R Wunderink

Summary

Affiliation: Methodist Healthcare
Country: USA

Publications

  1. ncbi " 'Tis a gift to be simple..."
    Richard G Wunderink
    Chest 124:777-8. 2003
  2. pmc Science review: Genetic variability in the systemic inflammatory response
    Grant W Waterer
    Department of Medicine, University of Western Australia, Australia
    Crit Care 7:308-14. 2003
  3. ncbi Filgrastim in patients with pneumonia and severe sepsis or septic shock
    R Wunderink
    University of Tennessee, College of Medicine, Memphis, TN, USA
    Chest 119:523-9. 2001
  4. ncbi Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia
    Richard G Wunderink
    Methodist Healthcare Memphis and the University of Tennessee, Memphis, Tennessee 38104 3499, USA
    Clin Ther 25:980-92. 2003
  5. ncbi Genetics of sepsis and pneumonia
    Richard G Wunderink
    Research Department, Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
    Curr Opin Crit Care 9:384-9. 2003
  6. ncbi Tumor necrosis factor gene polymorphisms and the variable presentation and outcome of community-acquired pneumonia
    Richard G Wunderink
    Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN, USA
    Chest 121:87S. 2002
  7. ncbi Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia
    Richard G Wunderink
    Methodist Healthcare Memphis and the University of Tennessee, Memphis, TN 38104 3499, USA
    Chest 124:1789-97. 2003
  8. ncbi Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia
    Michael W Quasney
    Division of Critical Care, Department of Pediatrics, University of Tennessee, Memphis, Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap, Memphis, TN 38103, USA
    Crit Care Med 32:1115-9. 2004
  9. ncbi Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgery
    Sachin Yende
    Methodist Healthcare University Hospital, Memphis, TN, USA
    Crit Care Med 31:133-40. 2003
  10. ncbi Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgery
    Sachin Yende
    Methodist Healthcare and University of Tennessee, Memphis, TN 38104, USA
    Chest 121:86S. 2002

