G Zhou

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. pmc Role of AMP-activated protein kinase in mechanism of metformin action
    G Zhou
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 108:1167-74. 2001
  2. ncbi request reprint Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer
    G Zhou
    Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Mol Endocrinol 12:1594-604. 1998
  3. ncbi request reprint 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    X Fu
    Department of Atherosclerosis and Endocrinology, and Metabolic Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 276:38378-87. 2001
  4. ncbi request reprint L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding
    A Elbrecht
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 274:7913-22. 1999
  5. ncbi request reprint Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects
    J Berger
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 274:6718-25. 1999
  6. ncbi request reprint Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
    X Gan
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 276:48702-8. 2001
  7. ncbi request reprint Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresso
    J W Lawrence
    Department of Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Biol Chem 276:31521-7. 2001
  8. ncbi request reprint Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation
    B A Johnson
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Mol Biol 298:187-94. 2000
  9. ncbi request reprint Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation
    G Zhou
    Department of Metabolic Disorders, Merck Laboratories, Rahway, New Jersey 07065, USA
    Methods 25:54-61. 2001
  10. ncbi request reprint A simple quantitative FT-IR approach for the study of a polymorphic transformation under crystallization slurry conditions
    P J Skrdla
    Merck and Co, Inc, P O Box 2000, Rahway, NJ 07065, USA
    J Pharm Biomed Anal 25:731-9. 2001

