James Galligan

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. pmc Deletion of P2X2 and P2X3 Receptor Subunits Does Not Alter Motility of the Mouse Colon
    Matthew P Devries
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
    Front Neurosci 4:22. 2010
  2. doi request reprint Visceral hypersensitivity in female but not in male serotonin transporter knockout rats
    J J Galligan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 25:e373-81. 2013
  3. doi request reprint Cannabinoid signalling in the enteric nervous system
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 21:899-902. 2009
  4. ncbi request reprint Increased substance P content in nerve fibers associated with mesenteric veins from deoxycorticosterone acetate (DOCA)-salt hypertensive rats
    James J Galligan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Regul Pept 133:97-104. 2006
  5. ncbi request reprint Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 15:523-9. 2003
  6. pmc Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome
    James J Galligan
    Department of Pharmacology and Toxicology, Neuroscience Program, Life Science B440, Michigan State University, East Lansing, MI 48824, U S A
    Br J Pharmacol 141:1294-302. 2004
  7. ncbi request reprint Basic and clinical pharmacology of new motility promoting agents
    J J Galligan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 17:643-53. 2005
  8. ncbi request reprint Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurogastroenterol Motil 16:64-70. 2004
  9. ncbi request reprint Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats
    Ronald J Johnson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 20:665-76. 2002
  10. ncbi request reprint Impaired function of alpha2-adrenergic autoreceptors on sympathetic nerves associated with mesenteric arteries and veins in DOCA-salt hypertension
    Min Luo
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Heart Circ Physiol 286:H1558-64. 2004

Research Grants

  1. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2000
  2. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2007
  3. Experimental approaches to understanding the ENS and its disorders
    James Galligan; Fiscal Year: 2006
  4. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2006
  5. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2005
  6. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2004
  7. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2003
  8. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2002
  9. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2001

