Steven P Arnoczky

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint Ex vivo static tensile loading inhibits MMP-1 expression in rat tail tendon cells through a cytoskeletally based mechanotransduction mechanism
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Orthop Res 22:328-33. 2004
  2. pmc Infrapatellar Straps Decrease Patellar Tendon Strain at the Site of the Jumper's Knee Lesion: A Computational Analysis Based on Radiographic Measurements
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, Michigan State University, East Lansing, Michigan
    Sports Health 3:296-302. 2011
  3. doi request reprint The microvasculature in the equine distal phalanx: Implications for fracture healing
    S M Schade
    Dr Steven P Arnoczky, DVM, Dipl ACVS, ACVSMR, 784 Wilson Road, Rm G 387, East Lansing, MI 48824, United States, Phone 1 517 353 8964, Fax 1 517 353 8980, E mail
    Vet Comp Orthop Traumatol 27:102-6. 2014
  4. pmc Refining animal models in fracture research: seeking consensus in optimising both animal welfare and scientific validity for appropriate biomedical use
    Jorg A Auer
    Equine Hospital, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
    BMC Musculoskelet Disord 8:72. 2007
  5. doi request reprint Translational models for studying meniscal repair and replacement: what they can and cannot tell us
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Tissue Eng Part B Rev 16:31-9. 2010
  6. ncbi request reprint The location in cartilage of infectious retrovirus in cats infected with feline leukemia virus
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research and Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Bone Joint Surg Am 89:2030-6. 2007
  7. pmc The mechanobiological aetiopathogenesis of tendinopathy: is it the over-stimulation or the under-stimulation of tendon cells?
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Int J Exp Pathol 88:217-26. 2007
  8. ncbi request reprint Matrix metalloproteinase inhibitors prevent a decrease in the mechanical properties of stress-deprived tendons: an in vitro experimental study
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Sports Med 35:763-9. 2007
  9. pmc Loss of homeostatic strain alters mechanostat "set point" of tendon cells in vitro
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, G 387, Michigan State University, East Lansing, MI, USA
    Clin Orthop Relat Res 466:1583-91. 2008
  10. ncbi request reprint Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: the effects of strain frequency, strain magnitude, and cytosolic calcium
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    J Orthop Res 20:947-52. 2002

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Ex vivo static tensile loading inhibits MMP-1 expression in rat tail tendon cells through a cytoskeletally based mechanotransduction mechanism
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Orthop Res 22:328-33. 2004
    ..The results of this study suggest that up-regulation of MMP-1 expression in tendon cells ex vivo can be inhibited by static tensile loading, presumably through a cytoskeletally based mechanotransduction pathway...
  2. pmc Infrapatellar Straps Decrease Patellar Tendon Strain at the Site of the Jumper's Knee Lesion: A Computational Analysis Based on Radiographic Measurements
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, Michigan State University, East Lansing, Michigan
    Sports Health 3:296-302. 2011
    ..A computational model suggests that patellar tendinopathy may be a result of high localized tendon strains that occur at smaller patella-patellar tendon angles (PPTAs)...
  3. doi request reprint The microvasculature in the equine distal phalanx: Implications for fracture healing
    S M Schade
    Dr Steven P Arnoczky, DVM, Dipl ACVS, ACVSMR, 784 Wilson Road, Rm G 387, East Lansing, MI 48824, United States, Phone 1 517 353 8964, Fax 1 517 353 8980, E mail
    Vet Comp Orthop Traumatol 27:102-6. 2014
    ..To describe the intra-osseous microvasculature of the distal phalanx of the equine forelimb with regard to its potential clinical relevance...
  4. pmc Refining animal models in fracture research: seeking consensus in optimising both animal welfare and scientific validity for appropriate biomedical use
    Jorg A Auer
    Equine Hospital, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
    BMC Musculoskelet Disord 8:72. 2007
    ....
  5. doi request reprint Translational models for studying meniscal repair and replacement: what they can and cannot tell us
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Tissue Eng Part B Rev 16:31-9. 2010
    ..Therefore, it is the purpose of this article to provide an overview of the considerations involved when selecting a translational model for meniscal research...
