Shireesh Srivastava

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition
    Shireesh Srivastava
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA
    Free Radic Res 41:38-49. 2007
  2. pmc Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells
    Shireesh Srivastava
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 8:364. 2007
  3. pmc A novel method incorporating gene ontology information for unsupervised clustering and feature selection
    Shireesh Srivastava
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA
    PLoS ONE 3:e3860. 2008
  4. ncbi request reprint Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity
    Zheng Li
    Cellular and Molecular Biology Lab, Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA
    Biotechnol Prog 24:29-37. 2008
  5. pmc A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways
    Zheng Li
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA
    BMC Bioinformatics 8:202. 2007
  6. ncbi request reprint Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line
    Shireesh Srivastava
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan 48824, USA
    Biotechnol Bioeng 99:399-410. 2008
  7. ncbi request reprint A knowledge driven regression model for gene expression and microarray analysis
    Rong Jin
    Faculty of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5326-9. 2006
  8. pmc A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells
    Zheng Li
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA
    BMC Syst Biol 1:21. 2007

Detail Information

Publications8

  1. ncbi request reprint Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition
    Shireesh Srivastava
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA
    Free Radic Res 41:38-49. 2007
    ..These results suggest that palmitate-cytotoxicity to hepatoma cells is mediated through the production of H2O2 and *OH and independent of MPT...
  2. pmc Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells
    Shireesh Srivastava
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 8:364. 2007
    ..We hypothesized that the genes which simultaneously regulate lipid accumulation as well as cytotoxicity may provide better targets to counter lipotoxicity of saturated FFA...
  3. pmc A novel method incorporating gene ontology information for unsupervised clustering and feature selection
    Shireesh Srivastava
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA
    PLoS ONE 3:e3860. 2008
    ..However, current methods that incorporate prior functional information do not provide a relative estimate of the effect of different genes on the biological processes of interest...
  4. ncbi request reprint Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity
    Zheng Li
    Cellular and Molecular Biology Lab, Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA
    Biotechnol Prog 24:29-37. 2008
    ..Some of the genes identified to be important were experimentally validated. It was found that ETC genes such as NADH dehydrogenase and succinate dehydrogenase were involved in palmitate induced cytotoxicity...
  5. pmc A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways
    Zheng Li
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA
    BMC Bioinformatics 8:202. 2007
    ..The approach was tested on human liver cells to identify pathways that confer cytotoxicity...
  6. ncbi request reprint Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line
    Shireesh Srivastava
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan 48824, USA
    Biotechnol Bioeng 99:399-410. 2008
    ..Thus, the metabolic alterations that contributed to the toxicity and suggested treatments to reduce the toxicity were identified, which were experimentally validated...
  7. ncbi request reprint A knowledge driven regression model for gene expression and microarray analysis
    Rong Jin
    Faculty of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5326-9. 2006
    ..Empirical studies show that the proposed knowledge driven regression model is effective in reducing the regression errors, and furthermore effective in identifying genes that are relevant to a given metabolite...
  8. pmc A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells
    Zheng Li
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA
    BMC Syst Biol 1:21. 2007
    ..A computational model was developed to integrate these disparate data to reveal the underlying pathways and mechanisms involved in saturated fatty acid toxicity...