneous tone only and do not rule out the possibility of interaction between these pathways in agonist-stimulated tone...
  28. ncbi request reprint Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension
    Lixin Li
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Circulation 107:1053-8. 2003
    ..However, the mechanisms underlying superoxide production in low-renin hypertension are undefined...
  29. doi request reprint Adenoviral inhibition of AT1a receptors in the paraventricular nucleus inhibits acute increases in mean arterial blood pressure in the rat
    Carrie A Northcott
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1202-11. 2010
    ..A sustained suppression of AT(1a)R expression by single administration of shRNA can interfere with short-term actions of ANG II...
  30. ncbi request reprint Preferential myosin heavy chain isoform B Expression may contribute to the faster velocity of contraction in veins versus arteries
    Catherine M Rondelli
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823, USA
    J Vasc Res 44:264-72. 2007
    ..9 +/- 1.2-fold higher in the aorta than vena cava. Thus, the SMB isoform is the predominant form expressed in rat veins, providing one possible mechanism for the faster response of veins to vasoconstrictors...
  31. pmc Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension
    Melissa Li
    Dept of Pharmacology and Toxicology, B440 Life Sciences, Michigan State Univ, East Lansing, MI 48824, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1546-54. 2008
    ..The results suggest that S6c-induced hypertension is partially mediated by sympathoexcitation to the splanchnic organs driven by increased oxidative stress in prevertebral sympathetic ganglia...
  32. pmc Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Eur J Pharmacol 589:225-7. 2008
    ..Moreover, blood pressure elevated similarly (~50 mm Hg) in all strains given DOCA and salt. Thus, the lack of functional SERT did not prevent development of DOCA-salt induced hypertension or modify basal blood pressure significantly...
  33. ncbi request reprint Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive rats
    Hong Wang
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Heart Circ Physiol 288:H729-36. 2005
    ..These results argue against the hypothesis that increased venomotor tone in DOCA-salt hypertension is caused by increased ET-1 concentration around splanchnic venous smooth muscle cells...
  34. doi request reprint 5-Hydroxytryptamine lowers blood pressure in normotensive and hypertensive rats
    Jessica Diaz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 325:1031-8. 2008
    ..5 g/l in water) prevented the fall in blood pressure to 5-HT. We conclude that chronic exogenous 5-HT reduces blood pressure in normotensive and hypertensive rats through mechanisms critically dependent on NOS...
  35. ncbi request reprint The serotonin transporter is present and functional in peripheral arterial smooth muscle
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    J Cardiovasc Pharmacol 43:770-81. 2004
    ..These studies show for the first time the presence of the 5-HTT in peripheral arterial smooth muscle and raise the question as to the function of the 5-HTT in regulating peripheral effects of 5-HT...
  36. ncbi request reprint Chronic activation of endothelin B receptors: new model of experimental hypertension
    Gregory Fink
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 50:512-8. 2007
    ..These experiments reveal for the first time that chronic activation of ET(B)R in rats causes sustained hypertension...
  37. ncbi request reprint The cytochrome p450 inhibitor ketoconazole potentiates 5-hydroxytryptamine-induced contraction in rat aorta
    Kevin K Ogden
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Pharmacol Exp Ther 323:606-13. 2007
    ..These data suggest KTZ acts by a potentially novel mechanism to potentiate 5-HT-induced contraction...
  38. ncbi request reprint Low [Mg2+]e enhances arterial spontaneous tone via phosphatidylinositol 3-kinase in DOCA-salt hypertension
    Carrie A Northcott
    Department of Pharmacology and To icology, Michigan State University, B445 Life Science Bldg, East Lansing, MI 48823, USA taetscar msu edu
    Hypertension 43:125-9. 2004
    ..1 +0.1). Moreover, this shift was inhibited by LY294002. In conclusion, low [Mg2+]e might activate PI3K, leading to enhanced tone and agonist-induced contraction observed in aortas from DOCA-salt hypertensive rats...
  39. pmc Pharmacological endothelin receptor interaction does not occur in veins from ET(B) receptor deficient rats
    Keshari Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823, USA
    Vascul Pharmacol 49:6-13. 2008
    ..Our data suggest that pharmacological ET A and ET B receptor interaction may be dependent on the presence of functional ET B receptors and independent of receptor location...
  40. pmc Serotonin receptors in rat jugular vein: presence and involvement in the contraction
    A Elizabeth Linder
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA
    J Pharmacol Exp Ther 334:116-23. 2010
    ..These results support the 5-HT(2A) receptor as the main subtype targeted by 5-HT to contract the RJV...
  41. ncbi request reprint A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction
    Kevin Ogden
    Dept of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Heart Circ Physiol 291:H2857-63. 2006
    ..These data are the first to implicate CAS in the signal transduction of 5-HT...
