Christian Meyer

Summary

Country: USA

Publications

  1. ncbi request reprint Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration
    Mandeep Bajaj
    School of Life Sciences, Arizona State University, P O Box 874501, Tempe, AZ 85287 4501, USA
    Diabetes 56:743-52. 2007
  2. ncbi request reprint Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans
    Christian Meyer
    Department of Medicine, University of Roichester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 285:E819-26. 2003
  3. ncbi request reprint Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 287:E1049-56. 2004
  4. ncbi request reprint Increased renal glucose metabolism in Type 1 diabetes mellitus
    C Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, USA
    Diabet Med 22:453-9. 2005
  5. ncbi request reprint Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans
    Niyaz R Gosmanov
    Carl T Hayden VA Medical Center, 650 E Indian School Road, Phoenix, AZ 85012, USA
    Diabetes Care 28:1124-31. 2005
  6. ncbi request reprint A potential important role of skeletal muscle in human counterregulation of hypoglycemia
    Christian Meyer
    Carl T Hayden Veteran Affairs Medical Center, Department of Endocrinology, 650 East Indian School Road, Phoenix, Arizona 85012, USA
    J Clin Endocrinol Metab 90:6244-50. 2005
  7. ncbi request reprint Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E67-E77. 2006
  8. ncbi request reprint Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 52:1386-92. 2003
  9. doi request reprint Metabolic fate of plasma glucose during hyperglycemia in impaired glucose tolerance: evidence for further early defects in the pathogenesis of type 2 diabetes
    Syed Bokhari
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Am J Physiol Endocrinol Metab 296:E440-4. 2009
  10. ncbi request reprint Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Metabolism 55:78-83. 2006

