Yi Pei

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. pmc Quantitative evaluation of siRNA delivery in vivo
    Yi Pei
    Department of RNA Therapeutics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    RNA 16:2553-63. 2010
  2. doi request reprint Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape
    Rene Bartz
    Department of RNA Therapeutics, Merck and Co Inc, 770 Sumneytown Pike, West Point, PA 19486, USA
    Biochem J 435:475-87. 2011
  3. doi request reprint RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice
    Jie Wei
    Sirna Therapeutics, San Francisco, CA 94158, USA
    Mol Pharmacol 79:953-63. 2011
  4. doi request reprint Assessing the heterogeneity level in lipid nanoparticles for siRNA delivery: size-based separation, compositional heterogeneity, and impact on bioperformance
    Jingtao Zhang
    Department of Pharmaceutical Sciences, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, United States
    Mol Pharm 10:397-405. 2013
  5. doi request reprint Effect of biological matrix and sample preparation on qPCR quantitation of siRNA drugs in animal tissues
    Jessica Seitzer
    Department of RNA Therapeutics, Merck and Co, Inc, West Point, PA 19486, USA
    J Pharmacol Toxicol Methods 63:168-73. 2011

Collaborators

Detail Information

Publications5

  1. pmc Quantitative evaluation of siRNA delivery in vivo
    Yi Pei
    Department of RNA Therapeutics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    RNA 16:2553-63. 2010
    ..The described methodologies have utility for the study of silencing mechanism, the development of siRNA therapeutics, and clinical trial design...
  2. doi request reprint Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape
    Rene Bartz
    Department of RNA Therapeutics, Merck and Co Inc, 770 Sumneytown Pike, West Point, PA 19486, USA
    Biochem J 435:475-87. 2011
    ..These results indicate a peptide-mediated siRNA delivery through a pH-dependent and conformation-specific interaction with cellular membranes and not with the cargo...
  3. doi request reprint RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice
    Jie Wei
    Sirna Therapeutics, San Francisco, CA 94158, USA
    Mol Pharmacol 79:953-63. 2011
    ....
  4. doi request reprint Assessing the heterogeneity level in lipid nanoparticles for siRNA delivery: size-based separation, compositional heterogeneity, and impact on bioperformance
    Jingtao Zhang
    Department of Pharmaceutical Sciences, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, United States
    Mol Pharm 10:397-405. 2013
    ..This capability in tandem with the pursuit of improved formulation and process design can lead to more facile development of LNP-based siRNA pharmaceuticals of higher quality...
  5. doi request reprint Effect of biological matrix and sample preparation on qPCR quantitation of siRNA drugs in animal tissues
    Jessica Seitzer
    Department of RNA Therapeutics, Merck and Co, Inc, West Point, PA 19486, USA
    J Pharmacol Toxicol Methods 63:168-73. 2011
    ..Stem-loop qRT-PCR is a sensitive and precise methodology, but the effect of biological matrix and purity of the input sample has yet to be investigated...