D W Nicholson

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Caspase structure, proteolytic substrates, and function during apoptotic cell death
    D W Nicholson
    Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada and Co, PO Box 1005, Pointe Claire Dorval, Quebec, Canada, H9R 4P8
    Cell Death Differ 6:1028-42. 1999
  2. ncbi request reprint ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis
    D W Nicholson
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Nat Biotechnol 14:297-301. 1996
  3. ncbi request reprint From bench to clinic with apoptosis-based therapeutic agents
    D W Nicholson
    Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Pointe Claire Dorval, Quebec, Canada
    Nature 407:810-6. 2000
  4. pmc Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide
    S Roy
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, PQ Canada
    Proc Natl Acad Sci U S A 98:6132-7. 2001
  5. ncbi request reprint Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis
    P Tawa
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada, H9H 3L1
    Cell Death Differ 8:30-7. 2001
  6. ncbi request reprint Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors
    P Tawa
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Cell Death Differ 11:439-47. 2004
  7. pmc Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis
    S Xanthoudakis
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada H9H 3L1
    EMBO J 18:2049-56. 1999
  8. ncbi request reprint Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
    F G Gervais
    Department of Pharmacology, Biochemistry, and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Kirkland, Quebec, Canada
    Cell 97:395-406. 1999
  9. ncbi request reprint Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
    D M Rasper
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada, H9R 4P8
    Cell Death Differ 5:271-88. 1998
  10. ncbi request reprint Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    D W Nicholson
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Nature 376:37-43. 1995

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Caspase structure, proteolytic substrates, and function during apoptotic cell death
    D W Nicholson
    Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada and Co, PO Box 1005, Pointe Claire Dorval, Quebec, Canada, H9R 4P8
    Cell Death Differ 6:1028-42. 1999
    ..In some cases, caspases also play a contributory role in escalating the propensity for apoptosis, and in doing so may exacerbate disease pathogenesis...
  2. ncbi request reprint ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis
    D W Nicholson
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Nat Biotechnol 14:297-301. 1996
    ..elegans. Among a growing number of potential molecular targets for the control of human diseases where inappropriate apoptosis is prominent, ICE/CED-3-like proteases may be an attractive and tangible point for therapeutic intervention...
  3. ncbi request reprint From bench to clinic with apoptosis-based therapeutic agents
    D W Nicholson
    Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Pointe Claire Dorval, Quebec, Canada
    Nature 407:810-6. 2000
    ..Nevertheless, practical therapeutics that modulate apoptosis will no doubt appear in the clinic or on the shelf in the next few years...
  4. pmc Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide
    S Roy
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, PQ Canada
    Proc Natl Acad Sci U S A 98:6132-7. 2001
    ..We propose that the caspase-3 safety catch is a key regulatory checkpoint in the apoptotic cascade that regulates terminal events in the caspase cascade by modulating the triggering of caspase-3 activation...
  5. ncbi request reprint Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis
    P Tawa
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada, H9H 3L1
    Cell Death Differ 8:30-7. 2001
    ..Based on a biochemical analysis of the compounds identified it is clear that this assay can be used to detect drugs which inhibit caspases directly as well as those which target upstream components of the caspase cascade...
  6. ncbi request reprint Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors
    P Tawa
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Cell Death Differ 11:439-47. 2004
    ..Furthermore, turnover of otherwise stable active site mutants of capase-3 is rescued by the presence of the active enzyme suggesting that turnover can be mediated in trans...
  7. pmc Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis
    S Xanthoudakis
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada H9H 3L1
    EMBO J 18:2049-56. 1999
    ..We propose that the ATP-dependent 'foldase' activity of Hsp60 improves the vulnerability of pro-caspase-3 to proteolytic maturation by upstream caspases and that this represents an important regulatory event in apoptotic cell death...
  8. ncbi request reprint Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
    F G Gervais
    Department of Pharmacology, Biochemistry, and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Kirkland, Quebec, Canada
    Cell 97:395-406. 1999
    ..Caspases thus appear to play a dual role in proteolytic processing of APP and the resulting propensity for A beta peptide formation, as well as in the ultimate apoptotic death of neurons in Alzheimer's disease...