  6. ncbi request reprint The location in cartilage of infectious retrovirus in cats infected with feline leukemia virus
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research and Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Bone Joint Surg Am 89:2030-6. 2007
    ..We hypothesized that articular cartilage fragments, but not isolated chondrocytes, from cats systemically infected with feline leukemia virus (FeLV) are capable of transmitting infectious retrovirus...
  7. pmc The mechanobiological aetiopathogenesis of tendinopathy: is it the over-stimulation or the under-stimulation of tendon cells?
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Int J Exp Pathol 88:217-26. 2007
    ..In this review, we examine the rationale for this hypothesis and provide evidence in support of this theory...
  8. ncbi request reprint Matrix metalloproteinase inhibitors prevent a decrease in the mechanical properties of stress-deprived tendons: an in vitro experimental study
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Sports Med 35:763-9. 2007
    ..Studies have documented the beneficial effects of MMP inhibitors used to treat pathologic conditions in which MMP activity has had a negative effect on connective tissues...
  9. pmc Loss of homeostatic strain alters mechanostat "set point" of tendon cells in vitro
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, G 387, Michigan State University, East Lansing, MI, USA
    Clin Orthop Relat Res 466:1583-91. 2008
    ..The data suggest loss of cytoskeletal tension alters the mechanostat set point and decreases the mechanoresponsiveness of tendon cells...
  10. ncbi request reprint Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: the effects of strain frequency, strain magnitude, and cytosolic calcium
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    J Orthop Res 20:947-52. 2002
    ..persistent JNK activation has been linked to the initiation of the apoptotic cascade. A similar mechanism could be responsible for initiating the pathological events (localized cell death) seen in tendon overuse injury...
  11. ncbi request reprint In situ cell nucleus deformation in tendons under tensile load; a morphological analysis using confocal laser microscopy
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    J Orthop Res 20:29-35. 2002
    ..This deformation may play a significant role in the mechanical signal transduction pathway of this tissue...
  12. doi request reprint Age-dependent effects of systemic administration of oxytetracycline on the viscoelastic properties of rat tail tendons as a mechanistic basis for pharmacological treatment of flexural limb deformities in foals
    Leslie R Wintz
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 73:1951-6. 2012
    ..To describe the effect of systemically administered oxytetracycline on the viscoelastic properties of rat tail tendon fascicles (TTfs) to provide a mechanistic rationale for pharmacological treatment of flexural limb deformities in foals...
  13. doi request reprint Age-related changes in the cellular, mechanical, and contractile properties of rat tail tendons
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Connect Tissue Res 54:70-5. 2013
    ..This, in turn, may place these structures at further risk for injury or altered function...
  14. doi request reprint Re-establishment of cytoskeletal tensional homeostasis in lax tendons occurs through an actin-mediated cellular contraction of the extracellular matrix
    Keri Gardner
    Laboratory for Comparative Orthopaedic Research, Michigan State University, East Lansing, MI, USA
    J Orthop Res 30:1695-701. 2012
    ....
  15. pmc Loss of homeostatic tension induces apoptosis in tendon cells: an in vitro study
    Monika Egerbacher
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, G 387, Michigan State University, East Lansing, MI 48824, USA
    Clin Orthop Relat Res 466:1562-8. 2008
    ..59% +/- 2.80) compared to controls (1.87% +/- 1.07) or cyclically loaded tendons (3.73% +/- 0.87). These data suggest loss of homeostatic tension following stress deprivation induces apoptosis in rat tail tendon cells...
  16. ncbi request reprint In vitro alterations in cytoskeletal tensional homeostasis control gene expression in tendon cells
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Orthop Res 23:1211-8. 2005
    ..Alterations in this tension appear to control the expression of both catabolic and anabolic genes in a reciprocal manner...
  17. ncbi request reprint The correlation of segment accelerations and impact forces with knee angle in jump landing
    Niell G Elvin
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing, MI, USA
    J Appl Biomech 23:203-12. 2007
    ..However, owing to the nonlinear relationship, peak forces and segment accelerations change more rapidly at smaller knee flexion angles (i.e., close to full extension) than at greater knee flexion angles...
