Annette Robichaud

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway
    A Robichaud
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire, Dorval, Quebec, Canada H9R 4P8
    Neuropharmacology 40:262-9. 2001
  2. pmc Assessing the emetic potential of PDE4 inhibitors in rats
    A Robichaud
    Merck Frosst Centre for Therapeutic Research, P O Box 1005 Pointe Claire Dorval, Qc H9R 4P8 Canada
    Br J Pharmacol 135:113-8. 2002
  3. pmc Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
    Annette Robichaud
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Clin Invest 110:1045-52. 2002
  4. ncbi request reprint Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma
    Annette Robichaud
    Department of Biochemistry and Molecular Biology, Merck Centre for Therapeutic Research, P O Box 1005, Pointe Claire Dorval, PQ, H9R 4P8 Canada
    Am J Respir Cell Mol Biol 33:303-14. 2005
  5. ncbi request reprint Action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret
    Tasia S W Sam
    Emesis Research Group, Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Pharmacol Sci 103:189-200. 2007

Collaborators

Detail Information

Publications5

  1. ncbi request reprint PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway
    A Robichaud
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire, Dorval, Quebec, Canada H9R 4P8
    Neuropharmacology 40:262-9. 2001
    ....
  2. pmc Assessing the emetic potential of PDE4 inhibitors in rats
    A Robichaud
    Merck Frosst Centre for Therapeutic Research, P O Box 1005 Pointe Claire Dorval, Qc H9R 4P8 Canada
    Br J Pharmacol 135:113-8. 2002
    ..5. In summary, this model is functionally coupled to PDE4, specific to alpha(2)-adrenoceptors and relevant to PDE4 inhibitor-induced emesis. It therefore provides a novel way of evaluating the emetic potential of PDE4 inhibitors in rats...
  3. pmc Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
    Annette Robichaud
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Clin Invest 110:1045-52. 2002
    ..These findings strongly support the hypothesis that inhibition of PDE4D is pivotal to the anesthesia-reversing effect of PMNPQ and is likely responsible for emesis induced by PDE4 inhibitors...
  4. ncbi request reprint Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma
    Annette Robichaud
    Department of Biochemistry and Molecular Biology, Merck Centre for Therapeutic Research, P O Box 1005, Pointe Claire Dorval, PQ, H9R 4P8 Canada
    Am J Respir Cell Mol Biol 33:303-14. 2005
    ....
  5. ncbi request reprint Action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret
    Tasia S W Sam
    Emesis Research Group, Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Pharmacol Sci 103:189-200. 2007
    ..p., three times per day; P<0.05). Inhibition of the cyclooxygenase and lipoxygenase pathways does not account for the anti-emetic of dexamethasone...