W R Swindell

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Selection and inbreeding depression: effects of inbreeding rate and inbreeding environment
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA
    Evolution 60:1014-22. 2006
  2. ncbi request reprint Associations between environmental stress, selection history, and quantitative genetic variation in Drosophila melanogaster
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403 0212, USA
    Genetica 127:311-20. 2006
  3. pmc The association among gene expression responses to nine abiotic stress treatments in Arabidopsis thaliana
    William R Swindell
    Department of Probability and Statistics, Michigan State University, East Lansing, Michigan 48824, USA
    Genetics 174:1811-24. 2006
  4. ncbi request reprint Plastic and adaptive gene expression patterns associated with temperature stress in Arabidopsis thaliana
    W R Swindell
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    Heredity (Edinb) 99:143-50. 2007
  5. pmc Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways
    William R Swindell
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 8:125. 2007
  6. pmc Genotype-by-age interaction and identification of longevity-associated genes from microarray data
    William R Swindell
    Department of Statistics and Probability, Michigan State University, A 413 Wells Hall, East Lansing, MI, 48824, USA
    Age (Dordr) 29:97-102. 2007
  7. pmc Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    William R Swindell
    Department of Pathology, University of Michigan, 3118 BSRB, Ann Arbor, MI, USA
    BMC Genomics 8:353. 2007
  8. ncbi request reprint Ancestral inbreeding reduces the magnitude of inbreeding depression in Drosophila melanogaster
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403 0212, USA
    Evolution 60:762-7. 2006
  9. pmc Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
    William R Swindell
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48103, United States
    Mech Ageing Dev 129:138-53. 2008
  10. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Selection and inbreeding depression: effects of inbreeding rate and inbreeding environment
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA
    Evolution 60:1014-22. 2006
    ..Overall, our findings show that inbreeding depression is reduced when inbreeding takes place in a stressful environment, possibly due to more effective purging under such conditions...
  2. ncbi request reprint Associations between environmental stress, selection history, and quantitative genetic variation in Drosophila melanogaster
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403 0212, USA
    Genetica 127:311-20. 2006
    ..These results demonstrate that high temperature stress increases quantitative genetic variation for bristle number, but do not support the selection history hypothesis as an explanation for this effect...
  3. pmc The association among gene expression responses to nine abiotic stress treatments in Arabidopsis thaliana
    William R Swindell
    Department of Probability and Statistics, Michigan State University, East Lansing, Michigan 48824, USA
    Genetics 174:1811-24. 2006
    ..Analysis of this gene set indicated that cell rescue/defense/virulence, energy, and metabolism functional classes were overrepresented, providing novel insight into the functional basis of multiple stress tolerance in Arabidopsis...
  4. ncbi request reprint Plastic and adaptive gene expression patterns associated with temperature stress in Arabidopsis thaliana
    W R Swindell
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    Heredity (Edinb) 99:143-50. 2007
    ..These selected genes represent strong candidates for future experimental investigations into the molecular basis of temperature acclimation in the A. thaliana model system...
  5. pmc Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways
    William R Swindell
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 8:125. 2007
    ....
  6. pmc Genotype-by-age interaction and identification of longevity-associated genes from microarray data
    William R Swindell
    Department of Statistics and Probability, Michigan State University, A 413 Wells Hall, East Lansing, MI, 48824, USA
    Age (Dordr) 29:97-102. 2007
    ..This approach may lend greater confidence to the inference that expression of identified genes specifically underlies aging differences between long-lived and normal genotypes...
  7. pmc Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    William R Swindell
    Department of Pathology, University of Michigan, 3118 BSRB, Ann Arbor, MI, USA
    BMC Genomics 8:353. 2007
    ..Points of overlap with the effects of calorie restriction (CR), CR mimetic compounds, low fat diets, gender dimorphism and aging were also examined...
  8. ncbi request reprint Ancestral inbreeding reduces the magnitude of inbreeding depression in Drosophila melanogaster
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403 0212, USA
    Evolution 60:762-7. 2006
    ..Our results demonstrate that high levels of ancestral inbreeding are associated with greater purging effects, which reduces the inbreeding depression that occurs in isolated populations of small size...
  9. pmc Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
    William R Swindell
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48103, United States
    Mech Ageing Dev 129:138-53. 2008
    ..These analyses shed light on the systemic transcriptional activity associated with CR diets, and also illustrate new approaches for comparative analysis of microarray datasets in the context of aging biology...
  10. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  11. pmc How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008
    ..Future work in this direction can provide tools for aging research and will shed light on associations between phenotypic traits and longevity...
  12. ncbi request reprint Modeling the adaptive potential of isolated populations: experimental simulations using Drosophila
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA
    Evolution 59:2159-69. 2005
    ..Our results validate the use of the drift-mutation model as a tool for understanding the dynamics of adaptive potential for peripheral fitness characters, but suggest caution in applying this model to recently bottlenecked populations...