I C Sinka

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Measurement of density variations in tablets using X-ray computed tomography
    I C Sinka
    Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire EN11 9BU, UK
    Int J Pharm 271:215-24. 2004
  2. ncbi request reprint Analysis of tablet compaction. II. Finite element analysis of density distributions in convex tablets
    I C Sinka
    Merck Sharp and Dohme Ltd, Development Laboratories, Hertford Road, Hoddesdon, EN11 9BU, United Kingdom
    J Pharm Sci 93:2040-53. 2004
  3. ncbi request reprint Measurement of the flow properties of powders with special reference to die fill
    I C Sinka
    Merck Sharp and Dohme Ltd, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, UK
    Int J Pharm 280:27-38. 2004
  4. ncbi request reprint NMR imaging of density distributions in tablets
    A Djemai
    Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire EN11 9BU, UK
    Int J Pharm 319:55-62. 2006
  5. ncbi request reprint Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction
    J C Cunningham
    Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Pharm Sci 93:2022-39. 2004
  6. ncbi request reprint The effect of suction during die fill on a rotary tablet press
    S Jackson
    Department of Engineering, University of Leicester, Leicester, UK
    Eur J Pharm Biopharm 65:253-6. 2007

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Measurement of density variations in tablets using X-ray computed tomography
    I C Sinka
    Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire EN11 9BU, UK
    Int J Pharm 271:215-24. 2004
    ..Density maps in tablets manufactured under controlled conditions are presented. The results are discussed with reference to the local properties of the material within the tablet and the tablet design features...
  2. ncbi request reprint Analysis of tablet compaction. II. Finite element analysis of density distributions in convex tablets
    I C Sinka
    Merck Sharp and Dohme Ltd, Development Laboratories, Hertford Road, Hoddesdon, EN11 9BU, United Kingdom
    J Pharm Sci 93:2040-53. 2004
    ..Also, tablet regions having lower density locally have higher propensity for damage. The applicability of finite element analysis for optimizations of formulation design, process development, tablet image, and tool design is discussed...
  3. ncbi request reprint Measurement of the flow properties of powders with special reference to die fill
    I C Sinka
    Merck Sharp and Dohme Ltd, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, UK
    Int J Pharm 280:27-38. 2004
    ..The initial conditioning of the material, the die opening and if die filling takes place in air or in vacuum, however, were found to change the flow behaviour significantly...
  4. ncbi request reprint NMR imaging of density distributions in tablets
    A Djemai
    Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire EN11 9BU, UK
    Int J Pharm 319:55-62. 2006
    ....
  5. ncbi request reprint Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction
    J C Cunningham
    Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Pharm Sci 93:2022-39. 2004
    ..The constitutive model and frictional properties are essential experimental inputs to the finite element-based model described in the companion article...
  6. ncbi request reprint The effect of suction during die fill on a rotary tablet press
    S Jackson
    Department of Engineering, University of Leicester, Leicester, UK
    Eur J Pharm Biopharm 65:253-6. 2007
    ..The results demonstrate the improvement offered by suction and illustrate how a fundamental understanding of die fill phenomena could assist the selection of process parameters to maximise the operational speed of a rotary press...