Research Topics
Genomes and GenesSpecies | Marc L ReitmanSummaryAffiliation: Merck Research Laboratories Country: USA Publications
| Collaborators
|
Detail Information
Publications
Diet induction of monocyte chemoattractant protein-1 and its impact on obesityAiru Chen
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA
Obes Res 13:1311-20. 2005....- Characterization of adiposity and metabolism in Lmna-deficient miceDedra A Cutler
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
Biochem Biophys Res Commun 291:522-7. 2002..In conclusion, Lmna+/- and -/- mice do not mimic Dunnigan's FPLD, and differential expression of lamins A and C does not appear to contribute to sex- or tissue-specific LMNA phenotypes... - The fat and thin of lipinMarc L Reitman
Merck Research Laboratories, Rahway, New Jersey 07065, USA
Cell Metab 1:5-6. 2005..Interestingly, mice overexpressing lipin in muscle are insulin resistant, while those overexpressing lipin in adipose tissue are insulin sensitive... - FGF21: a missing link in the biology of fastingMarc L Reitman
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA
Cell Metab 5:405-7. 2007.... 
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicitySu Qian
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, USA
Basic Clin Pharmacol Toxicol 103:36-42. 2008..In conclusion, our data indicate that ME-1 deficiency does not adversely affect GSH-dependent detoxification...
Pharmacogenetics of metformin response: a step in the path toward personalized medicineMarc L Reitman
Metabolic Disorders Department, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA
J Clin Invest 117:1226-9. 2007..We discuss metformin, OCT1, pharmacogenetics, and how the integrative genomics revolution is likely to change our understanding and treatment of diabetes...- Metabolic lessons from genetically lean miceMarc L Reitman
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1770, USA
Annu Rev Nutr 22:459-82. 2002..Mechanisms to produce depleted adipocytes include increased energy expenditure by peripheral tissues, peripheral mechanisms to decrease food intake, and altered central regulation of these processes... - Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivityMartin Haluzik
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Building 10, Room 8N 250, 10 Center Drive, Bethesda, MD 20892 1770, USA
Diabetes 51:2113-8. 2002..These results suggest that the chronically increased serum corticosterone levels contribute to the diabetes of the A-ZIP/F-1 mice and that removal of the glucocorticoid excess improves the insulin sensitivity in both muscle and liver... - Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob miceMartin Haluzik
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 145:3258-64. 2004.... - Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesityJian Liu
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 20:2074-7. 2010..After oral administration, compound 9 had sufficient exposure in diet induced obese mice to demonstrate efficacy in lowering food intake and body weight via BRS-3 activation... - Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearanceMin Chen
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Building 10, Room 8C101, Bethesda, Maryland 20892 1752, USA
Endocrinology 145:4094-102. 2004..Further studies will clarify whether XLalphas deficiency is responsible for these effects and if so, the mechanism by which XLalphas deficiency leads to this metabolic phenotype... - Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearanceCarlo Colombo
Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:3992-9. 2003..Thus, it is likely that increased triglyceride clearance in B6, as compared with FVB, mice contributes to the strain differences in insulin resistance and lipid metabolism... - Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat massOksana Gavrilova
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:34268-76. 2003..Thus, liver PPAR gamma regulates triglyceride homeostasis, contributing to hepatic steatosis, but protecting other tissues from triglyceride accumulation and insulin resistance... - Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesityXiao Ming Guan
Merck Research Laboratories, Rahway, NJ 07065, USA
Cell Metab 11:101-12. 2010..These results demonstrate that BRS-3 has a role in energy homeostasis that complements several well-known pathways and that BRS-3 agonists represent a potential approach to the treatment of obesity... - Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatmentsJoseph M Metzger
Departments of Pharmacology, Rahway, NJ 07065, USA
Am J Physiol Endocrinol Metab 299:E816-24. 2010..The T(b) assay is a robust, information-rich assay that is simpler and has a greater throughput than measuring metabolic rate and is a practical, effective tool for drug discovery... - Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasisHyunsook Kim
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1758, USA
Diabetes 52:1770-8. 2003..Taken together, these findings suggest that the reduction in circulating or intracellular lipids by activation of PPAR-alpha improved insulin sensitivity and the diabetic condition of MKR mice... - 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesityRichard Berger
Department of Medicinal Chemistry, Merck and Co, Inc, 126 East Lincoln Ave, PO Box 2000, Rahway, NJ 07065 0900, USA
Bioorg Med Chem Lett 18:4833-7. 2008..Optimization of this series resulted in the discovery of isopropyl carboxamide 40, a CCK1R agonist with sub-nanomolar functional and binding activity as well as excellent potency in a mouse overnight food intake reduction assay... - The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerizationHarry R Chobanian
