S Breedlove

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. pmc Prenatal hormone exposure and risk for eating disorders: a comparison of opposite-sex and same-sex twins
    Kristen M Culbert
    Department of Psychology, Michigan State University, East Lansing, MI 48824 1116, USA
    Arch Gen Psychiatry 65:329-36. 2008
  2. pmc Minireview: Organizational hypothesis: instances of the fingerpost
    S Marc Breedlove
    Neuroscience Program and Department of Psychology, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Endocrinology 151:4116-22. 2010
  3. pmc Androgen receptors are required for full masculinization of the ventromedial hypothalamus (VMH) in rats
    Brittany N Dugger
    Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Horm Behav 51:195-201. 2007
  4. pmc Sexual dimorphism and steroid responsiveness of the posterodorsal medial amygdala in adult mice
    John A Morris
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Brain Res 1190:115-21. 2008
  5. ncbi request reprint Sexual dimorphism in neuronal number of the posterodorsal medial amygdala is independent of circulating androgens and regional volume in adult rats
    John A Morris
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    J Comp Neurol 506:851-9. 2008
  6. ncbi request reprint Evidence that androgen acts through NMDA receptors to affect motoneurons in the rat spinal nucleus of the bulbocavernosus
    Cynthia L Jordan
    Neuroscience Program and Psychology Department, Michigan State University, East Lansing, Michigan 48824, USA
    J Neurosci 22:9567-72. 2002
  7. doi request reprint Neonatal androgen-dependent sex differences in lumbar spinal cord dopamine concentrations and the number of A11 diencephalospinal dopamine neurons
    Samuel S Pappas
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Comp Neurol 518:2423-36. 2010
  8. ncbi request reprint Steroid hormone masculinization of neural structure in rats: a tale of two nuclei
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI 48824 1101, USA
    Physiol Behav 83:271-7. 2004
  9. pmc Androgen-sensitivity of somata and dendrites of spinal nucleus of the bulbocavernosus (SNB) motoneurons in male C57BL6J mice
    Damian G Zuloaga
    Department of Psychology and Program in Neuroscience, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824 1101, USA
    Horm Behav 51:207-12. 2007
  10. ncbi request reprint Effects of the testicular feminization mutation (tfm) of the androgen receptor gene on BSTMPM volume and morphology in rats
    Alfredo Durazzo
    Neuroscience Program, Michigan State University, 108 Giltner Hall, East Lansing, MI 48824, USA
    Neurosci Lett 419:168-71. 2007

Detail Information

Publications42

  1. pmc Prenatal hormone exposure and risk for eating disorders: a comparison of opposite-sex and same-sex twins
    Kristen M Culbert
    Department of Psychology, Michigan State University, East Lansing, MI 48824 1116, USA
    Arch Gen Psychiatry 65:329-36. 2008
    ..Prenatal testosterone exposure is a promising candidate, since it masculinizes behavior in animals and humans via its permanent effects on the central nervous system...
  2. pmc Minireview: Organizational hypothesis: instances of the fingerpost
    S Marc Breedlove
    Neuroscience Program and Department of Psychology, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Endocrinology 151:4116-22. 2010
    ..Thus digit ratios offer a valid test of the organizational hypothesis that androgens act early in life to masculinize various human behaviors...
  3. pmc Androgen receptors are required for full masculinization of the ventromedial hypothalamus (VMH) in rats
    Brittany N Dugger
    Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Horm Behav 51:195-201. 2007
    ..ARs may regulate aromatase expression or activity to affect estrogen receptor activation, or may act independently of estrogen receptors to influence VMH morphology...
  4. pmc Sexual dimorphism and steroid responsiveness of the posterodorsal medial amygdala in adult mice
    John A Morris
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Brain Res 1190:115-21. 2008
    ..We detected little or no evidence that olfactory bulb afferents play a role in maintaining MePD morphology in adult mice...
  5. ncbi request reprint Sexual dimorphism in neuronal number of the posterodorsal medial amygdala is independent of circulating androgens and regional volume in adult rats
    John A Morris
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    J Comp Neurol 506:851-9. 2008
    ....
  6. ncbi request reprint Evidence that androgen acts through NMDA receptors to affect motoneurons in the rat spinal nucleus of the bulbocavernosus
    Cynthia L Jordan
    Neuroscience Program and Psychology Department, Michigan State University, East Lansing, Michigan 48824, USA
    J Neurosci 22:9567-72. 2002
    ..These results suggest that androgen affects the size of SNB motoneurons by influencing their expression of the NMDA receptor, and therefore the response of the motoneurons to endogenous glutamate...