  18. ncbi request reprint Effect of amplitude and frequency of cyclic tensile strain on the inhibition of MMP-1 mRNA expression in tendon cells: an in vitro study
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, Michigan State University, East Lansing, Michigan 48824, USA
    Connect Tissue Res 44:181-7. 2003
    ..The results of our study demonstrate that MMP-1 expression in tendon cells can be modulated by varying amplitudes and frequencies of cyclic tensile strain, presumably through a cytoskeletally based mechanotransduction pathway...
  19. doi request reprint Evaluation of the use of an autologous platelet-rich fibrin membrane to enhance tendon healing in dogs
    Lance C Visser
    Laboratory for Comparative Orthopaedic Research, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 72:699-705. 2011
    ..To examine effects of an autologous platelet-rich fibrin (PRF) membrane for enhancing healing of a defect of the patellar tendon (PT) in dogs...
  20. doi request reprint Growth factor-rich plasma increases tendon cell proliferation and matrix synthesis on a synthetic scaffold: an in vitro study
    Lance C Visser
    College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Tissue Eng Part A 16:1021-9. 2010
    ..These results indicate that GFRP can be used to enhance in vitro cellular population and matrix deposition of tissue-engineered scaffolds...
  21. doi request reprint Platelet-rich fibrin constructs elute higher concentrations of transforming growth factor-β1 and increase tendon cell proliferation over time when compared to blood clots: a comparative in vitro analysis
    Lance C Visser
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Vet Surg 39:811-7. 2010
    ....
  22. ncbi request reprint Lyophilization does not inactivate infectious retrovirus in systemically infected bone and tendon allografts
    Matthew J Crawford
    College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Sports Med 32:580-6. 2004
    ..The finding that 75% of the recipients of fresh-frozen bone from the same donor contracted human immunodeficiency virus has led to speculation that freeze-drying may render retroviral-infected musculoskeletal allografts noninfectious...
  23. ncbi request reprint Demineralization for inactivation of infectious retrovirus in systemically infected cortical bone: in vitro and in vivo experimental studies
    Cheryl L Swenson
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    J Bone Joint Surg Am 85:323-32. 2003
    ....
  24. doi request reprint Patellar tendon strain is increased at the site of the jumper's knee lesion during knee flexion and tendon loading: results and cadaveric testing of a computational model
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Sports Med 36:2110-8. 2008
    ..However, it is unclear why the lesion typically occurs in this area of the patellar tendon as surface strain gauge studies of the patellar tendon through the range of motion have produced conflicting results...
  25. ncbi request reprint A finite element model predicts the mechanotransduction response of tendon cells to cyclic tensile loading
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Biomech Model Mechanobiol 7:405-16. 2008
    ....
  26. doi request reprint The effect of stress-deprivation and cyclic loading on the TIMP/MMP ratio in tendon cells: an in vitro experimental study
    Keri Gardner
    The Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA
    Disabil Rehabil 30:1523-9. 2008
    ..To determine the effect of stress deprivation and cyclic loading on TIMP-1/MMP-13 mRNA expression ratio in rat tail tendon (RTT) cells...
  27. doi request reprint Effect of in vitro stress-deprivation and cyclic loading on the length of tendon cell cilia in situ
    Keri Gardner
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    J Orthop Res 29:582-7. 2011
    ..This suggests that, as in other tissues, cilia length in tendon cells is affected by mechanical signaling from the extracellular matrix...
  28. ncbi request reprint In vitro effects of oxytetracycline on matrix metalloproteinase-1 mRNA expression and on collagen gel contraction by cultured myofibroblasts obtained from the accessory ligament of foals
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 65:491-6. 2004
    ....
  29. ncbi request reprint Isolated fibrillar damage in tendons stimulates local collagenase mRNA expression and protein synthesis
    Michael Lavagnino
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Biomech 39:2355-62. 2006
    ..This collagenase production may weaken the tendon and put more of the extracellular matrix at risk for further damage during subsequent loading...
  30. ncbi request reprint The biology of allograft incorporation
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, Michigan State University, College of Veterinary Medicine, G 387, East Lansing, MI 48824, USA
    J Knee Surg 19:207-14. 2006
    ..Understanding the biologic factors that affect the donor-host interactions and ultimate incorporation and remodeling of various allograft tissues is an essential prerequisite for their successful clinical use...