  42. pmc Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure
    Robert Patrick Davis
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824 1317, USA
    Naunyn Schmiedebergs Arch Pharmacol 383:543-6. 2011
    ....
  43. pmc Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats
    Theodora Szasz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    J Pharmacol Exp Ther 333:758-63. 2010
    ..We conclude that, at least in vitro, UA does not affect the ACh-induced relaxation of normotensive and DOCA-salt hypertensive rats...
  44. doi request reprint Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues
    Theodora Szasz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Vasc Res 46:551-60. 2009
    ..To better characterize these expression patterns, and to identify candidate genes that could be manipulated selectively in the venous system, we performed whole genome expression profiling of arteries and veins...
  45. pmc Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein
    Nathan R Tykocki
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 329:875-81. 2009
    ..Moreover, the mechanisms of endothelial cell ET(B) receptor-mediated relaxation in RA and RVC are not the same...
  46. pmc A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase
    Theodora Szasz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
    Am J Physiol Heart Circ Physiol 295:H1341-H1350. 2008
    ..We propose XO to be an important source for these differences. The result of this particular comparison may be reflective of a general arteriovenous contrast...
  47. doi request reprint The interdependence of endothelin-1 and calcium: a review
    Nathan R Tykocki
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Clin Sci (Lond) 119:361-72. 2010
    ..A list of unanswered questions regarding ET-mediated calcium signals are also presented, as well as perspectives for future research of calcium mobilization by ET-1...
  48. pmc Allopurinol does not decrease blood pressure or prevent the development of hypertension in the deoxycorticosterone acetate-salt rat model
    Theodora Szasz
    Pharmacology and Toxicology Department, Michigan State University, East Lansing, MI 48824 1317, USA
    J Cardiovasc Pharmacol 56:627-34. 2010
    ..We conclude that XO does not play an important role in the development or maintenance of hypertension in the rat DOCA-salt hypertension model...
  49. doi request reprint Body distribution of infused serotonin in rats
    A Elizabeth Linder
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Clin Exp Pharmacol Physiol 36:599-601. 2009
    ....
  50. doi request reprint A serotonergic system in veins: serotonin transporter-independent uptake
    A Elizabeth Linder
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 325:714-22. 2008
    ..The differences in 5-HT handling between veins and arteries may represent alternative avenues for targeting the 5-HT system in the peripheral circulation for controlling vascular tone...
  51. ncbi request reprint Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension
    Amy K L Banes
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
    Hypertension 39:394-8. 2002
    ....
  52. ncbi request reprint The fenfluramine metabolite (+)-norfenfluramine is vasoactive
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 309:845-52. 2004
    ..v.) but not prazosin (0.2 mg/kg i.v.). Our findings demonstrate for the first time that (+)-norfenfluramine is vasoactive and has the potential to increase blood pressure...
  53. ncbi request reprint PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?
    Carrie A Northcott
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Science Bldg, East Lansing, MI 48823, USA
    Hypertension 43:885-90. 2004
    ..Collectively, these data further implicate the p110delta isoform of PI3-kinase in arterial hyperresponsiveness in hypertension at the level of both large and small arteries...
  54. ncbi request reprint 5-HT in systemic hypertension: foe, friend or fantasy?
    Stephanie W Watts
    Department of Pharmacology and Toxicology, B445 Life Sciences Building, Michigan State University, East Lansing, MI 48824 1317, USA
    Clin Sci (Lond) 108:399-412. 2005
    ..This review will discuss historical findings which both support and refute the involvement of 5-HT in hypertension, and pose some new questions that may reveal novel ways for 5-HT to modify vascular control of blood pressure...
  55. ncbi request reprint (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, 48824 1317, USA
    J Pharmacol Exp Ther 314:953-60. 2005
    ..Understanding of the mechanism by which (+)-norfenfluramine induces vasoconstriction is important to characterize and understand the function of the serotonergic system in peripheral arterial vasculature...
  56. ncbi request reprint Endothelin-1-induced contraction in veins is independent of hydrogen peroxide
    Keshari Thakali
    Department of Pharmacology and Toxicology, Michigan State University, E Lansing, MI 48824 1317, USA
    Am J Physiol Heart Circ Physiol 289:H1115-22. 2005
    ..In summary, ET-1 increased H(2)O(2) in veins but not arteries, and venous ET-1-induced H(2)O(2) production was independent of the contractile properties of ET-1...
  57. ncbi request reprint Activation of vascular BK channel by tempol in DOCA-salt hypertensive rats
    Hui Xu
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 46:1154-62. 2005
    ..Upregulation of the BK channel alpha subunit contributes to the enhanced depressor response caused by tempol in DOCA-salt hypertension...
