A P Owens
Affiliation: Merck Research Laboratories
- High affinity phenylglycinol-based NK1 receptor antagonistsA P Owens
Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, U K
Bioorg Med Chem Lett 8:51-6. 1998....
- High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitorsAndrew P Owens
Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
Bioorg Med Chem Lett 13:4143-5. 2003..We disclose structure-activity relationships based around the 1, 3 and 5 positions of the benzodiazepine core structure...
- An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administrationT Harrison
The Neuroscience Research Centre, Merck, Sharp and Dohme, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
J Med Chem 44:4296-9. 2001..Compound 3 is highly effective in pre-clinical tests that are relevant to clinical efficacy in emesis and depression...
- Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depressionM Guscott
Neuroscience Research Centre, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
Neuropharmacology 48:492-502. 2005..These pharmacological and genetic knockout studies provide the first direct evidence that 5-HT7 receptor antagonists should be investigated for efficacy in the treatment of depression...