Collaborators

Detail Information

Publications55

  1. pmc Deletion of P2X2 and P2X3 Receptor Subunits Does Not Alter Motility of the Mouse Colon
    Matthew P Devries
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
    Front Neurosci 4:22. 2010
    ..Synaptic transmission mediated by P2X2 or P2X3 subunit containing receptors is not required for propulsive motility in the mouse colon...
  2. doi request reprint Visceral hypersensitivity in female but not in male serotonin transporter knockout rats
    J J Galligan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 25:e373-81. 2013
    ..Serotonin signaling, including reduced serotonin transporter (SERT) expression, may be disrupted in IBS patients. We studied SERT gene knockout (KO) rats to determine if they exhibited sex-related alterations in visceral sensitivity...
  3. doi request reprint Cannabinoid signalling in the enteric nervous system
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 21:899-902. 2009
    ..It is necessary that future work extends these interesting findings to intact tissues and ideally to the in vivo setting...
  4. ncbi request reprint Increased substance P content in nerve fibers associated with mesenteric veins from deoxycorticosterone acetate (DOCA)-salt hypertensive rats
    James J Galligan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Regul Pept 133:97-104. 2006
    ..NK-3 receptors mediate venoconstriction which is unchanged in DOCA-salt hypertension. Increased release of SP from perivenous nerves might contribute to the increased venomotor tone in DOCA-salt hypertension...
  5. ncbi request reprint Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 15:523-9. 2003
    ..Protein kinase A activation leads to an increase in transmitter release from myenteric nerve terminals and a facilitation of fast excitatory synaptic transmission...
  6. pmc Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome
    James J Galligan
    Department of Pharmacology and Toxicology, Neuroscience Program, Life Science B440, Michigan State University, East Lansing, MI 48824, U S A
    Br J Pharmacol 141:1294-302. 2004
    ..Data on the distribution and function of P2X receptors on gastrointestinal immune cells would also provide insights into the therapeutic potential of P2X receptor agents in IBS...
  7. ncbi request reprint Basic and clinical pharmacology of new motility promoting agents
    J J Galligan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neurogastroenterol Motil 17:643-53. 2005
    ..Selection of appropriate patient populations for evaluation of new drugs is also critical...
  8. ncbi request reprint Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system
    J J Galligan
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurogastroenterol Motil 16:64-70. 2004
    ..P2X receptors mediating fast synaptic excitation are predominately P2X2 homomeric receptors...
  9. ncbi request reprint Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats
    Ronald J Johnson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 20:665-76. 2002
    ..To identify the receptors by which endothelin-1 (ET-1) increases venomotor tone in hypertension...
  10. ncbi request reprint Impaired function of alpha2-adrenergic autoreceptors on sympathetic nerves associated with mesenteric arteries and veins in DOCA-salt hypertension
    Min Luo
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Heart Circ Physiol 286:H1558-64. 2004
    ..In addition, impairment of alpha(2)-adrenergic autoreceptor function in sympathetic nerves associated with arteries and veins from DOCA-salt rats results in increased NE release...
  11. ncbi request reprint Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats
    Xiaoling Dai
    Department of Physiology, Michigan State University, East Lansing, MI 48823, USA
    Hypertension 43:1048-54. 2004
    ....
  12. pmc Cross-inhibition between nicotinic acetylcholine receptors and P2X receptors in myenteric neurons and HEK-293 cells
    Dima A Decker
    Dept of Biochemistry, Michigan State Univ, East Lansing, MI 48824, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1267-76. 2009
    ..In addition, active and desensitized conformations of the P2X receptor inhibit nAChR function. These molecular interactions may modulate the function of synapses that use ATP and ACh as fast synaptic transmitters in the ENS...
  13. ncbi request reprint NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension
    Lixin Li
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824 1317, USA
    Hypertension 42:316-21. 2003
    ..These results suggest that superoxide contributes to ET-1-induced venoconstriction through an elevated venous NADPH oxidase activity in mineralocorticoid hypertension...
  14. ncbi request reprint Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous function
    Keshari M Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Cardiovasc Pharmacol 47:742-50. 2006
    ..These data suggest that while NO deficiency increases oxidative stress and sympathetic activity in both arterial and venous vessels, the impact on veins does not make a major contribution to this form of hypertension...
  15. pmc Differential contributions of alpha-1 and alpha-2 adrenoceptors to vasoconstriction in mesenteric arteries and veins of normal and hypertensive mice
    ALEX A PEREZ-RIVERA
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Vascul Pharmacol 46:373-82. 2007
    ..This contribution of alpha(2)-ARs may account for the greater sensitivity of veins compared to arteries to the contractile effects of NE...
  16. ncbi request reprint Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension
    Lixin Li
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Circulation 107:1053-8. 2003
    ..However, the mechanisms underlying superoxide production in low-renin hypertension are undefined...
