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Genomes and GenesSpecies | Stephanie WattsSummaryAffiliation: Michigan State University Country: USA Publications
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Publications
5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involvedROBERT PATRICK DAVIS
Department of Pharmacology and Toxicology, Michigan State University, East, Lansing, MI 48824 1317, USA
BMC Pharmacol 12:4. 2012....
Smooth muscle pharmacology in the isolated virgin and pregnant rat uterus and cervixEmma S Darios
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Pharmacol Exp Ther 341:587-96. 2012..This work highlights the unappreciated smooth muscle function of the cervix versus uterus and cervical changes in pharmacology during pregnancy...- Serotonin and blood pressure regulationStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Pharmacol Rev 64:359-88. 2012..The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension... - Inability of serotonin to activate the c-Jun N-terminal kinase and p38 kinase pathways in rat aortic vascular smooth muscle cellsA K Banes
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Ml 48824, USA
BMC Pharmacol 1:8. 2001..Parallel MAPK pathways, the c-Jun N-terminal Kinase (JNK) and p38 pathway, are activated by stimulators of the ERK/MAPK pathway. We hypothesized that 5-HT would activate the JNK and p38 pathways in rat vascular smooth muscle cells... - Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertensionAmy K L Banes
Department of Pharmacology and Toxicology, Michigan State University, E Lansing, MI 48824, USA
BMC Pharmacol 3:12. 2003..We performed DOCA-salt time course (days 1, 3, 5 and 7) studies using treatment groups of: DOCA-high salt, DOCA-low salt, Sham and Sham-high salt rats... 
Characterization of the contractile 5-hydroxytryptamine receptor in the renal artery of the normotensive ratStephanie W Watts
Department of Pharmacology and Toxicology, B445 Life Sciences Bldg, Michigan State University, East Lansing, MI 48824 1317
J Pharmacol Exp Ther 309:165-72. 2004..This unique pharmacology may reflect differences in 5-HT receptor coupling between tissues or heterogeneity in the subtype(s) of 5-HT receptors expressed in the renal artery...- The love of a lifetime: 5-HT in the cardiovascular systemStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824 1317, USA
Am J Physiol Regul Integr Comp Physiol 296:R252-6. 2009..This work underscores that our knowledge of the functions of 5-HT in the cardiovascular system is significantly incomplete. As such, this field is an exciting one in which to be, because there are superb questions to be asked... - Big ET-1 processing into vasoactive peptides in arteries and veinsStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Vascul Pharmacol 47:302-12. 2007..These results suggest at least one potential significant difference - the role of chymase - in in vitro enzymatic processing of big ET-1 in arteries and veins... - Morphological and biochemical characterization of remodeling in aorta and vena cava of DOCA-salt hypertensive ratsStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823 1317, USA
Am J Physiol Heart Circ Physiol 292:H2438-48. 2007..These findings suggest that large veins may not undergo vascular remodeling in DOCA-salt hypertension... - Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptorsS W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
J Cardiovasc Pharmacol 38:539-51. 2001..Thus, while mRNA and possibly protein for multiple 5-HT receptors are present in aortic smooth muscle, only the 5-HT 2A receptor plays a significant role in directly modulating contractility and activating the Erk MAPK pathway... - Serotonylation of vascular proteins important to contractionStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States of America
PLoS ONE 4:e5682. 2009..We tested the hypothesis that 5-HT is a substrate for transglutaminase in arterial vascular smooth muscle, with protein serotonylation having physiological function... - 5-hydroxtryptamine receptors in systemic hypertension: an arterial focusStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Cardiovasc Ther 29:54-67. 2011..Serotonin (5-hydroxytryptamine [5-HT]) was named for its isolation from blood serum (sero-) and ability to contract smooth muscle (-tonin). Thus, its relationship with the cardiovascular system began with its discovery... - Endothelin receptors: what's new and what do we need to know?Stephanie W Watts
Dept of Pharmacology and Toxicology, B445 Life Sciences Bldg, East Lansing, MI 48824 1317, USA
Am J Physiol Regul Integr Comp Physiol 298:R254-60. 2010..Do these exist for ET receptors and can we take advantage of this possibility in drug design? These and other questions will be posed in this minireview on topics on ET receptors... - Comparison of the function of the serotonin transporter in the vasculature of male and female ratsAurea Elizabeth Linder
Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
