Research Topics
| James Edward TroskoSummaryAffiliation: Michigan State University Country: USA Publications
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Detail Information
Publications
Isolation and characterization of normal adult human epithelial pluripotent stem cellsJames E Trosko
National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
Oncol Res 13:353-7. 2003..The breast stem cells can be prevented from "mortalizing" and can be converted to neoplastic cells, which maintain many phenotypes of the stem cells...- The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessmentJames E Trosko
National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
Mutagenesis 20:81-92. 2005.... - Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cellsJames E Trosko
Department of Pediatrics and Human Development, National Food Safety Toxicology Center, College of Human Medicine, Michigan State University, East Lansing, Mich 48824, USA
Contrib Microbiol 13:45-65. 2006..The inhibition of GJIC might be the mechanism by which the inflammatory process affects cancer and that to intervene during tumor promotion with anti-inflammatory factors might be the most efficacious anti-cancer strategy... - Ignored hallmarks of carcinogenesis: stem cells and cell-cell communicationJames E Trosko
246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
Ann N Y Acad Sci 1028:192-201. 2004..Chemoprevention and chemotherapeutic implications suggest that one must induce connexin genes in initiated stem cells and restore GJIC in initiated early progenitor cells... - The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapyJ E Trosko
246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, 48824, USA
Biomed Pharmacother 59:S326-31. 2005..Human pluri-potent stem cell systems, that can be induced to form 3-dimensional "organoid" structures, will be discussed as a more realistic model system to screen for relevant chemopreventive agents... - From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotionJames E Trosko
Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
Ann N Y Acad Sci 1089:36-58. 2006..These Oct-4 positive cells might represent the "cancer stem cells." A strategy to target "cancer stem cells" is to suppress the Oct-4 gene in order to cause the cells to differentiate... 
Commentary: "re-programming or selecting adult stem cells?"James E Trosko
Center for Integrative Toxicology, Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
Stem Cell Rev 4:81-8. 2008..An examination of the rationale for this challenging hypothesis has been drawn from the hypothesis of the "stem cell theory of cancer", as well as from the field of human adult stem cells research...- Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of agingJ E Trosko
Center for Integrative Toxicology, Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
Curr Pharm Des 14:2707-18. 2008..This might explain the Barker hypothesis which suggests that prenatal and early postnatal exposures to toxic agents can lead to diseases later in life... - Review paper: cancer stem cells and cancer nonstem cells: from adult stem cells or from reprogramming of differentiated somatic cellsJ E Trosko
246 Food Safety and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Vet Pathol 46:176-93. 2009.... - The role of human adult stem cells and cell-cell communication in cancer chemoprevention and chemotherapy strategiesJames E Trosko
246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
Mutat Res 591:187-97. 2005.... - Gap junctions as targets for cancer chemoprevention and chemotherapyJ E Trosko
Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
Curr Drug Targets 3:465-82. 2002.... - Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessmentJames Edward Trosko
Center for Integrative Toxicology, Food Safety and Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
Toxicology 270:18-34. 2010..If the future utility of human stem cells proves to be valid, the elimination of less relevant, expensive and time-consuming rodent and 2-D human in vitro assays will be eliminated... - Commentary on ''Toxicity testing in the 21st century: a vision and a strategy'': stem cells and cell-cell communication as fundamental targets in assessing the potential toxicity of chemicalsJames E Trosko
Center for Integrative Toxicology, Food Safety Toxicology Center, Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 9924, USA
Hum Exp Toxicol 29:21-9. 2010..g., increase or decrease in the stem cell numbers in specific organs; altered apoptotic and differentiation frequencies), as well as measured cell-cell communication, should be seriously considered as toxicity endpoints... - From bacteria to humans: lessons learned from a reductionist's view of ultraviolet light-induced DNA lesionsJ E Trosko
Department of Pediatrics and Human Development, National Food Safety Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Mol Mutagen 38:118-21. 2001..Dr. Setlow's shoulders were indeed among those of all of us that have made some small contribution in trying to understand this extremely complex process of human carcinogenesis... - Low-dose ionizing radiation: induction of differential intracellular signalling possibly affecting intercellular communicationJames E Trosko
Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
Radiat Environ Biophys 44:3-9. 2005.... - The role of stem cells and gap junctional intercellular communication in carcinogenesisJames E Trosko
246 National Food Safety Toxicology Center, Dept Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
J Biochem Mol Biol 36:43-8. 2003.... - Human stem cells as targets for the aging and diseases of aging processesJames E Trosko
Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
Med Hypotheses 60:439-47. 2003..One clear example, that of carcinogenesis, illustrates this point... - Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristicsMei Hui Tai
Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