  17. pmc Alterations in sympathetic neuroeffector transmission to mesenteric arteries but not veins in DOCA-salt hypertension
    JinWoo Park
    Department of Chemistry, Michigan Sate University, East Lansing, MI 48824, USA
    Auton Neurosci 152:11-20. 2010
    ..alpha(2)-AR function is most prominent in MA and is impaired in DOCA-salt MA but not MV. Purinergic transmission predominates in sham MA. NE is the dominant vasoconstrictor in DOCA-salt MA and sham and DOCA-salt MV...
  18. ncbi request reprint Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive rats
    Hong Wang
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Heart Circ Physiol 288:H729-36. 2005
    ..These results argue against the hypothesis that increased venomotor tone in DOCA-salt hypertension is caused by increased ET-1 concentration around splanchnic venous smooth muscle cells...
  19. ncbi request reprint Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons
    Xiaoping Zhou
    Department of Pharmacology and Toxicology, Neuroscience Program, Life Science B400, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 302:889-97. 2002
    ..These subunits may be in a homogeneous population of receptors with unique pharmacological properties, or multiple receptors of different subunit composition may be expressed by individual neurons...
  20. pmc Differences in sympathetic neuroeffector transmission to rat mesenteric arteries and veins as probed by in vitro continuous amperometry and video imaging
    JinWoo Park
    Department of Chemistry and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    J Physiol 584:819-34. 2007
    ..We conclude that there are fundamental differences in sympathetic neuroeffector mechanisms in MA and MV, which are likely to contribute to their different haemodynamic functions...
  21. pmc P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine
    Jianhua Ren
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    J Physiol 552:809-21. 2003
    ..Gastrointestinal transit was similar in P2X2+/+ and P2X2-/- mice. It is concluded that P2X2 homomeric receptors contribute to fEPSPs in neural pathways underlying peristalsis studied in vitro...
  22. ncbi request reprint Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats
    Min Luo
    The Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Auton Neurosci 104:47-57. 2003
    ..In arteries, this results in an increase in the amplitude of neurogenic constrictions. In veins, increased norepinephrine release maintains neurogenic constrictions in the presence of increased NET levels...
  23. ncbi request reprint Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats
    Hui Xu
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Heart Circ Physiol 283:H885-92. 2002
    ..There is an additional interaction between NO and tempol that contributes to depressor responses in DOCA-salt rats...
  24. pmc Pharmacological endothelin receptor interaction does not occur in veins from ET(B) receptor deficient rats
    Keshari Thakali
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823, USA
    Vascul Pharmacol 49:6-13. 2008
    ..Our data suggest that pharmacological ET A and ET B receptor interaction may be dependent on the presence of functional ET B receptors and independent of receptor location...
  25. pmc P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons
    Hui Wang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1634-41. 2010
    ..We conclude that P2Y(2) receptor activation can maintain TRPV1 function perhaps during sustained episodes of activity of kidney projecting sensory neurons...
  26. ncbi request reprint Activation of ETB receptors increases superoxide levels in sympathetic ganglia in vivo
    Yanny E Lau
    Department of Pharmacology Toxicology, B327 Life Science, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Regul Integr Comp Physiol 290:R90-5. 2006
    ..We conclude that ET(B) receptor activation in vivo significantly enhances O2- levels in sympathetic ganglia, due to both pressor effects and direct stimulation of ET(B) receptors in ganglion cells...
  27. ncbi request reprint 5-HT4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons
    Jianhua Ren
    Neuroscience Program, Michigan State Univ, East Lansing, MI 48824, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1376-83. 2008
    ..These responses may contribute to the prokinetic actions of 5-HT(4) receptor agonists...
  28. ncbi request reprint Muscarinic receptors couple to modulation of nicotinic ACh receptor desensitization in myenteric neurons
    Erika N Brown
    Dept of Pharmacology and Toxicology, Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Gastrointest Liver Physiol 285:G37-44. 2003
    ..This effect may involve activation of a PKC-dependent pathway. These data also suggest that nAChRs and muscarinic receptors are coupled functionally through an intracellular signaling pathway in myenteric neurons...
  29. pmc Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit
    Xiaochun Bian
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    J Physiol 551:309-22. 2003
    ..P2X3 subunits are localized to AH (sensory) but not S neurons. P2X3 receptors may contribute to detection of distention or intraluminal pressure increases and initiation of reflex contractions...
  30. ncbi request reprint Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension
    Lixin Li
    Department of Pharmacology, Michigan State University, East Lansing 48824 1317, USA
    Arterioscler Thromb Vasc Biol 22:249-55. 2002
    ..These results suggest that gene transfer of MnSOD or eNOS suppresses arterial VCAM-1 expression in DOCA-salt hypertension by reducing the superoxide level...
  31. ncbi request reprint Increased reactivity of murine mesenteric veins to adrenergic agonists: functional evidence supporting increased alpha1-adrenoceptor reserve in veins compared with arteries
