J E Trosko

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer
    J E Trosko
    Department of Pediatrics and Human Development, Institute of Environmental Toxicology, 246 National Food Safety Toxicology Center, Michigan State University, B 240 Life Sciences Bldg, East Lansing, MI 48824, USA
    Mutat Res 480:219-29. 2001
  2. ncbi request reprint Gap junctions and the regulation of cellular functions of stem cells during development and differentiation
    J E Trosko
    Department of Pediatrics and Human Development, National Food Safety and Toxicology Center, East Lansing, Michigan 48824, USA
    Methods 20:245-64. 2000
  3. pmc Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents
    J E Trosko
    Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Environ Health Perspect 106:331-9. 1998
  4. ncbi request reprint Cell-cell communication in carcinogenesis
    J E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Front Biosci 3:d208-36. 1998
  5. ncbi request reprint Human health consequences of environmentally-modulated gene expression: potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease
    J E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
    Bioelectromagnetics 21:402-6. 2000
  6. ncbi request reprint Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication
    J E Trosko
    Department of Pediatrics and Human Development, Institute for Environmental Toxicology, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Toxicol Lett 102:71-8. 1998
  7. ncbi request reprint Inhibition of gap junctional intercellular communication in heptachlor- and heptachlor epoxide-treated normal human breast epithelial cells
    K Nomata
    Department of Pediatrics Human Development and Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Cell Biol Toxicol 12:69-78. 1996
  8. ncbi request reprint Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells
    D F Matesic
    Department of Pediatrics Human Development, Michigan State University, East Lansing 48824
    Mol Carcinog 10:226-36. 1994
  9. ncbi request reprint The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells
    B L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, 48824, USA
    Fundam Appl Toxicol 34:260-4. 1996
  10. ncbi request reprint Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis
    M R Wilson
    Department of Pediatrics and Human Development, College of Human Medicine, East Lansing, Michigan 48824, USA
    Exp Cell Res 254:257-68. 2000

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer
    J E Trosko
    Department of Pediatrics and Human Development, Institute of Environmental Toxicology, 246 National Food Safety Toxicology Center, Michigan State University, B 240 Life Sciences Bldg, East Lansing, MI 48824, USA
    Mutat Res 480:219-29. 2001
    ....
  2. ncbi request reprint Gap junctions and the regulation of cellular functions of stem cells during development and differentiation
    J E Trosko
    Department of Pediatrics and Human Development, National Food Safety and Toxicology Center, East Lansing, Michigan 48824, USA
    Methods 20:245-64. 2000
    ..We review a few techniques used to characterize the ability of stem and progenitor cells to perform GJIC...
  3. pmc Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents
    J E Trosko
    Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Environ Health Perspect 106:331-9. 1998
    ..Examples of the role of gap junctional intercellular communication in the adaptive response of cells and the bystander effect illustrate how the interaction of cells can modulate the effect of radiation on the single cell...
  4. ncbi request reprint Cell-cell communication in carcinogenesis
    J E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Front Biosci 3:d208-36. 1998
    ..From this background, implications to cancer prevention and cancer therapy are generated...
  5. ncbi request reprint Human health consequences of environmentally-modulated gene expression: potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease
    J E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
    Bioelectromagnetics 21:402-6. 2000
    ..Ultimately, epigenetic toxicants affect one of four potential cell states, namely alteration of cell proliferation, cell differentiation, programmed cell death (apoptosis) or adaptive responses of differentiated cells...
  6. ncbi request reprint Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication
    J E Trosko
    Department of Pediatrics and Human Development, Institute for Environmental Toxicology, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Toxicol Lett 102:71-8. 1998
    ..Implications for 'thresholds' to toxicants and for risk assessment are evident...
  7. ncbi request reprint Inhibition of gap junctional intercellular communication in heptachlor- and heptachlor epoxide-treated normal human breast epithelial cells
    K Nomata
    Department of Pediatrics Human Development and Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Cell Biol Toxicol 12:69-78. 1996
    ....