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration
    Mandeep Bajaj
    School of Life Sciences, Arizona State University, P O Box 874501, Tempe, AZ 85287 4501, USA
    Diabetes 56:743-52. 2007
    ..Changes in expression of nuclear-encoded mitochondrial genes do not always correlate with changes in insulin sensitivity...
  2. ncbi request reprint Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans
    Christian Meyer
    Department of Medicine, University of Roichester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 285:E819-26. 2003
    ....
  3. ncbi request reprint Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 287:E1049-56. 2004
    ..The latter may provide an explanation for the renal glycogen accumulation characteristic of diabetes mellitus as well as a mechanism by which hyperglycemia may lead to diabetic nephropathy...
  4. ncbi request reprint Increased renal glucose metabolism in Type 1 diabetes mellitus
    C Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, USA
    Diabet Med 22:453-9. 2005
    ..However, whether glucose uptake by the diabetic kidney is actually increased, especially in patients with Type 1 diabetes, is unclear...
  5. ncbi request reprint Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans
    Niyaz R Gosmanov
    Carl T Hayden VA Medical Center, 650 E Indian School Road, Phoenix, AZ 85012, USA
    Diabetes Care 28:1124-31. 2005
    ..However, in humans this role of decreased intraislet insulin is still unclear...
  6. ncbi request reprint A potential important role of skeletal muscle in human counterregulation of hypoglycemia
    Christian Meyer
    Carl T Hayden Veteran Affairs Medical Center, Department of Endocrinology, 650 East Indian School Road, Phoenix, Arizona 85012, USA
    J Clin Endocrinol Metab 90:6244-50. 2005
    ..Skeletal muscle appears to be primarily responsible for the reduced SGU and may be important for the increased EGR by providing lactate for gluconeogenesis (GN)...
  7. ncbi request reprint Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E67-E77. 2006
    ..g., liver and muscle) into other tissues...
  8. ncbi request reprint Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 52:1386-92. 2003
    ....
  9. doi request reprint Metabolic fate of plasma glucose during hyperglycemia in impaired glucose tolerance: evidence for further early defects in the pathogenesis of type 2 diabetes
    Syed Bokhari
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Am J Physiol Endocrinol Metab 296:E440-4. 2009
    ..An increased proportion of plasma glucose hence undergoes nonoxidative glycolysis, representing a novel early abnormality in the pathogenesis of T2DM...
  10. ncbi request reprint Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Metabolism 55:78-83. 2006
    ..This differential effect on insulin secretion may be an important factor in explaining why glyburide causes severe hypoglycemia more frequently than glimepiride...
  11. ncbi request reprint Multiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus
    Zarmen Israelian
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, and Department of Medicine, University of Rochester School of Medicine, NY 14642, USA
    Metabolism 55:593-8. 2006
    ..These include delayed and reduced decreases in insulin secretion, and impaired increases of plasma glucagon and growth hormone...
  12. ncbi request reprint Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes 52:918-25. 2003
    ....
  13. ncbi request reprint Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes
    Zarmen Israelian
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Diabetes Care 28:2691-6. 2005
    ..The present studies were therefore undertaken to test the hypothesis that these may be improved by increasing this decrement in insulin secretion...
  14. pmc Different pathophysiology of impaired glucose tolerance in first-degree relatives of individuals with type 2 diabetes mellitus
    Peter Emerson
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Metabolism 58:602-7. 2009
    ..We conclude that, in IGT, an increased genetic predisposition for T2DM increases the contribution of impaired insulin secretion to its pathophysiology. This effect is enhanced by obesity...
  15. ncbi request reprint Pathways for glucose disposal after meal ingestion in humans
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 284:E716-25. 2003
    ..The majority of glycogen is formed via the direct pathway ( approximately 73%)...
  16. ncbi request reprint Exogenous insulin replacement in type 2 diabetes reverses excessive hepatic glucose release, but not excessive renal glucose release and impaired free fatty acid clearance
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY, USA
    Metabolism 51:1494-500. 2002
    ..04) and was similar to DM(-) (7.3 +/- 0.5 mL x kg(-1) x min(-1), P >.9). We conclude that in contrast to the excessive HGR, excessive RGR and impaired FFA clearance are not corrected by acute exogenous insulin replacement...
  17. ncbi request reprint Renal substrate exchange and gluconeogenesis in normal postabsorptive humans
    Christian Meyer
    Department of Medicine and Physiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 282:E428-34. 2002
    ....
  18. ncbi request reprint Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes Care 31:539-43. 2008
    ..To examine the effect of aging on insulin secretion (first- and second-phase insulin release) and insulin sensitivity in people with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT)...
  19. ncbi request reprint Paradoxical changes of muscle glutamine release during hyperinsulinemia euglycemia and hypoglycemia in humans: further evidence for the glucose-glutamine cycle
    Christian Meyer
    Carl T Hyden VA Medical Center, Phoenix, AZ 85012, USA
    Metabolism 53:1208-14. 2004
    ....
  20. ncbi request reprint Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 282:E419-27. 2002
    ..We postulate that increases in postprandial renal glucose release may play a role in facilitating efficient liver glycogen repletion by permitting substantial suppression of hepatic glucose release...
