James Edward Trosko

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Isolation and characterization of normal adult human epithelial pluripotent stem cells
    James E Trosko
    National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Oncol Res 13:353-7. 2003
  2. ncbi request reprint The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment
    James E Trosko
    National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Mutagenesis 20:81-92. 2005
  3. ncbi request reprint Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells
    James E Trosko
    Department of Pediatrics and Human Development, National Food Safety Toxicology Center, College of Human Medicine, Michigan State University, East Lansing, Mich 48824, USA
    Contrib Microbiol 13:45-65. 2006
  4. ncbi request reprint Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication
    James E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Ann N Y Acad Sci 1028:192-201. 2004
  5. ncbi request reprint The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy
    J E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, 48824, USA
    Biomed Pharmacother 59:S326-31. 2005
  6. ncbi request reprint From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion
    James E Trosko
    Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Ann N Y Acad Sci 1089:36-58. 2006
  7. doi request reprint Commentary: "re-programming or selecting adult stem cells?"
    James E Trosko
    Center for Integrative Toxicology, Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Stem Cell Rev 4:81-8. 2008
  8. ncbi request reprint Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging
    J E Trosko
    Center for Integrative Toxicology, Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Curr Pharm Des 14:2707-18. 2008
  9. doi request reprint Review paper: cancer stem cells and cancer nonstem cells: from adult stem cells or from reprogramming of differentiated somatic cells
    J E Trosko
    246 Food Safety and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 46:176-93. 2009
  10. ncbi request reprint The role of human adult stem cells and cell-cell communication in cancer chemoprevention and chemotherapy strategies
    James E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Mutat Res 591:187-97. 2005

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Isolation and characterization of normal adult human epithelial pluripotent stem cells
    James E Trosko
    National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Oncol Res 13:353-7. 2003
    ..The breast stem cells can be prevented from "mortalizing" and can be converted to neoplastic cells, which maintain many phenotypes of the stem cells...
  2. ncbi request reprint The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment
    James E Trosko
    National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Mutagenesis 20:81-92. 2005
    ....
  3. ncbi request reprint Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells
    James E Trosko
    Department of Pediatrics and Human Development, National Food Safety Toxicology Center, College of Human Medicine, Michigan State University, East Lansing, Mich 48824, USA
    Contrib Microbiol 13:45-65. 2006
    ..The inhibition of GJIC might be the mechanism by which the inflammatory process affects cancer and that to intervene during tumor promotion with anti-inflammatory factors might be the most efficacious anti-cancer strategy...
  4. ncbi request reprint Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication
    James E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Ann N Y Acad Sci 1028:192-201. 2004
    ..Chemoprevention and chemotherapeutic implications suggest that one must induce connexin genes in initiated stem cells and restore GJIC in initiated early progenitor cells...
  5. ncbi request reprint The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy
    J E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, 48824, USA
    Biomed Pharmacother 59:S326-31. 2005
    ..Human pluri-potent stem cell systems, that can be induced to form 3-dimensional "organoid" structures, will be discussed as a more realistic model system to screen for relevant chemopreventive agents...
  6. ncbi request reprint From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion
    James E Trosko
    Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Ann N Y Acad Sci 1089:36-58. 2006
    ..These Oct-4 positive cells might represent the "cancer stem cells." A strategy to target "cancer stem cells" is to suppress the Oct-4 gene in order to cause the cells to differentiate...
  7. doi request reprint Commentary: "re-programming or selecting adult stem cells?"
    James E Trosko
    Center for Integrative Toxicology, Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Stem Cell Rev 4:81-8. 2008
    ..An examination of the rationale for this challenging hypothesis has been drawn from the hypothesis of the "stem cell theory of cancer", as well as from the field of human adult stem cells research...
  8. ncbi request reprint Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging
    J E Trosko
    Center for Integrative Toxicology, Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Curr Pharm Des 14:2707-18. 2008
    ..This might explain the Barker hypothesis which suggests that prenatal and early postnatal exposures to toxic agents can lead to diseases later in life...
  9. doi request reprint Review paper: cancer stem cells and cancer nonstem cells: from adult stem cells or from reprogramming of differentiated somatic cells
    J E Trosko
    246 Food Safety and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 46:176-93. 2009
    ....