  7. doi request reprint Neonatal androgen-dependent sex differences in lumbar spinal cord dopamine concentrations and the number of A11 diencephalospinal dopamine neurons
    Samuel S Pappas
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Comp Neurol 518:2423-36. 2010
    ..The AR-dependent sex difference suggests that this system serves a sexually dimorphic function in the lumbar spinal cord...
  8. ncbi request reprint Steroid hormone masculinization of neural structure in rats: a tale of two nuclei
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI 48824 1101, USA
    Physiol Behav 83:271-7. 2004
    ..The extended neural plasticity of the MePD may reflect annual "reorganization" of the brain in the seasonally breeding ancestors of laboratory rats...
  9. pmc Androgen-sensitivity of somata and dendrites of spinal nucleus of the bulbocavernosus (SNB) motoneurons in male C57BL6J mice
    Damian G Zuloaga
    Department of Psychology and Program in Neuroscience, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824 1101, USA
    Horm Behav 51:207-12. 2007
    ..This pattern of AR labeling is consistent with the possibility that androgens also act directly on SNB motoneurons in mice to regulate soma size in mice...
  10. ncbi request reprint Effects of the testicular feminization mutation (tfm) of the androgen receptor gene on BSTMPM volume and morphology in rats
    Alfredo Durazzo
    Neuroscience Program, Michigan State University, 108 Giltner Hall, East Lansing, MI 48824, USA
    Neurosci Lett 419:168-71. 2007
    ..We found no sex difference in BSTMPM somal areas. These findings support the role of androgen receptors in the sexual differentiation of this nucleus...
  11. pmc Spatial ability and prenatal androgens: meta-analyses of congenital adrenal hyperplasia and digit ratio (2D:4D) studies
    David A Puts
    Neuroscience Program, Department of Psychology, Michigan State University, East Lansing, MI, USA
    Arch Sex Behav 37:100-11. 2008
    ..Little or no relationship exists between 2D:4D and spatial ability. Implications for possible hormonal contributions and the developmental timing of sex differences in spatial cognition are discussed...
  12. ncbi request reprint Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus
    Erich N Ottem
    Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824, USA
    Endocrinology 148:3655-65. 2007
    ..These results suggest that androgen maintains a BDNF-signaling pathway in SNB motoneurons that may underlie the maintenance of dendritic structure and synaptic signaling...
  13. pmc The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation
    Damian G Zuloaga
    Department of Psychology and Program in Neuroscience, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Horm Behav 53:613-26. 2008
    ..We review the role of ARs in the development of the brain and behavior, with an emphasis on what has been learned from Tfm rodents as well as from related mutations in humans causing complete androgen insensitivity...
  14. pmc Masculinized finger-length ratios of boys, but not girls, are associated with attention-deficit/hyperactivity disorder
    Michelle M Martel
    Department of Psychology, Michigan State University, East Lansing 48823 1116, USA
    Behav Neurosci 122:273-81. 2008
    ..It is concluded that prenatal, organizational effects of gonadal hormones may play a role in the development of ADHD and contribute to explaining sex differences in the prevalence rates of this childhood disorder...
  15. doi request reprint Mice with the testicular feminization mutation demonstrate a role for androgen receptors in the regulation of anxiety-related behaviors and the hypothalamic-pituitary-adrenal axis
    Damian G Zuloaga
    Department of Psychology, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Horm Behav 54:758-66. 2008
    ..These findings demonstrate that ARs influence anxiety and stress responses in mice...
  16. pmc Sex differences and laterality in astrocyte number and complexity in the adult rat medial amygdala
    Ryan T Johnson
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    J Comp Neurol 511:599-609. 2008
    ..Moreover, functional ARs appear to be critical in establishing these sex differences in MePD astrocyte morphology...
  17. pmc Time course of adult castration-induced changes in soma size of motoneurons in the rat spinal nucleus of the bulbocavernosus
    Dwayne K Hamson
    Neuroscience Program and Department of Psychology, Michigan State University, 108 Giltner Hall, East Lansing, MI 48824, United States
    Neurosci Lett 454:148-51. 2009
    ..Androgenic effects on SNB somata may contribute to aspects of reproductive behavior that are not apparent in penile reflexes tested ex copula...
