Dana Ferraris

Summary

Affiliation: MGI Pharma
Country: USA

Publications

  1. ncbi request reprint Azetidine-based inhibitors of dipeptidyl peptidase IV (DPP IV)
    Dana Ferraris
    Senior Scientist II, MGI Pharma, 6611 Tributary Street, Baltimore, MD 21224, USA
    Curr Top Med Chem 7:597-608. 2007
  2. ncbi request reprint Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 14:5579-83. 2004
  3. ncbi request reprint Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, MA 21224, USA
    Bioorg Med Chem Lett 13:2513-8. 2003
  4. ncbi request reprint Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Bioorg Med Chem 11:3695-707. 2003
  5. pmc Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine
    Jesse Alt
    Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Anal Biochem 419:106-9. 2011
  6. ncbi request reprint DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice
    Susan L Lautar
    Guilford Pharmaceuticals, Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Brain Res 1048:177-84. 2005
  7. pmc Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system
    Mohamed H Farah
    Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:5744-54. 2011
  8. ncbi request reprint Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, Maryland 21224, USA
    J Med Chem 46:3138-51. 2003
  9. pmc Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
    Susan P Yates
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
    Biochem J 385:667-75. 2005
  10. doi request reprint Synthesis and biological evaluation of D-amino acid oxidase inhibitors
    Dana Ferraris
    MGI Pharma, Inc
    J Med Chem 51:3357-9. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Azetidine-based inhibitors of dipeptidyl peptidase IV (DPP IV)
    Dana Ferraris
    Senior Scientist II, MGI Pharma, 6611 Tributary Street, Baltimore, MD 21224, USA
    Curr Top Med Chem 7:597-608. 2007
    ..Select 3-fluoroazetidines also display inhibitory potencies below 1 microM without the propensity for cyclization and chemical instability associated with the other subseries...
  2. ncbi request reprint Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 14:5579-83. 2004
    ..In fact, certain stabilized ketoazetidines can maintain their in vitro potency and inhibit DPP IV in the plasma for up to 6h...
  3. ncbi request reprint Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, MA 21224, USA
    Bioorg Med Chem Lett 13:2513-8. 2003
    ..The general synthetic routes are presented herein as well as thorough in vitro potencies and SAR discussion for selected derivatives...
  4. ncbi request reprint Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Bioorg Med Chem 11:3695-707. 2003
    ..Furthermore, one such inhibitor (5g, IC(50)=26 nM) demonstrated significant reduction of infarct volume in the rat model of permanent focal cerebral ischemia...
  5. pmc Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine
    Jesse Alt
    Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Anal Biochem 419:106-9. 2011
    ..Plasma D-Serine determination using this assay could also be used as pharmacodynamic marker and as biomarker...
  6. ncbi request reprint DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice
    Susan L Lautar
    Guilford Pharmaceuticals, Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Brain Res 1048:177-84. 2005
    ..Taken together, these data suggest that the antipsychotic effects of AMAC are the result of DPP IV inhibition...
  7. pmc Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system
    Mohamed H Farah
    Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:5744-54. 2011
    ..These observations were reproduced in part by pharmacological inhibition of BACE1. These data suggest BACE1 inhibition as a therapeutic approach to accelerate regeneration and recovery after peripheral nerve damage...
  8. ncbi request reprint Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries
    Dana Ferraris
    Guilford Pharmaceuticals Inc, 6611 Tributary Street, Baltimore, Maryland 21224, USA
    J Med Chem 46:3138-51. 2003
    ..Most importantly, three compounds from this series demonstrated statistically significant protective effects in rat models of stroke and heart ischemia...
  9. pmc Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
    Susan P Yates
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
    Biochem J 385:667-75. 2005
    ..The present study provides insight into the important features required for inhibitors that mimic NAD+ and their binding to the mono-ADPRT family of toxins...
  10. doi request reprint Synthesis and biological evaluation of D-amino acid oxidase inhibitors
    Dana Ferraris
    MGI Pharma, Inc
    J Med Chem 51:3357-9. 2008
    ..Oral administration of CBIO in conjunction with d-serine enhanced the plasma and brain levels of d-serine in rats compared to the oral administration of d-serine alone...