  10. ncbi request reprint The role of human adult stem cells and cell-cell communication in cancer chemoprevention and chemotherapy strategies
    James E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Mutat Res 591:187-97. 2005
    ....
  11. ncbi request reprint Gap junctions as targets for cancer chemoprevention and chemotherapy
    J E Trosko
    Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Curr Drug Targets 3:465-82. 2002
    ....
  12. doi request reprint Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment
    James Edward Trosko
    Center for Integrative Toxicology, Food Safety and Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Toxicology 270:18-34. 2010
    ..If the future utility of human stem cells proves to be valid, the elimination of less relevant, expensive and time-consuming rodent and 2-D human in vitro assays will be eliminated...
  13. doi request reprint Commentary on ''Toxicity testing in the 21st century: a vision and a strategy'': stem cells and cell-cell communication as fundamental targets in assessing the potential toxicity of chemicals
    James E Trosko
    Center for Integrative Toxicology, Food Safety Toxicology Center, Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 9924, USA
    Hum Exp Toxicol 29:21-9. 2010
    ..g., increase or decrease in the stem cell numbers in specific organs; altered apoptotic and differentiation frequencies), as well as measured cell-cell communication, should be seriously considered as toxicity endpoints...
  14. ncbi request reprint From bacteria to humans: lessons learned from a reductionist's view of ultraviolet light-induced DNA lesions
    J E Trosko
    Department of Pediatrics and Human Development, National Food Safety Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Mol Mutagen 38:118-21. 2001
    ..Dr. Setlow's shoulders were indeed among those of all of us that have made some small contribution in trying to understand this extremely complex process of human carcinogenesis...
  15. ncbi request reprint Low-dose ionizing radiation: induction of differential intracellular signalling possibly affecting intercellular communication
    James E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Radiat Environ Biophys 44:3-9. 2005
    ....
  16. ncbi request reprint The role of stem cells and gap junctional intercellular communication in carcinogenesis
    James E Trosko
    246 National Food Safety Toxicology Center, Dept Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    J Biochem Mol Biol 36:43-8. 2003
    ....
  17. ncbi request reprint Human stem cells as targets for the aging and diseases of aging processes
    James E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
    Med Hypotheses 60:439-47. 2003
    ..One clear example, that of carcinogenesis, illustrates this point...
  18. ncbi request reprint Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics
    Mei Hui Tai
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Pancreas 26:e18-26. 2003
    ..Cancer cells, which have been viewed as "partially blocked stem cells," and which lack the ability for growth control, terminal differentiation, and apoptosis, also lack functional gap junctional communication...
  19. ncbi request reprint Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis
    Mei Hui Tai
    National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Carcinogenesis 26:495-502. 2005
    ..Oct4 is expressed in a few cells found in the basal layer of human skin epidermis. The data demonstrate that adult stem cells maintain expression of Oct4, consistent with the stem cell hypothesis of carcinogenesis...
  20. ncbi request reprint Isolation and differentiation of bovine mammary gland progenitor cell populations
    Margo S Holland
    Department of Veterinary Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 64:396-403. 2003
    ..To isolate bovine mammary gland cells with stem cell characteristics...
  21. ncbi request reprint Dietary modulation of the multistage, multimechanisms of human carcinogenesis: effects on initiated stem cells and cell-cell communication
    James E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Nutr Cancer 54:102-10. 2006
    ....
  22. ncbi request reprint Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells
    Mei Hui Tai
    Department of Physiology, Michigan State University, East Lansing, MI, USA
    Int J Cancer 120:1855-62. 2007
    ..These results indicate that a prominent component of cigarette smoke, namely methylanthracenes with distinct structural configurations, could be a potential etiological agent contributing to the epigenetic events of pancreatic cancer...
  23. ncbi request reprint Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol
    Brad L Upham
    Department of Pediatrics and Human Development and the National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824 1302, USA
    Nutr Cancer 57:38-47. 2007
    ..NAC did not prevent any of the peroxide effects on either GJIC or extracellular receptor kinase, suggesting a specific antioxidant effect of resveratrol...
  24. doi request reprint A paradigm shift is required for the risk assessment of potential human health after exposure to low level chemical exposures: a response to the toxicity testing in the 21st century report
    James E Trosko
    Department Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    Int J Toxicol 29:344-57. 2010
    ....
