Michael Kron

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease?
    Michael A Kron
    Institute of International Health, Colleges of Osteopathic and Human Medicine, B 301 West Fee Hall, Michigan State University, East Lansing, MI 48824, USA
    Med Hypotheses 65:1124-7. 2005
  2. ncbi request reprint Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi
    Michael Kron
    Department of Medicine, Michigan State University, B323 Life Science Building, East Lansing, MI 48824, USA
    Mol Biochem Parasitol 129:33-9. 2003
  3. ncbi request reprint Synthesis and activity of substituted anthraquinones against a human filarial parasite, Brugia malayi
    Mugunthu R Dhananjeyan
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, East Lansing, Michigan 48824, USA
    J Med Chem 48:2822-30. 2005
  4. ncbi request reprint Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change
    Sai Chetan K Sukuru
    Department of Biochemistry and Molecular Biology, Michigan State University, 502C Biochemistry Building, East Lansing, MI 48824, USA
    J Comput Aided Mol Des 20:159-78. 2006
  5. pmc Using structural analysis to generate parasite-selective monoclonal antibodies
    Michael A Kron
    Department of Medicine, Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Protein Sci 17:983-9. 2008

Collaborators

  • S Cusack
  • Sai Chetan K Sukuru
  • Mugunthu R Dhananjeyan
  • Youli Milev
  • Regan J Anderson
  • Thibaut Crepin
  • Jonathan B Hill
  • Gavin O'Mahony
  • Liesl C Marsh
  • Michael Hartlein
  • Franck Danel
  • Morten Gr√łtli
  • Leslie A Kuhn
  • Malcolm G P Page
  • Jonathan C Morris
  • Anjali Rohatgi
  • Muraleedharan G Nair
  • Youli P Milev

Detail Information

Publications5

  1. ncbi request reprint Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease?
    Michael A Kron
    Institute of International Health, Colleges of Osteopathic and Human Medicine, B 301 West Fee Hall, Michigan State University, East Lansing, MI 48824, USA
    Med Hypotheses 65:1124-7. 2005
    ..Thus, the local abundance of an endogenous pro-inflammatory autoantigen may provide one explanation for perpetuation or exacerbation of tissue specific immune-mediated pathologies...
  2. ncbi request reprint Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi
    Michael Kron
    Department of Medicine, Michigan State University, B323 Life Science Building, East Lansing, MI 48824, USA
    Mol Biochem Parasitol 129:33-9. 2003
    ..These data support the hypothesis that all AARS are not equally expressed in B. malayi and that these enzymes may demonstrate important alternative functions in filaria...
  3. ncbi request reprint Synthesis and activity of substituted anthraquinones against a human filarial parasite, Brugia malayi
    Mugunthu R Dhananjeyan
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, East Lansing, Michigan 48824, USA
    J Med Chem 48:2822-30. 2005
    ..Methylated products of anthraquinones did not affect the microfilaria. Histological examination of treated adult female parasites showed most of the anthraquinones caused marked effects on intrauterine embryos...
  4. ncbi request reprint Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change
    Sai Chetan K Sukuru
    Department of Biochemistry and Molecular Biology, Michigan State University, 502C Biochemistry Building, East Lansing, MI 48824, USA
    J Comput Aided Mol Des 20:159-78. 2006
    ..Combining ROCK and SLIDE provides a promising approach for exploiting conformational flexibility in structure-based screening and design of species selective inhibitors...
  5. pmc Using structural analysis to generate parasite-selective monoclonal antibodies
    Michael A Kron
    Department of Medicine, Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Protein Sci 17:983-9. 2008
    ..These results support the success of structural modeling to choose peptides for raising selective antibodies that bind to the native protein...