W Sun

Summary

Affiliation: Metabasis Therapeutics
Country: USA

Publications

  1. ncbi request reprint Isolation of a family of organic anion transporters from human liver and kidney
    W Sun
    Metabasis Therapeutics, Inc, San Diego, California 92121, USA
    Biochem Biophys Res Commun 283:417-22. 2001
  2. ncbi request reprint PAL31, a novel nuclear protein, expressed in the developing brain
    H Mutai
    Laboratory of Cellular Biochemistry, University of Tokyo, Tokyo, 113 8657, Japan
    Biochem Biophys Res Commun 274:427-33. 2000
  3. pmc Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
    R Planells-Cases
    Department of Biology, University of California, San Diego, La Jolla 92093 0319
    Proc Natl Acad Sci U S A 90:5057-61. 1993
  4. ncbi request reprint MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase
    W Sun
    Department of Pharmacology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Denver, Colorado 80262, USA
    J Biol Chem 275:24421-8. 2000
  5. ncbi request reprint Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression
    L Feng
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    Arch Biochem Biophys 307:361-8. 1993
  6. ncbi request reprint Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2)
    Z Sheng
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genomics 70:381-6. 2000
  7. ncbi request reprint Evidence for direct involvement of beta-catenin in phorbol ester-induced neurite outgrowth in GT1-1 hypothalamic neurones
    W Sun
    School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea
    J Neuroendocrinol 13:249-60. 2001
  8. ncbi request reprint Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase
    G K Dhoot
    Department of Basic Veterinary Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 OTU, UK
    Science 293:1663-6. 2001
  9. ncbi request reprint [Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes]
    W Sun
    Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Gan Zang Bing Za Zhi 9:300-2. 2001
  10. ncbi request reprint A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene
    W Sun
    Department of Biochemistry, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Matrix Biol 20:527-41. 2001

Collaborators

  • M Takeda
  • Y Xie
  • Y Huang
  • Y Cao
  • Y Wang
  • Yi Li
  • Caroline Cohen
  • Tomohisa Ogawa
  • J Yao
  • T Ikeda
  • Z Sheng
  • K Iwatsuki
  • S P Rivera
  • M T Kaartinen
  • S Tanaka
  • K Shiota
  • H Gomi
  • G K Dhoot
  • S Liu
  • H Mutai
  • T Sassa
  • X X Xu
  • R F Thompson
  • S Itohara
  • P Czernic
  • S T Saarikoski
  • O Hankinson
  • M D McKee
  • N Kaipatur
  • C P Emerson
  • M K Gustafsson
  • X Ai
  • D M Standiford
  • M Shinozaki
  • E Smith
  • Y Toyoshima
  • Z Fazili
  • N Hattori
  • E R Smith
  • J He
  • J A Tuppen
  • F B Dong
  • S Yagi
  • N Verbruggen
  • L Deslandes
  • A Savoure
  • C E Finch
  • B Visser
  • M Van Montagu
  • K Yoshimi
  • Y Marco
  • D K Lee
  • M Oda
  • L Feng
  • R Planells-Cases
  • K Rhee
  • C C Lee
  • H Cho
  • K Kim
  • Y Xia
  • E Soyoola
  • M Montal
  • C B Wilson
  • P Chanmugam
  • A V Ferrer-Montiel
  • D Hwang
  • W W Tang

