George S Abela
Affiliation: Michigan State University
- Atheromatous plaque cap thickness can be determined by quantitative color analysis during angioscopy: implications for identifying the vulnerable plaqueAkira Miyamoto
Institute for Prevention of Cardiovascular Disease, Cardiovascular Division, Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Cardiol 27:9-15. 2004..Coronary angioscopy in acute myocardial infarction has frequently revealed disrupted yellow lesions. Furthermore, postmortem studies have demonstrated that these lesions have thin collagenous caps with underlying lipid-rich cores...
- Quadricuspid aortic valve: a rare entityAnand Cholia
Division of Cardiology, Department of Medicine, Michigan State University, East Lansing, Michigan, USA
Clin Cardiol 28:395. 2005
- Arterial wall cholesterol content is a predictor of development and severity of arterial thrombosisHongbao Ma
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan 48824, USA
J Thromb Thrombolysis 22:5-11. 2006..This study evaluated relationships between cholesterol levels and the amount of thrombosis in an atherosclerotic rabbit model of plaque disruption and thrombosis...
- Unusual complications of coronary artery bypass graft surgeryChotikorn Khunnawat
Division of Cardiology, Department of Medicine, Michigan State University, East Lansing, MI, USA
Am J Cardiol 98:1665-6. 2006..In conclusion, the development of heart failure led to the detection of this rare complication...
- Effect of statins on cholesterol crystallization and atherosclerotic plaque stabilizationGeorge S Abela
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan, USA
Am J Cardiol 107:1710-7. 2011..03). In conclusion, statins decreased ΔVE by altering cholesterol crystallization and blunting sharp-tipped crystal structure and dissolving cholesterol crystals in human arteries in vivo and in vitro, providing plaque stabilization...
- Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromesGeorge S Abela
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, MI, USA
Am J Cardiol 103:959-68. 2009..Crystal content was significantly associated with clinical events, suggesting that cholesterol crystallization may have a role in PD...
- Laser-light scattering, a new method for continuous monitoring of platelet activation in circulating fluidGeorge S Abela
Division of Cardiology, Department of Medicine, Michigan State University, East Lansing 48824, USA
J Lab Clin Med 141:50-7. 2003..The peak of P-selectin expression coincided with peak platelet volume. These data demonstrate that increases in circulating-platelet size stimulated by endovascular injury can be reliably and continuously monitored with the use of LLS...
- Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events--a novel insight into plaque rupture by scanning electron microscopyGeorge S Abela
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing 48824, USA
Scanning 28:1-10. 2006..Observations by scanning electron microscopy confirmed similar findings of cholesterol crystals perforating the lumen surface in human coronary artery segments with ruptured plaque...
- Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammationGeorge S Abela
Division of Cardiology, Department of Medicine, and Division of Pathology, Department of Physiology, Michigan State University, B208 Clinical Center, East Lansing, MI, USA
J Clin Lipidol 4:156-64. 2010..This was demonstrated in an atherosclerotic rabbit model. Therefore, we propose that cholesterol crystallization could help explain in part both local and systemic inflammation associated with atherosclerosis...
- Cholesterol crystals cause mechanical damage to biological membranes: a proposed mechanism of plaque rupture and erosion leading to arterial thrombosisGeorge S Abela
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan 48824, USA
Clin Cardiol 28:413-20. 2005..To elucidate the process of plaque rupture, we investigated the transformation of cholesterol from liquid to solid crystal to determine whether growing crystals are capable of injuring the plaque cap...
- Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injuryAlejandro R Prieto
Department of Internal Medicine, Division of Cardiology, Michigan State University, East Lansing, MI 48824, USA
Cardiovasc Res 53:984-92. 2002..We hypothesized that thrombostatin prevents platelet aggregation and adhesion after balloon angioplasty (BA)...
- Plaque rupture and thrombosis are reduced by lowering cholesterol levels and crystallization with ezetimibe and are correlated with fluorodeoxyglucose positron emission tomographyRoshan Patel
Division of Cardiology, Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
Arterioscler Thromb Vasc Biol 31:2007-14. 2011..This study evaluated effects of lipid lowering with ezetimibe on plaque burden and associated cholesterol crystallization and inflammation in a rabbit model of plaque disruption and thrombosis...
