Martin Thompson

Summary

Affiliation: Michigan Technological University
Country: USA

Publications

  1. pmc Polybromo-1: the chromatin targeting subunit of the PBAF complex
    Martin Thompson
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Biochimie 91:309-19. 2009
  2. pmc Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions
    Martin Thompson
    Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA
    Anal Biochem 374:304-12. 2008
  3. doi request reprint Thermodynamic and kinetic analysis of bromodomain-histone interactions
    Martin Thompson
    Department of Chemistry, Michigan Technological University, Houghton, Michigan, USA
    Methods Enzymol 466:383-407. 2009
  4. ncbi request reprint Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions
    Renu Chandrasekaran
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Biochem Biophys Res Commun 355:661-6. 2007
  5. pmc Kinetic analysis of acetylation-dependent Pb1 bromodomain-histone interactions
    Christopher Kupitz
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, United States
    Biophys Chem 136:7-12. 2008
  6. ncbi request reprint Expression, purification and characterization of individual bromodomains from human Polybromo-1
    Renu Chandrasekaran
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Protein Expr Purif 50:111-7. 2006
  7. ncbi request reprint Synthesis, photophysical effects, and DNA targeting properties of oxazole yellow-peptide bioconjugates
    Martin Thompson
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
    Bioconjug Chem 17:507-13. 2006
  8. ncbi request reprint Spectral properties and DNA targeting features of a thiazole orange-peptide bioconjugate
    Martin Thompson
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Biomacromolecules 8:3628-33. 2007

Collaborators

  • Renu Chandrasekaran
  • Christopher Kupitz

Detail Information

Publications8

  1. pmc Polybromo-1: the chromatin targeting subunit of the PBAF complex
    Martin Thompson
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Biochimie 91:309-19. 2009
    ..The newly identified regulatory role of this important protein is also examined to explain both native function and the emerging role of Pb1 as a tumor suppressor found to be mutated in breast cancer...
  2. pmc Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions
    Martin Thompson
    Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA
    Anal Biochem 374:304-12. 2008
    ....
  3. doi request reprint Thermodynamic and kinetic analysis of bromodomain-histone interactions
    Martin Thompson
    Department of Chemistry, Michigan Technological University, Houghton, Michigan, USA
    Methods Enzymol 466:383-407. 2009
    ..A thermodynamic and kinetic analysis is performed to determine the factors that drive molecular recognition and binding affinity, resulting in the identification of an induced-folding mechanism...
  4. ncbi request reprint Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions
    Renu Chandrasekaran
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Biochem Biophys Res Commun 355:661-6. 2007
    ..Quantitative analysis of single bromodomain-histone interactions can be used to develop hypotheses regarding the histone acetylation pattern that acts as the binding target of the native polybromo-1 protein...
  5. pmc Kinetic analysis of acetylation-dependent Pb1 bromodomain-histone interactions
    Christopher Kupitz
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, United States
    Biophys Chem 136:7-12. 2008
    ..4 and 12.9 microM for high- and low-affinity complexes, respectively. This work represents the first examination of kinetic mechanisms of acetylation-dependent bromodomain-histone interactions...
  6. ncbi request reprint Expression, purification and characterization of individual bromodomains from human Polybromo-1
    Renu Chandrasekaran
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Protein Expr Purif 50:111-7. 2006
    ..This is the first report of recombinant active form of bromodomains obtained from PB1...
  7. ncbi request reprint Synthesis, photophysical effects, and DNA targeting properties of oxazole yellow-peptide bioconjugates
    Martin Thompson
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
    Bioconjug Chem 17:507-13. 2006
    ..Using the synthetic route described here, bioconjugates could be designed using different combinations of DNA recognition polypeptides and cyanine dyes to generate an array of sequence specific and wavelength specific probes...
  8. ncbi request reprint Spectral properties and DNA targeting features of a thiazole orange-peptide bioconjugate
    Martin Thompson
    Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
    Biomacromolecules 8:3628-33. 2007
    ..The attachment of a sequence-specific binding peptide onto a functional probe provides a viable strategy for construction of synthetic enzymes and repressors, and facilitates dynamic studies of protein-DNA interactions...