  18. pmc Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI 48109, USA
    Neurodegener Dis 8:25-34. 2011
    ..We have previously reported that AR toxicity was ligand dependent in our model, and that very few transgenic (tg) males survived beyond birth...
  19. ncbi request reprint Partial demasculinization of several brain regions in adult male (XY) rats with a dysfunctional androgen receptor gene
    John A Morris
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    J Comp Neurol 487:217-26. 2005
    ..Although estrogen receptor activation has been shown to be vital for masculinization of the rodent brain, our results indicate that ARs also contribute to this process in several brain regions...
  20. doi request reprint Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurobiol Dis 34:113-20. 2009
    ..Our results argue that SBMA may be caused by AR acting in muscle...
  21. ncbi request reprint Sexual differentiation of the vertebrate nervous system
    John A Morris
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Neurosci 7:1034-9. 2004
    ..However, more work is needed to uncover the particular cells and specific genes on which testosterone acts to initiate these events...
  22. doi request reprint Astrocytes in the amygdala
    Ryan T Johnson
    Neuroscience Program, Michigan State University, East Lansing, Michigan, USA
    Vitam Horm 82:23-45. 2010
    ..Despite a wide range of research topics, the collected findings make it clear that glia in the amygdala are sensitive and plastic cells that respond and develop in a highly region specific manner...
  23. pmc Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease
    Douglas Ashley Monks
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 104:18259-64. 2007
    ....
  24. doi request reprint Gonadal steroids regulate neural plasticity in the sexually dimorphic nucleus of the preoptic area of adult male and female rats
    Brittany N Dugger
    Neuroscience Program, Michigan State University, East Lansing, MI 48824 1101, USA
    Neuroendocrinology 88:17-24. 2008
    ..The densely staining sexually dimorphic nucleus of the preoptic area (SDNPOA) is profoundly affected by gonadal steroids during perinatal development...
  25. ncbi request reprint Brain aromatase: dyed-in-the-wool homosexuality
    John A Morris
    Neuroscience Program, Michigan State University, 108 Giltner Hall, East Lansing, MI 48824 1101, USA
    Endocrinology 145:475-7. 2004
  26. pmc O brother, where art thou? The fraternal birth-order effect on male sexual orientation
    David A Puts
    Neuroscience Program and Psychology Department, Michigan State University, East Lansing, MI 48824 1101, USA
    Proc Natl Acad Sci U S A 103:10531-2. 2006
  27. ncbi request reprint Both estrogen receptors and androgen receptors contribute to testosterone-induced changes in the morphology of the medial amygdala and sexual arousal in male rats
    Bradley M Cooke
    Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006 3499, USA
    Horm Behav 43:336-46. 2003
    ....
  28. pmc Pubertal growth of the medial amygdala delayed by short photoperiods in the Siberian hamster, Phodopus sungorus
    Bradley M Cooke
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Horm Behav 52:283-8. 2007
    ....
  29. ncbi request reprint Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia
    Windy M Brown
    Department of Psychology, City University, London, United Kingdom
    Horm Behav 42:380-6. 2002
    ..Finger lengths may therefore offer a retrospective marker of perinatal androgen exposure in humans...
  30. doi request reprint Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
    Hirotaka Sakamoto
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Nat Neurosci 11:634-6. 2008
    ..GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction...
  31. ncbi request reprint A reanalysis of five studies on sexual orientation and the relative length of the 2nd and 4th fingers (the 2D:4D ratio)
    Dennis McFadden
    Department of Psychology and Center for Perceptual Systems, University of Texas, Austin, Texas 78712 0187, USA
    Arch Sex Behav 34:341-56. 2005
    ..The constancy of the 2D:4D ratio for the White homosexuals did not appear to extend to homosexuals of three other ethnicities, and there were also subpopulation differences related to right or left hands...
  32. ncbi request reprint Hand asymmetry in heterosexual and homosexual men and women: relationship to 2D:4D digit ratios and other sexually dimorphic anatomical traits
    James T Martin
    Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E 2nd Street, Pomona, CA 91766, USA
    Arch Sex Behav 37:119-32. 2008
    ....