  8. ncbi request reprint Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells
    D F Matesic
    Department of Pediatrics Human Development, Michigan State University, East Lansing 48824
    Mol Carcinog 10:226-36. 1994
    ....
  9. ncbi request reprint The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells
    B L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, 48824, USA
    Fundam Appl Toxicol 34:260-4. 1996
    ....
  10. ncbi request reprint Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis
    M R Wilson
    Department of Pediatrics and Human Development, College of Human Medicine, East Lansing, Michigan 48824, USA
    Exp Cell Res 254:257-68. 2000
    ..This model system is useful for further studies on the relationships among inter- and intracellular mechanisms of homeostasis...
  11. ncbi request reprint Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer
    J E Trosko
    National Food Safety and Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
    Biofactors 12:259-63. 2000
    ....
  12. pmc Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship
    B L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
    Environ Health Perspect 106:975-81. 1998
    ..PAHs containing a bay or baylike region were more potent inhibitors of GJIC than the linear PAHs that do not contain these regions. These are some of the first studies of determine the epigenetic toxicity of PAHs at the epigenetic level...
  13. ncbi request reprint Inhibition of gap junctional-mediated intercellular communication in vitro by aldrin, dieldrin, and toxaphene: a possible cellular mechanism for their tumor-promoting and neurotoxic effects
    J E Trosko
    Department of Pediatrics Human Development, Michigan State University, East Lansing 48824
    Mol Toxicol 1:83-93. 1987
    ..Interpretation of results suggests that chemical inhibition of gap junctional communication could be a possible mechanism to explain their tumor-promoting and neurotoxic effects...
  14. ncbi request reprint Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines
    S J Masten
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing 48824, USA
    Chemosphere 44:457-65. 2001
    ..These results suggest that ozone can effectively remove malathion from solution without forming GJIC-toxic products, but is less effective in eliminating DEET and DDT from solution...
  15. ncbi request reprint The epigenetic toxicity of pyrene and related ozonation byproducts containing an aldehyde functional group
    H A Herner
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing 48824-1326, USA
    Environ Sci Technol 35:3576-83. 2001
    ..Toxicological evaluation and GC/MS of impure byproduct mixtures showed that two common compounds were found in inhibiting fractions. These common compounds contained both a bay region and at least one aldehyde group...
  16. ncbi request reprint Homologous and heterologous gap-junctional intercellular communication in v-raf-, v-myc-, and v-raf/v-myc-transduced rat liver epithelial cell lines
    G H Kalimi
    Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824
    Mol Carcinog 5:301-10. 1992
    ....
  17. ncbi request reprint The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy
    J E Trosko
    246 National Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, 48824, USA
    Biomed Pharmacother 59:S326-31. 2005
    ..Human pluri-potent stem cell systems, that can be induced to form 3-dimensional "organoid" structures, will be discussed as a more realistic model system to screen for relevant chemopreventive agents...
  18. ncbi request reprint Inhibition of gap junctional intercellular communication in rat liver epithelial cells with transforming RNA
    T Hayashi
    Department of Pediatrics/Human Development, Institute of Environmental Toxicology and the Center of MSU, Michigan State University, East Lansing 48824, USA
    FEBS Lett 491:200-6. 2001
    ..Together with previous data, this implies that altered expression of transforming RNA itself is a potential mechanism in inhibiting gap junction function during carcinogenesis...
  19. ncbi request reprint Inhibition of gap junctional intercellular communication by perfluorinated fatty acids is dependent on the chain length of the fluorinated tail
    B L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824, USA
    Int J Cancer 78:491-5. 1998
    ..Our results suggest that PFFAs could potentially act as hepatocarcinogens at the level of gap junctions in addition to or instead of through peroxisome proliferation...
  20. ncbi request reprint Commentary: is the concept of "tumor promotion" a useful paradigm?
    J E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Carcinog 30:131-7. 2001
    ..Mol. Carcinog. 30:131--137, 2001...