Clin Exp Pharmacol Physiol 38:314-22. 2011..5. Collectively, these data suggest that SERT function, when challenged with 5-HT, is modestly more important in the vasculature of the female compared with male rat... - Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contractionStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
Am J Physiol Heart Circ Physiol 301:H1236-47. 2011..We conclude that IDO is an enzyme active primarily in brown fat surrounding the thoracic aorta and depresses aortic contractility... - Endothelin-1-induced venous contraction is maintained in DOCA-salt hypertension; studies with receptor agonistsStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
Br J Pharmacol 137:69-79. 2002..The ET(B) receptor was present in the aorta but, unlike in veins, does not mediate contraction directly. A sustained response to ET-1 in the venous circulation may contribute to the elevated blood pressure in the DOCA-salt model... - Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertensionStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
Hypertension 39:825-9. 2002..Although similarities were observed for large and small arteries, differences under the condition of DOCA-salt hypertension exist that may determine serotonergic compounds effective in lowering blood pressure... - Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractilityCarrie A Northcott
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824-1317, USA
Clin Exp Pharmacol Physiol 32:851-8. 2005..4. These data underscore the relevance of an enzyme historically classified as one committed to growth/anti-apoptosis in modifying contractility and supports involvement of PI3K in genetically based hypertension... - Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout ratA Elizabeth Linder
Dept of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Am J Physiol Heart Circ Physiol 294:H1745-52. 2008.... - NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertensionLixin Li
Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824-1317, USA
Hypertension 42:316-21. 2003..These results suggest that superoxide contributes to ET-1-induced venoconstriction through an elevated venous NADPH oxidase activity in mineralocorticoid hypertension... - Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive ratsRonald J Johnson
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
J Hypertens 20:665-76. 2002..To identify the receptors by which endothelin-1 (ET-1) increases venomotor tone in hypertension... - Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive ratsCarrie A Northcott
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Mich 48824-1317, USA. taetscar@ msu.edu
Circ Res 91:360-9. 2002..These data support an increase in PI3-kinase activity and p110delta density in aorta from L-NNA and DOCA-salt rats. Importantly, this increase contributes to the enhanced contractility observed in two models of hypertension... - Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous functionKeshari M Thakali
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA
J Cardiovasc Pharmacol 47:742-50. 2006..These data suggest that while NO deficiency increases oxidative stress and sympathetic activity in both arterial and venous vessels, the impact on veins does not make a major contribution to this form of hypertension... - 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive ratAmber Russell
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
J Pharmacol Exp Ther 303:179-87. 2002..Thus, these data suggest that the up-regulated 5-HT(2B) receptor in the LNNA hypertensive rats is physiologically activated to maintain elevated blood pressure... - Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertensionErica A Wehrwein
Department of Pharmacology and Toxicology, B445 Life Science Bldg, Michigan State University, East Lansing, MI 48824-1317, USA
J Pharmacol Exp Ther 309:1011-9. 2004..These data reflect spontaneous tone only and do not rule out the possibility of interaction between these pathways in agonist-stimulated tone... - Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive ratsXiaoling Dai
Department of Physiology, Michigan State University, East Lansing, MI 48823, USA
Hypertension 43:1048-54. 2004.... - Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertensionLixin Li
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317, USA
Circulation 107:1053-8. 2003..CONCLUSIONS: These findings suggest that ET-1 augments vascular superoxide production at least in part via an ET(A)/NADPH oxidase pathway in low-renin mineralocorticoid hypertension... - Preferential myosin heavy chain isoform B Expression may contribute to the faster velocity of contraction in veins versus arteriesCatherine M Rondelli
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823, USA
J Vasc Res 44:264-72. 2007..9 +/- 1.2-fold higher in the aorta than vena cava. Thus, the SMB isoform is the predominant form expressed in rat veins, providing one possible mechanism for the faster response of veins to vasoconstrictors... - Adenoviral inhibition of AT1a receptors in the paraventricular nucleus inhibits acute increases in mean arterial blood pressure in the ratCarrie A Northcott