  58. ncbi request reprint Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive rats
    Keshari Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Hypertension 47:482-7. 2006
    ..In DOCA-salt hypertension, arterial but not venous contraction to H2O2 is enhanced, and relaxation to H2O2 is reduced...
  59. ncbi request reprint Arterial 5-hydroxytryptamine transporter function is impaired in deoxycorticosterone acetate and Nomega-nitro-L-arginine but not spontaneously hypertensive rats
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Hypertension 48:134-40. 2006
    ..Our study suggested that an altered serotonergic system by impaired 5-HTT function might play a role in blood pressure regulation in DOCA-salt and LNNA-hypertensive rats...
  60. ncbi request reprint Cyclooxygenase, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase MAPK, Rho kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava
    Keshari Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 320:236-43. 2007
    ....
  61. ncbi request reprint Arteries and veins desensitize differently to endothelin
    Keshari Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Cardiovasc Pharmacol 43:387-93. 2004
    ..05 +/- 0.05 mol/L; atrasentan = unmeasurable). Maintained responsiveness to ET-1 in veins occurs primarily via the ETA receptor, while in arteries the ETA receptor is responsible for desensitization to ET-1...
  62. ncbi request reprint The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 321:485-91. 2007
    ..However, it is the 5-HT2A receptor and not the 5-HT2B receptor that participates in these effects...
  63. ncbi request reprint Methyl-beta-cyclodextrin prevents angiotensin II-induced tachyphylactic contractile responses in rat aorta
    A Elizabeth Linder
    Department of Pharmacology and Toxicology, Michigan State University, B 445 Life Sciences Building, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 323:78-84. 2007
    ..Our data suggest that caveolae are involved in the tachyphylactic contractile response induced by angiotensin II in rat aorta, and this effect is related to receptor internalization...
  64. ncbi request reprint A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease
    Theodora Szasz
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences, East Lansing, MI 48825, USA
    Exp Biol Med (Maywood) 232:27-37. 2007
    ..Our understanding of the mechanisms underlying vascular diseases would greatly benefit from a more thorough exploration of the role of veins and venous oxidative stress...
  65. ncbi request reprint Serotonin (5-HT) in veins: not all in vain
    A Elizabeth Linder
    Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Building, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 323:415-21. 2007
    ..In addition, the serotonergic system from synthesis to metabolism, 5-HT receptor activation and venous diseases will also be discussed...
  66. ncbi request reprint 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT)
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
    Clin Exp Pharmacol Physiol 33:575-83. 2006
    ..6. In summary, the function of SERT in the CV system is just beginning to be revealed...
  67. doi request reprint Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite
    James Huang
    Department of Surgery, San Francisco Veteran s Affairs Medical Center, Division of Vascular Surgery, University of California, San Francisco, USA
    J Vasc Surg 47:599-607. 2008
    ..We sought to define the intracellular effects and signaling mechanisms of nitric oxide and peroxynitrite in smooth muscle cells...
  68. ncbi request reprint PI3-kinase-induced hyperreactivity in DOCA-salt hypertension is independent of GSK-3 activity
    Robert D Loberg
    Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48109 0676, USA
    Hypertension 41:898-902. 2003
    ..Thus, enhanced GSK-3 activity modestly augments the effects of PI3K but does not appear to contribute greatly to the altered arterial reactivity in DOCA-salt hypertension...
  69. ncbi request reprint Increased vascular sensitivity and connexin43 expression after sympathetic denervation
    David P Slovut
    Department of Physiology, University of Michigan, Ann Arbor, MI, USA
    Cardiovasc Res 62:388-96. 2004
    ..Hence, we wanted to study the effect of sympathetic denervation on connexin43 (Cx43) expression and agonist-induced contractility in the vascular smooth muscle (VSM)...
  70. ncbi request reprint C3 or not C3: that is the question
    Stephanie W Watts
    Hypertension 44:25-6. 2004
  71. ncbi request reprint Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries
    Kevin B Atkins
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0676, USA
    Am J Physiol Heart Circ Physiol 288:H235-43. 2005
    ....
  72. ncbi request reprint The beginning of a fantastic, unanswered question: is 5-HT involved in systemic hypertension?
    Stephanie W Watts
    Am J Physiol Heart Circ Physiol 295:H915-H916. 2008
    ..This essay examines the historical significance of an APS classic paper that is freely available online:..
  73. ncbi request reprint Vasoconstriction caused by the ATP synthase subunit-coupling factor 6: a new function for a historical enzyme
    Stephanie W Watts
    Hypertension 46:1100-2. 2005

Research Grants5

  1. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2007
    ..Moreover, because SERT is a target for the commonly prescribed serotonin reuptake inhibitors such as ProzacZ, these studies provide potential insight into cardiovascular complications experienced by those taking SERT inhibitors. ..
  2. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..