P J Shughrue

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain
    Melinda E Wilson
    Department of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Mech Ageing Dev 123:593-601. 2002
  2. ncbi request reprint Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain
    Paul J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 143:1643-50. 2002
  3. ncbi request reprint Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study
    Paul J Shughrue
    Department of Neuroscience, Merck Research Laboratories, Sumneytown Pike and Broad Street, WP26A 3000, West Point, PA 19486, USA
    J Comp Neurol 465:372-84. 2003
  4. ncbi request reprint Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-beta
    Paul J Shughrue
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Prog Brain Res 139:15-29. 2002
  5. ncbi request reprint Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury
    P J Shughrue
    The Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Neuroscience 116:851-61. 2003
  6. ncbi request reprint Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 436:64-81. 2001
  7. ncbi request reprint Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERalpha and ERbeta)
    Paul J Shughrue
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Exp Neurol 190:468-77. 2004
  8. ncbi request reprint Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
  9. ncbi request reprint Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 388:507-25. 1997
  10. pmc Responses in the brain of estrogen receptor alpha-disrupted mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Proc Natl Acad Sci U S A 94:11008-12. 1997

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain
    Melinda E Wilson
    Department of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Mech Ageing Dev 123:593-601. 2002
    ..In summary, the expression of ERalpha and ERbeta mRNAs is differentially modulated in the aging brain and changes are region specific...
  2. ncbi request reprint Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain
    Paul J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 143:1643-50. 2002
    ..These data demonstrate the presence and functionality of an ERalpha variant in ERalpha/betaKO brain and suggest that the residual binding and regulation of PR in ERalpha/betaKO brain can be accounted for by the variant...
  3. ncbi request reprint Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study
    Paul J Shughrue
    Department of Neuroscience, Merck Research Laboratories, Sumneytown Pike and Broad Street, WP26A 3000, West Point, PA 19486, USA
    J Comp Neurol 465:372-84. 2003
    ..Moreover, these data provide a foundation for understanding the central actions of kinins and their putative role in mediating a number of processes, including pain and nociception...
  4. ncbi request reprint Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-beta
    Paul J Shughrue
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Prog Brain Res 139:15-29. 2002
    ....
  5. ncbi request reprint Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury
    P J Shughrue
    The Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Neuroscience 116:851-61. 2003
    ....
  6. ncbi request reprint Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 436:64-81. 2001
    ..Together, these data provide an anatomic foundation for future studies and advance our understanding of estrogen action in hypothalamic and extrahypothalamic brain regions...
  7. ncbi request reprint Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERalpha and ERbeta)
    Paul J Shughrue
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Exp Neurol 190:468-77. 2004
    ..This observation and the finding that estrogen affords some protection against MPTP suggest that estrogen may act via nuclear receptor independent mechanisms to protect dopamine neurons from toxins such as MPTP...
  8. ncbi request reprint Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
    ..These data provide the first evidence that ER beta mRNA is translated into a biologically active protein in the rodent brain...
  9. ncbi request reprint Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 388:507-25. 1997
    ..In addition, this comparative study provides evidence that the region-specific expression of ER-alpha, ER-beta, or both may be important in determining the physiological responses of neuronal populations to estrogen action...
  10. pmc Responses in the brain of estrogen receptor alpha-disrupted mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Proc Natl Acad Sci U S A 94:11008-12. 1997
    ..The results demonstrate that estrogen binds in the ERalphaKO brain and is capable of modulating PR gene expression, thus supporting the presence and functionality of a nonclassical estrogen receptor...
  11. ncbi request reprint Estrogen action in the estrogen receptor alpha-knockout mouse: is this due to ER-beta?
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Mol Psychiatry 3:299-302. 1998
    ..Moreover, the localization of ER-beta mRNA in many new brain regions, including those associated with learning and memory, may provide new insight about the anatomical substrate for estrogen action in the brain...
