Menghang Xia

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells
    M Xia
    Department of Molecular Pharmacology, Merck and Co, Inc, WP26A 2000, West Point, PA 19486, USA
    J Mol Cell Cardiol 36:111-9. 2004
  2. ncbi State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format
    Menghang Xia
    Department of Molecular Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA
    Anal Biochem 327:74-81. 2004
  3. ncbi Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels
    Menghang Xia
    Department of Molecular Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA
    Assay Drug Dev Technol 1:637-45. 2003
  4. ncbi Characterization and localization of a human serine racemase
    Menghang Xia
    Merck Research Laboratory, Department of Molecular Pharmacology, Merck and Co, Inc, 770 Sumneytown Pike, West Point, PA 19486, USA
    Brain Res Mol Brain Res 125:96-104. 2004
  5. ncbi NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles
    John A McCauley
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    J Med Chem 47:2089-96. 2004
  6. ncbi Identification of new human cadherin genes using a combination of protein motif search and gene finding methods
    Julia C Höng
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Mol Biol 337:307-17. 2004
  7. pmc Identification of a potent new chemotype for the selective inhibition of PDE4
    Amanda P Skoumbourdis
    NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892 3370, USA
    Bioorg Med Chem Lett 18:1297-303. 2008
  8. pmc Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening
    Ruili Huang
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892 3370, USA
    Chem Res Toxicol 21:659-67. 2008
  9. pmc A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker
    Ming Hsuang Cho
    NIH Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892 3370, USA
    Toxicol In Vitro 22:1099-106. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells
    M Xia
    Department of Molecular Pharmacology, Merck and Co, Inc, WP26A 2000, West Point, PA 19486, USA
    J Mol Cell Cardiol 36:111-9. 2004
    ..Taken together, these findings indicate that HL-1 cells express L- and T-subtypes of VGCC and are a unique in vitro model system for the study of native, mammalian cardiac Ca2+ channels...
  2. ncbi State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format
    Menghang Xia
    Department of Molecular Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA
    Anal Biochem 327:74-81. 2004
    ..Overall, this novel assay can be used to identify state-dependent calcium channel antagonists and should be useful for evaluating state-dependent inhibitory potency of a large number of samples...
  3. ncbi Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels
    Menghang Xia
    Department of Molecular Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA
    Assay Drug Dev Technol 1:637-45. 2003
    ..Overall, this inducible alpha1H Ca(2+) channel-expressing cell line is useful for the study of human T-type Ca(2+) channel function, and offers advantages over a similar cell line that constitutively expresses the channel...
  4. ncbi Characterization and localization of a human serine racemase
    Menghang Xia
    Merck Research Laboratory, Department of Molecular Pharmacology, Merck and Co, Inc, 770 Sumneytown Pike, West Point, PA 19486, USA
    Brain Res Mol Brain Res 125:96-104. 2004
    ..Furthermore, its presence in human periphery such as in heart and kidney suggest a potential biological role for D-serine in the regulation of N-methyl-D-aspartate (NMDA) receptor activity in these peripheral organs as well...
  5. ncbi NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles
    John A McCauley
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    J Med Chem 47:2089-96. 2004
    ..Benzimidazole 37a shows excellent activity in the carrageenan-induced mechanical hyperalgesia assay in rats as well as good pharmacokinetic behavior in dogs...
  6. ncbi Identification of new human cadherin genes using a combination of protein motif search and gene finding methods
    Julia C Höng
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Mol Biol 337:307-17. 2004
    ..The described methodology can be applied to discover new genes encoding proteins from families with well-characterized structural and functional domains...
  7. pmc Identification of a potent new chemotype for the selective inhibition of PDE4
    Amanda P Skoumbourdis
    NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892 3370, USA
    Bioorg Med Chem Lett 18:1297-303. 2008
    ..Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented...
  8. pmc Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening
    Ruili Huang
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892 3370, USA
    Chem Res Toxicol 21:659-67. 2008
    ..The performance of this clustering method is evaluated by comparing the clustering results against literature annotations of compound mechanisms...
  9. pmc A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker
    Ming Hsuang Cho
    NIH Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892 3370, USA
    Toxicol In Vitro 22:1099-106. 2008
    ..This cytotoxicity assay, combined with the qHTS platform, allowed us to quickly and efficiently evaluate compound toxicities related to cell membrane integrity...