- Aspirin reduces platelet aggregation during high-energy excimer laserRuiping Huang
Division of Cardiology, Department of Medicine, Michigan State, University, East Lansing, Michigan 48824, USA
Lasers Surg Med 38:875-9. 2006..Excimer laser is used clinically in arterial revascularization procedures. This study evaluated the efficacy of aspirin in reducing platelet aggregation during high-energy excimer lasing...
- The impact of circulating cholesterol crystals on vasomotor function: implications for no-reflow phenomenonNitesh Gadeela
College of Human Medicine, Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan
JACC Cardiovasc Interv 4:521-9. 2011..The purpose of this study was to determine if cholesterol crystals can injure the endothelial surface by their jagged edges altering vasoreactivity and contributing to no-reflow after intervention...
- Physical factors that trigger cholesterol crystallization leading to plaque ruptureAmeeth Vedre
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, MI 48824, United States
Atherosclerosis 203:89-96. 2009..This study examined the effect of physical conditions including saturation, temperature, hydration, pH on cholesterol crystallization...
- Noninvasive detection and localization of vulnerable plaque and arterial thrombosis with computed tomography angiography/positron emission tomographyKusai Aziz
Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, MI 48824, USA
Circulation 117:2061-70. 2008..We tested the hypothesis that arterial thrombosis occurs in areas with high fluorodeoxyglucose uptake and that computed tomography angiography (CTA) can detect thrombi in vessels...
- Update on coronary angioscopy: review of a 20-year experience and potential application for detection of vulnerable plaqueFumiyuki Ishibashi
Department of Medicine, Cardiology, Lahey Clinic, Burlington, Massachusetts 01805, USA
J Interv Cardiol 19:17-25. 2006....
- CD44 targeting magnetic glyconanoparticles for atherosclerotic plaque imagingMohammad H El-Dakdouki
Department of Chemistry, Michigan State University, Chemistry Building, Room 426, 578 S Shaw Lane, East Lansing, Michigan, 48824, USA
Pharm Res 31:1426-37. 2014..We aim to develop nanoparticles that can selectively target CD44 for the non-invasive detection of atherosclerotic plaques by magnetic resonance imaging...
- Cardiac tissue Doppler and tissue velocity imaging in anesthetized New Zealand white rabbitsAugusta Pelosi
Small Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, USA
J Am Assoc Lab Anim Sci 50:317-21. 2011..The values from the current study, obtained in normal rabbits, can be used as reference values to improve characterization of cardiac disease in this species...
- Distinguishing characteristics of erythrocyte-rich and platelet-rich thrombus by intravascular ultrasound catheter systemEric Johnstone
Cardiovascular Division, Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, MA, USA
J Thromb Thrombolysis 24:233-9. 2007..To determine whether intravascular ultrasound (IVUS) could be used to detect specific characteristics of WT and RT, two experiments were performed...
- Cardiovascular complications of the Guillain-Barré syndromeSiddharth Mukerji
Department of Medicine, Michigan State University, East Lansing, Michigan, USA
Am J Cardiol 104:1452-5. 2009..In conclusion, it is necessary to recognize the potentially fatal cardiovascular complications associated with the GBS and treat them accordingly...
- Amiodarone - a 'broad spectrum' antiarrhythmic drugSujeeth R Punnam
Sparrow Health System, Division of Cardiology, Michigan State University, East Lansing, MI, USA
Cardiovasc Hematol Disord Drug Targets 10:73-81. 2010..Amiodarone, a category D drug, is contraindicated in pregnant and breast feeding women. This review discusses the pharmacokinetics of amiodarone, its evolving clinical indications, management of toxicity and drug interactions...
- Prophylaxis to prevent infective endocarditis: to use or not to use?Abhijeet Dhoble
Department of Internal Medicine, Michigan State University, East Lansing, Michigan 48824 1313, USA
Clin Cardiol 32:429-33. 2009..Patients have the right to make the final decision, and they should be allowed to participate in choosing for or against this approach until adequate clinical evidence is available...
- Cardiovascular manifestations in human immunodeficiency virus-infected patientsChotikorn Khunnawat
Department of Internal Medicine, Division of Cardiology, Michigan State University East Lansing, Michigan, USA
Am J Cardiol 102:635-42. 2008..In conclusion, this review describes cardiac abnormalities associated with HIV, including possible molecular mechanisms. The co-morbid sequelae, their presentation, and pharmacologic management are also discussed...