  9. ncbi request reprint Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
    D M Rasper
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada, H9R 4P8
    Cell Death Differ 5:271-88. 1998
    ..Usurpin thus appears to be an endogenous modulator of apoptosis sensitivity in mammalian cells, including the susceptibility of cardiac myocytes to apoptotic death following ischemia/ reperfusion injury...
  10. ncbi request reprint Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    D W Nicholson
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Nature 376:37-43. 1995
    ..A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death...
  11. pmc Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits
    D W Nicholson
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, PQ, Canada
    Proc Natl Acad Sci U S A 90:2015-9. 1993
    ..We therefore conclude that human LTC4 synthase is a glutathione S-transferase composed of an 18-kDa polypeptide that is enzymatically active as a homodimer and may be phosphoregulated in vivo...
  12. ncbi request reprint Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities
    K Hell
    Merck Research Laboratories, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire Dorval, Quebec, Canada H9R 4P8
    Cell Death Differ 10:1234-9. 2003
    ..In addition, this may be particularly relevant in Alzheimer's disease since the caspase-generated C31 peptide, an established cytotoxin, acquires Smac/Diablo-like properties after apoptotic processing...
  13. ncbi request reprint Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung
    E A Frey
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire, Dorval, Quebec, Canada
    Eur J Pharmacol 244:239-50. 1993
    ..In conclusion, the leukotriene D4 receptor in differentiated U937 cell membranes resembles that in human lung, validating the use of this cell line as a suitable source of receptor in the development of potent specific antagonists...
  14. ncbi request reprint Demonstration of cell-specific phosphorylation of LTC4 synthase
    N Gupta
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Que, Canada
    FEBS Lett 449:66-70. 1999
    ..This represents the first direct demonstration of LTC4S phosphorylation in whole cells...
  15. ncbi request reprint Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide
    F G Gervais
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec H9R 4P8, Canada
    J Biol Chem 273:17102-8. 1998
    ..This appears to be the first example of a caspase substrate where the cleavage sites are not conserved between species...
  16. ncbi request reprint Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases
    N A Munday
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Biol Chem 270:15870-6. 1995
    ..ICErel-II and ICErel-III may, therefore, participate in proteolytic events culminating in the apoptotic death of human cells...
  17. ncbi request reprint Purification and catalytic properties of human caspase family members
    M Garcia-Calvo
    Department of Enzymology, Merck Research Laboratories, R80W 250, P O Box 2000, Rahway, New Jersey 07065, USA
    Cell Death Differ 6:362-9. 1999
    ..g. pH, NaCl, Ca2+) on the activities of these enzymes. Some of these variables have a profound effect on the rate of catalysis, a finding that may have important biological implications...
  18. ncbi request reprint A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
    N A Thornberry
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 272:17907-11. 1997
    ....
  19. ncbi request reprint Pharmacological cross-reactivity between 5-lipoxygenase-activating protein, 5-lipoxygenase, and leukotriene C4 synthase
    N Gupta
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Can J Physiol Pharmacol 75:1212-9. 1997
    ..These results implicate that compounds that bind competitively to arachidonic acid binding sites on FLAP and 5-LO recognize motifs that are also weakly conserved on the binding site of LTC4 synthase...
  20. ncbi request reprint Inhibition of human caspases by peptide-based and macromolecular inhibitors
    M Garcia-Calvo
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 273:32608-13. 1998
    ....
  21. ncbi request reprint Neuroprotection by the inhibition of apoptosis
    G S Robertson
    Merck Frosst Institute for Therapeutic Research, Department of Pharmacology, Kirkland, Quebec, Canada
    Brain Pathol 10:283-92. 2000
    ..The present review will summarize some of the recent evidence suggesting that apoptosis inhibitors may become a practical therapeutic approach for both acute and chronic neurodegenerative conditions...
  22. ncbi request reprint Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells
    D W Nicholson
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Biol Chem 267:17849-57. 1992
    ..An 18-kDa membrane polypeptide, specifically labeled by a photoaffinity derivative of LTC4, is a candidate for being either LTC4 synthase or a subunit thereof...