    ALEX A PEREZ-RIVERA
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Pharmacol Exp Ther 308:350-7. 2004
    ..These data suggest that mesenteric veins express more alpha1-adrenoceptors than arteries, accounting for greater reactivity and resistance to desensitization compared with arteries...
  32. pmc Impaired purinergic neurotransmission to mesenteric arteries in deoxycorticosterone acetate-salt hypertensive rats
    Stacie L Demel
    Neuroscience Program, B328 Life Science Building, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 52:322-9. 2008
    ..These data highlight the potential importance of impaired purinergic regulation of arterial tone as a target for drug treatment of hypertension...
  33. ncbi request reprint Pharmacology of synaptic transmission in the enteric nervous system
    James J Galligan
    Department of Pharmacology and Toxicology Life Science B440, Michigan State University, 48824, East Lansing, MI 48824, USA
    Curr Opin Pharmacol 2:623-9. 2002
    ....
  34. ncbi request reprint Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neurons
    Jianguo Tan
    Department of Entomology, Michigan State University, East Lansing, MI 48824, USA
    Neurotoxicology 28:829-42. 2007
    ....
  35. ncbi request reprint Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats
    Hui Xu
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, Mich 48824, USA
    Hypertension 43:329-34. 2004
    ..It is concluded that depressor responses and decreases in HR and RSNA caused by acute tempol treatment are caused by direct sympathetic nerve activity inhibition that is not accompanied by SOD-mimetic action in the aorta or vena cava...
  36. ncbi request reprint Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice
    ALEX A PEREZ-RIVERA
    Department of Pharmacology and Toxicology, Michigan State University, B 328 Life Sciences Building, East Lansing, MI 48824, USA
    Auton Neurosci 121:64-73. 2005
    ..Nerve-released NE acts primarily at alpha1B-and to a lesser extent at alpha1A-ARs in SHAM arteries whereas NE mediates neurogenic constrictions in DOCA-salt arteries by acting at alpha1B-ARs...
  37. ncbi request reprint Increased sympathetic venoconstriction and reactivity to norepinephrine in mesenteric veins in anesthetized DOCA-salt hypertensive rats
    Hui Xu
    Department of Pharmacology and Toxicology, Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Heart Circ Physiol 293:H160-8. 2007
    ..In DOCA-salt rats, in vivo ET-1 reactivity is maintained in MV, but reduced in MA...
  38. ncbi request reprint Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats
    Hui Xu
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 48:1080-7. 2006
    ..We conclude that upregulation of the BK channel alpha-subunit protein and tempol-induced increases in BK channel P(o) contribute to the enhanced depressor response caused by tempol in DOCA-salt hypertensive rats...
  39. ncbi request reprint Nicotinic acetylcholine and P2X receptors in the enteric nervous system
    James J Galligan
    Department of Pharmacology and Toxicology, Neuroscience Program, Life Science B440, Michigan State University, East Lansing, MI 48824, USA
    Proc West Pharmacol Soc 45:231-4. 2002
    ..Noncholinergic mechanisms of fast excitatory synaptic transmission may provide new targets for drugs that could be useful in the treatment of gastrointestinal motility disorders...
  40. pmc Endothelin-1-induced venous contraction is maintained in DOCA-salt hypertension; studies with receptor agonists
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 1317, USA
    Br J Pharmacol 137:69-79. 2002
    ..The ET(B) receptor was present in the aorta but, unlike in veins, does not mediate contraction directly. A sustained response to ET-1 in the venous circulation may contribute to the elevated blood pressure in the DOCA-salt model...
  41. ncbi request reprint Differential trafficking and desensitization of human ET(A) and ET(B) receptors expressed in HEK 293 cells
    Xiaoling Dai
    Department of Pharmacology and Toxicology and Neuroscience Program, Life Science Building Room B308, Michigan State University, East Lansing, MI 48824, USA
    Exp Biol Med (Maywood) 231:746-51. 2006
    ..Finally, ET(A) and ET(B) receptors interact to change receptor trafficking which may modify ET receptor function in vascular SMCs coexpressing these receptors...
  42. pmc Large-conductance Ca2+-activated K+ channel beta1-subunit knockout mice are not hypertensive
    Hui Xu
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
    Am J Physiol Heart Circ Physiol 300:H476-85. 2011
    ..BK and L-type Ca(2+) channels do not modulate murine venous tone. It appears that selective loss of BK channel function in arteries only is not sufficient to cause sustained hypertension...
  43. pmc Dynamics of fast synaptic excitation during trains of stimulation in myenteric neurons of guinea-pig ileum
    Jianhua Ren
    The Neuroscience Program and the Department of Pharmacology and Toxicology, Life Science B308, Michigan State University, East Lansing, MI 48824, United States
    Auton Neurosci 117:67-78. 2005
    ..Synaptic rundown is likely due to depletion of a readily releasable pool (RRP) of neurotransmitter...
  44. ncbi request reprint Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure
    ALEX A PEREZ-RIVERA
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, B 440 Life Sciences Building, East Lansing, MI 48824, USA
    Vascul Pharmacol 43:1-10. 2005
    ..There was a prominent role for ET-mediated nitric oxide release in DOCA-salt but not SHAM arteries. In summary, these studies showed a differential regulation of ET-1 contractile mechanisms between murine mesenteric arteries and veins...