Collaborators

Detail Information

Publications39

  1. pmc Role of AMP-activated protein kinase in mechanism of metformin action
    G Zhou
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 108:1167-74. 2001
    ..Activation of AMPK provides a unified explanation for the pleiotropic beneficial effects of this drug; these results also suggest that alternative means of modulating AMPK should be useful for the treatment of metabolic disorders...
  2. ncbi request reprint Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer
    G Zhou
    Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Mol Endocrinol 12:1594-604. 1998
    ..Relative affinities for the individual receptor-coactivator pairs were determined as follows: PPARgamma-CBP = ERalpha-SRC-1 > PPARgamma-SRC-1 >> ERalpha-CBP...
  3. ncbi request reprint 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    X Fu
    Department of Atherosclerosis and Endocrinology, and Metabolic Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 276:38378-87. 2001
    ..We conclude that 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload...
  4. ncbi request reprint L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding
    A Elbrecht
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 274:7913-22. 1999
    ..The results suggest a critical functional role for Cys313, and helix 3, in contributing to ligand binding and subsequent agonist-induced conformational changes...
  5. ncbi request reprint Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects
    J Berger
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 274:6718-25. 1999
    ....
  6. ncbi request reprint Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
    X Gan
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 276:48702-8. 2001
    ..These data indicate that activation of the Rho proteins may change the activation status of LXR...
  7. ncbi request reprint Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresso
    J W Lawrence
    Department of Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Biol Chem 276:31521-7. 2001
    ..These results suggest that other factors besides PPAR alpha levels determine the species-specific response of human and rat hepatocytes to the induction of PP...
  8. ncbi request reprint Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation
    B A Johnson
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Mol Biol 298:187-94. 2000
    ..Our results have important implications for the mechanisms by which antagonists, partial agonists, and agonists of nuclear receptor function operate...
  9. ncbi request reprint Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation
    G Zhou
    Department of Metabolic Disorders, Merck Laboratories, Rahway, New Jersey 07065, USA
    Methods 25:54-61. 2001
    ....
  10. ncbi request reprint A simple quantitative FT-IR approach for the study of a polymorphic transformation under crystallization slurry conditions
    P J Skrdla
    Merck and Co, Inc, P O Box 2000, Rahway, NJ 07065, USA
    J Pharm Biomed Anal 25:731-9. 2001
    ..Performing the experiment at various temperatures allowed the energy of activation for the process to be estimated (42 kJ/mol)...
  11. doi request reprint AMPK activators--potential therapeutics for metabolic and other diseases
    G Zhou
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, USA
    Acta Physiol (Oxf) 196:175-90. 2009
    ..Activators of AMPK that target selected tissues hold potential as novel therapeutics for diseases in which altered energy metabolism contributes to aetiology...
  12. ncbi request reprint Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma
    B Zhang
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 271:31771-4. 1996
    ..2) PPARgamma is phosphorylated in vivo by insulin stimulation or activation of the MAP kinase pathway. 3) MAP kinase is an important mediator of cross-talk between insulin signal transduction pathways and PPARgamma function...
  13. ncbi request reprint Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome
    R Morello
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 27:205-8. 2001
    ....
  14. ncbi request reprint Components of a new human protein kinase signal transduction pathway
    G Zhou
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606, USA
    J Biol Chem 270:12665-9. 1995
    ..Both MEK5 and ERK5 are expressed in many adult tissue and are abundant in heart and skeletal muscle. A recombinant GST-ERK5 kinase domain displays autophosphorylation on Ser/Thr and Tyr residues...
  15. ncbi request reprint p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively
    L Gelman
    Unité 325 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, 1, Rue du Prof Calmette, 59019 Lille Cedex, France
    J Biol Chem 274:7681-8. 1999
    ..p300/CBP displays itself at least two docking sites for PPARgamma located in its N terminus (between residues 1 and 113 for CBP) and in the middle of the protein (between residues 1099 and 1460)...
  16. ncbi request reprint A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway
    Z Yao
    Amgen, Inc, Boulder, Colorado 80301, USA
    J Biol Chem 274:2118-25. 1999
    ..These results indicate that HGK, a novel activator of the JNK pathway, may function through TAK1, and that the HGK --> TAK1 --> MKK4, MKK7 --> JNK kinase cascade may mediate the TNF-alpha signaling pathway...
  17. ncbi request reprint Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
    X Wu
    Department of Biological Chemistry and the Institute of Gerontology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:3265-71. 1996
    ..Interestingly, A-Raf does not activate MEK2, although c-Raf can activate both MEK1 and MEK2. Our data demonstrated that A-Raf is, indeed, a MEK1 activator and may play a role in growth factor signaling...
  18. ncbi request reprint A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice
    G Zhou
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    J Cell Sci 108:3677-84. 1995
    ....
  19. pmc Quantitative detection of single nucleotide polymorphisms for a pooled sample by a bioluminometric assay coupled with modified primer extension reactions (BAMPER)
    G Zhou
    Hitachi Ltd, Central Research Laboratory, 1-280 Higashi-Koigakubo, Kokubunji-shi, Tokyo 185-8601, Japan
    Nucleic Acids Res 29:E93. 2001
    ..The method is sensitive enough to detect 14 amol ssM13 DNA. The proposed method seems very promising in terms of realizing a cost-effective, large-scale human genetic testing system...
  20. ncbi request reprint Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed
    K A Brayton
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907
    J Biol Chem 269:5313-21. 1994
    ..Expression of a luciferase reporter from the GPAT promoter was approximately 3-4-fold higher than from the AIRC promoter. The GPAT gene was mapped to the q12 region of chromosome 4...
  21. ncbi request reprint Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells
