Denise A Mills

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Membrane potential-controlled inhibition of cytochrome c oxidase by zinc
    Denise A Mills
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824 1319, USA
    J Biol Chem 277:14894-901. 2002
  2. ncbi request reprint Influence of structure, pH and membrane potential on proton movement in cytochrome oxidase
    Denise A Mills
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing 48824, USA
    Biochim Biophys Acta 1555:96-100. 2002
  3. ncbi request reprint Understanding the mechanism of proton movement linked to oxygen reduction in cytochrome c oxidase: lessons from other proteins
    Denise A Mills
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, MI 48824, USA
    FEBS Lett 545:47-51. 2003
  4. pmc An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase
    Denise A Mills
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 44:10457-65. 2005
  5. pmc Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 47:11499-509. 2008
  6. pmc Redox-dependent conformational changes in cytochrome C oxidase suggest a gating mechanism for proton uptake
    Ling Qin
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 48:5121-30. 2009
  7. ncbi request reprint Slow proton transfer through the pathways for pumped protons in cytochrome c oxidase induces suicide inactivation of the enzyme
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48109, USA
    Biochemistry 44:4656-66. 2005
  8. ncbi request reprint Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant
    Steve A Seibold
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 44:10475-85. 2005
  9. pmc A conserved steroid binding site in cytochrome C oxidase
    Ling Qin
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 47:9931-3. 2008
  10. pmc Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidase
    Ling Qin
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 46:6239-48. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Membrane potential-controlled inhibition of cytochrome c oxidase by zinc
    Denise A Mills
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824 1319, USA
    J Biol Chem 277:14894-901. 2002
    ..The physiological and mechanistic significance of proton movement in the exit pathway and its blockage by zinc is discussed in terms of regulation of the efficiency of energy transduction...
  2. ncbi request reprint Influence of structure, pH and membrane potential on proton movement in cytochrome oxidase
    Denise A Mills
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing 48824, USA
    Biochim Biophys Acta 1555:96-100. 2002
    ..The importance of the protein structure above the hemes in proton exit, back leak and respiratory control is discussed...
  3. ncbi request reprint Understanding the mechanism of proton movement linked to oxygen reduction in cytochrome c oxidase: lessons from other proteins
    Denise A Mills
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, MI 48824, USA
    FEBS Lett 545:47-51. 2003
    ..Evidence for the applicability of these concepts to cytochrome c oxidase is discussed...
  4. pmc An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase
    Denise A Mills
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 44:10457-65. 2005
    ..The results are consistent with an important role of R481 and heme a/a(3) propionates in proton movement in a reversible exit path...
  5. pmc Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 47:11499-509. 2008
    ..We further demonstrate that the heme a redox potential can be dramatically altered by a nearby carboxyl, whose protonation leads to a proton-coupled electron transfer process...
  6. pmc Redox-dependent conformational changes in cytochrome C oxidase suggest a gating mechanism for proton uptake
    Ling Qin
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 48:5121-30. 2009
    ....
  7. ncbi request reprint Slow proton transfer through the pathways for pumped protons in cytochrome c oxidase induces suicide inactivation of the enzyme
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48109, USA
    Biochemistry 44:4656-66. 2005
    ..The experiments suggest that increased lifetimes of the heme a(3) oxoferryl intermediates as well as the anionic form of Glu286 of the D pathway cause suicide inactivation in the active site...
  8. ncbi request reprint Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant
    Steve A Seibold
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 44:10475-85. 2005
    ..The results suggest a possible gating mechanism for proton movement that includes key residues W172 and Y175 on the loop and F282 on helix VI...
  9. pmc A conserved steroid binding site in cytochrome C oxidase
    Ling Qin
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 47:9931-3. 2008
    ....
  10. pmc Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidase
    Ling Qin
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 46:6239-48. 2007
    ....
  11. ncbi request reprint A role for subunit III in proton uptake into the D pathway and a possible proton exit pathway in Rhodobacter sphaeroides cytochrome c oxidase
    Denise A Mills
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 42:7410-7. 2003
    ..Thus, subunit III appears to affect the transfer of protons from both the inner and outer surfaces of cytochrome oxidase, perhaps accounting for the long-observed lower efficiency of proton pumping by the subunit III-depleted oxidase...
  12. ncbi request reprint Role of the conserved arginine pair in proton and electron transfer in cytochrome C oxidase
    Jie Qian
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824 1319, USA
    Biochemistry 43:5748-56. 2004
    ..In neither case is the approximately 2000-fold change in the rate accounted for by the altered redox potentials, suggesting that both cause a major modification in the path or reorganization energy of electron transfer...
  13. ncbi request reprint The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase
    Gisela Brändén
    Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochemistry 44:10466-74. 2005
    ..The results indicate that the protonation state of the Arg481 heme a(3) D-ring propionate cluster having a pK(a) of approximately 6.3 modulates the rate of internal electron transfer and may act as an acceptor of pumped protons...
  14. pmc Energy transduction: proton transfer through the respiratory complexes
    Jonathan P Hosler
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Annu Rev Biochem 75:165-87. 2006
    ..There is evidence for an important role of subunit III and proton backflow, but the number and nature of gating mechanisms remain elusive, as does the mechanism of physiological control of efficiency...
  15. ncbi request reprint Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases
    Steve A Seibold
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 278:46163-70. 2003
    ..Being less bulky than AA, linoleic acid is apparently unable to reopen this constriction...