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA
Am J Physiol Regul Integr Comp Physiol 299:R1202-11. 2010..A sustained suppression of AT(1a)R expression by single administration of shRNA can interfere with short-term actions of ANG II... - Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertensionMelissa Li
Dept of Pharmacology and Toxicology, B440 Life Sciences, Michigan State Univ, East Lansing, MI 48824, USA
Am J Physiol Regul Integr Comp Physiol 295:R1546-54. 2008..The results suggest that S6c-induced hypertension is partially mediated by sympathoexcitation to the splanchnic organs driven by increased oxidative stress in prevertebral sympathetic ganglia... - 5-Hydroxytryptamine lowers blood pressure in normotensive and hypertensive ratsJessica Diaz
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Pharmacol Exp Ther 325:1031-8. 2008..5 g/l in water) prevented the fall in blood pressure to 5-HT. We conclude that chronic exogenous 5-HT reduces blood pressure in normotensive and hypertensive rats through mechanisms critically dependent on NOS... - Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive ratsHong Wang
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Am J Physiol Heart Circ Physiol 288:H729-36. 2005..These results argue against the hypothesis that increased venomotor tone in DOCA-salt hypertension is caused by increased ET-1 concentration around splanchnic venous smooth muscle cells... - The serotonin transporter is present and functional in peripheral arterial smooth muscleWei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317, USA
J Cardiovasc Pharmacol 43:770-81. 2004..These studies show for the first time the presence of the 5-HTT in peripheral arterial smooth muscle and raise the question as to the function of the 5-HTT in regulating peripheral effects of 5-HT... - Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouseWei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Eur J Pharmacol 589:225-7. 2008..Moreover, blood pressure elevated similarly (~50 mm Hg) in all strains given DOCA and salt. Thus, the lack of functional SERT did not prevent development of DOCA-salt induced hypertension or modify basal blood pressure significantly... - Chronic activation of endothelin B receptors: new model of experimental hypertensionGregory Fink
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Hypertension 50:512-8. 2007..These experiments reveal for the first time that chronic activation of ET(B)R in rats causes sustained hypertension... - Serotonin receptors in rat jugular vein: presence and involvement in the contractionA Elizabeth Linder
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA
J Pharmacol Exp Ther 334:116-23. 2010..These results support the 5-HT(2A) receptor as the main subtype targeted by 5-HT to contract the RJV... - The cytochrome p450 inhibitor ketoconazole potentiates 5-hydroxytryptamine-induced contraction in rat aortaKevin K Ogden
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
J Pharmacol Exp Ther 323:606-13. 2007..These data suggest KTZ acts by a potentially novel mechanism to potentiate 5-HT-induced contraction... - Pharmacological endothelin receptor interaction does not occur in veins from ET(B) receptor deficient ratsKeshari Thakali
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823, USA
Vascul Pharmacol 49:6-13. 2008..Our data suggest that pharmacological ET A and ET B receptor interaction may be dependent on the presence of functional ET B receptors and independent of receptor location... - Low [Mg2+]e enhances arterial spontaneous tone via phosphatidylinositol 3-kinase in DOCA-salt hypertensionCarrie A Northcott
Department of Pharmacology and To-icology, Michigan State University, B445 Life Science Bldg, East Lansing, MI 48823, USA. taetscar @msu.edu
Hypertension 43:125-9. 2004..1 +0.1). Moreover, this shift was inhibited by LY294002. In conclusion, low [Mg2+]e might activate PI3K, leading to enhanced tone and agonist-induced contraction observed in aortas from DOCA-salt hypertensive rats... - A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contractionKevin Ogden
Dept of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Am J Physiol Heart Circ Physiol 291:H2857-63. 2006..These data are the first to implicate CAS in the signal transduction of 5-HT... - Body distribution of infused serotonin in ratsA Elizabeth Linder
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Clin Exp Pharmacol Physiol 36:599-601. 2009.... - The fenfluramine metabolite (+)-norfenfluramine is vasoactiveWei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Pharmacol Exp Ther 309:845-52. 2004..v.) but not prazosin (0.2 mg/kg i.v.). Our findings demonstrate for the first time that (+)-norfenfluramine is vasoactive and has the potential to increase blood pressure... - Endothelin ET(B) receptors in arteries and veins: multiple actions in the veinNathan R Tykocki
