Beatriz A Rocha

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi 17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice
    Beatriz A Rocha
    Department of Pharmacology, Merck Research Laboratories, Rahway, NJ 07065, USA
    Psychopharmacology (Berl) 179:637-43. 2005
  2. ncbi Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice
    Beatriz A Rocha
    Merck Research Laboratories, Department of Pharmacology, RY80Y 140, PO Box 2000, Rahway, NJ 07065, USA
    Eur J Pharmacol 479:107-15. 2003
  3. ncbi Increased vulnerability to self-administer cocaine in mice prenatally exposed to cocaine
    Beatriz A Rocha
    Behavioral Neuroscience Branch, National Institute of Drug Abuse Intramureal Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:221-9. 2002
  4. ncbi Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice
    Beatriz A Rocha
    National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 22:10039-45. 2002
  5. ncbi Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice
    Andy N Mead
    Behavioural Neuroscience Branch, National Institute of Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 16:514-20. 2002
  6. ncbi Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice
    Agustin Zapata
    Integrative Neuroscience Section, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore MD 2122, USA
    Eur J Neurosci 17:590-6. 2003
  7. ncbi Sensitization of psychomotor stimulation and conditioned reward in mice: differential modulation by contextual learning
    Andy N Mead
    Behavioural Neuroscience Branch, The National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
    Neuropsychopharmacology 29:249-58. 2004
  8. pmc Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures
    Rafal M Kaminski
    Integrative Neuroscience Section, NIDA IRP, Baltimore, MD, USA
    Neurosci Lett 382:51-5. 2005
  9. ncbi Reinstatement of cocaine seeking in 129X1/SvJ mice: effects of cocaine priming, cocaine cues and food deprivation
    David A Highfield
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:417-24. 2002
  10. ncbi Intravenous cocaine-induced activity in A/J and C57BL/6J mice: behavioral sensitization and conditioned activity
    Andy N Mead
    Behavioral Neuroscience Branch, National Institute of Drug Abuse Intramural Research Program, Baltimore, MD 21222, USA
    Neuropharmacology 42:976-86. 2002

Detail Information

Publications11

  1. ncbi 17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice
    Beatriz A Rocha
    Department of Pharmacology, Merck Research Laboratories, Rahway, NJ 07065, USA
    Psychopharmacology (Berl) 179:637-43. 2005
    ..17beta-Estradiol (E2) induces expression of the enzyme implicated in 5-HT synthesis - tryptophan hydroxylase (TPH), and this effect is mediated through ER-beta located in 5-HT cell bodies of the dorsal raphe nucleus (DRN)...
  2. ncbi Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice
    Beatriz A Rocha
    Merck Research Laboratories, Department of Pharmacology, RY80Y 140, PO Box 2000, Rahway, NJ 07065, USA
    Eur J Pharmacol 479:107-15. 2003
    ..Overall, these studies provide evidence that cocaine dynamically acts at multiple sites through pathways that might be exchangeable under certain circumstances...
  3. ncbi Increased vulnerability to self-administer cocaine in mice prenatally exposed to cocaine
    Beatriz A Rocha
    Behavioral Neuroscience Branch, National Institute of Drug Abuse Intramureal Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:221-9. 2002
    ..At least 40,000 infants born each year in the U.S. are estimated to have been exposed to crack cocaine and, therefore, may be at risk for increased vulnerability to cocaine addiction...
  4. ncbi Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice
    Beatriz A Rocha
    National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 22:10039-45. 2002
    ..These findings strongly implicate 5-HT2C receptors in the serotonergic suppression of DA-mediated behavioral responses to cocaine and as a potential therapeutic target for cocaine abuse...
  5. ncbi Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice
    Andy N Mead
    Behavioural Neuroscience Branch, National Institute of Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 16:514-20. 2002
    ..In addition to existing data concerning the reinforcing effects of cocaine in DAT-KO mice, these data suggest a dissociation between the reinforcing and locomotor stimulant effects of cocaine...
  6. ncbi Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice
    Agustin Zapata
    Integrative Neuroscience Section, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore MD 2122, USA
    Eur J Neurosci 17:590-6. 2003
    ..Furthermore, control over cocaine infusion does not significantly alter the magnitude of the sensitized behavioural and presynaptic dopamine responses observed in response to a challenge dose of cocaine...
  7. ncbi Sensitization of psychomotor stimulation and conditioned reward in mice: differential modulation by contextual learning
    Andy N Mead
    Behavioural Neuroscience Branch, The National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
    Neuropsychopharmacology 29:249-58. 2004
    ....
  8. pmc Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures
    Rafal M Kaminski
    Integrative Neuroscience Section, NIDA IRP, Baltimore, MD, USA
    Neurosci Lett 382:51-5. 2005
    ..For all drugs tested, the response of NET-HT mice was always intermediate. These data provide further support for a role of endogenous NE in the control of seizure susceptibility...
  9. ncbi Reinstatement of cocaine seeking in 129X1/SvJ mice: effects of cocaine priming, cocaine cues and food deprivation
    David A Highfield
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:417-24. 2002
    ..Here we describe a reinstatement method for studying relapse to cocaine seeking in mice, a suitable species for studying the effect of genetic manipulations such as gene knockout or gene over-expression on compulsive drug use...
  10. ncbi Intravenous cocaine-induced activity in A/J and C57BL/6J mice: behavioral sensitization and conditioned activity
    Andy N Mead
    Behavioral Neuroscience Branch, National Institute of Drug Abuse Intramural Research Program, Baltimore, MD 21222, USA
    Neuropharmacology 42:976-86. 2002
    ..In summary, these data extend to the i.v. route of administration previous observations on cocaine-induced activity and conditioned activity...
  11. ncbi Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines
    Jose A Morón
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:389-95. 2002
    ..These data underscore the fact that which transporter clears dopamine from a given region depends on both the affinities and the local densities of the transporters...