  23. ncbi request reprint L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition
    Z Huang
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Biochem Pharmacol 73:1971-81. 2007
    ..Therefore, L-454,560 is a novel PDE4 inhibitor with an overall in vivo efficacy profile at least comparable to roflumilast and clearly superior to cilomilast...
  24. ncbi request reprint Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis
    R Petric
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, QC, Canada
    Biochim Biophys Acta 1254:207-15. 1995
    ..05). These results suggest a potential mechanism for enhanced cysteinyl LT formation in the development of experimental GN and further support their causal role in the etiology of this disease...
  25. ncbi request reprint Differential regulation of caspase-3 by pharmacological and developmental stimuli as demonstrated using humanised caspase-3 mice
    L E Kerr
    Fujisawa Institute of Neuroscience in Edinburgh, University of Edinburgh, EH8 9JZ, UK
    Apoptosis 9:739-47. 2004
    ..These data suggest that there is a fundamental difference between the activation pathways leading to caspase-3 cleavage during naturally occurring cell death in development/embryogenesis and following an apoptotic stimulus in the adult...
  26. ncbi request reprint Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
    C L Wellington
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 275:19831-8. 2000
    ..These results suggest that inhibiting caspase cleavage of htt may therefore be of potential therapeutic benefit in Huntington's disease...
  27. ncbi request reprint The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
    J Rotonda
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065 0900, USA
    Nat Struct Biol 3:619-25. 1996
    ....
  28. pmc Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
    M Mancini
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 149:603-12. 2000
    ..We propose that the Golgi complex, like mitochondria, senses and integrates unique local conditions, and transduces pro-apoptotic signals through local caspases, which regulate local effectors...
  29. pmc Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
    E A Slee
    Molecular Cell Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    J Cell Biol 144:281-92. 1999
    ..Caspase-3 is required for the activation of four other caspases (-2, -6, -8, and -10) in this pathway and also participates in a feedback amplification loop involving caspase-9...
  30. ncbi request reprint Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
    C L Wellington
    Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    J Biol Chem 273:9158-67. 1998
    ..Our results suggest that by generation of truncated polyglutamine-containing proteins, caspase cleavage may represent a common step in the pathogenesis of each of these neurodegenerative diseases...
  31. ncbi request reprint Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
    A J Darmon
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Nature 377:446-8. 1995
    ..Here we show that granzyme B cleaves and activates CPP32, the precursor of the protease responsible for cleavage of poly(ADP-ribose) polymerase...
  32. ncbi request reprint Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
    Y P Goldberg
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Genet 13:442-9. 1996
    ..Our results show that huntingtin is cleaved by cysteine proteases and suggest that HD might be a disorder of inappropriate apoptosis...
  33. ncbi request reprint Human ICE/CED-3 protease nomenclature
    E S Alnemri
    Cell 87:171. 1996
  34. ncbi request reprint Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice
    M T Simpson
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 21:7089-98. 2001
    ..These findings suggest that PNS neurons are dependent on caspase 3 for the execution of apoptosis and that caspase 3 may serve as a key therapeutic target for neuroprotection after injury of this cell type...
  35. ncbi request reprint Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons
    C M Cowan
    Centre for Molecular Medicine and Therapeutics, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 21:7099-109. 2001
    ....
  36. ncbi request reprint Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis
    B L Schwab
    Molecular Toxicology, Faculty of Biology, University of Konstanz, Germany
    Cell Death Differ 9:818-31. 2002
    ..These findings suggest that caspase-mediated cleavage and inactivation of PMCAs can lead to necrosis, an event that is reduced by caspase inhibitors in brain ischemia...
  37. ncbi request reprint Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
    S P Cregan
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 19:7860-9. 1999
    ..These studies demonstrate that p53-induced cell death in postmitotic neurons involves a Bax-dependent caspase-3 activation, suggesting that these molecules are important determinants in neuronal cell death after injury...
