Paul J Whiting

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Molecular and functional diversity of the expanding GABA-A receptor gene family
    P J Whiting
    Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, England, UK
    Ann N Y Acad Sci 868:645-53. 1999
  2. ncbi request reprint The GABA-A receptor gene family: new targets for therapeutic intervention
    P J Whiting
    Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Neurochem Int 34:387-90. 1999
  3. ncbi request reprint GABA-A receptors: a viable target for novel anxiolytics?
    Paul J Whiting
    Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Curr Opin Pharmacol 6:24-9. 2006
  4. ncbi request reprint The GABAA receptor gene family: new opportunities for drug development
    Paul J Whiting
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Curr Opin Drug Discov Devel 6:648-57. 2003
  5. ncbi request reprint GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?
    Paul J Whiting
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, UK CM20 2QR
    Drug Discov Today 8:445-50. 2003
  6. ncbi request reprint Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands
    Rosa L Fradley
    Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    J Psychopharmacol 21:384-91. 2007
  7. ncbi request reprint A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor
    Thomas W Rosahl
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 33:47-56. 2006
  8. pmc Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors
    Marcello Usala
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR
    Br J Pharmacol 140:1045-50. 2003
  9. ncbi request reprint Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors
    Sally Anne Thompson
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Essex, United Kingdom
    Mol Pharmacol 61:861-9. 2002
  10. ncbi request reprint Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms
    David S Reynolds
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Harlow, Essex CM20 2QR, United Kingdom
    J Neurosci 23:8608-17. 2003

Detail Information

Publications17

  1. ncbi request reprint Molecular and functional diversity of the expanding GABA-A receptor gene family
    P J Whiting
    Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, England, UK
    Ann N Y Acad Sci 868:645-53. 1999
    ..The structure, function, and distribution of theta-containing receptors, and receptors containing the recently reported epsilon subunit, are described...
  2. ncbi request reprint The GABA-A receptor gene family: new targets for therapeutic intervention
    P J Whiting
    Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK
    Neurochem Int 34:387-90. 1999
    ..The identification of these new members of the gene family, and the characterisation of the receptor subtypes into which they are incorporated, is reviewed...
  3. ncbi request reprint GABA-A receptors: a viable target for novel anxiolytics?
    Paul J Whiting
    Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Curr Opin Pharmacol 6:24-9. 2006
    ..However, it remains to be determined whether promising preclinical data are recapitulated in the clinic...
  4. ncbi request reprint The GABAA receptor gene family: new opportunities for drug development
    Paul J Whiting
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Curr Opin Drug Discov Devel 6:648-57. 2003
    ..In this review, we will primarily focus on progress achieved in the understanding of the function of this receptor family, and potential exploitation for drug development...
  5. ncbi request reprint GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?
    Paul J Whiting
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, UK CM20 2QR
    Drug Discov Today 8:445-50. 2003
    ....
  6. ncbi request reprint Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands
    Rosa L Fradley
    Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    J Psychopharmacol 21:384-91. 2007
    ....
  7. ncbi request reprint A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor
    Thomas W Rosahl
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 33:47-56. 2006
    ..The NR2B KI mice exhibited normal locomotor activity making this ifenprodil-insensitive mouse model a valuable tool to test the specificity of NR2B selective antagonists in vivo...
  8. pmc Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors
    Marcello Usala
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR
    Br J Pharmacol 140:1045-50. 2003
    ..IC50's were approximately 500 microm that likely exceed the therapeutic dose range for chlormethiazole, indicating that the primary mechanism of the compounds in vivo activity is via GABAA receptors...
  9. ncbi request reprint Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors
    Sally Anne Thompson
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Essex, United Kingdom
    Mol Pharmacol 61:861-9. 2002
    ....
  10. ncbi request reprint Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms
    David S Reynolds
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Harlow, Essex CM20 2QR, United Kingdom
    J Neurosci 23:8608-17. 2003
    ..These findings show that anesthesia and sedation are mediated by distinct GABA(A) receptor subtypes...
  11. ncbi request reprint Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines
    Rebecca Dias
    The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    J Neurosci 25:10682-8. 2005
    ..Together, these data show that potentiation of alpha3-containing GABA(A) receptors is sufficient to produce the anxiolytic effects of BZs and that alpha2 potentiation may not be necessary...
  12. ncbi request reprint Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors
    Peter B Wingrove
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Essex CM20 2QR, Harlow, UK
    Eur J Pharmacol 437:31-9. 2002
    ....
  13. ncbi request reprint Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor
    Neil Collinson
    Neuroscience Research Center, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, CM20 2QR, United Kingdom
    J Neurosci 22:5572-80. 2002
    ..These data suggest that alpha5-containing GABA(A) receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus...
  14. ncbi request reprint gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions
    Stephen L Boehm
    Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
    Biochem Pharmacol 68:1581-602. 2004
    ..However, three-way validation is hampered by the incomplete behavioral characterization of many of the mutant mice, and additional subunits are likely to be linked to alcohol actions as behavioral testing progresses...
  15. pmc Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors
    Brian L Jones
    Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Physiol 573:571-93. 2006
    ....
  16. ncbi request reprint Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes
    Se Eun Choi
    Department of Physiology, College of Veterinary Medicine Konkuk University, Seoul 143 701, Korea
    Arch Pharm Res 26:28-33. 2003
    ..This study suggests that ginsenosides regulated GABA(A) receptor expressed in Xenopus oocytes and implies that this regulation might be one of the pharmacological actions of Panax ginseng...
  17. ncbi request reprint DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    J Kirsty Millar
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
    Science 310:1187-91. 2005
    ..We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP...