Jay I Goodman

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. pmc Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 108:273-89. 2009
  2. ncbi request reprint Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 96:72-82. 2007
  3. pmc The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 110:319-33. 2009
  4. ncbi request reprint Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice
    Ammie N Bachman
    Department of Pharmacology and Toxicology and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 91:393-405. 2006
  5. ncbi request reprint Altered methylation in gene-specific and GC-rich regions of DNA is progressive and nonrandom during promotion of skin tumorigenesis
    Ammie N Bachman
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 91:406-18. 2006
  6. ncbi request reprint Progressive alterations in global and GC-rich DNA methylation during tumorigenesis
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 75:289-99. 2003
  7. doi request reprint Inhalation of cigarette smoke induces regions of altered DNA methylation (RAMs) in SENCAR mouse lung
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    Toxicology 260:7-15. 2009
  8. doi request reprint Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 104:86-99. 2008
  9. pmc Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 109:193-205. 2009
  10. ncbi request reprint Increased DNA methylation in the HoxA5 promoter region correlates with decreased expression of the gene during tumor promotion
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Carcinog 41:54-66. 2004

Collaborators

Detail Information

Publications18

  1. pmc Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 108:273-89. 2009
    ....
  2. ncbi request reprint Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 96:72-82. 2007
    ..We hypothesize that these unique RAMs may be facilitating the tumorigenesis process, and these data support the view that DNA methylation plays a causative role in PB-induced tumorigenesis...
  3. pmc The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 110:319-33. 2009
    ..e., changes in gene expression and DNA methylation) that can facilitate hepatocarcinogenesis. Notably, candidate genes for initial "fingerprints" of early and late stages of PB-induced tumorigenesis are proposed...
  4. ncbi request reprint Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice
    Ammie N Bachman
    Department of Pharmacology and Toxicology and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 91:393-405. 2006
    ....
  5. ncbi request reprint Altered methylation in gene-specific and GC-rich regions of DNA is progressive and nonrandom during promotion of skin tumorigenesis
    Ammie N Bachman
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 91:406-18. 2006
    ....
  6. ncbi request reprint Progressive alterations in global and GC-rich DNA methylation during tumorigenesis
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 75:289-99. 2003
    ..Progressive alterations in global and GC-rich methylation appear to be mechanistically important during tumor promotion...
  7. doi request reprint Inhalation of cigarette smoke induces regions of altered DNA methylation (RAMs) in SENCAR mouse lung
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    Toxicology 260:7-15. 2009
    ..Thus, altered methylation might serve as a biomarker of CS exposure, and, in light of the fact that methylation changes are linked to CS-induced lung tumorigenesis, might also be useful as biomarkers of effect...
  8. doi request reprint Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 104:86-99. 2008
    ..We hypothesize that at least some of the unique PB-induced B6C3F1 RAMs represent key events facilitating transformation, which is consistent with a causative role of altered DNA methylation during early stages of tumorigenesis...
  9. pmc Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice
    Jennifer M Phillips
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 109:193-205. 2009
    ..It is instructive to consider the possibility that, in a hypothesis-driven fashion, these genes are initial candidates that could be utilized to develop a biomarker "fingerprint" of early exposure to PB and PB-like compounds...
  10. ncbi request reprint Increased DNA methylation in the HoxA5 promoter region correlates with decreased expression of the gene during tumor promotion
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Carcinog 41:54-66. 2004
    ..These data suggest that increased DNA methylation contributes to the downregulation of HoxA5, and combined with hypermethylation of p16 or MGMT, this might facilitate the clonal expansion of increasingly aberrant cells during promotion...
  11. pmc Changes in DNA methylation and gene expression during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced suppression of the lipopolysaccharide-stimulated IgM response in splenocytes
    Emily A McClure
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 120:339-48. 2011
    ..Thus, we have identified cross talk between LPS and TCDD at the level of DNA methylation and gene expression...
  12. ncbi request reprint Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency
    Ammie N Bachman
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 90:317-25. 2006
    ..Altered patterns of methylation in GC-rich regions induced by DEA and PB resemble that of CD and indicate that altered DNA methylation is an epigenetic mechanism involved in the facilitation of mouse liver tumorigenesis...
  13. ncbi request reprint The value of DNA methylation analysis in basic, initial toxicity assessments
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 79:178-88. 2004
    ..Altered methylation per se is not proof of toxicity; this needs to be viewed as a component of an evaluation...
  14. ncbi request reprint Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis
    Rebecca E Watson
    Department of Pharmacology and Toxicology, Michigan State University, B440 Life Sciences Building, East Lansing 48824, USA
    Toxicol Sci 68:51-8. 2002
    ..Therefore, this study supports our hypothesis that the capacity to maintain normal methylation patterns is related inversely to tumor susceptibility...
  15. ncbi request reprint Altered DNA methylation: a secondary mechanism involved in carcinogenesis
    Jay I Goodman
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Annu Rev Pharmacol Toxicol 42:501-25. 2002
    ..One key question is: does the mechanism of action of the chemical in question involve a secondary mechanism and, if so, what dose may be below its threshold?..
  16. ncbi request reprint What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?
    Jay I Goodman
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 116:375-81. 2010
    ....
  17. ncbi request reprint The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity
    Ammie N Carnell
    Department of Pharmacology and Toxicology, Michigan State University, B 440 Life Science Building, East Lansing, Michigan 48824, USA
    Toxicol Sci 75:229-35. 2003
    ....
  18. ncbi request reprint Epigenetics and DNA methylation come of age in toxicology
    Rebecca E Watson
    Department of Pharmacology and Toxicology, B 440 Life Science Building, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 67:11-6. 2002
    ....