Research Topics
Species | William L SmithSummaryAffiliation: Michigan State University Country: USA Publications
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Publications
Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor geneT Arakawa
Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 271:29569-75. 1996..7 cells indicated that there is a constitutive negative regulatory region between -992 and -928 bp, a constitutive positive region between -928 and -554 bp, and an LPS/serum-responsive region between -554 and -116 bp...- Sphingolipid metabolism and signaling minireview seriesWilliam L Smith
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 277:25841-2. 2002 - Cyclooxygenases: structural, cellular, and molecular biologyW L Smith
Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
Annu Rev Biochem 69:145-82. 2000..We further examine the evidence for independent signaling by PGHS-1 and PGHS-2, and the complex mechanisms for regulation of PGHS-2 gene expression... - Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamidesChristine A Harman
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 282:28096-105. 2007.... - Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acidChristine A Harman
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 279:42929-35. 2004.... - Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activationJiayan Liu
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 282:18233-44. 2007..However, no cross-talk between the POX and COX sites of monomers was detected in a PGHS-2 heterodimer comprised of a Q203R monomer having an inactive POX site and a G533A monomer with an inactive COX site... - PGG2, 11R-HPETE and 15R/S-HPETE are formed from different conformers of arachidonic acid in the prostaglandin endoperoxide H synthase-1 cyclooxygenase siteElizabeth D Thuresson
Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA
Adv Exp Med Biol 507:67-72. 2002 - Cyclooxygenase-2 gene transcription in a macrophage model of inflammationYeon Joo Kang
Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA
J Immunol 177:8111-22. 2006.... - Different suicide inactivation processes for the peroxidase and cyclooxygenase activities of prostaglandin endoperoxide H synthase-1I Song
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
Biochem Biophys Res Commun 289:869-75. 2001..However, another species, probably an Intermediate II-like species but with a radical centered on a tyrosine other than Tyr385, is the immediate precursor for POX inactivation... - A procedure for preparing oxazolines of highly unsaturated fatty acids to determine double bond positions by mass spectrometryDmitry V Kuklev
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
J Lipid Res 44:1060-6. 2003..The utility of the method is illustrated with several fatty acids, including the conjugated 4E,6E,8E,10E,13Z,16Z,19Z-docosaheptaenoic acid... - The enzymology of prostaglandin endoperoxide H synthases-1 and -2William L Smith
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing 48824, USA
Prostaglandins Other Lipid Mediat 68:115-28. 2002..Recently, it has become possible to distinguish kinetically between the cyclooxygenase and peroxidase suicide inactivation reactions... - Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acidE D Thuresson
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 276:10347-57. 2001.... - Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopyA G Spencer
Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 273:9886-93. 1998.... - Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated productsE D Thuresson
Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 275:8501-7. 2000..These latter results are most simply rationalized by a kinetic model in which arachidonate forms various catalytically competent arrangements only after entering the cyclooxygenase active site... - Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthasesE D Thuresson
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 276:10358-65. 2001..Ser-530 also influences the substrate specificity of PGHS-1; an S530T substitution causes 40- and 750-fold decreases in oxygenation efficiencies for AA and DHLA, respectively... - N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulumJ C Otto
Department of Biochemistry, Michigan State University, East Lansing 48824
J Biol Chem 268:18234-42. 1993..A similar orientation is predicted for PGH synthase-2... - Cyclooxygenases, peroxide tone and the allure of fish oilWilliam L Smith
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Curr Opin Cell Biol 17:174-82. 2005.... - High-field EPR study of tyrosyl radicals in prostaglandin H(2) synthase-1Pierre Dorlet
Section de Bioenergetique, CNRS URA 2096, CEA Saclay, Bat 532, 91191 Gif sur Yvette Cedex, France
Biochemistry 41:6107-14. 2002..The 130 GHz pulsed EPR experiments performed on the wide-doublet species indicated that the possible interaction between the radical and the oxoferryl heme species was very weak... - Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthasesSteve A Seibold
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606, USA
J Biol Chem 278:46163-70. 2003..Being less bulky than AA, linoleic acid is apparently unable to reopen this constriction... - Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasiaHenry J Lin
Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin... - Synthesis of long chain n-3 and n-6 fatty acids having a photoactive conjugated tetraene groupDmitry V Kuklev
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA
Chem Phys Lipids 130:145-58. 2004.... - Nutritionally essential fatty acids and biologically indispensable cyclooxygenasesWilliam L Smith
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Trends Biochem Sci 33:27-37. 2008.... - Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and productsMasayuki Wada
Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 282:22254-66. 2007.... 
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradationYeon Joo Kang
Department of Biological Chemistry, University of Michigan Medical School, 5301 Medical Science Research Building III, Ann Arbor, MI 48109, USA
Prog Lipid Res 46:108-25. 2007....- Chemical C2-elongation of polyunsaturated fatty acidsDmitry V Kuklev
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Chem Phys Lipids 144:172-7. 2006..The elongated fatty acids were free of byproducts that could result from Z-E isomerization or migration of double bonds... - Partnering between monomers of cyclooxygenase-2 homodimersChong Yuan
Department of Biological Chemistry, University of Michigan Medical School, 5416 Medical Science Building I, 1301 East Catherine Street, Ann Arbor, MI 48109 0606, USA
Proc Natl Acad Sci U S A 103:6142-7. 2006..The nonfunctioning subunit may provide structural support enabling its partner monomer to catalyze the COX reaction. This subunit complementarity may prove to be characteristic of other dimeric enzymes having tightly associated monomers... - An intronic enhancer regulates cyclooxygenase-1 gene expressionCynthia J DeLong
Department of Biological Chemistry, University of Michigan Medical School, 5416 Medical Science I, 1301 Catherine St, Ann Arbor, MI 48109 0606, USA
Biochem Biophys Res Commun 338:53-61. 2005..Our results suggest that inducible PGHS-1 gene expression involves the coordinate functioning of a Sp1 site in the promoter and an AP-1 site in intron 8... 
Two distinct pathways for cyclooxygenase-2 protein degradationUri R Mbonye
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
J Biol Chem 283:8611-23. 2008..The pathway involving the 27-IM occurs at a constant rate, whereas degradation through the substrate-dependent process is coupled to the rate of substrate turnover...