  38. ncbi request reprint Effects of fimbria-fornix transection on calpain and choline acetyl transferase activities in the septohippocampal pathway
    C Ayala-Grosso
    Department of Pharmacology and Therapeutics, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montreal, Canada H3G 1Y6
    Neuroscience 126:927-40. 2004
    ..These findings suggest that calpain activation contributes to the cholinergic cell body response and hippocampal axonal cytoskeletal degradation produced by transection of the septohippocampal pathway...
  39. ncbi request reprint Caspase-3 cleaved spectrin colocalizes with neurofilament-immunoreactive neurons in Alzheimer's disease
    C Ayala-Grosso
    Unidad de Bioquimica, Facultad de Farmacia, Universidad Central de Venezuela, Nueva Granada, Apartado postal 40109, Caracas, Venezuela
    Neuroscience 141:863-74. 2006
    ....
  40. ncbi request reprint Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q
    J Nasir
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Mamm Genome 8:56-9. 1997
  41. ncbi request reprint Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2
    S Hadano
    NeuroGenes, International Cooperative Research Project, Japan Science and Technology Corporation, Isehara, 259 1193, Japan
    Genomics 71:200-13. 2001
    ..These data strongly indicate that ALS2CR1, ALS2CR2, ALS2CR3, CFLAR, CASP10, and CASP8 are not causative genes for ALS2...
  42. pmc Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim
    Z Song
    Departments of Biology and Brain and Cognitive Sciences, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 20:2907-14. 2000
    ..Significantly, GMR-rpr and GMR-grim, but not GMR-hid, dramatically enhanced the eye phenotype of GMR-fl-dcp-1 flies. These results indicate that Reaper and Grim, but not HID, can activate DCP-1 in vivo...
  43. ncbi request reprint Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3
    S Hadano
    Department of Medical Genetics, and Centre for Molecular Medicine and Therapeutics, University of British Columbia, 980 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada
    Mamm Genome 10:757-60. 1999
  44. ncbi request reprint Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage
    E Keramaris
    Neuroscience Research Institute, University of Ottawa, Ontario, Canada
    Mol Cell Neurosci 15:368-79. 2000
    ..This suggests that the requirement for caspase 3 in death of neurons evoked by DNA damage may differ depending upon the developmental state of the cell...
  45. ncbi request reprint Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain
    A S Hackam
    Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 275:41299-308. 2000
    ..Our data identify HIP-1 as a novel proapoptotic mediator and suggest that HIP-1 may be a molecular accomplice in the pathogenesis of Huntington disease...
  46. ncbi request reprint Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents
    J L Vanderluit
    CORD Collaboration On Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Neurosci 12:3469-80. 2000
    ..These results demonstrate that caspase-3 activation plays important roles in the rapid demise of axotomized neonatal motoneurons...
  47. pmc p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
    F W Ng
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Cell Biol 139:327-38. 1997
    ..This raises the possibility that the p28 complex contributes to the regulation of procaspase-8 or a related caspase in response to E1A, dependent on the status of the Bcl-2 setpoint within the complex...
  48. ncbi request reprint Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Med 6:1241-7. 2000
    ..Our findings provide direct experimental evidence for compensatory pathways of caspase activation. This issue should therefore be considered in developing caspase inhibitors for therapeutic applications...
  49. ncbi request reprint HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin
    V S Chopra
    Department of Medical Genetics, and Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
    Mamm Genome 11:1006-15. 2000
    ..Interestingly, HIP12 does not interact with huntingtin but can interact with HIP1. suggesting a potential interaction in vivo that may influence the function of each respective protein...
  50. ncbi request reprint Actin cleavage by CPP-32/apopain during the development of apoptosis
    T Mashima
    Laboratory of Biomedical Research, Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Oncogene 14:1007-12. 1997
    ..Our present results indicate that actin is the substrate of CPP-32/apopain(-like) protease both in vitro and in vivo and suggest the role of actin in the control of cell growth and apoptosis...
  51. ncbi request reprint Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 1:496-501. 2000
    ..Thus, caspase inhibitors enhance immunity by preventing lymphocyte apoptosis and lymphocytes act rapidly, within 24 h, to control infection...