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824, USA
J Pharmacol Exp Ther 329:875-81. 2009..Moreover, the mechanisms of endothelial cell ET(B) receptor-mediated relaxation in RA and RVC are not the same... - Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissuesTheodora Szasz
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Vasc Res 46:551-60. 2009..To better characterize these expression patterns, and to identify candidate genes that could be manipulated selectively in the venous system, we performed whole genome expression profiling of arteries and veins... - Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive ratsTheodora Szasz
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
J Pharmacol Exp Ther 333:758-63. 2010..We conclude that, at least in vitro, UA does not affect the ACh-induced relaxation of normotensive and DOCA-salt hypertensive rats... - Arteries and veins desensitize differently to endothelinKeshari Thakali
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Cardiovasc Pharmacol 43:387-93. 2004..05 +/- 0.05 mol/L; atrasentan = unmeasurable). Maintained responsiveness to ET-1 in veins occurs primarily via the ETA receptor, while in arteries the ETA receptor is responsible for desensitization to ET-1... - The interdependence of endothelin-1 and calcium: a reviewNathan R Tykocki
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Clin Sci (Lond) 119:361-72. 2010..A list of unanswered questions regarding ET-mediated calcium signals are also presented, as well as perspectives for future research of calcium mobilization by ET-1... - (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporterWei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, 48824 1317, USA
J Pharmacol Exp Ther 314:953-60. 2005..Understanding of the mechanism by which (+)-norfenfluramine induces vasoconstriction is important to characterize and understand the function of the serotonergic system in peripheral arterial vasculature... - Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressureRobert Patrick Davis
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824 1317, USA
Naunyn Schmiedebergs Arch Pharmacol 383:543-6. 2011.... - Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertensionAmy K L Banes
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
Hypertension 39:394-8. 2002.... - Allopurinol does not decrease blood pressure or prevent the development of hypertension in the deoxycorticosterone acetate-salt rat modelTheodora Szasz
Pharmacology and Toxicology Department, Michigan State University, East Lansing, MI 48824 1317, USA
J Cardiovasc Pharmacol 56:627-34. 2010..We conclude that XO does not play an important role in the development or maintenance of hypertension in the rat DOCA-salt hypertension model... - A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidaseTheodora Szasz
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
Am J Physiol Heart Circ Physiol 295:H1341-H1350. 2008..We propose XO to be an important source for these differences. The result of this particular comparison may be reflective of a general arteriovenous contrast... - A serotonergic system in veins: serotonin transporter-independent uptakeA Elizabeth Linder
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg, East Lansing, MI 48824, USA
J Pharmacol Exp Ther 325:714-22. 2008..The differences in 5-HT handling between veins and arteries may represent alternative avenues for targeting the 5-HT system in the peripheral circulation for controlling vascular tone... - 5-HT in systemic hypertension: foe, friend or fantasy?Stephanie W Watts
Department of Pharmacology and Toxicology, B445 Life Sciences Building, Michigan State University, East Lansing, MI 48824 1317, USA
Clin Sci (Lond) 108:399-412. 2005..This review will discuss historical findings which both support and refute the involvement of 5-HT in hypertension, and pose some new questions that may reveal novel ways for 5-HT to modify vascular control of blood pressure... - Endothelin-1-induced contraction in veins is independent of hydrogen peroxideKeshari Thakali
Department of Pharmacology and Toxicology, Michigan State University, E Lansing, MI 48824 1317, USA
Am J Physiol Heart Circ Physiol 289:H1115-22. 2005..In summary, ET-1 increased H(2)O(2) in veins but not arteries, and venous ET-1-induced H(2)O(2) production was independent of the contractile properties of ET-1... - Activation of vascular BK channel by tempol in DOCA-salt hypertensive ratsHui Xu
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Hypertension 46:1154-62. 2005..Upregulation of the BK channel alpha subunit contributes to the enhanced depressor response caused by tempol in DOCA-salt hypertension... - Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive ratsKeshari Thakali
