S Spence

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint The heart rate-corrected QT interval of conscious beagle dogs: a formula based on analysis of covariance
    S Spence
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Sci 45:247-58. 1998
  2. ncbi request reprint Effects of VLA-4 antagonists in rat whole embryo culture
    Stan Spence
    Developmental and Reproductive Toxicology, Merck Research Labs, West Point, Pennsylvania 19486, USA
    Teratology 65:26-37. 2002
  3. ncbi request reprint The Dutch-Belted rabbit: an alternative breed for developmental toxicity testing
    Stan Spence
    Developmental and Reproductive Toxicology, Safety Assessment Operations, Merck Research Laboratories WP45 118, West Point, PA 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 68:439-48. 2003
  4. ncbi request reprint Teratogenic effects of the endothelin receptor antagonist L-753,037 in the rat
    S Spence
    Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19486, USA
    Reprod Toxicol 13:15-29. 1999
  5. ncbi request reprint Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity
    Russell J Mortishire-Smith
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    Chem Res Toxicol 17:165-73. 2004
  6. ncbi request reprint An alternative Alcian Blue dye variant for the evaluation of fetal cartilage
    Brian G Redfern
    Developmental and Reproductive Toxicology, Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 80:171-6. 2007
  7. ncbi request reprint Assessment of female and male fertility in Sprague-Dawley rats administered vorinostat, a histone deacetylase inhibitor
    L David Wise
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 83:19-26. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The heart rate-corrected QT interval of conscious beagle dogs: a formula based on analysis of covariance
    S Spence
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Sci 45:247-58. 1998
    ....
  2. ncbi request reprint Effects of VLA-4 antagonists in rat whole embryo culture
    Stan Spence
    Developmental and Reproductive Toxicology, Merck Research Labs, West Point, Pennsylvania 19486, USA
    Teratology 65:26-37. 2002
    ..Although gene knockout phenotypes are not always manifested by pharmacological antagonism, those studies suggested that VLA-4 antagonists might cause embryo-lethality or drug-induced malformations...
  3. ncbi request reprint The Dutch-Belted rabbit: an alternative breed for developmental toxicity testing
    Stan Spence
    Developmental and Reproductive Toxicology, Safety Assessment Operations, Merck Research Laboratories WP45 118, West Point, PA 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 68:439-48. 2003
    ..Historical control data play a crucial role in the interpretation of observations made from developmental and reproductive toxicity studies...
  4. ncbi request reprint Teratogenic effects of the endothelin receptor antagonist L-753,037 in the rat
    S Spence
    Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19486, USA
    Reprod Toxicol 13:15-29. 1999
    ..The phenotype observed suggests that ET(A) receptor antagonism may have specific effects on cranial neural crest cell migration and/or proliferation...
  5. ncbi request reprint Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity
    Russell J Mortishire-Smith
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    Chem Res Toxicol 17:165-73. 2004
    ..The successful application of metabonomics to characterize an otherwise ill-defined mechanism of drug-induced toxicity supports the practicality of this approach for resolving toxicity issues for drugs in discovery and development...
  6. ncbi request reprint An alternative Alcian Blue dye variant for the evaluation of fetal cartilage
    Brian G Redfern
    Developmental and Reproductive Toxicology, Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 80:171-6. 2007
    ..However, the global supply of this specific dye has been exhausted. Several forms of the dye marketed as Alcian Blue 8GX are now available, although they are not synthesized via the original 8GX manufacturing process...
  7. ncbi request reprint Assessment of female and male fertility in Sprague-Dawley rats administered vorinostat, a histone deacetylase inhibitor
    L David Wise
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 83:19-26. 2008
    ..These compounds are now marketed or are in clinical development. One such HDAC inhibitor, vorinostat (suberoylanilide hydroxamic acid [SAHA], Zolinza), was assessed for its potential effects on fertility in Sprague-Dawley rats...