Vincenzo Pucci

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Development of a simple and reliable accurate mass liquid chromatography/electrospray ionization mass spectrometry method for high-resolution accurate mass determinations of new drug entities on a triple quadrupole mass spectrometer
    Vincenzo Pucci
    Department of Drug Metabolism and Pharmacokinetics, Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Merck Sharp and Dohme Research Laboratories, Via Pontina Km 30 600, 00040 Pomezia, Roma, Italy
    Rapid Commun Mass Spectrom 21:3051-9. 2007
  2. ncbi Liquid chromatographic analysis of the cis(Z)- and trans(E)-isomers of clopenthixol in human plasma using a novel solid phase extraction procedure
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 792:313-21. 2003
  3. ncbi High-performance liquid chromatographic determination of Levetiracetam in human plasma: comparison of different sample clean-up procedures
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Biomed Chromatogr 18:37-44. 2004
  4. ncbi Enhanced mass resolution method development, validation and assay application to support preclinical studies of a new drug candidate
    Vincenzo Pucci
    Department of Pharmacology, Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Merck Sharp and Dohme Research Laboratories, Via Pontina Km 30 600, 00040 Pomezia, Roma, Italy
    Rapid Commun Mass Spectrom 20:1240-6. 2006
  5. ncbi HILIC LC-MS for the determination of 2'-C-methyl-cytidine-triphosphate in rat liver
    Vincenzo Pucci
    Department of Drug Metabolism and Pharmaceuticals, Merck and Co, Inc, Boston, MA 02115, USA
    J Sep Sci 32:1275-83. 2009
  6. ncbi Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
    M Emilia Di Francesco
    Istituto di Ricerche di Biologia Molecolare P Angeletti S p A, Merck Research Laboratories Rome, Via Pontina Km 30, 600, 00040 Pomezia, Italy
    Bioorg Med Chem 20:4801-11. 2012
  7. ncbi Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection
    Cristina Gardelli
    Department of Medicinal Chemistry, Istituto di Ricerche di Biologia Molecolare, P Angeletti SpA IRBM MRL Rome, Pomezia, Italy
    J Med Chem 52:5394-407. 2009
  8. ncbi A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of HybridSPE
    Vincenzo Pucci
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA vincenzo
    J Pharm Biomed Anal 50:867-71. 2009
  9. ncbi Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine
    Malte Meppen
    Department of Chemistry Istituto di Ricerche di Biologia Molecolare, P Angeletti S p A IRBM MRL Rome, Via Pontina Km 30 600, 00040 Pomezia, Italy
    Eur J Med Chem 44:3765-70. 2009
  10. ncbi High sensitivity determination of valproic acid in mouse plasma using semi-automated sample preparation and liquid chromatography with tandem mass spectrometric detection
    Vincenzo Pucci
    Istituto di Ricerche di Biologia Molecolare P. Angeletti, Merck Sharp and Dohme Research Laboratories, Via Pontina Km 30.600, 00040 Pomezia, Roma, Italy
    Rapid Commun Mass Spectrom 19:3713-8. 2005

