Cheppail Ramachandran

Summary

Affiliation: Miami Children's Hospital
Country: USA

Publications

  1. doi request reprint The effects of CO2 on cytokine concentrations in endotoxin-stimulated human whole blood
    Dai Kimura
    Division of Critical Care Medicine, Miami Children s Hospital, Miami, FL, USA
    Crit Care Med 36:2823-7. 2008
  2. doi request reprint Potentiation of etoposide and temozolomide cytotoxicity by curcumin and turmeric force™ in brain tumor cell lines
    Cheppail Ramachandran
    Miami Children s Hospital, Miami, FL 33155, USA
    J Complement Integr Med 9:Article 20. 2012
  3. doi request reprint Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation on the CCL-110 skin fibroblast cell line
    C Ramachandran
    Dharma Biomedical LLC, 12777 Old Cutler Road, Miami, FL 33156, USA
    Int J Cosmet Sci 34:155-60. 2012
  4. ncbi request reprint Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin
    C Ramachandran
    Department of Radiation Oncology, University of Miami School of Medicine, FL, USA
    Breast Cancer Res Treat 54:269-78. 1999
  5. ncbi request reprint Investigation of cytokine expression in human leukocyte cultures with two immune-modulatory homeopathic preparations
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, Florida 33155, USA
    J Altern Complement Med 13:403-7. 2007
  6. ncbi request reprint Drug resistance in renal tumors of childhood
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Curr Pharm Biotechnol 8:99-104. 2007
  7. ncbi request reprint Potentiation of gemcitabine by Turmeric Force in pancreatic cancer cell lines
    Cheppail Ramachandran
    Department of Pathology, Miami Children s Hospital Research Institute, Miami, FL 33155, USA
    Oncol Rep 23:1529-35. 2010
  8. ncbi request reprint Anticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts
    Cheppail Ramachandran
    Division of Hematology Oncology, Research Institute, Miami Children s Hospital, FL 33155, USA
    Int J Cancer 119:2443-54. 2006
  9. ncbi request reprint Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Anticancer Res 25:3293-302. 2005
  10. ncbi request reprint Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, FL 33155, USA
    J Neurooncol 67:19-28. 2004

