D Shaw

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint 2-Aryl indole NK(1) antagonists: optimisation of the amide substituent
    D Shaw
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 11:3031-4. 2001
  2. ncbi request reprint 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors
    Duncan Shaw
    Department of Medicinal Chemistry, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:3073-7. 2006
  3. ncbi request reprint Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254
    C Fantz
    Department of Chemistry, Columbia, South Carolina, USA
    Mol Pharmacol 57:359-66. 2000

Collaborators

Detail Information

Publications3

  1. ncbi request reprint 2-Aryl indole NK(1) antagonists: optimisation of the amide substituent
    D Shaw
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 11:3031-4. 2001
    ..Replacement of this amine moiety by a 4-benzyl-4-hydroxypiperidine resulted in a compound 18 with reduced clearance and improved central duration of action...
  2. ncbi request reprint 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors
    Duncan Shaw
    Department of Medicinal Chemistry, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 16:3073-7. 2006
    ....
  3. ncbi request reprint Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254
    C Fantz
    Department of Chemistry, Columbia, South Carolina, USA
    Mol Pharmacol 57:359-66. 2000
    ..When compared with wild-type TS, the structure shows local conformational changes affecting mostly Asp-253; its carbonyl is rotated approximately 40 degrees, and the side chain forms an ion pair with Arg-225...