  33. ncbi request reprint Photoperiod-dependent response to androgen in the medial amygdala of the Siberian hamster, Phodopus sungorus
    Bradley M Cooke
    Oregon Regional Primate Research Center, Beaverton 97006 3499, USA
    J Biol Rhythms 17:147-54. 2002
    ..The authors conclude that photoperiod influences the sensitivity of the MeA to androgen...
  34. ncbi request reprint Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor
    Deborah J Walder
    Psychology Department at Brooklyn College City University of New York, Brooklyn, NY 11210, USA
    Schizophr Res 86:118-22. 2006
    ..Diagnostic group differences were restricted to White/Caucasian males with greater right 2D:4D in SPDs. Findings suggest disruptions in prenatal gonadal hormones in vulnerability for schizophrenia...
  35. ncbi request reprint Sexual dimorphism in digit-length ratios of laboratory mice
    Windy M Brown
    Department of Psychology, University of California Berkeley, Berkeley, California, USA
    Anat Rec 267:231-4. 2002
    ..The mouse may therefore be a useful animal model for studying the factors that influence finger length patterns, which have recently been correlated with several specific behaviors and disease predispositions in humans...
  36. ncbi request reprint Got milk? Oxytocin triggers hippocampal plasticity
    Douglas A Monks
    Nat Neurosci 6:327-8. 2003
  37. ncbi request reprint Genetic and environmental influences on 2D:4D finger length ratios: a study of monozygotic and dizygotic male and female twins
    Kyle L Gobrogge
    Department of Psychology, Florida State University, Tallahassee, FL, USA
    Arch Sex Behav 37:112-8. 2008
    ..Findings suggest greater similarity between 2D:4D ratios in MZ relative to DZ twins that can be accounted for by genetic and nonshared environmental factors...
  38. ncbi request reprint Defending the brain from estrogen
    David A Puts
    Nat Neurosci 9:155-6. 2006
  39. pmc Effects of sex hormones on associative learning in spontaneously hypertensive rats
    David J Bucci
    Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA
    Physiol Behav 93:651-7. 2008
    ..To the extent that SHR serves as a model of ADHD in humans, the influence of steroids on associative learning may play a role in the expression of ADHD-like behaviors...
  40. ncbi request reprint Differences in finger length ratios between self-identified "butch" and "femme" lesbians
    Windy M Brown
    Department of Psychology, University of California, Berkeley, California, USA
    Arch Sex Behav 31:123-7. 2002
    ..quot; We conclude that increased early androgen exposure plays a role in only some cases of female homosexuality, and that the sexual orientation of "femme" lesbians is unlikely to have been influenced by early androgens...
  41. ncbi request reprint Behavioural neurobiology: females can also be from Mars
    Nirao M Shah
    Nature 448:999-1000. 2007
  42. ncbi request reprint Anabolic responsiveness of skeletal muscles correlates with androgen receptor protein but not mRNA
    Douglas A Monks
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada
    Can J Physiol Pharmacol 84:273-7. 2006
    ....

Research Grants25

  1. DIMORPHIC CHANGES IN BRAIN AND BEHAVIOR
    S Breedlove; Fiscal Year: 2004
    ..Such analyses may offer insights into possible mechanisms underlying sex differences in human behavior and psychopathology. ..
  2. Integrative Neurobiology of Social Processes
    S Breedlove; Fiscal Year: 2007
    ..We have assembled a unique program to train the next generation of researchers to tackle the challenge of studying the contextual determinants of behavior. ..
  3. HORMONAL EFFECTS ON BEHAVIOR AND SPINAL CORD MORPHOLOGY
    S Breedlove; Fiscal Year: 2007
    ....
  4. HORMONAL EFFECTS ON BEHAVIOR AND SPINAL CORD MORPHOLOGY
    S Breedlove; Fiscal Year: 2002
    ..Furthermore, by studying the mechanisms of neural plasticity, a greater understanding of learning and memory processes may be gained. ..
  5. HORMONAL EFFECTS ON BEHAVIOR AND SPINAL CORD MORPHOLOGY
    S Breedlove; Fiscal Year: 1993
    ..In specific aim 3, two additional experiments are proposed: one to examine the role of local NMDA receptors mediate the morphological changes in SNB and a second to examine the role of copulatory experience...
  6. HORMONAL EFFECTS ON BEHAVIOR & SPINAL CORD MORPHOLOGY
    S Breedlove; Fiscal Year: 1992
    ..Furthermore, by studying the mechanisms of neural plasticity, one can gain a greater understanding of learning and memory processes...