  25. ncbi request reprint Gap junctional intercellular communication as a biological "Rosetta stone" in understanding, in a systems biological manner, stem cell behavior, mechanisms of epigenetic toxicology, chemoprevention and chemotherapy
    James E Trosko
    Center for Integrative Toxicology, National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Membr Biol 218:93-100. 2007
    ..The implications of these observations to a "systems biological" view of the role of gap junctions and the nutritional prevention and treatment of several chronic diseases and cancer will be discussed...
  26. pmc Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C
    Brad L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA
    Cancer Sci 99:696-705. 2008
    ....
  27. pmc Oxidative-dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expression
    Brad L Upham
    Department of Pediatrics and Human Development, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Antioxid Redox Signal 11:297-307. 2009
    ..Thus, any comprehensive-systems biology approach to understanding oxidative signaling must also include gap junctions, in which aberrant gap junctions have been clearly implicated in many human diseases...
  28. pmc Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems
    Brad L Upham
    Department of Pediatrics and Human Development, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Health Perspect 117:545-51. 2009
    ..This inhibition of GJIC is known to be a function of perfluorinated carbon lengths ranging from 7 to 10...
  29. ncbi request reprint Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43
    Brad L Upham
    National Food Safety and Toxicology Center, and Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Carcinog 37:192-201. 2003
    ..e., differentiation, are dependent upon either small or high MW intercellular signals...
  30. ncbi request reprint Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line
    Yasushi Nakamura
    Department of Pediatrics and Human Development, National Food Safety and Toxicology Bldg Center, Michigan State University, 243 Food Safety and Toxicology, East Lansing, MI 48824, USA
    Cancer Lett 203:13-24. 2004
    ..In conclusion, the ethanol extract of psyllium reversed two tumor cell phenotypes, namely reduced GJIC and AIG, induced by the Ha-ras oncogene...
  31. ncbi request reprint Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line
    Brad L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824 1302, USA
    Int J Cancer 104:12-8. 2003
    ..Cannabinoids affected crucial epigenetic pathways associated with cell proliferation in a rodent liver epithelial cell model system...
  32. ncbi request reprint Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo
    Wenyue Hu
    Aquatic Toxicology Laboratory, Department of Zoology, National Food Safety and Toxicology Center and Institute of Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 68:429-36. 2002
    ....
  33. ncbi request reprint Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis
    Brad L Upham
    Department of Pediatrics and Human Development, Michigan State University, 243 Food Safety and Toxicology, East Lansing, MI 48824, USA
    Cancer Lett 191:27-34. 2003
    ..In conclusion, these results suggest that a chronic release of ceramides with acyl groups larger than C6 might act as tumor promoters...
  34. ncbi request reprint Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential
    Katrina D Linning
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Pancreas 29:e64-76. 2004
    ..The objective of this study was to determine whether modulation of intracellular redox state with N-acetyl-L-cysteine (NAC) would allow for the propagation of pancreatic stem/progenitor cells from adult human pancreatic tissue...
  35. ncbi request reprint Epigenetic toxicity of hydroxylated biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells
    Andrea Y Satoh
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Sci Technol 37:2727-33. 2003
    ..The more noncoplanar conformation of 2,2'-biphenyldiol and 2-biphenylol might explain their more inhibitory behavior in comparison to 3,3'-biphenyldiol and 3-biphenylol, respectively...
  36. ncbi request reprint Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH(3), is mediated by inhibition of cytokinesis
    Hye Kyung Na
    Department of Pediatrics and Human Development, National Food Safety Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Cancer Chemother Pharmacol 51:209-15. 2003
    ....
  37. ncbi request reprint Effect of byproducts from the ozonation of pyrene: biphenyl-2,2',6,6'-tetracarbaldehyde and biphenyl-2,2',6,6'-tetracarboxylic acid on gap junction intercellular communication and neutrophil function
    Stephanie L Luster-Teasley
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Toxicol Chem 24:733-40. 2005
    ..Neither exposure to pyrene nor biphenyl-2,2',6,6'-tetracarboxylic acid caused a significant toxic effect on neutrophil function...
  38. ncbi request reprint Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action
    Miroslav Machala
    Veterinary Research Institute, Department of Chemistry and Toxicology, Hudcova 70, 62132 Brno, Czech Republic
    Toxicol Sci 76:102-11. 2003
    ....
