John L McCracken

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi ESEEM studies of peptide nitrogen hyperfine coupling in tyrosyl radicals and model peptides
    John McCracken
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Phys Chem B 111:6586-92. 2007
  2. ncbi Probing the iron-substrate orientation for taurine/alpha-ketoglutarate dioxygenase using deuterium electron spin echo envelope modulation spectroscopy
    Rajendra Bose Muthukumaran
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 46:5951-9. 2007
  3. ncbi O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase
    Matthew J Ryle
    Department of Microbiology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 42:1854-62. 2003
  4. ncbi The use of stable isotopes and spectroscopy to investigate the energy transducing function of cytochrome c oxidase
    Bryan Schmidt
    Department of Chemistry, Michigan State University, East Lansing MI 48824, USA
    Biochim Biophys Acta 1655:248-55. 2004
  5. ncbi Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 47:11499-509. 2008
  6. ncbi EPR evidence of cyanide binding to the Mn(Mg) center of cytochrome c oxidase: support for Cu(A)-Mg involvement in proton pumping
    Martyn A Sharpe
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1319, USA
    Biochemistry 48:328-35. 2009
  7. ncbi Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes
    Zahra MirAfzali
    Encapsula NanoSciences, Nashville, Tennessee 37203, USA
    J Biol Chem 281:28354-64. 2006

Research Grants

  1. EPR STUDIES OF RADICALS IN BIOLOGICAL CATALYSIS
    John McCracken; Fiscal Year: 2002
  2. FREE RADICALS IN BIOLOGICAL REDOX PROCESSES
    John McCracken; Fiscal Year: 2002
  3. 94 GHZ/9 GHZ CONTINUOUS WAVE AND PULSED EPR SPECTROMETER
    John McCracken; Fiscal Year: 2001
  4. ADVANCED EPR STUDIES OF RADICALS IN BIOLOGICAL CATALYSIS
    John McCracken; Fiscal Year: 2006

Collaborators

  • BRIDGETTE BARRY
  • Martyn A Sharpe
  • Shelagh Ferguson-Miller
  • Rajendra Bose Muthukumaran
  • Shujuan Xu
  • Denise A Mills
  • Zahra MirAfzali
  • Robert P Hausinger
  • Bryan Schmidt
  • Matthew J Ryle
  • Matthew D Krzyaniak
  • Bill Durham
  • Carrie Hiser
  • Francis Millett
  • Lois Geren
  • Ling Qin
  • Piotr K Grzyska
  • Jeffrey R Leipprandt
  • David L DeWitt
  • Warwick Hillier
  • Aimin Liu
  • Raymond Y N Ho
  • Kevin D Koehntop
  • Lawrence Que

Detail Information

Publications7

  1. ncbi ESEEM studies of peptide nitrogen hyperfine coupling in tyrosyl radicals and model peptides
    John McCracken
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Phys Chem B 111:6586-92. 2007
    ..These results suggest sequence- or conformation-induced changes in the ionic character of the NH bond in different tyrosine-containing peptides...
  2. ncbi Probing the iron-substrate orientation for taurine/alpha-ketoglutarate dioxygenase using deuterium electron spin echo envelope modulation spectroscopy
    Rajendra Bose Muthukumaran
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 46:5951-9. 2007
    ..These results are discussed in terms of previous X-ray crystallographic studies and the proposed catalytic mechanism for this family of enzymes...
  3. ncbi O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase
    Matthew J Ryle
    Department of Microbiology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 42:1854-62. 2003
    ....
  4. ncbi The use of stable isotopes and spectroscopy to investigate the energy transducing function of cytochrome c oxidase
    Bryan Schmidt
    Department of Chemistry, Michigan State University, East Lansing MI 48824, USA
    Biochim Biophys Acta 1655:248-55. 2004
    ....
  5. ncbi Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase
    Denise A Mills
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 47:11499-509. 2008
    ..We further demonstrate that the heme a redox potential can be dramatically altered by a nearby carboxyl, whose protonation leads to a proton-coupled electron transfer process...
  6. ncbi EPR evidence of cyanide binding to the Mn(Mg) center of cytochrome c oxidase: support for Cu(A)-Mg involvement in proton pumping
    Martyn A Sharpe
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1319, USA
    Biochemistry 48:328-35. 2009
    ..This new observation of anion binding at the Mg/Mn site is of interest in terms of accessibility of the buried site and its potential role in redox-dependent proton pumping...
  7. ncbi Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes
    Zahra MirAfzali
    Encapsula NanoSciences, Nashville, Tennessee 37203, USA
    J Biol Chem 281:28354-64. 2006
    ....

Research Grants15

  1. EPR STUDIES OF RADICALS IN BIOLOGICAL CATALYSIS
    John McCracken; Fiscal Year: 2002
    ..Such information will be correlated with the results of kinetic and other structural measurements. In particular the results will be related to electron transferring oxidation/reduction processes. ..
  2. FREE RADICALS IN BIOLOGICAL REDOX PROCESSES
    John McCracken; Fiscal Year: 2002
    ....
  3. 94 GHZ/9 GHZ CONTINUOUS WAVE AND PULSED EPR SPECTROMETER
    John McCracken; Fiscal Year: 2001
    ..Purchase of an E-680 spectrometer will shift our development efforts away from hardware building and towards solving biomedical problems. ..
  4. ADVANCED EPR STUDIES OF RADICALS IN BIOLOGICAL CATALYSIS
    John McCracken; Fiscal Year: 2006
    ..The Fet3p enzyme is a multicopper oxidase that shows ferroxidase activity and thus, shares a common reactivity with ceruloplasrnin, a mammalian rnulticopper ferroxidase that is vital to metal ion homeostasis. ..