William L Smith

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene
    T Arakawa
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 271:29569-75. 1996
  2. ncbi request reprint Sphingolipid metabolism and signaling minireview series
    William L Smith
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 277:25841-2. 2002
  3. ncbi request reprint Cyclooxygenases: structural, cellular, and molecular biology
    W L Smith
    Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
    Annu Rev Biochem 69:145-82. 2000
  4. ncbi request reprint Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides
    Christine A Harman
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 282:28096-105. 2007
  5. ncbi request reprint Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid
    Christine A Harman
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 279:42929-35. 2004
  6. ncbi request reprint Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activation
    Jiayan Liu
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 282:18233-44. 2007
  7. ncbi request reprint PGG2, 11R-HPETE and 15R/S-HPETE are formed from different conformers of arachidonic acid in the prostaglandin endoperoxide H synthase-1 cyclooxygenase site
    Elizabeth D Thuresson
    Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
    Adv Exp Med Biol 507:67-72. 2002
  8. ncbi request reprint Cyclooxygenase-2 gene transcription in a macrophage model of inflammation
    Yeon Joo Kang
    Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA
    J Immunol 177:8111-22. 2006
  9. ncbi request reprint Different suicide inactivation processes for the peroxidase and cyclooxygenase activities of prostaglandin endoperoxide H synthase-1
    I Song
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochem Biophys Res Commun 289:869-75. 2001
  10. ncbi request reprint A procedure for preparing oxazolines of highly unsaturated fatty acids to determine double bond positions by mass spectrometry
    Dmitry V Kuklev
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 44:1060-6. 2003

Collaborators

  • Tetsuo Arakawa
  • Robert I Cukier
  • Kevin R Kozak
  • R M Garavito
  • Garret A Fitzgerald
  • Alfred H Merrill Jr
  • Henry J Lin
  • Ah Lim Tsai
  • Pierre Dorlet
  • Lawrence J Marnett
  • Dmitry V Kuklev
  • Chong Yuan
  • Yeon Joo Kang
  • Cynthia J DeLong
  • E D Thuresson
  • Christine A Harman
  • Uri R Mbonye
  • Inseok Song
  • Masayuki Wada
  • Steve A Seibold
  • Caroline Jill Rieke
  • Ranjinder S Sidhu
  • Jiayan Liu
  • Caroline J Rieke
  • Byron A Wingerd
  • K M Lakkides
  • Elizabeth D Thuresson
  • C J Rieke
  • M G Malkowski
  • A M Mulichak
  • I Song
  • Clair E Harris
  • John W Regan
  • Emer M Smyth
  • Stephen J Wilson
  • Chieko Yokoyama
  • Yu H Hong
  • Mark Warnock
  • MELISSA V TURMAN
  • Alvin H Schmaier
  • De Xin Sui
  • Gilad Rimon
  • A G Spencer
  • Terry Ball
  • Renee Micielli
  • Linda C Hsi
  • Rajeewa D Abeysinghe
  • Denise A Mills
  • Karen M Lakkides
  • R Micielli
  • Y Sun
  • B A Wingerd
  • T M Ball
  • S L Ginell
  • J W Woods
  • I I Singer
  • J C Otto
  • D L DeWitt

