Hao Wang

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects
    Hao Wang
    Department of Experimental Medicine, Merck Research Laboratories, North Wales, PA 19454 2505, USA
    J Pain 9:1088-95. 2008
  2. doi request reprint Impact of responder definition on the enriched enrollment randomized withdrawal trial design for establishing proof of concept in neuropathic pain
    David J Hewitt
    Merck Research Laboratories, White house Station, NJ 19454, USA
    Pain 152:514-21. 2011
  3. pmc Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists
    Mark E Layton
    Departments of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    ACS Chem Neurosci 2:352-62. 2011
  4. ncbi request reprint Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist
    Nigel J Liverton
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Med Chem 50:807-19. 2007

Detail Information

Publications4

  1. doi request reprint Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects
    Hao Wang
    Department of Experimental Medicine, Merck Research Laboratories, North Wales, PA 19454 2505, USA
    J Pain 9:1088-95. 2008
    ..This platform may provide a means to rapidly assess new analgesics and enhance dose selection and decision-making during clinical development...
  2. doi request reprint Impact of responder definition on the enriched enrollment randomized withdrawal trial design for establishing proof of concept in neuropathic pain
    David J Hewitt
    Merck Research Laboratories, White house Station, NJ 19454, USA
    Pain 152:514-21. 2011
    ....
  3. pmc Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists
    Mark E Layton
    Departments of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    ACS Chem Neurosci 2:352-62. 2011
    ..Compound 22 was efficacious following oral administration in a spinal nerve ligation model of neuropathic pain and in an acute model of Parkinson's disease in a dose dependent manner...
  4. ncbi request reprint Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist
    Nigel J Liverton
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Med Chem 50:807-19. 2007
    ..Compound 20j demonstrated efficacy in in vivo rodent models of antinociception, allodynia, and Parkinson's disease...