A P Owens

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint High affinity phenylglycinol-based NK1 receptor antagonists
    A P Owens
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, U K
    Bioorg Med Chem Lett 8:51-6. 1998
  2. ncbi request reprint High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors
    Andrew P Owens
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 13:4143-5. 2003
  3. ncbi request reprint An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration
    T Harrison
    The Neuroscience Research Centre, Merck, Sharp and Dohme, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    J Med Chem 44:4296-9. 2001
  4. ncbi request reprint Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression
    M Guscott
    Neuroscience Research Centre, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Neuropharmacology 48:492-502. 2005

Detail Information

Publications4

  1. ncbi request reprint High affinity phenylglycinol-based NK1 receptor antagonists
    A P Owens
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, U K
    Bioorg Med Chem Lett 8:51-6. 1998
    ....
  2. ncbi request reprint High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors
    Andrew P Owens
    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Bioorg Med Chem Lett 13:4143-5. 2003
    ..We disclose structure-activity relationships based around the 1, 3 and 5 positions of the benzodiazepine core structure...
  3. ncbi request reprint An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration
    T Harrison
    The Neuroscience Research Centre, Merck, Sharp and Dohme, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    J Med Chem 44:4296-9. 2001
    ..Compound 3 is highly effective in pre-clinical tests that are relevant to clinical efficacy in emesis and depression...
  4. ncbi request reprint Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression
    M Guscott
    Neuroscience Research Centre, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Neuropharmacology 48:492-502. 2005
    ..These pharmacological and genetic knockout studies provide the first direct evidence that 5-HT7 receptor antagonists should be investigated for efficacy in the treatment of depression...