Wei Tong

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi Coupling of UHPLC with fast fraction collection-microplate scintillation counting and MS for radiolabeled metabolite profiling
    Wei Tong
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA
    Bioanalysis 4:1299-309. 2012
  2. doi Quantitation of parent drug and its unstable metabolites by in situ coulometric oxidation and liquid chromatography-tandem mass spectrometry
    Wei Tong
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States
    Anal Chem 82:10251-7. 2010
  3. ncbi Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration
    Wei Tong
    Department of Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Mass Spectrom 41:1430-41. 2006
  4. doi Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 39:510-21. 2011
  5. doi An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS data
    Peijuan Zhu
    Drug Disposition, Pharmaceutical Sciences and Drug Metabolism, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033 1300, USA
    Anal Chem 81:5910-7. 2009
  6. doi A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices
    Peijuan Zhu
    Drug Disposition, Pharmaceutical Sciences, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 1300, USA
    Rapid Commun Mass Spectrom 23:1563-72. 2009
  7. ncbi Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Rd, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 34:628-35. 2006

Detail Information

Publications7

  1. doi Coupling of UHPLC with fast fraction collection-microplate scintillation counting and MS for radiolabeled metabolite profiling
    Wei Tong
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA
    Bioanalysis 4:1299-309. 2012
    ..2 s/fraction) followed by MSC using 384-deep-well LumaPlateā„¢ (PerkinElmer, MA, USA) for profiling of radiolabeled metabolites in plasma, urine, bile and feces...
  2. doi Quantitation of parent drug and its unstable metabolites by in situ coulometric oxidation and liquid chromatography-tandem mass spectrometry
    Wei Tong
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States
    Anal Chem 82:10251-7. 2010
    ....
  3. ncbi Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration
    Wei Tong
    Department of Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Mass Spectrom 41:1430-41. 2006
    ..A and C readily interconvert through hydration/dehydration, and B and C through addition/elimination of methanol present in the sample-processing solvents. Finally, NMR experiments were performed to confirm the structures of A and C...
  4. doi Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 39:510-21. 2011
    ....
  5. doi An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS data
    Peijuan Zhu
    Drug Disposition, Pharmaceutical Sciences and Drug Metabolism, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033 1300, USA
    Anal Chem 81:5910-7. 2009
    ..The ability to detect and identify metabolites from nonradiolabeled studies will be extremely beneficial to achieve compliance with FDA's most recent guidance on metabolites in safety testing (MIST)...
  6. doi A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices
    Peijuan Zhu
    Drug Disposition, Pharmaceutical Sciences, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 1300, USA
    Rapid Commun Mass Spectrom 23:1563-72. 2009
    ..Data from these types of studies are critical to meet the latest FDA guidance on Metabolite in Safety Testing (MIST)...
  7. ncbi Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Rd, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 34:628-35. 2006
    ..In conclusion, the formation of metabolites M1, M2, and M3 from lonafarnib was mediated via CYP3A4 and CYP3A5...