Detail Information

Publications42

  1. ncbi " 'Tis a gift to be simple..."
    Richard G Wunderink
    Chest 124:777-8. 2003
  2. pmc Science review: Genetic variability in the systemic inflammatory response
    Grant W Waterer
    Department of Medicine, University of Western Australia, Australia
    Crit Care 7:308-14. 2003
    ..However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions...
  3. ncbi Filgrastim in patients with pneumonia and severe sepsis or septic shock
    R Wunderink
    University of Tennessee, College of Medicine, Memphis, TN, USA
    Chest 119:523-9. 2001
    ....
  4. ncbi Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia
    Richard G Wunderink
    Methodist Healthcare Memphis and the University of Tennessee, Memphis, Tennessee 38104 3499, USA
    Clin Ther 25:980-92. 2003
    ....
  5. ncbi Genetics of sepsis and pneumonia
    Richard G Wunderink
    Research Department, Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
    Curr Opin Crit Care 9:384-9. 2003
    ..Recent association studies in pneumonia and sepsis will be reviewed...
  6. ncbi Tumor necrosis factor gene polymorphisms and the variable presentation and outcome of community-acquired pneumonia
    Richard G Wunderink
    Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN, USA
    Chest 121:87S. 2002
  7. ncbi Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia
    Richard G Wunderink
    Methodist Healthcare Memphis and the University of Tennessee, Memphis, TN 38104 3499, USA
    Chest 124:1789-97. 2003
    ..To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA)...
  8. ncbi Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia
    Michael W Quasney
    Division of Critical Care, Department of Pediatrics, University of Tennessee, Memphis, Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap, Memphis, TN 38103, USA
    Crit Care Med 32:1115-9. 2004
    ..The objective was to determine whether the SP-B + 1580 CC genotype is associated with an increased risk of respiratory failure and ARDS in adults with community-acquired pneumonia...
  9. ncbi Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgery
    Sachin Yende
    Methodist Healthcare University Hospital, Memphis, TN, USA
    Crit Care Med 31:133-40. 2003
    ....
  10. ncbi Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgery
    Sachin Yende
    Methodist Healthcare and University of Tennessee, Memphis, TN 38104, USA
    Chest 121:86S. 2002
  11. ncbi Clinical relevance of angiotensin-converting enzyme gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass graft surgery
    Sachin Yende
    Physician Research Network SY, Methodist Healthcare Memphis, Memphis, TN, USA
    Crit Care Med 32:922-7. 2004
    ..Therefore, we examined interactions between these polymorphisms...
  12. ncbi Use and limitations of clinical and radiologic diagnosis of pneumonia
    Matthew Mabie
    Research Department, Methodist University Hospital, Memphis, TN, USA
    Semin Respir Infect 18:72-9. 2003
    ..An accurate assessment of the normal, expected response of pneumonia to antibiotic therapy is therefore crucial. A discussion of the clinical response to treatment concludes the article...
  13. ncbi Pharmaceutical industry research and cost savings in community-acquired pneumonia
    Lori A Kessler
    Physicians Research Network, Methodist Le Bonheur Healthcare Foundation, Memphis, Tenn 38104, USA
    Am J Manag Care 8:798-800. 2002
    ..To provide financial justification for continuing pharmaceutical research in an environment that has met with increasing resistance from insurance carriers to paying for the care of patients enrolled in research studies...
  14. ncbi Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumonia
    Michael W Quasney
    Department of Pediatrics, Crippled Children s Foundation Research Center, University of Tennessee, Memphis, 38103, USA
    Chest 121:85S-86S. 2002
  15. doi Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
    Daniel H Kett
    Department of Medicine, Division of Pulmonary and Critical Care, The University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, FL, USA
    Crit Care Med 39:665-70. 2011
    ..To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection...
  16. ncbi A CAP on antibiotic duration
    Richard G Wunderink
    Am J Respir Crit Care Med 174:3-5. 2006
  17. ncbi Delayed administration of antibiotics and atypical presentation in community-acquired pneumonia
    Grant W Waterer
    University of Western Australia, School of Medicine and Pharmacology, 4th Floor MRF Building, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6847
    Chest 130:11-5. 2006
    ..We investigated the factors that predict a prolonged TFAD and their association with mortality...
  18. ncbi Potential impact of vancomycin pulmonary distribution on treatment outcomes in patients with methicillin-resistant Staphylococcus aureus pneumonia
    Marc H Scheetz
    Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois 60611, USA
    Pharmacotherapy 26:539-50. 2006
    ..The possibility of increased serum vancomycin concentrations as a method to optimize current treatment outcomes is also explored...
  19. ncbi [Assessment of patients with poor resolution of HAP]
    Richard G Wunderink
    Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine Chicago, Illinois, USA
    Enferm Infecc Microbiol Clin 23:52-7. 2005
    ..Biochemical markers may be more accurate than clinical but still don't discriminate between causes. The appropriate diagnostic strategy and treatment algorithms have not been fully addressed and more research is clearly needed...
  20. ncbi Healthcare-associated bacteremia: Stirring the mud
    Richard G Wunderink
    Crit Care Med 34:2685-6. 2006
  21. ncbi Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
    Lionel A Mandell
    McMaster University Medical School, Hamilton, Ontario, Canada
    Clin Infect Dis 44:S27-72. 2007
