Stacey L Polsky-Fisher

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers
    Stacey L Polsky-Fisher
    Department of Drug Metabolism, WP75B 200, Merck Research Laboratories, West Point PA 19486, USA
    Drug Metab Dispos 34:1004-11. 2006
  2. ncbi request reprint Effect of cytochromes P450 chemical inhibitors and monoclonal antibodies on human liver microsomal esterase activity
    Stacey L Polsky-Fisher
    M S, Department of Drug Metabolism, WP75B 200, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 34:1361-6. 2006
  3. ncbi request reprint Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 35:1301-7. 2007
  4. doi request reprint CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist
    Cuyue Tang
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, WP75A 203, Merck and Co, Inc, West Point, PA 19486, USA
    J Pharmacol Exp Ther 325:935-46. 2008

Detail Information

Publications4

  1. ncbi request reprint Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers
    Stacey L Polsky-Fisher
    Department of Drug Metabolism, WP75B 200, Merck Research Laboratories, West Point PA 19486, USA
    Drug Metab Dispos 34:1004-11. 2006
    ..In healthy male subjects, therefore, TPA023 is well absorbed and is metabolized extensively (t-butyl hydroxylation and N-deethylation > glucuronidation), and the metabolites are excreted in urine and feces...
  2. ncbi request reprint Effect of cytochromes P450 chemical inhibitors and monoclonal antibodies on human liver microsomal esterase activity
    Stacey L Polsky-Fisher
    M S, Department of Drug Metabolism, WP75B 200, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 34:1361-6. 2006
    ..Additional experiments to assess the contribution of oxidative enzymes in the metabolism of esters may include incubations in the presence and absence of beta-nicotinamide adenine dinucleotide 2'-phosphate reduced...
  3. ncbi request reprint Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 35:1301-7. 2007
    ..It is concluded that CYP3A4 plays a major role in TPA023 metabolism, and CYP3A5 may also contribute at higher concentrations of the compound...
  4. doi request reprint CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist
    Cuyue Tang
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, WP75A 203, Merck and Co, Inc, West Point, PA 19486, USA
    J Pharmacol Exp Ther 325:935-46. 2008
    ..Therefore, MK-0686, both a substrate and inducer for CYP2C75, caused autoinduction of its own metabolism in rhesus monkeys by increasing the expression of this enzyme...