  45. doi request reprint The effects of celiac ganglionectomy on sympathetic innervation to the splanchnic organs in the rat
    Melissa Li
    Department of Pharmacology and Toxicology, B440 Life Sciences, Michigan State University, East Lansing, MI 48824, USA
    Auton Neurosci 154:66-73. 2010
    ..Therefore, CGX is an effective means to impair sympathetic input to the splanchnic organs, but the effect of the procedure is not permanent...
  46. ncbi request reprint Vasopressin induces vascular superoxide via endothelin-1 in mineralocorticoid hypertension
    Lixin Li
    Department of Pharmacology and Toxicology, B403 Life Sciences Building, Michigan State University, East Lansing, MI 48824 1317, USA
    Hypertension 41:663-8. 2003
    ..These results suggest that vasopressin increases vascular superoxide levels by stimulating ET-1 formation in mineralocorticoid hypertension, and that V1-vasopressin receptors play an important role in this process...
  47. pmc Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons
    Wei Huang
    Department of Medicine and Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 26:1966-75. 2008
    ....
  48. pmc Localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers
    Xian Cao
    The Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Auton Neurosci 151:90-7. 2009
    ..The presence of a O(2)(-*)-generating enzyme in close vicinity to the sites of neurotransmitter handling in the nerve fibers suggests the possibility of novel redox-mediated mechanisms in peripheral neurovascular control...
  49. pmc High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression
    Xiaochun Bian
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Gastroenterology 132:2438-47. 2007
    ..Paracrine signaling by enterochromaffin cells (EC), which release 5-HT, has not been studied in neonates. Our aim was to compare 5-HT disposition in the intestinal mucosa of neonatal and adult guinea pigs...
  50. ncbi request reprint In vitro continuous amperometry with a diamond microelectrode coupled with video microscopy for simultaneously monitoring endogenous norepinephrine and its effect on the contractile response of a rat mesenteric artery
    JinWoo Park
    Department of Chemistry, Department of Pharmacology and Toxicology, and the Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    Anal Chem 78:6756-64. 2006
    ....
  51. ncbi request reprint R-type calcium channels in myenteric neurons of guinea pig small intestine
    Xiaochun Bian
    Department of Pharmacology and Toxicology, B 440 Life Science Bldg, Michigan State University, East Lansing, MI 48823, USA
    Am J Physiol Gastrointest Liver Physiol 287:G134-42. 2004
    ..The relatively positive half-activation voltage and rapid activation kinetics suggest that R-type channels could contribute to calcium entry during somal action potentials or during action potential-induced neurotransmitter release...
  52. ncbi request reprint In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum
    Bhavik Anil Patel
    Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK
    Analyst 132:41-7. 2007
    ..The 5-HT oxidation current increased in the presence of the serotonin transporter (SERT) inhibitor, fluoxetine (1 microM), providing evidence that the oxidation current was associated with 5-HT...
  53. ncbi request reprint Impaired vasodilation in response to perivascular nerve stimulation in mesenteric arteries of TRPV1-null mutant mice
    Li Hong Wang
    Department of Cardiovascular Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, China
    J Hypertens 24:2399-408. 2006
    ....
  54. ncbi request reprint 5-hydroxytryptamine, ulcerative colitis, and irritable bowel syndrome: molecular connections
    James J Galligan
    Gastroenterology 126:1897-9. 2004
  55. ncbi request reprint Recent advances in understanding the role of serotonin in gastrointestinal motility and functional bowel disorders
    James J Galligan
    Neurogastroenterol Motil 19:1-4. 2007

Research Grants11

  1. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2000
    ..It is anticipated that these studies will provide new insights into mechanisms of synaptic transmission in the gut which could lead to the development of new and effect drug treatments for motility disorders. ..
  2. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2007
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  3. Experimental approaches to understanding the ENS and its disorders
    James Galligan; Fiscal Year: 2006
    ..This will help the attendees develop a network of professional contacts who can help the young investigator in the career development process. ..
  4. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2006
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  5. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2005
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  6. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2004
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  7. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2003
    ..It is anticipated that these studies will provide new insights into mechanisms of synaptic transmission in the gut which could lead to the development of new and effect drug treatments for motility disorders. ..
  8. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2002
    ..It is anticipated that these studies will provide new insights into mechanisms of synaptic transmission in the gut which could lead to the development of new and effect drug treatments for motility disorders. ..
  9. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2001
    ..It is anticipated that these studies will provide new insights into mechanisms of synaptic transmission in the gut which could lead to the development of new and effect drug treatments for motility disorders. ..