  12. ncbi request reprint Evidence for novel estrogen binding sites in the rat hippocampus
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, 145 King of Prussia Road, Radnor, PA 19087, USA
    Neuroscience 99:605-12. 2000
    ..These observations challenge our current thinking about steroid hormones and their mechanism(s) of action in a region associated with learning and memory and affected by the neurodegenerative conditions of aging...
  13. ncbi request reprint Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 138:5476-84. 1997
    ..Together, the results of these studies provide important information about the central activity of estrogens and provide evidence for their tissue-specifc actions in the rat...
  14. ncbi request reprint In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 372:395-414. 1996
    ....
  15. doi request reprint Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons
    P J Shughrue
    Department of Alzheimer s Research, Merck Research Laboratories, West Point, PA 19486, USA paul
    Neurobiol Aging 31:189-202. 2010
    ....
  16. ncbi request reprint Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 139:5267-70. 1998
    ....
  17. ncbi request reprint Expression of growth differentiation factor-9 messenger ribonucleic acid in ovarian and nonovarian rodent and human tissues
    S L Fitzpatrick
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 139:2571-8. 1998
    ..The function and relevance of nongonadal GDF-9 mRNA are not known, but may affect strategies for contraception and fertility that are based on GDF-9 activity...
  18. ncbi request reprint Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development
    C P Austin
    Department of Neuroscience, Merck Research Laboratories, WP26A 3000, PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, USA
    Neuroscience 124:3-10. 2004
    ..These results demonstrate that Disc1 marks the hippocampus from its earliest stages, and suggest that developmental Disc1 dysfunction may lead to defects in hippocampal function that are associated with schizophrenia...
  19. ncbi request reprint DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain
    Christopher P Austin
    Department of Neuroscience, Merck Reserach Laboratories, West Point, PA 19486, USA
    Neuroreport 14:951-4. 2003
    ..Given that many of these regions have been implicated in schizophrenia pathogenesis, these results suggest brain circuits through which DISC1 truncation may predispose to schizophrenia...
  20. ncbi request reprint Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment
    Brian D West
    Neuroscience Drug Discovery, Merck Research Laboratories, P O Box 4, WP44E 200, West Point, PA 19486, USA
    Pharmacol Biochem Behav 84:158-61. 2006
    ..Further, the potential for use of this endpoint to evaluate putative therapeutics is exemplified by the amelioration of these effects following pre-treatment with the MAO-B inhibitor selegiline...
  21. ncbi request reprint Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death
    Dena B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Endocrinology 147:3076-84. 2006
    ..These findings indicate that physiological levels of estradiol protect against delayed cell death after stroke-like injury through mechanisms requiring ERalpha...
  22. pmc Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Neurobiol Aging 29:1334-47. 2008
    ..A beta oligomers have been increasingly implicated as the main neurotoxins in AD, and the current results provide a unifying mechanism in which oligomer activity is directly linked to tau hyperphosphorylation in AD pathology...
  23. ncbi request reprint Neuroprotection by estrogen in animal models of global and focal ischemia
    Istvan Merchenthaler
    Women s Health Research Institute, Wyeth Research, Collegeville, Pennsylvania 19526, USA
    Ann N Y Acad Sci 1007:89-100. 2003
    ..Together, these observations demonstrate that estrogen protects from ischemic injury in both the focal and global ischemia models by acting primarily via classical nuclear receptors...
  24. ncbi request reprint Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1)
    Lei Ma
    Department of Neuroscience, West Point, Pennsylvania 19486, USA
    Genomics 80:662-72. 2002
    ..Identification of Disc1 will facilitate the study of DISC1's function and creation of mouse models of DISC1 disruption...
  25. ncbi request reprint Methods to enhance signal using isotopic in situ hybridization
    Betty Ky
    Merck Research Laboratories, Merck and Co, West Point, Pennsylvania 19486, USA
    J Histochem Cytochem 50:1031-7. 2002
    ..These two methods of enhancement independently and in combination demonstrated a dramatic increase in signal, allowing the visualization of low levels of gene expression previously undetectable by conventional methods...