Collaborators

Detail Information

Publications28

  1. doi request reprint The effects of CO2 on cytokine concentrations in endotoxin-stimulated human whole blood
    Dai Kimura
    Division of Critical Care Medicine, Miami Children s Hospital, Miami, FL, USA
    Crit Care Med 36:2823-7. 2008
    ..To test this hypothesis, we measured the production of pro- and anti-inflammatory cytokines in endotoxin-stimulated human whole blood cultures under hypercapnic, normocapnic, and hypocapnic conditions...
  2. doi request reprint Potentiation of etoposide and temozolomide cytotoxicity by curcumin and turmeric force™ in brain tumor cell lines
    Cheppail Ramachandran
    Miami Children s Hospital, Miami, FL 33155, USA
    J Complement Integr Med 9:Article 20. 2012
    ..These pre-clinical results suggest that TF may be useful as an adjuvant with ETP and TMZ for brain tumor chemotherapy...
  3. doi request reprint Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation on the CCL-110 skin fibroblast cell line
    C Ramachandran
    Dharma Biomedical LLC, 12777 Old Cutler Road, Miami, FL 33156, USA
    Int J Cosmet Sci 34:155-60. 2012
    ..These results suggest that GU-TC7 possesses properties that are applicable to the treatment of wrinkles and may be considered for its further evaluation in skin care products...
  4. ncbi request reprint Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin
    C Ramachandran
    Department of Radiation Oncology, University of Miami School of Medicine, FL, USA
    Breast Cancer Res Treat 54:269-78. 1999
    ..The results suggest that apoptosis is involved in the curcumin-induced inhibition of tumor cell growth, and genes associated with cell proliferation and apoptosis may be playing a role in the chemopreventive action of curcumin...
  5. ncbi request reprint Investigation of cytokine expression in human leukocyte cultures with two immune-modulatory homeopathic preparations
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, Florida 33155, USA
    J Altern Complement Med 13:403-7. 2007
    ..However, there is a paucity of preclinical evaluations of the effects of homeopathic medicinal preparations on cellular signaling pathways relevant to the applications of these preparations...
  6. ncbi request reprint Drug resistance in renal tumors of childhood
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Curr Pharm Biotechnol 8:99-104. 2007
    ....
  7. ncbi request reprint Potentiation of gemcitabine by Turmeric Force in pancreatic cancer cell lines
    Cheppail Ramachandran
    Department of Pathology, Miami Children s Hospital Research Institute, Miami, FL 33155, USA
    Oncol Rep 23:1529-35. 2010
    ..This synergistic effect is due to the increased inhibitory effect of the combination on nuclear factor-kappaB activity and signal transducer and activator of transcription factor 3 expression as compared to the single agent...
  8. ncbi request reprint Anticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts
    Cheppail Ramachandran
    Division of Hematology Oncology, Research Institute, Miami Children s Hospital, FL 33155, USA
    Int J Cancer 119:2443-54. 2006
    ..These results suggest that the anticancer properties of AMR in SW620 human colon carcinoma cell line are mediated through its effects on functional genomics, targeting the apoptotic process...
  9. ncbi request reprint Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Anticancer Res 25:3293-302. 2005
    ..These results suggest that curcumin induces apoptosis in breast cancer cells by regulation of multiple signaling pathways, indicating its potential use for prevention and treatment of cancer...
  10. ncbi request reprint Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, FL 33155, USA
    J Neurooncol 67:19-28. 2004
    ..2% for etoposide alone and 26.2% for tamoxifen alone treatments. These results suggest that inhibitory effect of tamoxifen on brain tumor cells manifest through different mechanisms involving inhibition of targets such as PKC and IGF-II...
  11. pmc Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin
    Cheppail Ramachandran
    Dharma Biomedical LLC, Miami, FL, 33156, USA
    BMC Complement Altern Med 11:59. 2011
    ..In this report we tested the ability of MCP to induce the activation of human blood lymphocyte subsets like T, B and NK-cells...
  12. ncbi request reprint Effect of MDR1 phosphorothioate antisense oligodeoxynucleotides in multidrug-resistant human tumor cell lines and xenografts
    Cheppail Ramachandran
    Department of Radiation Oncology, University of Miami School of Medicine, Research Institute, Miami, Children s Hospital, Miami, FL, USA
    Anticancer Res 23:2681-90. 2003
    ..Our results suggest that MDR1 antisense S-ODN treatment can increase the efficiency of chemotherapy by suppressing gene expression and resistant phenotype...
  13. ncbi request reprint Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Int J Cancer 105:784-9. 2003
    ..Our results show that AMR competitively inhibits P-gp-mediated DOX efflux, suggestive of a mechanism underlying the enhanced DOX accumulation and reversal of multidrug resistance by AMR...
  14. ncbi request reprint Molecular studies in pediatric medulloblastomas
    Cheppail Ramachandran
    Miami Children s Hospital, Research Institute, 3100 SW 62nd Avenue, Miami, FL 33155, USA
    Brain Tumor Pathol 19:15-22. 2002