Detail Information

Publications27

  1. ncbi request reprint Isolation of a family of organic anion transporters from human liver and kidney
    W Sun
    Metabasis Therapeutics, Inc, San Diego, California 92121, USA
    Biochem Biophys Res Commun 283:417-22. 2001
    ..These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters...
  2. ncbi request reprint PAL31, a novel nuclear protein, expressed in the developing brain
    H Mutai
    Laboratory of Cellular Biochemistry, University of Tokyo, Tokyo, 113 8657, Japan
    Biochem Biophys Res Commun 274:427-33. 2000
    ..Considering the primary structure of PAL31 and its spatiotemporal expression pattern, PAL31 is a novel nuclear protein related to the development of the brain through the proliferation of neuronal cells...
  3. pmc Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
    R Planells-Cases
    Department of Biology, University of California, San Diego, La Jolla 92093 0319
    Proc Natl Acad Sci U S A 90:5057-61. 1993
    ..Therefore, the cDNA clone hNR1 codes for a human brain NMDA receptor subunit cognate to the rodent and murine brain NR1 subunits...
  4. ncbi request reprint MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase
    W Sun
    Department of Pharmacology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Denver, Colorado 80262, USA
    J Biol Chem 275:24421-8. 2000
    ..MEKK2 activation of PRK2 is independent of MEKK2 regulation of the c-Jun NH(2)-terminal kinase pathway. MEKK2 activation of PRK2 results in a bifurcation of signaling for the dual control of MAPK pathways and PRK2 regulated responses...
  5. ncbi request reprint Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression
    L Feng
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    Arch Biochem Biophys 307:361-8. 1993
    ..Thus, the two COX isoforms were differentially expressed, and COX-2 was selectively induced in response to inflammatory stimuli in rats...
  6. ncbi request reprint Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2)
    Z Sheng
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genomics 70:381-6. 2000
    ..The information about the gene structure of DAB2 will enable us to analyze possible mutations and the mechanisms of loss of DAB2 expression in tumors...
  7. ncbi request reprint Evidence for direct involvement of beta-catenin in phorbol ester-induced neurite outgrowth in GT1-1 hypothalamic neurones
    W Sun
    School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea
    J Neuroendocrinol 13:249-60. 2001
    ..Moreover, TPA was found to increase the transcription-activational roles of beta-catenin. Together, these data provide evidence that beta-catenin is involved in the TPA-induced functional differentiation of immortalized GnRH neurones...
  8. ncbi request reprint Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase
    G K Dhoot
    Department of Basic Veterinary Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 OTU, UK
    Science 293:1663-6. 2001
    ....
  9. ncbi request reprint [Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes]
    W Sun
    Research Center for Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Gan Zang Bing Za Zhi 9:300-2. 2001
    ..CONCLUSIONS: Combined gene therapy with IL-18 and CD/5FC can reduce the tumor volume and elicit the antitumor immunity of the host, which is superior to the single gene therapy for murine liver cancer...
  10. ncbi request reprint A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene
    W Sun
    Department of Biochemistry, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Matrix Biol 20:527-41. 2001
    ..YB-1 protein activates the collagen promoter and translocates into the nucleus during TGF-beta addition to fibroblasts, suggesting a role for this protein in TGF-beta signaling...
  11. ncbi request reprint [Study on anti-HBV effects by antisense oligodeoxynucleotides in vitro]
    S Liu
    Department of Microbiology and Immunology, Shandong University, Ji'nan 250012, China
    Zhonghua Yu Fang Yi Xue Za Zhi 35:338-40. 2001
    ..Using the 3-(4,5-dimethythiazol-xyl)-2,5-diphnyl tetrazolium bromide method, there was no cytotoxicity at 40 mumol/L of AsON. CONCLUSION: AsONs on three key region of X gene were effective drugs to inhibit the expression of HBV...
  12. ncbi request reprint [Sequencing and analysis of a cDNA clone CO111 of Plasmodium falciparum]
    Y Wang
    Department of Immunology, Zunyi Medical College, Zunyi 563003
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17:285-7. 1999
    ..Comparison among cDNA of P. falciparum from GenBank of EMBL showed that no sequence identical to this cDNA was found. CONCLUSION: A novel cDNA clone reacted with the antibodies against P. falciparum was isolated...
  13. ncbi request reprint Transglutaminase crosslinking of SIBLING proteins in teeth
    M T Kaartinen
    Division of Oral Biology, Faculty of Dentistry, McGill University, Strathcona Bldg Room M34, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    J Dent Res 84:607-12. 2005
    ....
  14. pmc Irsogladine maleate potentiates the effects of nitric oxide on activation of cAMP signalling pathways and suppression of mesangial cell mitogenesis