  21. ncbi request reprint Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Arch Intern Med 164:1627-32. 2004
    ....
  22. ncbi request reprint Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans
    Christian Meyer
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Diabetes Care 29:1909-14. 2006
    ..To compare the pathophysiology of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in a more comprehensive and standardized fashion than has hitherto been done...
  23. ncbi request reprint Role of the kidney in hyperglycemia in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Box MED CRC, Rochester, NY 14642, USA
    Curr Diab Rep 2:237-41. 2002
    ....
  24. pmc Glulisine versus human regular insulin in combination with glargine in noncritically ill hospitalized patients with type 2 diabetes: a randomized double-blind study
    Christian Meyer
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, Arizona, USA
    Diabetes Care 33:2496-501. 2010
    ..To compare the efficacy and safety of the rapid-acting insulin analog glulisine and regular insulin in hyperglycemic hospitalized patients...
  25. doi request reprint Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    ..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
  26. ncbi request reprint Renal gluconeogenesis: its importance in human glucose homeostasis
    J E Gerich
    Department of Medicine, University of Rochester, New York 14642, USA
    Diabetes Care 24:382-91. 2001
    ....
  27. doi request reprint Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the Veterans Affairs Diabetes Trial (VADT)
    Peter D Reaven
    Carl T Hayden VA Medical Center, Phoenix, Arizona 85012 1892, USA
    Diabetes Care 31:952-7. 2008
    ..We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC)...
  28. ncbi request reprint Islet transplantation
    Christian Meyer
    N Engl J Med 356:963; author reply 964-5. 2007
  29. ncbi request reprint Effects of angiotensin II type 1 receptor blockade on beta-cell function in humans
    Syed Bokhari
    Diabetes Care 30:181. 2007
  30. ncbi request reprint Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes
    Andreas Kjaer
    Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Nucl Med 44:19-23. 2003
    ..In addition, we studied the effect of acute angiotensin-converting enzyme (ACE) inhibition on the flow response...
  31. ncbi request reprint Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy: normalisation by acute angiotensin-converting enzyme inhibition
    Birger Hesse
    Department of Clinical Physiology and Nuclear Medicine, KF 4011, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 31:362-8. 2004
    ..It is concluded that acute ACE inhibition with perindoprilat improves maximal achieved myocardial perfusion in non-hypertensive patients with diabetes and LVH...
  32. pmc Relation between awareness of circulatory disorders and smoking in a general population health examination
    Ulrich John
    University of Greifswald, Institute of Epidemiology and Social Medicine, Walther Rathenau Str 48, D 17487, Germany
    BMC Public Health 6:48. 2006
    ..Little is known about proportions of smokers who maintain smoking after they are aware of a circulatory disorder. The goal was to analyze the extent to which the number of circulatory disorders may be related to being a current smoker...
  33. ncbi request reprint Clinical research for patient empowerment--a qualitative approach on the improvement of heart health promotion in chronic illness
    Christian Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, Europian Master in Health Promotion, University of Aachen, Medical Clinic I, Aachen, Germany
    Med Sci Monit 14:CR358-65. 2008
    ..The aim of the present study was to investigate whether theory-based empowerment, using motivational interviewing, can be facilitated within clinical research in patients with severe chronic diseases...
  34. doi request reprint Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise
    Elena De Filippis
    Center for Metabolic Biology, Arizona State University, P O Box 873704 Tempe, AZ 85287 3704, USA
    Am J Physiol Endocrinol Metab 294:E607-14. 2008
    ..Insulin-resistant subjects have a reduced response of nuclear-encoded mitochondrial genes to exercise, and this could contribute to the origin and maintenance of mitochondrial dysfunction...
  35. ncbi request reprint Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy
    Andreas Kjaer
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet University Hospital, Copenhagen, Denmark
    Am J Cardiol 96:1692-8. 2005
    ..Endothelial dysfunction may contribute to the reduced perfusion reserve seen in hypertensive LVH...
  36. ncbi request reprint [Particulate matter and cardiovascular health in the European Union: time for prevention?]
    Christian Meyer
    Klinik fur Kardiologie, Pneumologie und Angiologie, Universitätsklinikum RWTH Aachen, Aachen, Germany
    Med Klin (Munich) 102:899-903. 2007
    ..In conclusion, further investigations are necessary to deepen the understanding of PM exposure and its consequences for the cardiovascular system and evaluate the success of preventive strategies...
  37. ncbi request reprint Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo
    Erica E Edison
    Dept of Biochemistry, Memorial Univ of Newfoundland, St John s, NL, Canada, A1B 3X9
    Am J Physiol Renal Physiol 293:F1799-804. 2007
    ..9 microM. In humans, [GAA] was 2.4 microM in arterial plasma, with a renal A-V difference of -1.1 microM. These studies show, for the first time, that GAA is produced by both rat and human kidneys in vivo...
  38. ncbi request reprint Predictors of increased body mass index following cessation of smoking
    Ulrich John
    University of Greifswald, Institute of Epidemiology and Social Medicine, Greifswald, Germany
    Am J Addict 15:192-7. 2006
    ..They concluded that IAW after quitting might be a specific determinant of the BMI increase following smoking cessation in a subgroup of smokers...