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Hypertension 47:482-7. 2006..In DOCA-salt hypertension, arterial but not venous contraction to H2O2 is enhanced, and relaxation to H2O2 is reduced... - Arterial 5-hydroxytryptamine transporter function is impaired in deoxycorticosterone acetate and Nomega-nitro-L-arginine but not spontaneously hypertensive ratsWei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Hypertension 48:134-40. 2006..Our study suggested that an altered serotonergic system by impaired 5-HTT function might play a role in blood pressure regulation in DOCA-salt and LNNA-hypertensive rats... - Cyclooxygenase, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase MAPK, Rho kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cavaKeshari Thakali
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Pharmacol Exp Ther 320:236-43. 2007.... - PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?Carrie A Northcott
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Science Bldg, East Lansing, MI 48823, USA
Hypertension 43:885-90. 2004..Collectively, these data further implicate the p110delta isoform of PI3-kinase in arterial hyperresponsiveness in hypertension at the level of both large and small arteries... - The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertensionWei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
J Pharmacol Exp Ther 321:485-91. 2007..However, it is the 5-HT2A receptor and not the 5-HT2B receptor that participates in these effects... - Methyl-beta-cyclodextrin prevents angiotensin II-induced tachyphylactic contractile responses in rat aortaA Elizabeth Linder
Department of Pharmacology and Toxicology, Michigan State University, B 445 Life Sciences Building, East Lansing, MI 48824 1317, USA
J Pharmacol Exp Ther 323:78-84. 2007..Our data suggest that caveolae are involved in the tachyphylactic contractile response induced by angiotensin II in rat aorta, and this effect is related to receptor internalization... - Serotonin (5-HT) in veins: not all in vainA Elizabeth Linder
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Building, East Lansing, MI 48824, USA
J Pharmacol Exp Ther 323:415-21. 2007..In addition, the serotonergic system from synthesis to metabolism, 5-HT receptor activation and venous diseases will also be discussed... - A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and diseaseTheodora Szasz
Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences, East Lansing, MI 48825, USA
Exp Biol Med (Maywood) 232:27-37. 2007..Our understanding of the mechanisms underlying vascular diseases would greatly benefit from a more thorough exploration of the role of veins and venous oxidative stress... - 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT)Wei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
Clin Exp Pharmacol Physiol 33:575-83. 2006..6. In summary, the function of SERT in the CV system is just beginning to be revealed... - C3 or not C3: that is the questionStephanie W Watts
Hypertension 44:25-6. 2004 - Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteriesKevin B Atkins
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0676, USA
Am J Physiol Heart Circ Physiol 288:H235-43. 2005.... - Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitriteJames Huang
Department of Surgery, San Francisco Veteran s Affairs Medical Center, Division of Vascular Surgery, University of California, San Francisco, USA
J Vasc Surg 47:599-607. 2008..We sought to define the intracellular effects and signaling mechanisms of nitric oxide and peroxynitrite in smooth muscle cells... - The beginning of a fantastic, unanswered question: is 5-HT involved in systemic hypertension?Stephanie W Watts
Am J Physiol Heart Circ Physiol 295:H915-H916. 2008..This essay examines the historical significance of an APS classic paper that is freely available online:.. - PI3-kinase-induced hyperreactivity in DOCA-salt hypertension is independent of GSK-3 activityRobert D Loberg
Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48109-0676, USA
Hypertension 41:898-902. 2003..Thus, enhanced GSK-3 activity modestly augments the effects of PI3K but does not appear to contribute greatly to the altered arterial reactivity in DOCA-salt hypertension... - Increased vascular sensitivity and connexin43 expression after sympathetic denervationDavid P Slovut
Department of Physiology, University of Michigan, Ann Arbor, MI, USA
Cardiovasc Res 62:388-96. 2004..05). Conclusion: We conclude that sympathetic denervation results in increased expression of Cx43, which in turn, contributes to increased spontaneous and agonist-induced OA in VSM... - Vasoconstriction caused by the ATP synthase subunit-coupling factor 6: a new function for a historical enzymeStephanie W Watts
Hypertension 46:1100-2. 2005
Research Grants
- Arterial 5-HT Transporter FunctionStephanie Watts; Fiscal Year: 2007..Moreover, because SERT is a target for the commonly prescribed serotonin reuptake inhibitors such as ProzacZ, these studies provide potential insight into cardiovascular complications experienced by those taking SERT inhibitors. ..
- Arterial 5-HT Transporter FunctionStephanie Watts; Fiscal Year: 2009..abstract_text> ..