    ..The relationship between these markers indicates their relative and cumulative effect on cellular drug resistance, apoptosis, and/or cell proliferation in pediatric medulloblastomas...
  15. ncbi request reprint Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line
    Cheppail Ramachandran
    Department of Pathology, Miami Children s Hospital, 3100 SW 62nd Avenue, FL 33155, USA
    Cancer Lett 184:1-6. 2002
    ..Our results suggest that curcumin inhibits telomerase activity by down-regulating hTERT expression in breast cancer cells and this down-regulation is not through the c-myc pathway...
  16. ncbi request reprint Anticancer effects of Annona glabra plant extracts in human leukemia cell lines
    Curtis Bruce Cochrane
    Department of Pathology, Miami Children s Hospital, Miami, FL 33155, USA
    Anticancer Res 28:965-71. 2008
    ..These results support the traditional use of A. glabra and the alcoholic seed extract is a potent source of anticancer compounds that could be utilized pharmaceutically...
  17. ncbi request reprint Novel drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines
    Thangaiyan Rabi
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Breast Cancer Res Treat 80:321-30. 2003
    ..8-71% MCF-7, 28.5-43.2% MCF-7/TH and 4-32.8% MCF-10A cells at 1-8 microg/ml concentrations. Our results suggest that AMR is a novel drug having potential for clinical development against human malignancies...
  18. doi request reprint Inhibition of nitric oxide synthesis in mouse macrophage cells by feverfew supercritical extract
    Anat Aviram
    Miami Children s Hospital, Department of Pathology, Miami, FL 33155, USA
    Phytother Res 26:541-5. 2012
    ..However, eNOS and iNOS proteins were significantly down-regulated by the feverfew extract. Feverfew inhibition of NO is due to the down-regulation of both eNOS and iNOS enzymes at the translational and/or post-translational level...
  19. ncbi request reprint Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia
    P K Raveendran Nair
    Research Institute, Miami Children s Hospital, 3100 SW 62nd Avenue, Miami, FL 33155, USA
    Int Immunopharmacol 4:1645-59. 2004
    ....
  20. doi request reprint Immunological response to (1,4)-alpha-D-glucan in the lung and spleen of endotoxin-stimulated juvenile rats
    Ectis A Velazquez
    Division of Critical Care Medicine, Miami Children s Hospital, Miami, FL, USA
    Basic Clin Pharmacol Toxicol 105:301-6. 2009
    ..These data suggest that alpha-DG differentially modulates cytokine response in the lung and spleen and modifies the pro- and anti-inflammatory balance during an early period of endotoxaemia in juvenile rats...
  21. ncbi request reprint Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia
    P K Raveendran Nair
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Int Immunopharmacol 6:1815-24. 2006
    ..These results show that the novel (1,4)-alpha-D-glucan from Tinospora cordifolia activates the immune system through the activation of macrophages that occurs through TLR6 signaling, NF-kappaB translocation and cytokine production...
  22. doi request reprint Physiological effects of a novel immune stimulator drug, (1,4)-α-D-glucan, in rats
    Ravishankar Koppada
    Division of Critical Care Medicine, Miami Children s Hospital, Miami, FL, USA
    Basic Clin Pharmacol Toxicol 105:217-21. 2009
    ..We suggest that these in vivo effects of α-D-glucan should be considered for future clinical and/or experimental trials...
  23. ncbi request reprint Expression of apoptosis, cell proliferation, and drug resistance genes in pediatric Wilms' tumors
    C Ramachandran
    Division of Pathology, Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Anticancer Res 20:3759-65. 2000
    ....
  24. pmc Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas
    Jingxin Qiu
    Department of Pathology, UF Shands Cancer Center Program in Cancer Genetics, Epigenetics, and Tumor Virology, University of Florida College of Medicine, Gainesville, FL, USA
    Lab Invest 88:910-25. 2008
    ..CST6 methylation may therefore represent a novel prognostic marker and therapeutic target specifically altered in TICs...
  25. ncbi request reprint Cytogenetic and molecular characterization of a congenital mesoblastic nephroma
    C Ramachandran
    Department of Pathology, Miami Children's Hospital, 3100 SW 62nd Avenue, Miami, FL 33155, USA
    Pediatr Dev Pathol 4:402-11. 2001
    ..4 h). Our results showed that MCH-MN-1 might be a good model cell line for investigations on mesoblastic nephroma...
  26. doi request reprint Improved Neuroprotective Effects by Combining Bacopa monnieri and Rosmarinus officinalis Supercritical CO2 Extracts
    Cheppail Ramachandran
    Dharma Biomedical LLC, Miami, FL, USA
    J Evid Based Complementary Altern Med 19:119-27. 2014
    ..These results suggest that the extract of Bacopa monnieri + rosemary antioxidant is more neuroprotective than Bacopa monnieri or rosemary antioxidant extract. ..
  27. ncbi request reprint Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo
    Masakazu Toi
    Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Angiogenesis 6:121-8. 2003
    ..com)...
  28. ncbi request reprint Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer
    Nam Deuk Kim
    Department of Pharmacy, Pusan National University, Korea
    Breast Cancer Res Treat 71:203-17. 2002
    ..The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of pomegranate in human breast cancer may be warranted...