M S Shearman

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Cellular MTT reduction distinguishes the mechanism of action of beta-amyloid from that of tachykinin receptor peptides
    M S Shearman
    Merck Sharp and Dohme Research Laboratories Neuroscience Research Centre, Harlow, Essex, UK
    Neuropeptides 30:125-32. 1996
  2. ncbi request reprint L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity
    M S Shearman
    Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, England
    Biochemistry 39:8698-704. 2000
  3. ncbi request reprint Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site
    N J Brandon
    Merck Sharp and Dohme Research Labs, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 28:613-24. 2005
  4. ncbi request reprint Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology
    D Beher
    Department of Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    J Biol Chem 276:45394-402. 2001
  5. ncbi request reprint Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor
    S Grimwood
    Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Neuropharmacology 48:1002-11. 2005
  6. ncbi request reprint Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay
    E E Clarke
    Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    J Neurosci Methods 102:61-8. 2000
  7. ncbi request reprint Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
    N J Brandon
    Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, CM20 2QR, UK
    Mol Cell Neurosci 25:42-55. 2004
  8. ncbi request reprint Gamma-secretase inhibition
    D Beher
    Department of Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Biochem Soc Trans 30:534-7. 2002
  9. ncbi request reprint Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia
    H Lewis
    Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Essex
    Neuropathol Appl Neurobiol 32:103-18. 2006
  10. ncbi request reprint Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
    H Steiner
    Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, 80036 Munich, Germany
    Neurobiol Dis 8:717-22. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Cellular MTT reduction distinguishes the mechanism of action of beta-amyloid from that of tachykinin receptor peptides
    M S Shearman
    Merck Sharp and Dohme Research Laboratories Neuroscience Research Centre, Harlow, Essex, UK
    Neuropeptides 30:125-32. 1996
    ....
  2. ncbi request reprint L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity
    M S Shearman
    Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, England
    Biochemistry 39:8698-704. 2000
    ..Specific and potent inhibitors of A beta PP gamma-secretase activity such as L-685,458 will enable important advances toward the identification and elucidation of the mechanism of action of this enigmatic protease...
  3. ncbi request reprint Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site
    N J Brandon
    Merck Sharp and Dohme Research Labs, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 28:613-24. 2005
    ....
  4. ncbi request reprint Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology
    D Beher
    Department of Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    J Biol Chem 276:45394-402. 2001
    ..Even though the beta-amyloid precursor protein cleavage and the S3 cleavage of the Notch receptor are inhibited by CBAP, an impairment of Trk receptor maturation was not observed...
  5. ncbi request reprint Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor
    S Grimwood
    Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Neuropharmacology 48:1002-11. 2005
    ....
  6. ncbi request reprint Quantitation of amyloid-beta peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay
    E E Clarke
    Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    J Neurosci Methods 102:61-8. 2000
    ....
  7. ncbi request reprint Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
    N J Brandon
    Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, CM20 2QR, UK
    Mol Cell Neurosci 25:42-55. 2004
    ....
  8. ncbi request reprint Gamma-secretase inhibition
    D Beher
    Department of Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Biochem Soc Trans 30:534-7. 2002
    ....
  9. ncbi request reprint Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia
    H Lewis
    Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Essex
    Neuropathol Appl Neurobiol 32:103-18. 2006
    ..Our findings suggest that brain Abeta accumulates increasingly with age in VaD subjects more so than in elderly without cerebrovascular disease and support the notion that they acquire Alzheimer-like pathology in older age...
  10. ncbi request reprint Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
    H Steiner
    Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, 80036 Munich, Germany
    Neurobiol Dis 8:717-22. 2001
    ..This finding indicates that gamma-secretase inhibitors, which are currently developed as therapeutic agents to lower the A beta burden in brains of AD patients, do not interfere with the UPR response...
  11. ncbi request reprint Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
    F G Gervais
    Department of Pharmacology, Biochemistry, and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Kirkland, Quebec, Canada
    Cell 97:395-406. 1999
    ..Caspases thus appear to play a dual role in proteolytic processing of APP and the resulting propensity for A beta peptide formation, as well as in the ultimate apoptotic death of neurons in Alzheimer's disease...
  12. ncbi request reprint Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity
    A L Brunkan
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 94:1315-28. 2005
    ....
  13. ncbi request reprint The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
    J Nunan
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Biochem 268:5329-36. 2001
    ..These results raise the possibility that defective proteasome function could lead to an increase in Abeta production in the AD brain...