Oscar Puig

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi Understanding Forkhead box class O function: lessons from Drosophila melanogaster
    Oscar Puig
    Molecular Profiling Research Informatics, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Antioxid Redox Signal 14:635-47. 2011
  2. doi A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status
    Oscar Puig
    Department of Molecular Profiling, Merck Research Laboratories, Rahway, NJ 07033, USA
    Circ Cardiovasc Genet 4:595-604. 2011
  3. pmc Insights to transcriptional networks by using high throughput RNAi strategies
    Jaakko Mattila
    Merck Research Laboratories, Department of Molecular Profiling Research Informatics, Rahway, NJ 07065, USA
    Brief Funct Genomics 9:43-52. 2010
  4. pmc siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids
    Marija Tadin-Strapps
    Sirna Therapeutics, Inc, San Francisco, CA, USA
    J Lipid Res 52:1084-97. 2011
  5. pmc Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase
    Jaakko Mattila
    Department of Molecular Profiling, Merck Research Laboratories, 126 East Lincoln Ave, RY80M 179, Rahway, NJ 07065, USA
    Mol Cell Biol 29:5357-65. 2009
  6. doi Metabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissue
    Liwen Zhang
    Department of Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    Transgenic Res 21:633-44. 2012
  7. doi Altered lipoprotein metabolism in P2Y(13) knockout mice
    Daniel Blom
    Department of Cardiovascular Diseases, Merck and Co, Inc, Rahway, NJ 07065, USA
    Biochim Biophys Acta 1801:1349-60. 2010
  8. doi Transcriptome profiling and network analysis of genetically hypertensive mice identifies potential pharmacological targets of hypertension
    Oscar Puig
    Department of Molecular Profiling Research Informatics, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Physiol Genomics 42:24-32. 2010

Collaborators

Detail Information

Publications8

  1. doi Understanding Forkhead box class O function: lessons from Drosophila melanogaster
    Oscar Puig
    Molecular Profiling Research Informatics, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Antioxid Redox Signal 14:635-47. 2011
    ..In this review, we summarize the studies leading to dFOXO identification and its characterization as a central regulator of metabolism, life span, cell cycle, growth, and stress resistance...
  2. doi A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status
    Oscar Puig
    Department of Molecular Profiling, Merck Research Laboratories, Rahway, NJ 07033, USA
    Circ Cardiovasc Genet 4:595-604. 2011
    ..Both improvements will be facilitated by greater exploration of the biology of atherosclerotic plaque. To this end, we carried out large-scale gene expression analysis of human atherosclerotic lesions...
  3. pmc Insights to transcriptional networks by using high throughput RNAi strategies
    Jaakko Mattila
    Merck Research Laboratories, Department of Molecular Profiling Research Informatics, Rahway, NJ 07065, USA
    Brief Funct Genomics 9:43-52. 2010
    ..We focus our discussion in experimental approaches designed to uncover regulatory interactions modulating transcription factor activity...
  4. pmc siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids
    Marija Tadin-Strapps
    Sirna Therapeutics, Inc, San Francisco, CA, USA
    J Lipid Res 52:1084-97. 2011
    ..Results presented here demonstrate a new mouse model for investigating additional targets within the ApoB pathways using the siRNA modality...
  5. pmc Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase
    Jaakko Mattila
    Department of Molecular Profiling, Merck Research Laboratories, 126 East Lincoln Ave, RY80M 179, Rahway, NJ 07065, USA
    Mol Cell Biol 29:5357-65. 2009
    ..dFoxO activation of AC76E in the CA increases starvation resistance and limits growth. Our results unravel a new role for dFoxO, integrating cAMP and insulin signaling to adapt organism growth to the existing nutritional conditions...
  6. doi Metabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissue
    Liwen Zhang
    Department of Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    Transgenic Res 21:633-44. 2012
    ..Transient transfection of rtTA, but not tTS, into 3T3-L1 cells resulted in lipid accumulation. We conclude that expression of rtTA in adipose tissue causes metabolic syndrome in mice...
  7. doi Altered lipoprotein metabolism in P2Y(13) knockout mice
    Daniel Blom
    Department of Cardiovascular Diseases, Merck and Co, Inc, Rahway, NJ 07065, USA
    Biochim Biophys Acta 1801:1349-60. 2010
    ..Taken together, our experiments assess a role for the purinergic receptor P2Y(13) in the regulation of lipoprotein metabolism and demonstrate that modulating its activity could be of benefit to the treatment of dyslipidemia in people...
  8. doi Transcriptome profiling and network analysis of genetically hypertensive mice identifies potential pharmacological targets of hypertension
    Oscar Puig
    Department of Molecular Profiling Research Informatics, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Physiol Genomics 42:24-32. 2010
    ..The integration of data from gene expression profiling and genetics networks is a valuable approach to identify novel potential targets for the pharmacological treatment of hypertension...