  21. ncbi request reprint Role of stem cells and gap junctional intercellular communication in human carcinogenesis
    J E Trosko
    National Food Safety and Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Radiat Res 155:175-180. 2001
    ..Promotion would involve the reversible inhibition of gap junctional intercellular communication (GJIC) and while progression occurs with the stable down-regulation of GJIC...
  22. ncbi request reprint A human breast epithelial cell type with stem cell characteristics as target cells for carcinogenesis
    C C Chang
    National Food Safety and Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Radiat Res 155:201-207. 2001
    ....
  23. ncbi request reprint Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging
    J E Trosko
    Center for Integrative Toxicology, Food Safety Toxicology Center, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Curr Pharm Des 14:2707-18. 2008
    ..This might explain the Barker hypothesis which suggests that prenatal and early postnatal exposures to toxic agents can lead to diseases later in life...
  24. ncbi request reprint Gap junctions as targets for cancer chemoprevention and chemotherapy
    J E Trosko
    Department of Pediatrics Human Development, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Curr Drug Targets 3:465-82. 2002
    ....
  25. ncbi request reprint Oxidative stress in laboratory-incubated double-crested cormorant eggs collected from the Great Lakes
    K Hilscherova
    Department of Environmental Chemistry and Ecotoxicology, Faculty of Science, Masaryk University, Brno 61137, Czech Republic
    Arch Environ Contam Toxicol 45:533-46. 2003
    ..While exposure to PCDD/DF and PCBs does not seem to explain the observed oxidative stress, the potential of these compounds to cause the observed effects can not be completely excluded...
  26. ncbi request reprint Response of tobacco and Haplopappus cells to ultraviolet irradiation after posttreatment with photoreactivating light
    J E Trosko
    Natural Science Department, Michigan State University, East Lansing, Michigan, USA
    Radiat Res 36:333-43. 1968
    ..On the other hand, neither increase in growth nor monomerization of dimers was observed in the UV-irradiated Haplopappus cell culture after treatment with photoreactivating light...
  27. ncbi request reprint Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia
    J D Webster
    Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
    Vet Pathol 44:893-900. 2007
    ....
  28. doi request reprint Review paper: cancer stem cells and cancer nonstem cells: from adult stem cells or from reprogramming of differentiated somatic cells
    J E Trosko
    246 Food Safety and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 46:176-93. 2009
    ....
  29. ncbi request reprint Ozonation of chrysene: evaluation of byproduct mixtures and identification of toxic constituent
    S L Luster-Teasley
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing 48824, USA
    Environ Sci Technol 36:869-76. 2002
    ..2-(2'-Formyl) phenyl-1-naphthaldehyde was determined to be the compound causing GJIC inhibition in sample fractions and byproduct mixtures...
  30. ncbi request reprint From bacteria to humans: lessons learned from a reductionist's view of ultraviolet light-induced DNA lesions
    J E Trosko
    Department of Pediatrics and Human Development, National Food Safety Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Mol Mutagen 38:118-21. 2001
    ..Dr. Setlow's shoulders were indeed among those of all of us that have made some small contribution in trying to understand this extremely complex process of human carcinogenesis...
  31. pmc Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling
    L Umannov√°
    Department of Cytokinetics, Institute of Biophysics ASCR, 612 65 Brno, Czech Republic
    Toxicology 247:55-60. 2008
    ..Our results suggest that more attention should be paid to cell signalling pathways regulated by AA or eicosanoids after PCB exposure, which might be involved in their toxic effects...
  32. ncbi request reprint Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD
    K Hilscherova
    Department of Environmental Chemistry and Ecotoxicology, Faculty of Science, Masaryk University, Brno, Czech Republic
    Comp Biochem Physiol C Toxicol Pharmacol 136:29-45. 2003
    ..Responsiveness varied among individual animals, but measures of the oxidative stress were correlated...
  33. pmc Radiation risk to low fluences of alpha particles may be greater than we thought
    H Zhou
    Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:14410-5. 2001
    ....