  39. ncbi request reprint Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells
    Yasushi Nakamura
    Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Japan
    Nutr Cancer 51:218-25. 2005
    ..We discuss implications for dietary modulation of cancer by beta-sitosterol...
  40. ncbi request reprint Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line
    Anelia Horvath
    Department of Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria
    Toxicon 40:273-82. 2002
    ....
  41. ncbi request reprint Regulation of cell-to-cell communication in non-tumorigenic and malignant human prostate epithelial cells
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo, Italy
    Prostate 50:73-82. 2002
    ..Gap-junction-mediated intercellular communication (GJIC) is required for normal development and tissue homeostasis. However, the role of GJIC in human prostate carcinogenesis and progression remains ill-defined...
  42. ncbi request reprint Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines
    Jan Vondracek
    Institute of Biophysics, Academy of Sciences of the Czech Republic, 61265 Brno, Czech Republic
    Environ Toxicol Chem 26:2308-16. 2007
    ..In summary, inhibition of GJIC and partial activation of AhR seem to be the most prominent toxic effects of the methylated PAHs in the present study...
  43. ncbi request reprint Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway
    Takahiko Ogawa
    Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    J Cell Sci 117:2087-96. 2004
    ....
  44. ncbi request reprint Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells
    Rita Loch Caruso
    Toxicology Program, Department of Environmental Health, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109 2029, USA
    Toxicol Sci 86:417-26. 2005
    ....
  45. ncbi request reprint MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Environ Mol Mutagen 47:48-55. 2006
    ..These findings indicate that MX is not mutagenic, mitogenic or carcinogenic in mice, and suggest that the compound exerts epigenetic actions leading to GJIC inhibition...
  46. ncbi request reprint Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus
    Takahiko Ogawa
    Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    Cancer Res 65:9771-8. 2005
    ..These results support a cancer therapeutic and preventive role for specific HDAC inhibitors...
  47. ncbi request reprint Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions
    Rita Loch-Caruso
    Toxicology Program, Department of Environmental Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Toxicol Sci 85:694-702. 2005
    ..These results suggest that GSH is required in the acute phase but protects against the secondary phase of lindane-induced inhibition of myometrial gap junctions...
  48. ncbi request reprint Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells
    Yasushi Nakamura
    Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Shimogamo Hangi, Sakyo, Kyoto 606 8522, Japan
    Carcinogenesis 26:665-71. 2005
    ..In contrast, kaempferol had no effect in a tumorigenic colon cancer cell line that did not express connexin43 mRNA and was deficient in GJIC...
  49. ncbi request reprint Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine
    Silvio De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, I 16132 Genoa, Italy
    Int J Oncol 29:521-9. 2006
    ..Thus, the immortal cell line derived from the normal human adult breast stem cell without further tumorigenic progression is the most susceptible both to DMBA-related alterations and to the protective effects of NAC...
  50. ncbi request reprint Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray
    Joon Suk Park
    Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
    Int J Oncol 24:1545-58. 2004
    ..Furthermore, these results will open up an avenue for more detailed understanding of breast stem cell and tumor biology...
  51. ncbi request reprint Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    Exp Biol Med (Maywood) 232:700-12. 2007
    ..The results indicate that Cx32 in wild-type mice protects HSCs from chemical abrasion and leukemogenic impacts...
  52. ncbi request reprint Epigenetics and cancer: implications for drug discovery and safety assessment
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, UK
    Toxicol Appl Pharmacol 196:422-30. 2004
    ..In this paper, we describe the potential for interplay between genetic alteration and epigenetic changes in cell growth regulation and discuss the implications for drug discovery and safety assessment...
  53. ncbi request reprint Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycle
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    J Membr Biol 217:105-13. 2007
    ..e., being quiescent and noncycling; and once Cx32 is knocked out, these progenitor cells are expected to enter the cell cycle, followed by proliferation and differentiation for maintaining the number of peripheral blood cells...
  54. pmc 3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells
    Yasushi Nakamura
    Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Shimogamo Hangi, Sakyo, Kyoto 606 8522, Japan
    J Agric Food Chem 56:2977-84. 2008
    ..Previously, the role of 3-methylthiopropionic acid ethyl ester was considered as an odor producing compound in many fruits, but this study indicates potential medical benefits of this compound...