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
Bioorg Med Chem 20:2845-9. 2012..This would thereby make clinical development of this class of compounds more cost effective by inhibiting racemization which can occur over long periods of time at room/elevated temperature... - Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonistsLiping Wang
Department of Medicinal Chemistry, Merck and Co Inc, PO Box 2000, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 21:2911-5. 2011..A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and structurally diverse CCK1R agonist... - Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonistXiao Ming Guan
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey 07065 0900, USA
J Pharmacol Exp Ther 336:356-64. 2011..Our results demonstrate antiobesity efficacy for MK-5046 in rodents and dogs and further support BRS-3 agonism as a new approach to the treatment of obesity... - Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple speciesYue Feng
Department of Diabetes and Obesity, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Endocrinology 152:4106-15. 2011..Thus, in addition to its potential role in the treatment of obesity, BRS-3 may also regulate blood glucose levels and have a role in the treatment of diabetes mellitus... - Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patientsMarc L Reitman
Clinical Pharmacology, Merck Research Laboratories, Rahway, New Jersey 07065 0900, USA
J Clin Pharmacol 52:1306-16. 2012..Oral administration of MK-5046 achieves plasma concentrations that are projected to activate BRS-3 and therefore should be suitable for exploring its biological role in humans... - Leptin-replacement therapy for lipodystrophyElif Arioglu Oral
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1770, USA
N Engl J Med 346:570-8. 2002..Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic steatosis, we assessed whether leptin replacement would ameliorate this condition... - WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 miceChieh J Chou
Diabetes Branch, NIDDK and the Metabolism Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:24484-9. 2002.... - Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophyCarlo Colombo
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Diabetes 51:2727-33. 2002..Taken together, these results suggest that sequestration of triglycerides into fat may not be enough to restore a nondiabetic phenotype and that leptin deficiency plays a major role in causing the metabolic complications of lipoatrophy... - A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohortDanielle M Greenawalt
Merck Research Laboratories, Boston, MA 02115, USA
Genome Res 21:1008-16. 2011..These data can aid in elucidating the key networks associated with morbid obesity, response to RYGB, and disease as a whole... - Why do obese patients not lose more weight when treated with low-calorie diets? A mechanistic perspectiveSteven B Heymsfield
Merck and Company, Rahway, NJ, USA
Am J Clin Nutr 85:346-54. 2007.... - Discovery of imidazole carboxamides as potent and selective CCK1R agonistsCheng Zhu
Department of Medicinal Chemistry, Merck Research Laboratories, Merck and Co Inc, PO Box 2000, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 18:4393-6. 2008..Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities... - Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonistsMichael M C Lo
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 21:2040-3. 2011..We describe the discovery of 2a, which has mid-nanomolar potency, selectivity for human BRS-3 versus the other bombesin-like receptors, and good bioavailability... - Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonistsShuwen He
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 20:1913-7. 2010..This effort led to the discovery of compound 22e with significantly improved potency at both rodent and human BRS-3... - Characterization of the bombesin-like peptide receptor family in primatesHideki Sano
Department of Metabolic Disorders, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
Genomics 84:139-46. 2004.... - Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless miceJason K Kim
Department of Internal Medicine, Section of Endocrinology, Howard Hughes Medical Institute, Yale University School of Medicine, S269C CAB, PO Box 208020, New Haven, CT 06520 8020, USA
Diabetes 52:1311-8. 2003..In conclusion, these data support the hypothesis that rosiglitazone treatment enhanced insulin action in skeletal muscle mostly by its ability to repartition fat away from skeletal muscle... - Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypesKimihiko Matsusue
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892, USA
J Clin Invest 111:737-47. 2003..These data indicate that hepatic PPARgamma plays a critical role in the regulation of TG content and in the homeostasis of blood glucose and insulin resistance in steatotic diabetic mice... - Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenaseLaura J Brown
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
J Biol Chem 277:32892-8. 2002..We conclude that, although mGPD is not essential for thyroid thermogenesis, variations in its function affect viability and adiposity in mice... - Genetics of gene expression and its effect on diseaseValur Emilsson
deCODE Genetics, 101 Reykjavik, Iceland
Nature 452:423-8. 2008..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits... - Magic bullets melt fatMarc L Reitman
Nat Med 10:581-2. 2004