Collaborators

Detail Information

Publications16

  1. ncbi Development of a simple and reliable accurate mass liquid chromatography/electrospray ionization mass spectrometry method for high-resolution accurate mass determinations of new drug entities on a triple quadrupole mass spectrometer
    Vincenzo Pucci
    Department of Drug Metabolism and Pharmacokinetics, Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Merck Sharp and Dohme Research Laboratories, Via Pontina Km 30 600, 00040 Pomezia, Roma, Italy
    Rapid Commun Mass Spectrom 21:3051-9. 2007
    ..Moreover, all the experimentally determined accurate mass measurements gave satisfactory results in terms of accuracy (lower than 5 ppm)...
  2. ncbi Liquid chromatographic analysis of the cis(Z)- and trans(E)-isomers of clopenthixol in human plasma using a novel solid phase extraction procedure
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 792:313-21. 2003
    ..The method was successfully applied to the determination of cis(Z)-clopenthixol and trans(E)-clopenthixol in plasma samples of schizophrenic patients undergoing therapy with zuclopenthixol...
  3. ncbi High-performance liquid chromatographic determination of Levetiracetam in human plasma: comparison of different sample clean-up procedures
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Biomed Chromatogr 18:37-44. 2004
    ..However, they are cheaper and faster when compared with the solid-phase extraction procedure...
  4. ncbi Enhanced mass resolution method development, validation and assay application to support preclinical studies of a new drug candidate
    Vincenzo Pucci
    Department of Pharmacology, Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Merck Sharp and Dohme Research Laboratories, Via Pontina Km 30 600, 00040 Pomezia, Roma, Italy
    Rapid Commun Mass Spectrom 20:1240-6. 2006
    ..The enhanced mass resolution method herein described was successfully applied to the evaluation of the pharmacokinetic profile of a new drug candidate in rat, rabbit and dog plasma samples...
  5. ncbi HILIC LC-MS for the determination of 2'-C-methyl-cytidine-triphosphate in rat liver
    Vincenzo Pucci
    Department of Drug Metabolism and Pharmaceuticals, Merck and Co, Inc, Boston, MA 02115, USA
    J Sep Sci 32:1275-83. 2009
    ..6-11.5%) and accuracy (94.4-102.4%) as well as for recovery (82.0-112.6%) and selectivity. The method has been successfully applied for pharmacokinetic studies of 2'-C-methyl-cytidine-triphosphate in liver tissue samples...
  6. ncbi Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
    M Emilia Di Francesco
    Istituto di Ricerche di Biologia Molecolare P Angeletti S p A, Merck Research Laboratories Rome, Via Pontina Km 30, 600, 00040 Pomezia, Italy
    Bioorg Med Chem 20:4801-11. 2012
    ....
  7. ncbi Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection
    Cristina Gardelli
    Department of Medicinal Chemistry, Istituto di Ricerche di Biologia Molecolare, P Angeletti SpA IRBM MRL Rome, Pomezia, Italy
    J Med Chem 52:5394-407. 2009
    ..Our SAR studies ultimately led to compounds that gave high levels of NTP in hamster and rat liver after subcutaneous dosing and that were devoid of the toxic phenol moiety usually found in ProTides...
  8. ncbi A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of HybridSPE
    Vincenzo Pucci
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA vincenzo
    J Pharm Biomed Anal 50:867-71. 2009
    ....
  9. ncbi Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine
    Malte Meppen
    Department of Chemistry Istituto di Ricerche di Biologia Molecolare, P Angeletti S p A IRBM MRL Rome, Via Pontina Km 30 600, 00040 Pomezia, Italy
    Eur J Med Chem 44:3765-70. 2009
    ..The application of a monophosphate prodrug approach based on unprecedented cyclic phosphoramidates is reported. Our SAR studies led to compounds that are efficiently converted to the active triphosphate in human hepatocytes...
  10. ncbi High sensitivity determination of valproic acid in mouse plasma using semi-automated sample preparation and liquid chromatography with tandem mass spectrometric detection
    Vincenzo Pucci
    Istituto di Ricerche di Biologia Molecolare P. Angeletti, Merck Sharp and Dohme Research Laboratories, Via Pontina Km 30.600, 00040 Pomezia, Roma, Italy
    Rapid Commun Mass Spectrom 19:3713-8. 2005
    ..15-100 microg/mL. The limit of detection was 75 ng/mL and the lower limit of quantitation was 150 ng/mL. Intra- and inter-day validation assays of the semi-automated plasma analysis showed satisfactory accuracy and precision...
  11. ncbi Quantitation of oxcarbazepine and its metabolites in human plasma by micellar electrokinetic chromatography
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Biomed Chromatogr 17:231-8. 2003
    ..1%, both expressed as RSD%. The results obtained analysing real plasma samples from epileptic patients under therapy with Tolep were satisfactory in terms of precision, accuracy and detectability...
  12. ncbi Analysis of lamotrigine and its metabolites in human plasma and urine by micellar electrokinetic capillary chromatography
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alma Mater Studiorum - University of Bologna, Bologna, Italy
    Electrophoresis 26:935-42. 2005
    ....
  13. ncbi Reversed-phase capillary electrochromatography for the simultaneous determination of acetylsalicylic acid, paracetamol, and caffeine in analgesic tablets
    Vincenzo Pucci
    University of Bologna, Department of Pharmaceutical Sciences, Bologna, Italy
    Electrophoresis 25:615-21. 2004
    ..1-0.8% was found for retention times, while the RSD values for the peak area ratios (Aanalyte/AIS) were in the range of 1.9-2.9%. The optimized CEC method was applied to the analysis of the studied compounds present in commercial tablets...
  14. ncbi Determination of progesterone in commercial formulations and in non conventional micellar systems
    Vincenzo Pucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, Italy
    J Pharm Biomed Anal 30:1549-59. 2003
    ..The results obtained with the two methods are in good agreement and always satisfactory in terms of precision and accuracy...
  15. ncbi Determination of melatonin in galenic preparations by LC and voltammetry
    Maria Augusta Raggi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 29:283-9. 2002
    ..0 and 101.3%. Both methods are suitable for quality control of melatonin in galenic preparations; the LSV procedure is more rapid, the HPLC method is more sensitive and more precise...
  16. ncbi Separation of carbamazepine and five metabolites, and analysis in human plasma by micellar electrokinetic capillary chromatography
    Maria Augusta Raggi
    Department of Pharmaceutical Sciences, University of Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 770:217-25. 2002
    ..The overall precision of the method gives a mean RSD of about 1.8%. The limit of quantitation for all analytes is < or = 0.30 microg ml(-1), the limit of detection < or = 0.12 microg ml(-1)...