Pancreas 26:e18-26. 2003..Cancer cells, which have been viewed as "partially blocked stem cells," and which lack the ability for growth control, terminal differentiation, and apoptosis, also lack functional gap junctional communication... - Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesisMei Hui Tai
National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
Carcinogenesis 26:495-502. 2005..Oct4 is expressed in a few cells found in the basal layer of human skin epidermis. The data demonstrate that adult stem cells maintain expression of Oct4, consistent with the stem cell hypothesis of carcinogenesis... - Isolation and differentiation of bovine mammary gland progenitor cell populationsMargo S Holland
Department of Veterinary Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Am J Vet Res 64:396-403. 2003..To isolate bovine mammary gland cells with stem cell characteristics... - Dietary modulation of the multistage, multimechanisms of human carcinogenesis: effects on initiated stem cells and cell-cell communicationJames E Trosko
246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
Nutr Cancer 54:102-10. 2006.... - Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cellsMei Hui Tai
Department of Physiology, Michigan State University, East Lansing, MI, USA
Int J Cancer 120:1855-62. 2007..These results indicate that a prominent component of cigarette smoke, namely methylanthracenes with distinct structural configurations, could be a potential etiological agent contributing to the epigenetic events of pancreatic cancer... - Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrolBrad L Upham
Department of Pediatrics and Human Development and the National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824 1302, USA
Nutr Cancer 57:38-47. 2007..NAC did not prevent any of the peroxide effects on either GJIC or extracellular receptor kinase, suggesting a specific antioxidant effect of resveratrol... - A paradigm shift is required for the risk assessment of potential human health after exposure to low level chemical exposures: a response to the toxicity testing in the 21st century reportJames E Trosko
Department Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
Int J Toxicol 29:344-57. 2010.... - Gap junctional intercellular communication as a biological "Rosetta stone" in understanding, in a systems biological manner, stem cell behavior, mechanisms of epigenetic toxicology, chemoprevention and chemotherapyJames E Trosko
Center for Integrative Toxicology, National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
J Membr Biol 218:93-100. 2007..The implications of these observations to a "systems biological" view of the role of gap junctions and the nutritional prevention and treatment of several chronic diseases and cancer will be discussed... 
Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase CBrad L Upham
Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
Cancer Sci 99:696-705. 2008....- Oxidative-dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expressionBrad L Upham
Department of Pediatrics and Human Development, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Antioxid Redox Signal 11:297-307. 2009..Thus, any comprehensive-systems biology approach to understanding oxidative signaling must also include gap junctions, in which aberrant gap junctions have been clearly implicated in many human diseases... - Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systemsBrad L Upham
Department of Pediatrics and Human Development, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Health Perspect 117:545-51. 2009..This inhibition of GJIC is known to be a function of perfluorinated carbon lengths ranging from 7 to 10... - Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43Brad L Upham
National Food Safety and Toxicology Center, and Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
Mol Carcinog 37:192-201. 2003..e., differentiation, are dependent upon either small or high MW intercellular signals... - Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell lineYasushi Nakamura
Department of Pediatrics and Human Development, National Food Safety and Toxicology Bldg Center, Michigan State University, 243 Food Safety and Toxicology, East Lansing, MI 48824, USA
Cancer Lett 203:13-24. 2004..In conclusion, the ethanol extract of psyllium reversed two tumor cell phenotypes, namely reduced GJIC and AIG, induced by the Ha-ras oncogene... - Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell lineBrad L Upham
Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824 1302, USA
Int J Cancer 104:12-8. 2003..Cannabinoids affected crucial epigenetic pathways associated with cell proliferation in a rodent liver epithelial cell model system... - Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivoWenyue Hu
Aquatic Toxicology Laboratory, Department of Zoology, National Food Safety and Toxicology Center and Institute of Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Toxicol Sci 68:429-36. 2002.... - Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesisBrad L Upham
Department of Pediatrics and Human Development, Michigan State University, 243 Food Safety and Toxicology, East Lansing, MI 48824, USA
Cancer Lett 191:27-34. 2003..In conclusion, these results suggest that a chronic release of ceramides with acyl groups larger than C6 might act as tumor promoters... - Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potentialKatrina D Linning
Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
Pancreas 29:e64-76. 2004..The objective of this study was to determine whether modulation of intracellular redox state with N-acetyl-L-cysteine (NAC) would allow for the propagation of pancreatic stem/progenitor cells from adult human pancreatic tissue... - Epigenetic toxicity of hydroxylated biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cellsAndrea Y Satoh
Department of Civil and Environmental Engineering, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 37:2727-33. 2003..The more noncoplanar conformation of 2,2'-biphenyldiol and 2-biphenylol might explain their more inhibitory behavior in comparison to 3,3'-biphenyldiol and 3-biphenylol, respectively... - Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH(3), is mediated by inhibition of cytokinesisHye Kyung Na