Detail Information

Publications28

  1. ncbi request reprint Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene
    T Arakawa
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 271:29569-75. 1996
    ..7 cells indicated that there is a constitutive negative regulatory region between -992 and -928 bp, a constitutive positive region between -928 and -554 bp, and an LPS/serum-responsive region between -554 and -116 bp...
  2. ncbi request reprint Sphingolipid metabolism and signaling minireview series
    William L Smith
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 277:25841-2. 2002
  3. ncbi request reprint Cyclooxygenases: structural, cellular, and molecular biology
    W L Smith
    Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
    Annu Rev Biochem 69:145-82. 2000
    ..We further examine the evidence for independent signaling by PGHS-1 and PGHS-2, and the complex mechanisms for regulation of PGHS-2 gene expression...
  4. ncbi request reprint Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides
    Christine A Harman
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 282:28096-105. 2007
    ....
  5. ncbi request reprint Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid
    Christine A Harman
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 279:42929-35. 2004
    ....
  6. ncbi request reprint Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activation
    Jiayan Liu
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 282:18233-44. 2007
    ..However, no cross-talk between the POX and COX sites of monomers was detected in a PGHS-2 heterodimer comprised of a Q203R monomer having an inactive POX site and a G533A monomer with an inactive COX site...
  7. ncbi request reprint PGG2, 11R-HPETE and 15R/S-HPETE are formed from different conformers of arachidonic acid in the prostaglandin endoperoxide H synthase-1 cyclooxygenase site
    Elizabeth D Thuresson
    Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
    Adv Exp Med Biol 507:67-72. 2002
  8. ncbi request reprint Cyclooxygenase-2 gene transcription in a macrophage model of inflammation
    Yeon Joo Kang
    Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA
    J Immunol 177:8111-22. 2006
    ....
  9. ncbi request reprint Different suicide inactivation processes for the peroxidase and cyclooxygenase activities of prostaglandin endoperoxide H synthase-1
    I Song
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochem Biophys Res Commun 289:869-75. 2001
    ..However, another species, probably an Intermediate II-like species but with a radical centered on a tyrosine other than Tyr385, is the immediate precursor for POX inactivation...
  10. ncbi request reprint A procedure for preparing oxazolines of highly unsaturated fatty acids to determine double bond positions by mass spectrometry
    Dmitry V Kuklev
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 44:1060-6. 2003
    ..The utility of the method is illustrated with several fatty acids, including the conjugated 4E,6E,8E,10E,13Z,16Z,19Z-docosaheptaenoic acid...
  11. ncbi request reprint The enzymology of prostaglandin endoperoxide H synthases-1 and -2
    William L Smith
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing 48824, USA
    Prostaglandins Other Lipid Mediat 68:115-28. 2002
    ..Recently, it has become possible to distinguish kinetically between the cyclooxygenase and peroxidase suicide inactivation reactions...
  12. ncbi request reprint Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid
    E D Thuresson
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 276:10347-57. 2001
    ....
  13. ncbi request reprint Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy
    A G Spencer
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 273:9886-93. 1998
    ....
  14. ncbi request reprint Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products
    E D Thuresson
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 275:8501-7. 2000
    ..These latter results are most simply rationalized by a kinetic model in which arachidonate forms various catalytically competent arrangements only after entering the cyclooxygenase active site...
  15. ncbi request reprint Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases
    E D Thuresson
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 276:10358-65. 2001
    ..Ser-530 also influences the substrate specificity of PGHS-1; an S530T substitution causes 40- and 750-fold decreases in oxygenation efficiencies for AA and DHLA, respectively...
  16. ncbi request reprint N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum
    J C Otto
    Department of Biochemistry, Michigan State University, East Lansing 48824
    J Biol Chem 268:18234-42. 1993
    ..A similar orientation is predicted for PGH synthase-2...
  17. ncbi request reprint Cyclooxygenases, peroxide tone and the allure of fish oil
    William L Smith
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Curr Opin Cell Biol 17:174-82. 2005
    ....
  18. ncbi request reprint High-field EPR study of tyrosyl radicals in prostaglandin H(2) synthase-1
    Pierre Dorlet
    Section de Bioenergetique, CNRS URA 2096, CEA Saclay, Bat 532, 91191 Gif sur Yvette Cedex, France
    Biochemistry 41:6107-14. 2002
    ..The 130 GHz pulsed EPR experiments performed on the wide-doublet species indicated that the possible interaction between the radical and the oxoferryl heme species was very weak...
  19. ncbi request reprint Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases
    Steve A Seibold
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 278:46163-70. 2003
    ..Being less bulky than AA, linoleic acid is apparently unable to reopen this constriction...
  20. ncbi request reprint Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia
    Henry J Lin
    Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
    Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002
    ..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin...
  21. ncbi request reprint Synthesis of long chain n-3 and n-6 fatty acids having a photoactive conjugated tetraene group
    Dmitry V Kuklev
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA
    Chem Phys Lipids 130:145-58. 2004
    ....
  22. ncbi request reprint Nutritionally essential fatty acids and biologically indispensable cyclooxygenases
    William L Smith
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Biochem Sci 33:27-37. 2008
    ....
  23. ncbi request reprint Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products
    Masayuki Wada
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:22254-66. 2007
    ....
  24. pmc Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation
    Yeon Joo Kang
    Department of Biological Chemistry, University of Michigan Medical School, 5301 Medical Science Research Building III, Ann Arbor, MI 48109, USA
    Prog Lipid Res 46:108-25. 2007
    ....
  25. pmc Chemical C2-elongation of polyunsaturated fatty acids
    Dmitry V Kuklev
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Chem Phys Lipids 144:172-7. 2006
    ..The elongated fatty acids were free of byproducts that could result from Z-E isomerization or migration of double bonds...
  26. pmc Partnering between monomers of cyclooxygenase-2 homodimers
    Chong Yuan
    Department of Biological Chemistry, University of Michigan Medical School, 5416 Medical Science Building I, 1301 East Catherine Street, Ann Arbor, MI 48109 0606, USA
    Proc Natl Acad Sci U S A 103:6142-7. 2006
    ..The nonfunctioning subunit may provide structural support enabling its partner monomer to catalyze the COX reaction. This subunit complementarity may prove to be characteristic of other dimeric enzymes having tightly associated monomers...
  27. ncbi request reprint An intronic enhancer regulates cyclooxygenase-1 gene expression
    Cynthia J DeLong
    Department of Biological Chemistry, University of Michigan Medical School, 5416 Medical Science I, 1301 Catherine St, Ann Arbor, MI 48109 0606, USA
    Biochem Biophys Res Commun 338:53-61. 2005
    ..Our results suggest that inducible PGHS-1 gene expression involves the coordinate functioning of a Sp1 site in the promoter and an AP-1 site in intron 8...
  28. doi request reprint Two distinct pathways for cyclooxygenase-2 protein degradation
    Uri R Mbonye
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    J Biol Chem 283:8611-23. 2008
    ..The pathway involving the 27-IM occurs at a constant rate, whereas degradation through the substrate-dependent process is coupled to the rate of substrate turnover...