  31. doi request reprint In situ deflection of tendon cell-cilia in response to tensile loading: an in vitro study
    Michael Lavagnino
    College of Veterinary Medicine, Michigan State University East Lansing, MI, USA
    J Orthop Res 29:925-30. 2011
    ..025). These results demonstrate that tensile loading produces in situ deflection of tendon cell-cilia and supports the concept that cilia are involved in the mechanotransduction response of tendon cells...
  32. ncbi request reprint The basic science of platelet-rich plasma (PRP): what clinicians need to know
    Steven P Arnoczky
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing Department of Orthopaedic Surgery, McLaren Flint Michigan State University, Flint, MI
    Sports Med Arthrosc 21:180-5. 2013
    ..This article will review the basic principles involved in creating PRP and examine the potential basic scientific significance of the individual blood components contained in the various forms of PRP currently used in sports medicine. ..
  33. ncbi request reprint Microvasculature of the suspensory ligament of the forelimb of horses
    Megan R Williams
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824
    Am J Vet Res 74:1481-6. 2013
    ..To determine the microvascular anatomy of the suspensory ligament of the forelimb of horses...
  34. ncbi request reprint The effect of cranial cruciate ligament insufficiency on caudal cruciate ligament morphology: An experimental study in dogs
    Terri A Zachos
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    Vet Surg 31:596-603. 2002
    ..To investigate the effect of cranial cruciate ligament (CrCL) insufficiency on morphology of the canine caudal cruciate ligament (CdCL)...
  35. ncbi request reprint The split-line pattern of the distal femur: A consideration in the orientation of autologous cartilage grafts
    Steven Below
    Department of Orthopedic Surgery, McLaren Regional Medical Center, Flint, Michigan, USA
    Arthroscopy 18:613-7. 2002
    ..To identify the surface collagen orientations of the distal femur and create a generic cartilage split-line map that could be used as a reference guide for the proper alignment of autogenous cartilage transplants...
  36. ncbi request reprint Correlation between ground reaction force and tibial acceleration in vertical jumping
    Niell G Elvin
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing, MI, USA
    J Appl Biomech 23:180-9. 2007
    ..Whereas the device also permitted an accurate determination of jump height, there was no correlation between peak ground reaction force and jump height...
  37. ncbi request reprint Fibrochondrogenesis of free intraarticular small intestinal submucosa scaffolds
    Derek B Fox
    Comparative Orthopedic Laboratory, University of Missouri, Columbia, Missouri 65211, USA
    Tissue Eng 10:129-37. 2004
    ....
  38. ncbi request reprint Healing of a surgically created partial detachment of the posterior cruciate ligament using marrow stimulation: an experimental study in dogs
    William G Rodkey
    Steadman Hawkins Research Foundation, Vail, CO 81657, USA
    J Knee Surg 19:14-8. 2006
    ..Our hypothesis was confirmed. Marrow stimulation can induce a "healing response" in intra-articular (cruciate) ligaments. This technique may have clinical applications in primary surgical repair of these structures...
  39. ncbi request reprint Arthroscopic repair of the acetabular labrum: a histologic assessment of healing in an ovine model
    Marc J Philippon
    Steadman Hawkins Clinic, Vail, Colorado, USA
    Arthroscopy 23:376-80. 2007
    ..Recently, arthroscopic repair has been advocated for the treatment of labral tears. The purpose of this study was to document the histologic healing process in an arthroscopically repaired acetabular-labral detachment in an ovine model...
  40. ncbi request reprint The inferior glenohumeral ligament: a correlative investigation
    Jonathan B Ticker
    New York Orthopaedic Hospital Research Laboratory, Columbia Presbyterian Medical Center, New York, NY, USA
    J Shoulder Elbow Surg 15:665-74. 2006
    ....
  41. ncbi request reprint Microvascular supply of the lateral epicondyle and common extensor origin
    Chris P Bales
    Department of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Shoulder Elbow Surg 16:497-501. 2007
    ..These hypovascular regions may preclude the normal inflammatory cascade and healing response to microtearing in this region. Thus, these zones may play a role in the etiology of lateral epicondylitis...