Department of Pediatrics and Human Development, National Food Safety Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Cancer Chemother Pharmacol 51:209-15. 2003.... - Effect of byproducts from the ozonation of pyrene: biphenyl-2,2',6,6'-tetracarbaldehyde and biphenyl-2,2',6,6'-tetracarboxylic acid on gap junction intercellular communication and neutrophil functionStephanie L Luster-Teasley
Department of Civil and Environmental Engineering, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 24:733-40. 2005..Neither exposure to pyrene nor biphenyl-2,2',6,6'-tetracarboxylic acid caused a significant toxic effect on neutrophil function... - Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of actionMiroslav Machala
Veterinary Research Institute, Department of Chemistry and Toxicology, Hudcova 70, 62132 Brno, Czech Republic
Toxicol Sci 76:102-11. 2003.... - Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cellsYasushi Nakamura
Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Japan
Nutr Cancer 51:218-25. 2005..We discuss implications for dietary modulation of cancer by beta-sitosterol... - Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell lineAnelia Horvath
Department of Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria
Toxicon 40:273-82. 2002.... - Regulation of cell-to-cell communication in non-tumorigenic and malignant human prostate epithelial cellsGiuseppe Carruba
Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo, Italy
Prostate 50:73-82. 2002..Gap-junction-mediated intercellular communication (GJIC) is required for normal development and tissue homeostasis. However, the role of GJIC in human prostate carcinogenesis and progression remains ill-defined... - Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell linesJan Vondracek
Institute of Biophysics, Academy of Sciences of the Czech Republic, 61265 Brno, Czech Republic
Environ Toxicol Chem 26:2308-16. 2007..In summary, inhibition of GJIC and partial activation of AhR seem to be the most prominent toxic effects of the methylated PAHs in the present study... - Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathwayTakahiko Ogawa
Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
J Cell Sci 117:2087-96. 2004.... - Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cellsRita Loch Caruso
Toxicology Program, Department of Environmental Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109 2029, USA
Toxicol Sci 86:417-26. 2005.... - MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cellsAkiyoshi Nishikawa
Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
Environ Mol Mutagen 47:48-55. 2006..These findings indicate that MX is not mutagenic, mitogenic or carcinogenic in mice, and suggest that the compound exerts epigenetic actions leading to GJIC inhibition... - Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locusTakahiko Ogawa
Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
Cancer Res 65:9771-8. 2005..These results support a cancer therapeutic and preventive role for specific HDAC inhibitors... - Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctionsRita Loch-Caruso
Toxicology Program, Department of Environmental Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
Toxicol Sci 85:694-702. 2005..These results suggest that GSH is required in the acute phase but protects against the secondary phase of lindane-induced inhibition of myometrial gap junctions... - Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cellsYasushi Nakamura
Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Shimogamo Hangi, Sakyo, Kyoto 606 8522, Japan
Carcinogenesis 26:665-71. 2005..In contrast, kaempferol had no effect in a tumorigenic colon cancer cell line that did not express connexin43 mRNA and was deficient in GJIC... - Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteineSilvio De Flora
Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, I 16132 Genoa, Italy
Int J Oncol 29:521-9. 2006..Thus, the immortal cell line derived from the normal human adult breast stem cell without further tumorigenic progression is the most susceptible both to DMBA-related alterations and to the protective effects of NAC... - Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarrayJoon Suk Park
Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
Int J Oncol 24:1545-58. 2004..Furthermore, these results will open up an avenue for more detailed understanding of breast stem cell and tumor biology... - Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesisYoko Hirabayashi
Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
Exp Biol Med (Maywood) 232:700-12. 2007..The results indicate that Cx32 in wild-type mice protects HSCs from chemical abrasion and leukemogenic impacts... - Epigenetics and cancer: implications for drug discovery and safety assessmentJonathan G Moggs
Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, UK
Toxicol Appl Pharmacol 196:422-30. 2004..In this paper, we describe the potential for interplay between genetic alteration and epigenetic changes in cell growth regulation and discuss the implications for drug discovery and safety assessment... - Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycleYoko Hirabayashi
Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
J Membr Biol 217:105-13. 2007..e., being quiescent and noncycling; and once Cx32 is knocked out, these progenitor cells are expected to enter the cell cycle, followed by proliferation and differentiation for maintaining the number of peripheral blood cells... - 3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cellsYasushi Nakamura
Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Shimogamo Hangi, Sakyo, Kyoto 606 8522, Japan
J Agric Food Chem 56:2977-84. 2008..Previously, the role of 3-methylthiopropionic acid ethyl ester was considered as an odor producing compound in many fruits, but this study indicates potential medical benefits of this compound...