Jinyou Zhang

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Toward consistent and productive complex media for industrial fermentations: studies on yeast extract for a recombinant yeast fermentation process
    Jinyou Zhang
    Bioprocess R and D, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065, USA
    Biotechnol Bioeng 82:640-52. 2003
  2. pmc Development of Animal-free, Protein-Free and Chemically-Defined Media for NS0 Cell Culture
    Jinyou Zhang
    Bioprocess R and D, Merck Research Laboratories, PO Box 2000, 07065, Rahway, NJ, USA
    Cytotechnology 48:59-74. 2005
  3. ncbi request reprint Cholesterol delivery to NS0 cells: challenges and solutions in disposable linear low-density polyethylene-based bioreactors
    Jessica Okonkowski
    Merck Research Laboratories, Bioprocess R and D, PO Box 2000, RY80Y 105, Rahway, NJ 07065, USA
    J Biosci Bioeng 103:50-9. 2007
  4. ncbi request reprint A novel function for selenium in biological system: selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production
    Jinyou Zhang
    Bioprocess R and D, Merck and Co, Inc, Rahway, New Jersey 07065, USA
    Biotechnol Bioeng 95:1188-97. 2006
  5. doi request reprint Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures
    Ashraf Amanullah
    Vaccine and Biologics Process Development, Merck Research Laboratories, Merck and Co Inc, West Point, Pennsylvania 19486, USA
    Biotechnol Bioeng 106:57-67. 2010
  6. ncbi request reprint Use of glucose feeding to produce concentrated yeast cells
    Beth H Junker
    Bioprocess R and D, Merck Research Laboratories, Merck and Co, Inc, Rahway, NJ, 07065, USA
    Appl Biochem Biotechnol 97:63-78. 2002

Collaborators

  • Michel Chartrain
  • Mark Mikola
  • Beth Junker
  • Ashraf Amanullah
  • Jessica Okonkowski
  • H Brett Schreyer
  • Amy Hsu
  • James A Hope
  • A Peter Russo
  • John Aunins
  • Jose Manuel Otero
  • Craig Seamans
  • David Robinson
  • Peter Salmon
  • Serena Fries
  • Uma Balasubramanian

Detail Information

Publications6

  1. ncbi request reprint Toward consistent and productive complex media for industrial fermentations: studies on yeast extract for a recombinant yeast fermentation process
    Jinyou Zhang
    Bioprocess R and D, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065, USA
    Biotechnol Bioeng 82:640-52. 2003
    ....
  2. pmc Development of Animal-free, Protein-Free and Chemically-Defined Media for NS0 Cell Culture
    Jinyou Zhang
    Bioprocess R and D, Merck Research Laboratories, PO Box 2000, 07065, Rahway, NJ, USA
    Cytotechnology 48:59-74. 2005
    ..The medium also served well for cryopreservation of NS0 cells in the absence of serum...
  3. ncbi request reprint Cholesterol delivery to NS0 cells: challenges and solutions in disposable linear low-density polyethylene-based bioreactors
    Jessica Okonkowski
    Merck Research Laboratories, Bioprocess R and D, PO Box 2000, RY80Y 105, Rahway, NJ 07065, USA
    J Biosci Bioeng 103:50-9. 2007
    ..Controlling and mitigating these negative interactions enabled the routine utilization of disposable bioreactors for the cultivation of cholesterol-dependent NS0 cell lines in conjunction with an animal component-free cultivation medium...
  4. ncbi request reprint A novel function for selenium in biological system: selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production
    Jinyou Zhang
    Bioprocess R and D, Merck and Co, Inc, Rahway, New Jersey 07065, USA
    Biotechnol Bioeng 95:1188-97. 2006
    ..The preparation of the commercially unavailable iron-selenite compound from respective ions, and its effectiveness in cell-culture performance, were dependent on reaction time, substrates, and other conditions...
  5. doi request reprint Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures
    Ashraf Amanullah
    Vaccine and Biologics Process Development, Merck Research Laboratories, Merck and Co Inc, West Point, Pennsylvania 19486, USA
    Biotechnol Bioeng 106:57-67. 2010
    ..Cell growth, process parameters, metabolic and protein titer profiles were also compared to those from shake flask, bench-top, and pilot scale bioreactor cultivations and found to be within +/-20% of the historical averages...
  6. ncbi request reprint Use of glucose feeding to produce concentrated yeast cells
    Beth H Junker
    Bioprocess R and D, Merck Research Laboratories, Merck and Co, Inc, Rahway, NJ, 07065, USA
    Appl Biochem Biotechnol 97:63-78. 2002
    ..These results suggest that defined medium developed at the laboratory scale may need to be further optimized at the pilot scale for equivalent performance...