- Current concepts in triglyceride metabolism, pathophysiology, and treatmentGeorges AbouRjaili
Department of Medicine, Staten Island University Hospital, Staten Island, NY, USA
Metabolism 59:1210-20. 2010..In this review we will focus on triglycerides; their production, metabolism and influence on daily life, as well as the various methods for the treatment of hypertryglyceridemia and prevention of its sequelae...
- Amplification of atherosclerotic calcification and Mönckeberg's sclerosis: a spectrum of the same disease processPeter A McCullough
Department of Medicine, Divisions of Cardiology, William Beaumont Hospital, Royal Oak, MI 48073, USA
Adv Chronic Kidney Dis 15:396-412. 2008....
- Shaft aneurysm of femoropopliteal expanded polytetrafluoroethylene graft treated with a covered stentSujeeth R Punnam
Division of Cardiology, Sparrow Health System, East Lansing, Michigan, USA
Vasc Endovascular Surg 42:386-90. 2008..The aneurysm was treated percutaneously with a self-expanding covered stent resulting in complete isolation of the aneurysm with no complications encountered...
- Primary cardiac pleomorphic sarcoma presenting as back pain in an 18-year-old manOsama Alsara
Department of Internal Medicine, Division of General Internal Medicine, Michigan State University, East Lansing, Michigan 48824, USA
Tex Heart Inst J 40:339-42. 2013..The patient died 2 years later of diffuse metastases. In addition to the patient's case, we discuss the nature and treatment of cardiac sarcoma. ..
- Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystalsHongguang Li
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
Chem Commun (Camb) 48:3385-7. 2012..These particles showed selective binding to cholesterol crystals, which opens the door for the detection of cholesterol crystal-related diseases such as atherosclerosis by magnetic resonance imaging (MRI)...
- Symptomatic and asymptomatic carotid artery plaqueMajid M Mughal
Department of Medicine, Division of Cardiology, Michigan State University, 138 Service Road, B208 Clinical Center, East Lansing, MI 48824, USA
Expert Rev Cardiovasc Ther 9:1315-30. 2011....
- Plaque disruption and thrombus in Ambrose's angiographic coronary lesion typesSergio Waxman
Division of Cardiology, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Cardiol 92:16-20. 2003..We conclude that Ambrose's type II eccentric stenoses and angiographically complex lesions are strongly associated with disrupted plaques and/or thrombus as assessed by angioscopy in patients and represent unstable plaque substrates...
- Hemodynamic collapse during left ventricular lead implantationSujeeth R Punnam
Department of Internal Medicine, Division of Cardiology, Michigan State University, Sparrow Health System, Thoracic and Cardiovascular Institute, Lansing, Michigan 48910, USA
Pacing Clin Electrophysiol 30:1112-5. 2007..Cardiac tamponade as a possible cause was ruled out by echocardiography. We discuss possible mechanisms of sudden hemodynamic collapse during CRT implantation...
- Deletion of the mouse alpha-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injuryRuiping Huang
Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
Am J Physiol Heart Circ Physiol 294:H1291-7. 2008..Therefore, these data indicate that, in this in vitro setting, deletion of alpha-CGRP makes the heart more vulnerable to I/R injury, possibly due, at least in part, to increased oxidative stress...
- Statin therapy decreases myocardial function as evaluated via strain imagingJack Rubinstein
Cardiology Division, Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
Clin Cardiol 32:684-9. 2009..The purpose of this study was to evaluate the effects of statin therapy on myocardial function as measured with echocardiography with tissue Doppler imaging (TDI) and strain imaging (SI) independent of its lipid-lowering effect...
- Coronary artery fistula: a case series with review of the literatureManjunath G Raju
Department of Family Medicine, Michigan State University, East Lansing, MI 48824, USA
J Cardiol 53:467-72. 2009..They should be part of cardiac differential diagnosis particularly in patients without other risk factors. Correction of CAF is indicated if the patients are symptomatic or if other secondary complications develop...
- Relation of porphyria to atrial fibrillationAbhijeet Dhoble
Thoracic and Cardiovascular Institute, Michigan State University, Lansing, Michigan, USA
Am J Cardiol 104:373-6. 2009..028, relative risk 7.45, 95% confidence interval 1.01 to 66.14) compared with the age- and gender-matched control group (2%). In conclusion, our observations suggest that porphyria may be significantly associated with AF/AFl...
- A novel catheter design for laser photocoagulation of the myocardium to ablate ventricular tachycardiaAlan Wagshall
University of Massachusetts, Worchester, MA, USA
J Interv Card Electrophysiol 7:13-22. 2002....