STEPHEN PATRICK WALTON

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi Analysis of hybridization on the molecular barcode GeneChip microarray
    S Patrick Walton
    Stanford Genome Technology Center, Department of Biochemistry, Stanford University, 855 S California Ave, Palo Alto, CA 94304, USA
    Biochem Biophys Res Commun 348:689-96. 2006
  2. ncbi Proteomics: technology development and applications
    S Patrick Walton
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 1226, USA
    Expert Rev Proteomics 6:23-5. 2009
  3. ncbi Designing highly active siRNAs for therapeutic applications
    S Patrick Walton
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 1226, USA
    FEBS J 277:4806-13. 2010
  4. ncbi Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study
    Joseph A Gredell
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824 1226, USA
    Biotechnol Bioeng 100:744-55. 2008
  5. ncbi Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles
    Amanda M Portis
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA
    Microsc Res Tech 73:878-85. 2010
  6. ncbi Emerging affinity-based techniques in proteomics
    Shengnan Xie
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 1226, USA
    Expert Rev Proteomics 6:573-83. 2009
  7. ncbi Recognition of siRNA asymmetry by TAR RNA binding protein
    Joseph A Gredell
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824 1226, USA
    Biochemistry 49:3148-55. 2010

Research Grants

  1. Genomic measurement of DNA-binding protein expression
    Stephen Walton; Fiscal Year: 2003
  2. Aptamer-based Proteomic Analysis for Cancer Signatures
    Stephen Walton; Fiscal Year: 2007
  3. Maximizing siRNA Function through Mechanism-based Sequence and Vehicle Design
    STEPHEN PATRICK WALTON; Fiscal Year: 2010

Collaborators

  • Christina Chan
  • Arul Jayaraman
  • Joseph A Gredell
  • Amanda M Portis
  • Shengnan Xie
  • Ming Wu
  • Georgina Carballo
  • Gregory L Baker
  • Michael J Dittmer
  • Colby Moya
  • Betul Bilgin
  • Angela K Berger

Detail Information

Publications7

  1. ncbi Analysis of hybridization on the molecular barcode GeneChip microarray
    S Patrick Walton
    Stanford Genome Technology Center, Department of Biochemistry, Stanford University, 855 S California Ave, Palo Alto, CA 94304, USA
    Biochem Biophys Res Commun 348:689-96. 2006
    ..The data support the future application of MB GeneChips for quantitative applications. It is proposed that at least seven orders-of-magnitude in accurate concentration sensitivity could be achieved...
  2. ncbi Proteomics: technology development and applications
    S Patrick Walton
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 1226, USA
    Expert Rev Proteomics 6:23-5. 2009
    ..American Electrophoresis Society presenters offered further academic and industrial viewpoints on the still-developing role of proteomics and proteomic technologies in biological and clinical analyses...
  3. ncbi Designing highly active siRNAs for therapeutic applications
    S Patrick Walton
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 1226, USA
    FEBS J 277:4806-13. 2010
    ..As the understanding of how to control the activity and specificity of siRNAs improves, the potential utility of siRNAs as human therapeutics will concomitantly grow...
  4. ncbi Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study
    Joseph A Gredell
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824 1226, USA
    Biotechnol Bioeng 100:744-55. 2008
    ..Taken together, these results suggest minimal requirements for nucleation of hybridization between the siRNA guide strand and mRNA and that both mRNA and guide strand structure should be considered when choosing candidate siRNAs...
  5. ncbi Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles
    Amanda M Portis
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA
    Microsc Res Tech 73:878-85. 2010
    ..Nonetheless, the exceptionally low cytotoxicity of our NPs, and the simplicity with which they can be modified, makes them good candidates for further study to optimize their delivery profiles and, in turn, achieve efficient silencing...
  6. ncbi Emerging affinity-based techniques in proteomics
    Shengnan Xie
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 1226, USA
    Expert Rev Proteomics 6:573-83. 2009
    ..In addition, we will describe emerging methods with potential value to proteomics, as well as the challenges that remain for proteomic studies...
  7. ncbi Recognition of siRNA asymmetry by TAR RNA binding protein
    Joseph A Gredell
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824 1226, USA
    Biochemistry 49:3148-55. 2010
    ..Together, these results demonstrate the importance of the siRNA-TRBP interaction in the selection of the siRNA guide strand in RNAi...

Research Grants4

  1. Genomic measurement of DNA-binding protein expression
    Stephen Walton; Fiscal Year: 2003
    ..coil, yeast, and human DBP expression on a single microarray. Finally, mutation analysis will be used to determine the most critical bases involved in the DNA:DBP interactions. ..
  2. Aptamer-based Proteomic Analysis for Cancer Signatures
    Stephen Walton; Fiscal Year: 2007
    ....
  3. Maximizing siRNA Function through Mechanism-based Sequence and Vehicle Design
    STEPHEN PATRICK WALTON; Fiscal Year: 2010
    ..The proposed work will address two of these important steps to provide guidelines for the design of highly-active, highly-specific therapeutics based on RNAi. ..