David N Arnosti
Affiliation: Michigan State University
Wei Y, Arnosti D. Enhancer trafficking: free throws and three-pointers. Dev Cell. 2015;32:135-7 pubmed publisher
..Reporting recently in Nature, Zabidi et al. (2014) uncover, via a genome-wide analysis approach, two general classes of enhancer-promoter interactions differentially regulating "housekeeping" versus "developmental" genes. ..
Sengupta S, Lingnurkar R, Carey T, Pomaville M, Kar P, Feig M, et al
. The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency. J Biol Chem. 2015;290:14462-75 pubmed publisher
..These findings establish a mechanistic link between regulation of RB family repressor potency and the ubiquitin-proteasome system. ..
Dresch J, Arnosti D. The Wisdom of Crowds: Can Mathematical Models Crack the cis Regulatory Code?. Cell Syst. 2015;1:379-80 pubmed publisher
..To understand this more complex, deeper layer of biological information, recent efforts have turned to mathematical models as discovery engines of the cis regulatory code. ..
Zhang L, Wei Y, Pushel I, Heinze K, Elenbaas J, Henry R, et al
. Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein. J Biol Chem. 2014;289:24863-73 pubmed publisher
..Such functional relationships are likely to similarly impact mammalian RB family proteins, with important implications for development and disease. ..
Wei Y, Mondal S, Mouawad R, WilczyÅ„ski B, Henry R, Arnosti D. Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis. G3 (Bethesda). 2015;5:1503-15 pubmed publisher
..The presence of unique RBf2 targets suggest that evolutionary appearance of this corepressor represents the acquisition of potentially novel roles in gene regulation for the RB family. ..
Wei Y, Gokhale R, Sonnenschein A, Montgomery K, Ingersoll A, Arnosti D. Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator. Development. 2016;143:3591-3603 pubmed