    N Keshava
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505-2845, USA
    Mol Cell Biochem 222:69-76. 2001
    ..Also, cell transformation induced by BeSO4 may be attributed, in part, to the gene amplification of K-ras and c-jun and some BeSO4-induced transformed cells possess neoplastic potential resulting from genomic instability...
  22. ncbi request reprint Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice
    G Zhou
    Center for Neuroscience, University of Tennessee, Memphis, TN 38163, USA
    Mol Vis 7:253-60. 2001
    ..Rara is of particular interest because this gene is a candidate for Nnc1, a QTL that controls retinal ganglion cell proliferation...
  23. ncbi request reprint Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: implications for pharmacogenomic association studies
    H Wang
    Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing 100850 PR China
    Ann Hum Genet 68:563-73. 2004
    ..Our data will benefit genetic association studies of complex traits and drug response possibly related to these genes...
  24. ncbi request reprint A Chinese isolate of barley yellow dwarf virus-PAV represents a third distinct species within the PAV serotype
    F Liu
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, PR China
    Arch Virol 152:1365-73. 2007
    ..These data suggest that PAV-CN may have undergone a recombination event with GAV and that PAV-CN represents a third distinct species within the PAV serotype of BYDV...
  25. ncbi request reprint Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells
    C Zhang
    Institute of Pathology and Pathophysiology, Shandong University School of Medicine, Jinan 250012, People s Republic of China
    J Pathol 212:134-42. 2007
    ..Our results thus suggest that epigenetic inactivation of TMS1 expression is regulated by promoter hypermethylation and H3K9 modifications in a coordinated way...
  26. ncbi request reprint Gene expression profiling of breast cells induced by X-rays and heavy ions
    D Roy
    Department of Natural Sciences, Hostos College of the City University of New York, Bronx, NY 10541, USA
    Int J Mol Med 21:627-36. 2008
    ..A number of candidate genes reported here may be useful molecular biomarkers of radiation exposure in breast cells...
  27. ncbi request reprint Modulation of zeta-protein kinase C by cyclic AMP in PC12 cells occurs through phosphorylation by protein kinase A
    M W Wooten
    Department of Zoology, Auburn University, AL 36849-5414, USA
    J Neurochem 67:1023-31. 1996
    ..Taken together, these findings are consistent with the hypothesis that protein phosphorylation of PKC acts as a positive effector of its enzyme activity and may serve as a negative modulator for interaction with other proteins...
  28. pmc An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 16:4512-23. 1996
    ..Together, our results indicate that an 18-bp sequence in Col2a1 intron 1 controls chondrocyte expression and suggest that RCS cells and chondrocytes contain specific POU domain proteins involved in enhancer activity...
  29. ncbi request reprint Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo
    G Zhou
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:14989-97. 1998
    ..Overall our results suggest a model whereby both Sox9 and these other proteins bind to several HMG-like sites in the Col2a1 gene to cooperatively control its expression in cartilage...
  30. pmc The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
    F A Pereira
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:1037-49. 1999
    ..This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development...
  31. ncbi request reprint Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade
    G Zhou
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:13133-8. 1999
    ..Taken together, these studies establish a potential cascade of TGF-beta-activated interacting kinases beginning with HPK1, a Ste20 homolog, and ending in JNK1 activation: HPK1 --> TAK1 --> SEK --> JNK1...
  32. ncbi request reprint Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome
    S D Dreyer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA
    Nat Genet 19:47-50. 1998
    ..Furthermore, we provide evidence for the first described mutations in a LIM-homeodomain protein which account for an inherited form of abnormal skeletal patterning and renal failure...
  33. ncbi request reprint CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia
    G Zhou
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, 630E, Houston, TX 77030, USA
    Hum Mol Genet 8:2311-6. 1999
    ..Together these data show that variable loss of function due to alterations in the runt and PST domains of CBFA1 may give rise to clinical variability, including classic CCD, mild CCD and isolated primary dental anomalies...
  34. ncbi request reprint A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1
    D Ensenat
    Department of Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:33945-50. 1999
    ..Our results identify a novel protein, HIP-55, that binds to HPK1 and regulates the JNK1 signaling cascade...
  35. ncbi request reprint Partial cloning and sequencing of chick fibrillin-1 cDNA
    G Zhou
    Munroe Center for Human Genetics, University of Nebraska Medical Center, Omaha 68198 5430, USA
    In Vitro Cell Dev Biol Anim 36:19-25. 2000
    ..Antisense and sense riboprobes were synthesized and used in in situ hybridization in stage 14 chick embryos and high levels of FBN1 transcripts were observed in the heart...
  36. ncbi request reprint Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase
    Z Yao
    Amgen Inc, Boulder, Colorado 80301, USA
    J Biol Chem 272:32378-83. 1997
    ..Thus, MKK7 is a new member of the MAPK kinase family that functions upstream of SAPK/JNK in the SAPK/JNK signaling pathway...
  37. ncbi request reprint Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells
    G Zhou
    Department of Zoology, Auburn University, Auburn, Alabama 36849 5414, USA
    J Biol Chem 272:31130-7. 1997
    ..Taken together, the findings presented herein document that nucleolin is a target of PKC-zeta that serves to relay NGF signals from cell surface to nucleus in PC12 cells...
  38. ncbi request reprint Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction
    W Wang
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 272:22771-5. 1997
    ..Our results also suggest the potential roles of TAK1 not only in the TGF-beta pathway but also in the other HPK1/JNK1-mediated pathways...
  39. ncbi request reprint Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness
    Z Tang
    Liver Cancer Institute, Shanghai Medical University, China
    Chin Med J (Engl) 111:313-8. 1998
    ..To make a better understanding of the molecular mechanisms involved in recurrence and metastasis of the hepatocellular carcinoma (HCC), some invasion related oncogenes, and growth factors have been investigated...