Affiliation: Merck Research Laboratories
Nolte H, Maloney J, Nelson H, Bernstein D, Lu S, Li Z, et al
. Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber. J Allergy Clin Immunol. 2015;135:1494-501.e6 pubmed publisher
..The onset of action for 12 DU of MK-8237 was weekÂ 8.Â MK-8237, 12 DU, is appropriate for further evaluation to determine the magnitude of effect in an uncontrolled allergenÂ exposure environment. ..
Nolte M, Barber D, Maloney J, Li Z, Kaur A, Galán A, et al
. Timothy specific IgE levels are associated with efficacy and safety of timothy grass sublingual immunotherapy tablet. Ann Allergy Asthma Immunol. 2015;115:509-515.e2 pubmed publisher
..Sensitization profiles varied by region. Trends toward higher efficacy and increased TRAE incidence in subjects with higher pretreatment Phl p IgE levels were observed. www.clinicaltrials.gov, identifier NCT01385371. ..
Maloney J, Prenner B, Bernstein D, Lu S, Gawchik S, Berman G, et al
. Safety of house dust mite sublingual immunotherapy standardized quality tablet in children allergic to house dust mites. Ann Allergy Asthma Immunol. 2016;116:59-65 pubmed publisher
..The 6 and 12 SQ-HDM doses of the HDM SLIT tablet MK-8237 were well tolerated, and local AEs were of short duration. ClinicalTrials.gov, identifier NCT01678807. ..
Maloney J, Berman G, Gagnon R, Bernstein D, Nelson H, Kleine Tebbe J, et al
. Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated. J Allergy Clin Immunol Pract. 2016;4:301-9.e2 pubmed publisher
..In this trial, a 4-week sequential SLIT-tablet dosing schedule followed by simultaneous intake of timothy grass and ragweed tablets was well tolerated. ..
Creticos P, Bernstein D, Casale T, Lockey R, Maloney J, Nolte H. Coseasonal Initiation of Allergen Immunotherapy: A Systematic Review. J Allergy Clin Immunol Pract. 2016;4:1194-1204.e4 pubmed publisher
..No increase in AEs of concern was observed with SCIT or SLIT CSI; however, additional data with standardized regimens and doses are needed. ..
Durham S, Creticos P, Nelson H, Li Z, Kaur A, Meltzer E, et al
. Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses. J Allergy Clin Immunol. 2016;138:1081-1088.e4 pubmed publisher
..HDM SLIT-tablet effects were numerically greater than all pharmacotherapies for PAR. SLIT-tablets offer the additional benefit of long-term efficacy. ..
Nolte H, Casale T, Lockey R, Fogh B, Kaur A, Lu S, et al
. Epinephrine Use in Clinical Trials of Sublingual Immunotherapy Tablets. J Allergy Clin Immunol Pract. 2017;5:84-89.e3 pubmed publisher
..All SLIT-tablet-related events treated with epinephrine were nonserious. ..
Nolte H, Pavord I, Backer V, Spector S, Shekar T, Gates D, et al
. Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma. Respir Med. 2013;107:656-64 pubmed publisher
..These findings suggest both inflammatory markers may be useful in assessing corticosteroid responsiveness in asthma patients, and perhaps identifying the same asthma subphenotype. Clinical Trials.gov: NCT00635882. ..
Nolte H, Bernstein D, Nelson H, Kleine Tebbe J, Sussman G, Seitzberg D, et al
. Efficacy of house dust mite sublingual immunotherapy tablet in North American adolescents and adults in a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2016;138:1631-1638 pubmed publisher
..In the first North American trial of use of a SLIT-tablet for HDM allergy, 12 SQ-HDM was well tolerated and improved HDM-induced rhinitis symptoms in adults and adolescents. ..