Affiliation: Merck Research Laboratories
- Understanding Forkhead box class O function: lessons from Drosophila melanogasterOscar Puig
Molecular Profiling Research Informatics, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Antioxid Redox Signal 14:635-47. 2011..In this review, we summarize the studies leading to dFOXO identification and its characterization as a central regulator of metabolism, life span, cell cycle, growth, and stress resistance...
- A gene expression signature that classifies human atherosclerotic plaque by relative inflammation statusOscar Puig
Department of Molecular Profiling, Merck Research Laboratories, Rahway, NJ 07033, USA
Circ Cardiovasc Genet 4:595-604. 2011..Both improvements will be facilitated by greater exploration of the biology of atherosclerotic plaque. To this end, we carried out large-scale gene expression analysis of human atherosclerotic lesions...
- Insights to transcriptional networks by using high throughput RNAi strategiesJaakko Mattila
Merck Research Laboratories, Department of Molecular Profiling Research Informatics, Rahway, NJ 07065, USA
Brief Funct Genomics 9:43-52. 2010..We focus our discussion in experimental approaches designed to uncover regulatory interactions modulating transcription factor activity...
- siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipidsMarija Tadin-Strapps
Sirna Therapeutics, Inc, San Francisco, CA, USA
J Lipid Res 52:1084-97. 2011..Results presented here demonstrate a new mouse model for investigating additional targets within the ApoB pathways using the siRNA modality...
- Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclaseJaakko Mattila
Department of Molecular Profiling, Merck Research Laboratories, 126 East Lincoln Ave, RY80M 179, Rahway, NJ 07065, USA
Mol Cell Biol 29:5357-65. 2009..dFoxO activation of AC76E in the CA increases starvation resistance and limits growth. Our results unravel a new role for dFoxO, integrating cAMP and insulin signaling to adapt organism growth to the existing nutritional conditions...
- Metabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissueLiwen Zhang
Department of Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
Transgenic Res 21:633-44. 2012..Transient transfection of rtTA, but not tTS, into 3T3-L1 cells resulted in lipid accumulation. We conclude that expression of rtTA in adipose tissue causes metabolic syndrome in mice...
- Altered lipoprotein metabolism in P2Y(13) knockout miceDaniel Blom
Department of Cardiovascular Diseases, Merck and Co, Inc, Rahway, NJ 07065, USA
Biochim Biophys Acta 1801:1349-60. 2010..Taken together, our experiments assess a role for the purinergic receptor P2Y(13) in the regulation of lipoprotein metabolism and demonstrate that modulating its activity could be of benefit to the treatment of dyslipidemia in people...
- Transcriptome profiling and network analysis of genetically hypertensive mice identifies potential pharmacological targets of hypertensionOscar Puig
Department of Molecular Profiling Research Informatics, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Physiol Genomics 42:24-32. 2010..The integration of data from gene expression profiling and genetics networks is a valuable approach to identify novel potential targets for the pharmacological treatment of hypertension...