  22. pmc 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia
    Sachin Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 176:1129-37. 2007
    ..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
  23. doi Derivation of a triage algorithm for chest radiography of community-acquired pneumonia patients in the emergency department
    Demetrios N Kyriacou
    Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Acad Emerg Med 15:40-4. 2008
    ..Community-acquired pneumonia (CAP) accounts for 1.5 million emergency department (ED) patient visits in the United States each year...
  24. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  25. ncbi Genetics of community-acquired pneumonia
    Richard G Wunderink
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Respir Crit Care Med 26:553-62. 2005
    ..The real value of these genetic studies in CAP and other severe infections will be when the management of an individual patient can be optimized by therapy based on the individual's genotype for molecules important in outcome...
  26. ncbi Dollars and sense in the intensive care unit: the costs of ventilator-associated pneumonia
    Andrew F Shorr
    Crit Care Med 31:1582-3. 2003
  27. ncbi Methicillin-Resistant S. aureus Ventilator-Associated Pneumonia: Strategies to Prevent and Treat
    Anna P Lam
    Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Respir Crit Care Med 27:92-103. 2006
    ..Treatment with linezolid, which penetrates well into the lung, is associated with higher cure and survival rates. Further data are needed to evaluate the efficacy of new antibiotics in MRSA VAP...
  28. ncbi Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin
    Marin H Kollef
    Pulmonary and Critical Care Division, Department of Internal Medicine, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Intensive Care Med 30:388-94. 2004
    ..To assess the effect of baseline variables, including treatment, on clinical cure and survival rates in patients with Gram-positive, ventilator-associated pneumonia (VAP)...
  29. ncbi A long and winding road
    Richard G Wunderink
    Crit Care Med 32:1077-9. 2004
  30. ncbi Community-acquired pneumonia: pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infections
    Richard G Wunderink
    Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
    Infect Dis Clin North Am 18:743-59, vii. 2004
    ..This article reviews genetic variation in the molecules involved in the known patho-genic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response,and organ dysfunction...
  31. ncbi Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia
    Crit Care Med 31:1367-72. 2003
    ....
  32. ncbi High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigm
    Lala M Dunbar
    Louisiana State University Medical Center, New Orleans, Louisiana, USA
    Clin Infect Dis 37:752-60. 2003
    ..2% and 92.4% in the 750-mg and 500-mg groups, respectively. These data demonstrate that 750 mg of levofloxacin per day for 5 days is at least as effective as 500 mg per day for 10 days for treatment of mild-to-severe CAP...
  33. doi Evaluation of ICU admission criteria and diagnostic methods for patients with severe community-acquired pneumonia: current practice survey
    Marcos I Restrepo
    Chest 133:828-9. 2008
  34. doi There is no "cap" on the importance of community-acquired pneumonia in the ICU
    Andrew F Shorr
    Chest 133:590-2. 2008
  35. doi Health care-associated infection (HAI): a critical appraisal of the emerging threat-proceedings of the HAI Summit
    Marin H Kollef
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Infect Dis 47:S55-99; quiz S100-1. 2008
    ....
  36. ncbi Decreasing beta-lactam resistance in Pneumococci from the Memphis region: analysis of 2,152 isolates From 1996 to 2001
    Grant W Waterer
    Department of Medicine, University of Western Australia, Crawley, Australia
    Chest 124:519-25. 2003
    ..In recent years, we have seen a significant shift in antibiotic use away from beta-lactams toward the newer quinolones and macrolides. We hypothesized that these changes would cause a shift in pneumococcal antibiotic resistance patterns...
  37. ncbi Nosocomial pneumonia, including ventilator-associated pneumonia
    Richard G Wunderink
    Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
    Proc Am Thorac Soc 2:440-4. 2005
    ..Adequate treatment of an initial infection is required for reversal of the temporary immunoparalysis, whereas specific immunomodulatory therapies can reverse the markers of immunoparalysis and may decrease the risk of infection...
  38. ncbi Severe pseudomonal infections
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Curr Opin Crit Care 12:458-63. 2006
    ..To review the most recent data on severe Pseudomonas aeruginosa infections. The focus will be on clinical studies with an emphasis on the critically ill...
  39. ncbi Genetic susceptibility to pneumonia
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, GP0 Box X2213, Perth, Western Australia
    Clin Chest Med 26:29-38. 2005
    ..IL-10 and IL-1 receptor antagonist polymorphisms have an important role in the anti-inflammatory response. Specific organ dysfunction, such as ARDS or DIC, may be related to polymorphisms in specific effector genes...
  40. ncbi Medium-term survival after hospitalization with community-acquired pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
    Am J Respir Crit Care Med 169:910-4. 2004
    ....
  41. ncbi Slow response times: is it the pneumonia or the physician?
    Richard G Wunderink
    Crit Care Med 33:1429-30. 2005
  42. ncbi Genetic polymorphisms that predict outcome and need for treatment in cardiovascular disease
    Sachin Yende
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 12:420-5. 2006
    ..The focus is on risk of complications or differences in management, rather than only susceptibility to cardiovascular disease itself...