    J Yao
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Br J Pharmacol 151:457-66. 2007
    ..Irsogladine maleate (IM), an anti-ulcer drug, is reported to improve gastric blood flow via NO-dependent mechanisms. We, therefore, asked whether and how IM interacted with NO on glomerular mesangial cells...
  15. ncbi request reprint MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway
    W Sun
    Department of Pharmacology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Denver, CO 80262, USA
    J Biol Chem 276:5093-100. 2001
    ..MEKK2 and MEKK3 are differentially associated with signaling from specific upstream receptor systems, whereas both activate the MEK5-BMK1/ERK5 pathway...
  16. ncbi request reprint Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells
    Z Sheng
    Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Oncogene 19:4847-54. 2000
    ..Loss of Dab2 may contribute to the basement membrane-independent, disorganized proliferation of tumor cells in ovarian and breast carcinomas...
  17. ncbi request reprint Analysis of thymidine kinase gene expression in preimplantation mouse embryos
    D K Lee
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, Korea
    Mol Reprod Dev 39:259-67. 1994
    ..Also, it appears that the 5'-flanking sequence of TK may directly regulate the TK gene expression at the transcriptional level during preimplantation murine development...
  18. ncbi request reprint Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain
    W Sun
    Department of Biology, University of California, San Diego, La Jolla 92093 0319
    Neuroreport 5:441-4. 1994
    ..Hence, the HBGR2 subunit coassembles with the HBGR1 subunit to form heteromeric receptor channels akin to the glutamate receptors from rodent brain...
  19. ncbi request reprint Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle
    W Sun
    Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907
    Biochimie 75:931-6. 1993
    ..These clones will be used to evaluate the role of calpain expression in muscle hypertrophy...
  20. ncbi request reprint Differential expression of D-type G1 cyclins during mouse development and liver regeneration in vivo
    W Sun
    Department of Molecular Biology, Seoul National University, Korea
    Mol Reprod Dev 43:414-20. 1996
    ..In conclusion, this study indicates that cyclin D1 and D3 genes are differentially expressed in vivo in a tissue-specific, developmental stage-dependent, and cell cycle-dependent manner...
  21. ncbi request reprint Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H
    K Iwatsuki
    Laboratory of Cellular Biochemistry, Animal Resource Science Veterinary Medical Science, University of Tokyo, Japan
    Endocrinology 139:4976-83. 1998
    ..These data indicate that PLP-H and PLP-D are nonlactogenic hormones. Thus, we have cloned a new member of the PLP subfamily, PLP-H, which has features in common with PLP-C and PLP-D...
  22. ncbi request reprint Characterization of an Arabidopsis thaliana receptor-like protein kinase gene activated by oxidative stress and pathogen attack
    P Czernic
    Departement Planten genetica, Universiteit Gent, Belgium
    Plant J 18:321-7. 1999
    ..The involvement of At-RLK3 in signal transduction pathways during pathogen attack is discussed...
  23. ncbi request reprint Learning induces a CDC2-related protein kinase, KKIAMRE
    H Gomi
    Neuroscience Program, University of Southern California, Los Angeles, California 90089 2520, USA
    J Neurosci 19:9530-7. 1999
    ..These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory...
  24. ncbi request reprint A novel secretory protein produced by rat spongiotrophoblast
    K Iwatsuki
    Laboratory of Cellular Biochemistry, Animal Resource Science Veterinary Medical Science, University of Tokyo, Bunkyo ku, Tokyo 113, Japan
    Biol Reprod 62:1352-9. 2000
    ..Thus, we have identified and cloned a novel secretory protein, SSP, which is specifically expressed by rat spongiotrophoblast cells during the latter half of pregnancy...
  25. ncbi request reprint Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE
    T Sassa
    Laboratory for Behavioral Genetics, Brain Science Institute, RIKEN, Saitama, Japan
    J Neurochem 74:1809-19. 2000
    ..The gene was mapped on chromosomes 5 and 4 in mouse and human, respectively...
  26. pmc Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors
    W Sun
    Department of Biology, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 89:1443-7. 1992
    ..These results indicate that clone HBGR1 codes for a glutamate receptor of the kainate subtype cognate to members of the glutamate receptor family from rodent brain...
  27. ncbi request reprint Identification of novel dioxin-responsive genes by representational difference analysis
    S P Rivera
    Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA
    Xenobiotica 37:271-9. 2007
    ..Induction of these genes by dioxin in Hepa-1 cells was rapid. Furthermore, induction occurred in the presence of the protein synthesis inhibitor cycloheximide, indicating that in each case induction is a primary response...