Affiliation: Merck Research Laboratories
- Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjectsHao Wang
Department of Experimental Medicine, Merck Research Laboratories, North Wales, PA 19454 2505, USA
J Pain 9:1088-95. 2008..061). The relationship between the baseline area of hyperalgesia and assay sensitivity suggests that establishing minimum entry criteria for the baseline area of hyperalgesia requirement increases the sensitivity of the assay...
- Impact of responder definition on the enriched enrollment randomized withdrawal trial design for establishing proof of concept in neuropathic painDavid J Hewitt
Merck Research Laboratories, White house Station, NJ 19454, USA
Pain 152:514-21. 2011....
- Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonistsMark E Layton
Departments of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
ACS Chem Neurosci 2:352-62. 2011..Compound 22 was efficacious following oral administration in a spinal nerve ligation model of neuropathic pain and in an acute model of Parkinson's disease in a dose dependent manner...
- Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonistNigel J Liverton
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
J Med Chem 50:807-19. 2007..Compound 20j demonstrated efficacy in in vivo rodent models of antinociception, allodynia, and Parkinson's disease...