Wei Qin Zhao

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. pmc Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption
    Wei Qin Zhao
    Department of Neurology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 285:7619-32. 2010
  2. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
  3. doi High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays
    Wei Qin Zhao
    Department of Neurology, Merck Research Laboratories, West Point, PA 19486, USA
    J Alzheimers Dis 25:655-69. 2011
  4. ncbi Amyloid beta oligomers induce impairment of neuronal insulin receptors
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, Hogan 5 110, Evanston, IL 60280, USA
    FASEB J 22:246-60. 2008
  5. pmc Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:1971-6. 2009
  6. doi Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    Wei Qin Zhao
    Alzheimer s Research, Merck Research Laboratories, West Point, PA 19486, USA
    Biochim Biophys Acta 1792:482-96. 2009

Detail Information

Publications6

  1. pmc Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption
    Wei Qin Zhao
    Department of Neurology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 285:7619-32. 2010
    ..Validation of this model in human disease would identify therapeutic targets for Alzheimer disease...
  2. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    ..Our results suggest that dysfunctions of brain insulin and IGF-1 receptors contribute to Abeta aggregation and subsequent synaptic loss...
  3. doi High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays
    Wei Qin Zhao
    Department of Neurology, Merck Research Laboratories, West Point, PA 19486, USA
    J Alzheimers Dis 25:655-69. 2011
    ..After automation, the assay proved to be highly reproducible and effective for high throughput screening of small molecules that inhibit Aβ(42) oligomerization...
  4. ncbi Amyloid beta oligomers induce impairment of neuronal insulin receptors
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, Hogan 5 110, Evanston, IL 60280, USA
    FASEB J 22:246-60. 2008
    ....
  5. pmc Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:1971-6. 2009
    ..The finding that synapse vulnerability to ADDLs can be mitigated by insulin suggests that bolstering brain insulin signaling, which can decline with aging and diabetes, could have significant potential to slow or deter AD pathogenesis...
  6. doi Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    Wei Qin Zhao
    Alzheimer s Research, Merck Research Laboratories, West Point, PA 19486, USA
    Biochim Biophys Acta 1792:482-96. 2009
    ..Thus both disease processes contribute to overlapping pathology, thereby compounding disease symptoms and progression...